Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides

Authors: Clare, Rachel, Bardelle, Catherine, Harper, Paul, Hong, W., Börjesson, Ulf, Johnston, Kelly, Collier, Matthew, Myhill, Laura, Cassidy, Andrew, Plant, Darren, Plant, Helen, Clark, Roger, Cook, Darren, Steven, Andrew, Archer, John, McGillan, Paul, Charoensutthivarakul, Sitthivut, Bibby, Jaclyn, Sharma, Raman, Nixon, Gemma, Slatko, Barton, Cantin, Lindsey, Wu, Bo, Turner, Joseph, Ford, Louise, Rich, Kirsty, Wigglesworth, Mark, Berry, Neil, O'Neill, Paul, Taylor, Mark, Ward, Stephen

Source: Nature communications. 10(1):1-8

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100100186468.0x000001&indx=1&recIds=ETOCvdc_100100186468.0x000001

Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed

Authors: Stevenson, Bradley J., Bibby, Jaclyn, Pignatelli, Patricia, Muangnoicharoen, Sant, O’Neill, Paul M., Lian, Lu-Yun, Müller, Pie, Nikou, Dimitra, Steven, Andrew, Hemingway, Janet, Sutcliffe, Michael J., Paine, Mark J.I.

Source: In Insect Biochemistry and Molecular Biology July 2011 41(7):492-502

Application of the AMPLE cluster-and-truncate approach to NMR structures for molecular replacement

Authors: Bibby, Jaclyn

Contributors: Keegan, Ronan M., Mayans, Olga, Winn, Martyn D., Rigden, Daniel J.

Availability: http://data.europeana.eu/aggregation/europeana/2048441/item_VX77ZQJEXAN3DFT2VADQMSBH4AERPWNL

Identification of 2‑Aryl-Quinolone Inhibitors of Cytochrome bd and Chemical Validation of Combination Strategies for Respiratory Inhibitors against Mycobacterium tuberculosis.

Authors: Jeffreys, Laura N., Ardrey, Alison, Hafiz, Taghreed A., Dyer, Lauri-Anne, Warman, Ashley J., Mosallam, Nada, Nixon, Gemma L., Fisher, Nicholas E., Hong, W. David, Leung, Suet C., Aljayyoussi, Ghaith, Bibby, Jaclyn, Almeida, Deepak V., Converse, Paul J., Fotouhi, Nader, Berry, Neil G., Nuermberger, Eric L., Upton, Anna M., O'Neill, Paul M., Ward, Stephen A.

Source: ACS Infectious Diseases; 2/10/2023, Vol. 9 Issue 2, p221-238, 18p

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Allelic Variation of Cytochrome P450s Drives Resistance to Bednet Insecticides in a Major Malaria Vector.

Authors: Ibrahim, Sulaiman S.¹, SulaimanSadi.Ibrahim@lstmed.ac.uk, Riveron, Jacob M.¹, Bibby, Jaclyn², Irving, Helen¹, Yunta, Cristina¹, Paine, Mark J. I.¹, Wondji, Charles S.¹, charles.wondji@lstmed.ac.uk

Source: PLoS Genetics; 10/30/2015, Vol. 11 Issue 10, p1-25, 25p

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The central role of mosquito cytochrome P450 CYP6Zs in insecticidedetoxification revealed by functional expression and structural modelling.

Authors: CHANDOR-PROUST, Alexia, BIBBY, Jaclyn, RÉGENT-KLOECKNER, Myriam, ROUX, Jessica, GUITTARD-CRILAT, Emilie, POUPARDIN, Rodolphe, RIAZ, Muhammad Asam, PAINE, Mark, DAUPHIN-VILLEMANT, Chantal, REYNAUD, Stéphane, DAVID, Jean-Philippe

Source: Biochemical Journal; 10/1/2013, Vol. 455 Issue 1, p75-87, 13p

Subject Terms: CYTOCHROME P-450, MOSQUITO genetics, INSECTICIDE resistance, PYRETHROIDS, CARBOXYLESTERASES

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Exploring the speed and performance of molecular replacement with AMPLE using QUARK ab initio protein models

Authors: Keegan, Ronan M.

Contributors: Bibby, Jaclyn, Thomas, Jens, Xu, Dong, Zhang, Yang, Mayans, Olga, Winn, Martyn D., Rigden, Daniel J.

Availability: http://data.europeana.eu/aggregation/europeana/2048441/item_TNXTHNJ4JFQR2MJW5Z6P66UR6YVITKZD