C9orf72-associated dipeptide protein repeats form A11-positive oligomers in amyotrophic lateral sclerosis and frontotemporal dementia

Authors: Bhatt, Nemil, Puangmalai, Nicha, Sengupta, Urmi, Jerez, Cynthia, Kidd, Madison, Gandhi, Shailee, Kayed, Rakez

Source: In Journal of Biological Chemistry February 2024 300(2)

Traumatic brain injury derived pathological tau polymorphs induce the distinct propagation pattern and neuroinflammatory response in wild type mice

Authors: Puangmalai, Nicha, Bhatt, Nemil, Bittar, Alice, Jerez, Cynthia, Shchankin, Nikita, Kayed, Rakez

Source: In Progress in Neurobiology January 2024 232

Distinct neurotoxic TDP-43 fibril polymorphs are generated by heterotypic interactions with α-Synuclein

Authors: Dhakal, Shailendra, Robang, Alicia S., Bhatt, Nemil, Puangmalai, Nicha, Fung, Leiana, Kayed, Rakez, Paravastu, Anant K., Rangachari, Vijayaraghavan

Source: In Journal of Biological Chemistry November 2022 298(11)

Brain-derived tau oligomer polymorphs: distinct aggregations, stability profiles, and biological activities.

Authors: Lo Cascio, Filippa, Park, Suhyeorn, Sengupta, Urmi, Puangmalai, Nicha, Bhatt, Nemil, Shchankin, Nikita, Jerez, Cynthia, Moreno, Naomi, Bittar, Alice, Xavier, Rhea, Zhao, Yingxin, Wang, Cankun, Fu, Hongjun, Ma, Qin, Montalbano, Mauro, Kayed, Rakez

Source: Communications Biology; 1/15/2025, Vol. 8 Issue 1, p1-18, 18p

Subject Terms: LEWY body dementia, PROGRESSIVE supranuclear palsy, ALZHEIMER'S disease, TAUOPATHIES, MICROTUBULE-associated proteins, TAU proteins

Lysine 63-linked ubiquitination of tau oligomers contributes to the pathogenesis of Alzheimer’s disease

Authors: Puangmalai, Nicha, Sengupta, Urmi, Bhatt, Nemil, Gaikwad, Sagar, Montalbano, Mauro, Bhuyan, Arijit, Garcia, Stephanie, McAllen, Salome, Sonawane, Minal, Jerez, Cynthia, Zhao, Yingxin, Kayed, Rakez

Source: In Journal of Biological Chemistry April 2022 298(4)

Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer’s disease and frontotemporal dementia

Authors: Gaikwad, Sagar, Puangmalai, Nicha, Bittar, Alice, Montalbano, Mauro, Garcia, Stephanie, McAllen, Salome, Bhatt, Nemil, Sonawane, Minal, Sengupta, Urmi, Kayed, Rakez

Source: In Cell Reports 20 July 2021 36(3)

Generation of nanobodies with conformational specificity for tau oligomers that recognize tau aggregates from human Alzheimer's disease samples.

Authors: McArthur, Nikki, Squire, Jay D., Onyeachonam, Ogechukwu J., Bhatt, Nemil N., Jerez, Cynthia, Holberton, Abigail L., Tessier, Peter M., Wood, Levi B., Kayed, Rakez, Kane, Ravi S.

Source: Biomaterials Science (2047-4830); 12/7/2024, Vol. 12 Issue 23, p6033-6046, 14p

TDP-43 and Tau Oligomers in Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia

Authors: Montalbano, Mauro, McAllen, Salome, Cascio, Filippa Lo, Sengupta, Urmi, Garcia, Stephanie, Bhatt, Nemil, Ellsworth, Anna, Heidelman, Eric A., Johnson, Omar D., Doskocil, Samantha, Kayed, Rakez

Source: In Neurobiology of Disease December 2020 146

Advances and considerations in AD tau-targeted immunotherapy

Authors: Bittar, Alice, Bhatt, Nemil, Kayed, Rakez

Source: In Neurobiology of Disease February 2020 134

Polymorphic α-Synuclein Strains Modified by Dopamine and Docosahexaenoic Acid Interact Differentially with Tau Protein

Authors: Sengupta, Urmi, Puangmalai, Nicha, Bhatt, Nemil, Garcia, Stephanie, Zhao, Yingxin, Kayed, Rakez

Source: Molecular neurobiology. 57(6):2741-2765

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172090982.0x000001&indx=1&recIds=ETOCvdc_100172090982.0x000001

Development of a pan‐tau multivalent nanobody that binds tau aggregation motifs and recognizes pathological tau aggregates.

Authors: McArthur, Nikki¹, Kang, Bokyung¹, Rivera Moctezuma, Felix G.², Shaikh, Akber T.³, Loeffler, Kathryn¹, Bhatt, Nemil N.^4,5, Kidd, Madison^4,5, Zupancic, Jennifer M.^6,7, Desai, Alec A.^6,7, Djeddar, Naima⁸, Bryksin, Anton⁸, Tessier, Peter M.^6,7,9,10, Kayed, Rakez^4,5, Wood, Levi B.^2,3,8, Kane, Ravi S.^1,3,8, ravi.kane@chbe.gatech.edu

Source: Biotechnology Progress; Sep2024, Vol. 40 Issue 5, p1-13, 13p

Calcineurin inhibition prevents synaptic plasticity deficit induced by brain-derived tau oligomers.

Authors: Scaduto, Pietro, Marcatti, Michela, Bhatt, Nemil, Kayed, Rakez, Taglialatela, Giulio

Source: Brain Communications; 2024, Vol. 6 Issue 5, p1-12, 12p

MAPT mutations associated with familial tauopathies lead to formation of conformationally distinct oligomers that have cross‐seeding ability.

Authors: Bhopatkar, Anukool A., Bhatt, Nemil, Haque, Md Anzarul, Xavier, Rhea, Fung, Leiana, Jerez, Cynthia, Kayed, Rakez

Source: Protein Science: A Publication of the Protein Society; Sep2024, Vol. 33 Issue 9, p1-16, 16p

Targeted Musashi1 knockdown leads to reduce tau pathology and improves cognitive function in aged P301L mouse model

Authors: Montalbano, Mauro, Fung, Leiana, Bhatt, Nemil, Gaikwad, Sagar, Bittar, Alice, Puangmalai, Nicha, Sengupta, Urmi, Kayed, Rakez

Source: Alzheimer's & dementia. 18(3)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178388939.0x000001&indx=1&recIds=ETOCvdc_100178388939.0x000001

The synaptic interplay of Tau and Aβ oligomeric species in Alzheimer's disease and related tauopathies.

Authors: Marcatti, Michela, Fracassi, Anna, Montalbano, Mauro, Puangmalai, Nicha, Bhatt, Nemil, Natarajan, Chandramouli, Guptarak, Jutatip, Krishnan, Balaji, Kayed, Rakez, Taglialatela, Giulio

Source: Alzheimer's & dementia. 18(4)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100176987825.0x000001&indx=1&recIds=ETOCvdc_100176987825.0x000001

Effect of Natural Osmolytes on Recombinant Tau Monomer: Propensity of Oligomerization and Aggregation.

Authors: Arar, Sharif, Haque, Md Anzarul, Bhatt, Nemil, Zhao, Yingxin, Kayed, Rakez

Source: ACS Chemical Neuroscience; 4/3/2024, Vol. 15 Issue 7, p1366-1377, 12p

AD‐ and PSP‐specific brain‐derived tau oligomers engage synapses with different dynamic

Authors: Marcatti, Michela, Fracassi, Anna, Bhatt, Nemil, Natarajan, Chandramouli, Krishnan, Balaji, Kayed, Rakez, Taglialatela, Giulio

Source: Alzheimer's & dementia. 17(7)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138846274.0x000001&indx=1&recIds=ETOCvdc_100138846274.0x000001

In pursuit of degenerative brain disease diagnosis: Dementia biomarkers detected by DNA aptamer-attached portable graphene biosensor.

Authors: Bodily, Tyler Andrew, Ramanathan, Anirudh, Shanhong Wei, Karkisaval, Abhijith, Bhatt, Nemil, Jerez, Cynthia, Haque, Md Anzarul, Ramil, Armando, Heda, Prachi, Yi Wang, Kumar, Sanjeev, Leite, Mikayla, Tie Li, Jianlong Zhao, Lal, Ratnesh

Source: Proceedings of the National Academy of Sciences of the United States of America; 11/21/2023, Vol. 120 Issue 47, p1-14, 22p

Subject Terms: BRAIN degeneration, DIAGNOSIS, ALZHEIMER'S disease, SMALL molecules, BIOSENSORS, RADIO operators

P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer's disease

Authors: Farmer, Kathleen M., Ghag, Gaurav, Puangmalai, Nicha, Montalbano, Mauro, Bhatt, Nemil, Kayed, Rakez

Source: Acta neuropathologica communications. 8(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172014086.0x000001&indx=1&recIds=ETOCvdc_100172014086.0x000001

Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer's disease, progressive supranuclear palsy and dementia with Lewy bodies

Authors: Puangmalai, Nicha, Bhatt, Nemil, Montalbano, Mauro, Sengupta, Urmi, Gaikwad, Sagar, Ventura, Frank, McAllen, Salome, Ellsworth, Anna, Garcia, Stephanie, Kayed, Rakez

Source: Cell death and disease. 11(5)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174653183.0x000001&indx=1&recIds=ETOCvdc_100174653183.0x000001