Single-cell chromatin accessibility and transposable element landscapes reveal shared features of tissue-residing immune cells

Authors: Simon, Malte, Stüve, Philipp, Schmidleithner, Lisa, Bittner, Sebastian, Beumer, Niklas, Strieder, Nicholas, Schmidl, Christian, Pant, Asmita, Gebhard, Claudia, Eigenberger, Andreas, Rehli, Michael, Prantl, Lukas, Hehlgans, Thomas, Brors, Benedikt, Imbusch, Charles D., Delacher, Michael, Feuerer, Markus

Source: In Immunity 13 August 2024 57(8):1975-1993

Pathologic responses in oligometastatic NSCLC patients treated with neoadjuvant immune checkpoint blockade with and without chemotherapy followed by surgery

Authors: Boch, Tobias, Frost, Nikolaj, Sommer, Linna, Overbeck, Tobias R., Michaeli, Christoph T., Szuszies, Chrisoph J., Rieckmann, Lisa-Marie, Beumer, Niklas, Imbusch, Charles D., Winter, Hauke, Thomas, Michael, Roeper, Julia, Janning, Melanie, Griesinger, Frank, Wermke, Martin, Loges, Sonja

Source: Lung cancer. 164:46-51

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100154379805.0x000001&indx=1&recIds=ETOCvdc_100154379805.0x000001

Bemcentinib as monotherapy and in combination with low-dose cytarabine in acute myeloid leukemia patients unfit for intensive chemotherapy: a phase 1b/2a trial.

Authors: Loges, Sonja, Heuser, Michael, Chromik, Jörg, Sutamtewagul, Grerk, Kapp-Schwoerer, Silke, Crugnola, Monica, Di Renzo, Nicola, Lemoli, Roberto, Mattei, Daniele, Fiedler, Walter, Alvarado-Valero, Yesid, Ben-Batalla, Isabel, Waizenegger, Jonas, Rieckmann, Lisa-Marie, Janning, Melanie, Collienne, Maike, Imbusch, Charles D., Beumer, Niklas, Micklem, David, H Nilsson, Linn

Source: Nature Communications; 3/25/2025, Vol. 16 Issue 1, p1-12, 12p

Lorlatinib Induces Durable Disease Stabilization in a Pancreatic Cancer Patient with a ROS1 p.L1950F Mutation: Case Report

Authors: Velthaus, Janna-Lisa, Iglauer, Peter, Simon, Ronald, Bokemeyer, Carsten, Bannas, Peter, Beumer, Niklas, Imbusch, Charles D., Goekkurt, Eray, Loges, Sonja

Source: Oncology research and treatment. 44(9):495-502

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128776440.0x000001&indx=1&recIds=ETOCvdc_100128776440.0x000001

Multiple myeloma long-term survivors exhibit sustained immune alterations decades after first-line therapy.

Authors: Lutz, Raphael, Grünschläger, Florian, Simon, Malte, Awwad, Mohamed H. S., Bauer, Marcus, Yousefian, Schayan, Beumer, Niklas, Jopp-Saile, Lea, Sedlmeier, Anastasia, Solé-Boldo, Llorenç, Avanesyan, Bogdan, Vonficht, Dominik, Stelmach, Patrick, Steinbuss, Georg, Boch, Tobias, Steiger, Simon, Baertsch, Marc-Andrea, Prokoph, Nina, Rippe, Karsten, Durie, Brian G. M.

Source: Nature Communications; 11/29/2024, Vol. 15 Issue 1, p1-18, 18p

Subject Terms: MULTIPLE myeloma, BONE marrow, IMMUNE system, CANCER treatment, SCARS

Diagnostic leukapheresis reveals distinct phenotypes of NSCLC circulating tumor cells.

Authors: Rieckmann, Lisa-Marie, Spohn, Michael, Ruff, Lisa, Agorku, David, Becker, Lisa, Borchers, Alina, Krause, Jenny, O'Reilly, Roisin, Hille, Jurek, Velthaus-Rusik, Janna-Lisa, Beumer, Niklas, Günther, Armin, Willnow, Lena, Imbusch, Charles D., Iglauer, Peter, Simon, Ronald, Franzenburg, Sören, Winter, Hauke, Thomas, Michael, Bokemeyer, Carsten

Source: Molecular Cancer; 5/8/2024, Vol. 23 Issue 1, p1-9, 9p

Subject Terms: LEUKAPHERESIS, NON-small-cell lung carcinoma, PHENOTYPES, BLOOD volume

Using single-cell chromatin accessibility sequencing to characterize CD4+ T cells from murine tissues.

Authors: Braband, Kathrin Luise, Nedwed, Annekathrin Silvia, Helbich, Sara Salome, Simon, Malte, Beumer, Niklas, Brors, Benedikt, Marini, Federico, Delacher, Michael

Source: Frontiers in Immunology; 2023, p1-33, 33p

Subject Terms: T cells, LYMPHOID tissue, CHROMATIN, CD4 antigen, TISSUES

AML Treatment By the AXL Inhibitor Bemcentinib in Combination with Cytarabine Shows Clinical Efficacy Related to TNFα and Cytotoxic Immune Cells: A Single-Cell Translational Study from the BGBC003 Trial

Authors: Beumer, Niklas, Waizenegger, Jonas S., Heuser, Michael, Chromik, Jörg, Sutamtewagul, Grerk, Kapp-Schwoerer, Silke, Crugnola, Monica, Di Renzo, Nicola, Lemoli, Roberto M., Mattei, Daniele G., Fiedler, Walter, Alvarado-Valero, Yesid, Micklem, David, Nilsson, Linn H., Madeleine, Noelly, McCracken, Nigel, Oliva, Cristina, Gorcea-Carson, Claudia, Rieckmann, Lisa-Marie, Krause, Jenny, Gensch, Victoria, Ben Batalla, Isabel, Janning, Melanie, Gagliani, Nicola, Brors, Benedikt, Imbusch, Charles D., Gjertsen, Bjorn T., Loges, Sonja

Source: In Blood 2 November 2023 142 Supplement 1:1540-1540

Phase Ib/II Study (NCT02488408 / BGBC003) of Bemcentinib Monotherapy or in Combination with Cytarabine or Decitabine in Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS): FINAL Results

Authors: Loges, Sonja, Heuser, Michael, Chromik, Jolanta, Sutamtewagul, Grerk, Kapp-Schwoerer, Silke, Crugnola, Monica, Di Renzo, Nicola, Lemoli, Roberto Massimo, Mattei, Daniele Giovanni, Ben Batalla, Isabel, Waizenegger, Jonas, Janning, Melanie, Rieckmann, Lisa-Marie, Imbusch, Charles, Beumer, Niklas, Micklam, David, Gorcea-Carson, Claudia, Oliva, Cristina, Fiedler, Walter, Alvarado-Valero, Yesid, McCracken, Nigel, Gjertsen, Bjorn T.

Source: In Blood 2 November 2023 142 Supplement 1:4287-4287

Bemcentinib (Oral AXL Inhibitor) in Combination with Low-Dose Cytarabine Is Well Tolerated and Efficacious in Older Relapsed AML Patients.Updates from the Ongoing Phase II Trial (NCT02488408) and Preliminary Translational Results Indicating Bemcentinib Elicits Anti-AML Immune Responses

Authors: Loges, Sonja, Sutamtewagul, Grerk, Heuser, Michael, Chromik, Jörg, Kapp-Schwoerer, Silke, Crugnola, Monica, Di Renzo, Nicola, Lemoli, Roberto M., Mattei, Daniele Giovanni, Ben Batalla, Isabel, Hellesøy, Monica, Waizenegger, Jonas, Janning, Melanie, Imbusch, Charles D., Beumer, Niklas, Rayford, Austin, Nautiyal, Jaya, Berkman-Gottlieb, Tzivia, Micklem, David, Gabra, Hani, Gorcea-Carson, Claudia, Lorens, James B., Fiedler, Walter, Alvarado, Yesid, Gjertsen, Bjorn T., Rieckmann, Lisa-Marie

Source: In Blood 23 November 2021 138 Supplement 1:3410-3410