Systematic analysis of the design, methodology, and patient population characteristics of the pediatric direct oral anticoagulant trials of venous thromboembolism treatment

Authors: Betensky, Marisol ^{1, 2, ∗}, Albisetti, Manuela ³, Biss, Tina ⁴, Bhat, Rukhmi V. ⁵, Brandão, Leonardo R. ⁶, Diacovo, Thomas ⁷, Monagle, Paul ⁸, Raffini, Leslie ⁹, Revel-vilk, Shoshana ¹⁰, van Ommen, C. Heleen ¹¹, Whitworth, Hilary ⁹, Goldenberg, Neil A. ^{2, 12}, Male, Christoph ¹³

Source: In Journal of Thrombosis and Haemostasis December 2024

The Functional Characterization of Venous Thromboembolic Disease (FUVID) study: rationale, design, and methods of a prospective, observational, multicenter study to evaluate mechanisms of exercise intolerance and dyspnea following pediatric pulmonary embolism

Authors: Adix, Leah M., Ambrusko, Steven, Alaesa, Shames, Bradley, Kristen, Branchford, Brain R., Carlberg, Katie, Cooper, James D., Corley, Susan A., Di Miero, Marissa, Eidenberger, Anna, Freyer, Edith, Guerrero, Kevin, Gurunathan, Arun, Hathorn, Brandon, Khan, Muhammad, Lade, Shawn D., Maida, Deanna M., Martinelli, Marie, Mozingo, Corey, Moran, Raksa, Primeaux, Sharon A., Raffini, Leslie, Robinson, Rhea, Sabo, Cynthia, Saleh, Negin, Sharathkumar, Anjali A., Simon, Rachel, Srivaths, Lakshmi, Tasset, MacKenzie, Williams, Katrina, Woodward, Rebekah Summerall, Levine, Benjamin, Goldenberg, Neil A., Klok, Frederikus A., Male, Christoph, Babb, Tony G., Rajpurkar, Madhvi, Zhang, Song, Zia, Ayesha ^{1, ∗}, Nelson, Michael D. ², Ren, Jimin ^{1, 3}, Mattrey, Robert F. ^{1, 5}, Han, Brian L. ^{1, 6}, Hussain, Tarique ^{1, 7}, Greer, Joshua S. ^{1, 7}, Al-Qahtani, Manal ^{1, 7}, Malone, Kendra ⁸, Stutzman, Sonja E. ⁹, Sida, Deseray V. ⁹, Primeaux, Sharon ⁹, Torres, Marcela D. ¹⁰, Cohen, Clay T. ¹¹, Crary, Shelley ¹², Bernstein, Jonathan ¹³, Whitworth, Hilary B. ¹⁴, Kumar, Riten ¹⁵, Beg, Kisha A. ¹⁶, Khan, Osman ¹⁶, Hege, Kerry ¹⁸, Schaefer, Beverly A. ¹⁹, Woods, Gary M. ²⁰, Amos, Lauren E. ²¹, Betensky, Marisol ²², Bhat, Rukhmi V. ²³, O’ Brien, Sarah ²⁴, Jaffray, Julie ²⁵, Jesudas, Rohit ²⁶, Pacheco, Martha M. ²⁷, Tarango, Cristina ²⁸, Weyand, Angela C. ²⁹, Wilson, Hope P. ³⁰, Garcia, Jessica ^{1, 9}, Dang, Mary P. ^{1, 9}, Sharma, Ruchika ^{1, 9}, Balmain, Bryce N. ³⁵

Source: In Research and Practice in Thrombosis and Haemostasis January 2025 9(1)

Outcomes in children with provoked venous thrombosis and antiphospholipid antibodies: findings from the Kids-DOTT trial

Authors: Betensky, Marisol, Mosha, Maua, Tarango, Cristina, Verma, Anupam, Bhat, Rukhmi, Kucine, Nicole E., Nakano, Taizo, Nakar, Charles, Woods, Gary, Amankwah, Ernest, Brandão, Leonardo R., Schulman, Sam, Goldenberg, Neil A.

Source: In Blood Advances 26 November 2024 8(22):5790-5795

Clinical characteristics, treatment, and outcomes of provoked acute cerebral sinovenous thrombosis in patients

Authors: Woods, Gary M., Miller, Alexandra, Mosha, Maua, Male, Christoph, Verma, Anupam, Kucine, Nicole, Sabapathy, Christine, Beg, Kisha, Ahuja, Sanjay, Raybagkar, Deepti, Hege, Kerry, Lo, Clara, Bhat, Rukhmi, Abshire, Thomas, Goldenberg, Neil A.

Source: In Research and Practice in Thrombosis and Haemostasis October 2024 8(7)

Peri-operative Anticoagulation Strategies, Bleeding and Thrombotic Complications in Pediatric Patients Undergoing Intervention for Congenital Portosystemic Shunts

Authors: Haimed, Abraham, Brandt, Katherine A., Badawy, Sherif, Lemoine, Caroline P., Bhat, Rukhmi, Superina, Riccardo

Source: In Journal of Pediatric Surgery October 2024 59(10)

How I treat pediatric venous thromboembolism in the DOAC era

Authors: Bhat, Rukhmi V., Young, Guy, Sharathkumar, Anjali A.

Source: In Blood 1 February 2024 143(5):389-403

Luspatercept for the treatment of anaemia in non-transfusion-dependent β-thalassaemia (BEYOND): a phase 2, randomised, double-blind, multicentre, placebo-controlled trial

Authors: Buaboonnam, Jassada, Ekwattanakit, Supachai, Khunhapinant, Archrob, Loka, Efthalia, Moraki, Maria, Flevari, Pagona, Dimopoulou, Maria, Bartzi, Vasiliki, Daadaa, Hisham, El Hasbani, Georges, Koussa, Suzanne, Tartaglione, Immacolata, Ammendola, Federica, Scianguetta, Saverio, Puglia, Marta, Ferrara, Ilaria, Ferrero, Giovanni, Gaglioti, Carmen, Longo, Filomena, Turrini, Silvia, Voi, Vincenzo, Cassinerio, Elena, De, Anna, Graziadei, Giovanna, Marcon, Alessia, Migone De Amicis, Margherita, Motta, Irene, Cinque, Patrizia, Pannone, Bruno, Ricchi, Paolo, Balocco, Manuela, Carrara, Paola, Della Rovere, Francesco, Lamagna, Martina, Pinto, Valeria, Quintino, Sabrina, Eleftheriou, Perla, Garbowski, Maciej, de Kreuk, Arne, Carson, Susan, Denton, Christopher, Hofstra, Tom, Veluswamy, Sayany, Wood, John, Badawy, Sherif, Bercovitz, Rachel, Bhat, Rukhmi, Calamaras, Diane, Liem, Robert, Mack, Astrid, Taher, Ali T ^{*, *}, Cappellini, Maria Domenica ^*, Kattamis, Antonis, Voskaridou, Ersi, Perrotta, Silverio, Piga, Antonio G, Filosa, Aldo, Porter, John B, Coates, Thomas D, Forni, Gian Luca, Thompson, Alexis A, Musallam, Khaled M, Backstrom, Jay T, Esposito, Oriana, Giuseppi, Ana Carolina, Kuo, Wen-Ling, Miteva, Dimana, Lord-Bessen, Jennifer, Yucel, Aylin, Zinger, Tatiana, Shetty, Jeevan K, Viprakasit, Vip

Source: In The Lancet Haematology October 2022 9(10):e733-e744

Hemostasis in Pediatric Extracorporeal Life Support: Overview and Challenges

Authors: Martin, Amarilis A., Bhat, Rukhmi, Chitlur, Meera

Source: In The Pediatric Clinics of North America June 2022 69(3):441-464

Risk factors associated with venous and arterial neonatal thrombosis in the intensive care unit: a multicentre case-control study

Authors: Bhat, Rukhmi ^*, Kwon, Soyang, Zaniletti, Isabella, Murthy, Karna, Liem, Robert I

Source: In The Lancet Haematology March 2022 9(3):e200-e207

Safety and efficacy of rivaroxaban in pediatric cerebral venous thrombosis (EINSTEIN-Jr CVT): for the EINSTEIN-Jr Cerebral Venous Thrombosis trial investigators

Authors: Connor, Philip ^*, Sánchez van Kammen, Mayte ^*, Lensing, Anthonie W.A., Chalmers, Elizabeth, Kállay, Krisztián, Hege, Kerry, Simioni, Paolo, Biss, Tina, Bajolle, Fanny, Bonnet, Damien, Grunt, Sebastian, Kumar, Riten, Lvova, Olga, Bhat, Rukhmi, Van Damme, An, Palumbo, Joseph, Santamaria, Amparo, Saracco, Paola, Payne, Jeanette, Baird, Susan, Godder, Kamar, Labarque, Veerle, Male, Christoph, Martinelli, Ida, Morales Soto, Michelle, Motwani, Jayashree, Shah, Sanjay, Hooimeijer, Helene L., Prins, Martin H., Kubitza, Dagmar, Smith, William T., Berkowitz, Scott D., Pap, Akos F., Majumder, Madhurima, Monagle, Paul, Coutinho, Jonathan M.

Source: In Blood Advances 22 December 2020 4(24):6250-6258

Anticoagulation in preterm and term neonates: Why are they special?

Authors: Bhat, Rukhmi, Monagle, Paul

Source: In Thrombosis Research March 2020 187:113-121

Rivaroxaban compared with standard anticoagulants for the treatment of acute venous thromboembolism in children: a randomised, controlled, phase 3 trial

Authors: Molinari, Angelo C., Nowak Göttl, Ulrike, Chain, Juan, Robertson, Jeremy, Thom, Katharina, Streif, Werner, Schwarz, Rudolf, Schmitt, Klaus, Grangl, Gernot, Van Damme, An, Maes, Philip, Labarque, Veerle, Petrilli, Antonio, Loggeto, Sandra, Azeka, Estela, Brandao, Leonardo, Le, Doan, Sabapathy, Christine, Giordano, Paola, Wu, Runhui, Ding, Jie, Huang, Wenyan, Mao, Jianhua, Lähteenmäki, Päivi, Amedro, Pascal, Decramer, Stephane, Bernig, Toralf, Chada, Martin, Chan, Godfrey, Kally, Krisztian, Nolan, Beatrice, Revel-Vilk, Shoshana, Tamary, Hannah, Levin, Carina, Tormene, Daniela, Abbattista, Maria, Artoni, Andrea, Ikeyama, Takanari, Inuzuka, Ryo, Yasukochi, Satoshi, Morales Soto, Michelle, Solis Labastida, Karina A, Suijker, Monique H, Bartels, Marike, Tamminga, Rienk Y, Van Ommen, C Heleen, Te Loo, D. Maroeska, Anjos, Rui, Zubarovskaya, Lyudmila, Popova, Natalia, Samochatova, Elena, Belogurova, Margarita, Svirin, Pavel, Shutova, Tatiana, Lebedev, Vladimir, Barbarash, Olga, Koh, Pei L, Mei, Joyce C, Podracka, Ludmila, Berrueco, Ruben, Fernandez, Maria F, Frisk, Tony, Grunt, Sebastian, Rischewski, Johannes, Albisetti-Pedroni, Manuela, Antmen, Ali, Tokgoz, Huseyin, Karakas, Zeynep, Chalmers, Elizabeth, Motwani, Jayashree, Williams, Michael, Grainger, John, Payne, Jeanette, Richards, Mike, Baird, Susan, Bhatnagar, Neha, Aramburo, Angela, Crary, Shelley, Wynn, Tung, Carpenter, Shannon, Hege, Kerry, Ahuja, Sanjay, Goldenberg, Neil, Woods, Gary, Godder, Kamar, Scott-Emuakpor, Ajovi, Roach, Gavin, Raffini, Leslie, Shah, Nirmish, Shah, Sanjay, Thornburg, Courtney, Zia, Ayesha, Berkow, Roger, Male, Christoph ^*, Lensing, Anthonie W A, Palumbo, Joseph S, Kumar, Riten, Nurmeev, Ildar, Bonnet, Damien, Connor, Philip, Hooimeijer, Hélène L, Torres, Marcela, Chan, Anthony K C, Kenet, Gili, Holzhauer, Susanne, Santamaría, Amparo, Simioni, Paolo, Bhat, Rukhmi V, Yee, Donald L, Lvova, Olga, Beyer-Westendorf, Jan, Biss, Tina T, Martinelli, Ida, Saracco, Paola, Peters, Marjolein, Kállay, Krisztián, Gauger, Cynthia A, Massicotte, M Patricia, Young, Guy, Pap, Akos F, Majumder, Madhurima, Smith, William T, Heubach, Jürgen F ^*, Berkowitz, Scott D, Thelen, Kirstin, Kubitza, Dagmar, Crowther, Mark, Prins, Martin H, Monagle, Paul

Source: In The Lancet Haematology January 2020 7(1):e18-e27

Perioperative management in chronically anticoagulated children undergoing tonsillectomy

Authors: Hazkani, Inbal, Billings, Kathleen R., Edwards, Evan, Stein, Eli, Bhat, Rukhmi, Lavin, Jennifer

Source: Pediatrics international. 65(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195913358.0x000001&indx=1&recIds=ETOCvdc_100195913358.0x000001

Factors associated with thrombotic and hemorrhagic complications in pediatric liver transplant: A multi‐center analysis from the Starzl Network for Excellence in Pediatric Transplantation

Authors: Soltys, Kyle, Lemoine, Caroline, Zhang, Xingyu, Bhat, Rukhmi, Bucuvalas, John, Rasmussen, Sara, Romero, Rene, Batsis, Irini, Sayed, Blayne, Tunno, John, Confair, Cassandra, Vargas, Sarah, Superina, Riccardo, Mazariegos, George

Source: Pediatric transplantation. 27(4)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182908811.0x000001&indx=1&recIds=ETOCvdc_100182908811.0x000001

Fatigue in children and adolescents with immune thrombocytopenia

Authors: Grace, Rachael F., Klaassen, Robert J., Shimano, Kristin A., Lambert, Michele P., Grimes, Amanda, Bussel, James B., Breakey, Vicky R., Pastore, Yves D., Black, Vandy, Overholt, Kathleen, Bhat, Rukhmi, Forbes, Peter W., Neunert, Cindy

Source: British journal of haematology. 191(1):98-106

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110143677.0x000001&indx=1&recIds=ETOCvdc_100110143677.0x000001

Rivaroxaban compared with standard anticoagulants for the treatment of acute venous thromboembolism in children: a randomised, controlled, phase 3 trial

Authors: Male, Christoph, Lensing, Anthonie W A, Palumbo, Joseph S, Kumar, Riten, Nurmeev, Ildar, Hege, Kerry, Bonnet, Damien, Connor, Philip, Hooimeijer, Hélène L, Torres, Marcela, Chan, Anthony K C, Kenet, Gili, Holzhauer, Susanne, Santamaría, Amparo, Amedro, Pascal, Chalmers, Elizabeth, Simioni, Paolo, Bhat, Rukhmi V, Yee, Donald L, Lvova, Olga, Beyer-Westendorf, Jan, Biss, Tina T, Martinelli, Ida, Saracco, Paola, Peters, Marjolein, Kállay, Krisztián, Gauger, Cynthia A, Massicotte, M Patricia, Young, Guy, Pap, Akos F, Majumder, Madhurima, Smith, William T, Heubach, Jürgen F, Berkowitz, Scott D, Thelen, Kirstin, Kubitza, Dagmar, Crowther, Mark, Prins, Martin H, Monagle, Paul

Source: Lancet.Haematology. 7(1):e18-e27

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183216470.0x000001&indx=1&recIds=ETOCvdc_100183216470.0x000001

Risk Factors for Neonatal Venous and Arterial Thromboembolism in the Neonatal Intensive Care Unit—A Case Control Study

Authors: Bhat, Rukhmi, Kumar, Riten, Kwon, Soyang, Murthy, Karna, Liem, Robert I.

Source: In The Journal of Pediatrics April 2018 195:28-32

Second‐line treatments in children with immune thrombocytopenia: Effect on platelet count and patient‐centered outcomes

Authors: Grace, Rachael F., Shimano, Kristin A., Bhat, Rukhmi, Neunert, Cindy, Bussel, James B., Klaassen, Robert J., Lambert, Michele P., Rothman, Jennifer A., Breakey, Vicky R., Hege, Kerry, Bennett, Carolyn M., Rose, Melissa J., Haley, Kristina M., Buchanan, George R., Geddis, Amy, Lorenzana, Adonis, Jeng, Michael, Pastore, Yves D., Crary, Shelley E., Neier, Michelle, Neufeld, Ellis J., Neu, Nolan, Forbes, Peter W., Despotovic, Jenny M.

Source: American journal of hematology. 94(7):741-750

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100083916356.0x000001&indx=1&recIds=ETOCvdc_100083916356.0x000001

Recurrent thrombosis with a mispositioned stent after treatment of an adolescent with May–Thurner syndrome

Authors: O'Gorman, Thomas M., Bhat, Rukhmi V., Rajeswaran, Shankar, Badawy, Sherif M.

Source: Pediatric blood & cancer. 69(2)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100137357090.0x000001&indx=1&recIds=ETOCvdc_100137357090.0x000001

Early thrombotic and hemorrhagic complications associated with a risk‐adjusted postoperative anticoagulation protocol after pediatric liver transplantation

Authors: Lemoine, Caroline P., Brandt, Katherine A., Mohammad, Saeed, Bhat, Rukhmi, Superina, Riccardo

Source: Pediatric blood & cancer. 69(10)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100158999827.0x000001&indx=1&recIds=ETOCvdc_100158999827.0x000001