Assessing human B cell responses to influenza virus vaccines and adjuvants in a PBMC-derived in vitro culture system

Authors: Gong, Shuran, Beukema, Martin, De Vries-Idema, Jacqueline, Huckriede, Anke ^⁎

Source: In Vaccine 12 January 2025 44

Efficient fabrication of thermo-stable dissolving microneedle arrays for intradermal delivery of influenza whole inactivated virus vaccine

Authors: Lee, Jihui, Beukema, Martin, Zaplatynska, Oliwia A., O'Mahony, Conor, Hinrichs, Wouter L. J., Huckriede, Anke L. W., Bouwstra, Joke A., van der Maaden, Koen

Source: Biomaterials science. 11(20):6790-6800

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Efficacy of pectins with different degrees of methyl-esterification and of blockiness in preventing gut epithelial cell barrier disruption and the impact on sodium–glucose co-transporter expression under low and high glucose conditionsElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3fo01436c

Authors: Tang, Xin, Beukema, Martin, Ferrari, Michela, Walvoort, Marthe T. C., de Haan, Bart J., de Vos, Paul

Source: Food & function. 14(13):6226-6235

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TLR 2/1 interaction of pectin depends on its chemical structure and conformation

Authors: Jermendi, Éva, Fernández-Lainez, Cynthia, Beukema, Martin, López-Velázquez, Gabriel, van den Berg, Marco A., de Vos, Paul, Schols, Henk A.

Source: In Carbohydrate Polymers 1 March 2023 303

Combining galacto-oligosaccharides and 2′-fucosyllactose alters their fermentation kinetics by infant fecal microbiota and influences AhR-receptor dependent cytokine responses in immature dendritic cellsElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2fo00550f

Authors: Akkerman, Renate, Logtenberg, Madelon J., Beukema, Martin, de Haan, Bart J., Faas, Marijke M., Zoetendal, Erwin G., Schols, Henk A., de Vos, Paul

Source: Food & function. 13(12):6510-6521

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Comparison of air-liquid interface transwell and airway organoid models for human respiratory virus infection studies.

Authors: Ekanger, Camilla T., Dinesh Kumar, Nilima, Koutstaal, Rosanne W., Zhou, Fan, Beukema, Martin, Waldock, Joanna, Jochems, Simon P., Mulder, Noa, van Els, Cécile A. C. M., Engelhardt, Othmar G., Mantel, Nathalie, Buno, Kevin P., Brokstad, Karl Albert, Engelsen, Agnete S. T., Cox, Rebecca J., Melgert, Barbro N., Huckriede, Anke L. W., van Kasteren, Puck B.

Source: Frontiers in Immunology; 2025, p1-16, 16p

Subject Terms: VIRUS diseases, AIRWAY (Anatomy), INFLUENZA A virus, RESPIRATORY infections, VIRAL replication

Revealing methyl-esterification patterns of pectins by enzymatic fingerprinting: Beyond the degree of blockiness

Authors: Jermendi, Éva, Beukema, Martin, van den Berg, Marco A., de Vos, Paul, Schols, Henk A.

Source: In Carbohydrate Polymers 1 February 2022 277

2′-Fucosyllactose impacts the expression of mucus-related genes in goblet cells and maintains barrier function of gut epithelial cells

Authors: Figueroa-Lozano, Susana, Akkerman, Renate, Beukema, Martin, van Leeuwen, Sander S., Dijkhuizen, Lubbert, de Vos, Paul

Source: In Journal of Functional Foods October 2021 85

Toll-like receptor 2-modulating pectin-polymers in alginate-based microcapsules attenuate immune responses and support islet-xenograft survival

Authors: Hu, Shuxian, Kuwabara, Rei, Navarro Chica, Carlos E., Smink, Alexandra M., Koster, Taco, Medina, Juan D., de Haan, Bart J., Beukema, Martin, Lakey, Jonathan R.T., García, Andrés J., de Vos, Paul

Source: In Biomaterials January 2021 266

Distinct fermentation of human milk oligosaccharides 3-FL and LNT2 and GOS/inulin by infant gut microbiota and impact on adhesion of Lactobacillus plantarum WCFS1 to gut epithelial cellsElectronic supplementary information (ESI) available. See DOI: 10.1039/d1fo02563e

Authors: Kong, Chunli, Akkerman, Renate, Klostermann, Cynthia E., Beukema, Martin, Oerlemans, Marjolein M. P., Schols, Henk A., de Vos, Paul

Source: Food & function. 12(24):12513-12525

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Chicory inulin enhances fermentation of 2′-fucosyllactose by infant fecal microbiota and differentially influences immature dendritic cell and T-cell cytokine responses under normal and Th2-polarizing conditionsElectronic supplementary information (ESI) available. See DOI: 10.1039/d1fo00893e

Authors: Akkerman, Renate, Logtenberg, Madelon J., Beukema, Martin, de Haan, Bart J., Faas, Marijke M., Zoetendal, Erwin G., Schols, Henk A., de Vos, Paul

Source: Food & function. 12(19):9018-9029

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Human milk oligosaccharides and non-digestible carbohydrates prevent adhesion of specific pathogens via modulating glycosylation or inflammatory genes in intestinal epithelial cells

Authors: Kong, Chunli, Beukema, Martin, Wang, Min, de Haan, Bart J., de Vos, Paul

Source: Food & function. 12(17):8100-8119

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Low methyl-esterified pectin protects pancreatic β-cells against diabetes-induced oxidative and inflammatory stress via galectin-3

Authors: Hu, Shuxian ^*, Kuwabara, Rei, Beukema, Martin, Ferrari, Michela, de Haan, Bart J., Walvoort, Marthe T.C., de Vos, Paul, Smink, Alexandra M.

Source: In Carbohydrate Polymers 1 December 2020 249

A Single Injection with Sustained-Release Microspheres and a Prime-Boost Injection of Bovine Serum Albumin Elicit the Same IgG Antibody Response in Mice.

Authors: van der Kooij, Renée S.¹ (AUTHOR), Beukema, Martin² (AUTHOR), Huckriede, Anke L. W.² (AUTHOR), Zuidema, Johan³ (AUTHOR), Steendam, Rob³ (AUTHOR), Frijlink, Henderik W.¹ (AUTHOR), Hinrichs, Wouter L. J.¹ (AUTHOR) w.l.j.hinrichs@rug.nl

Source: Pharmaceutics. Feb2023, Vol. 15 Issue 2, p676. 23p.

Subject Terms: *SERUM albumin, *IMMUNOGLOBULINS, *BLOCK copolymers, *ANTIBODY formation, *MICROSPHERES, *VACCINE effectiveness, *BOOSTER vaccines, *IMMUNOGLOBULIN G

The influence of calcium on pectin's impact on TLR2 signalling

Authors: Beukema, Martin, Jermendi, Éva, Schols, Henk A., de Vos, Paulus

Source: Food & function. 11(9):7427-7432

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The effects of different dietary fiber pectin structures on the gastrointestinal immune barrier: impact via gut microbiota and direct effects on immune cells

Authors: Beukema, Martin, Faas, Marijke M., de Vos, Paul

Source: Experimental & molecular medicine. 52(9):1364-1376

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Pectins that Structurally Differ in the Distribution of Methyl‐Esters Attenuate Citrobacter rodentium‐Induced Colitis

Authors: Beukema, Martin, Akkerman, Renate, Jermendi, Éva, Koster, Taco, Laskewitz, Anne, Kong, Chunli, Schols, Henk A., Faas, Marijke M., Vos, Paul

Source: Molecular nutrition & food research. 65(19)

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Attenuation of Doxorubicin‐Induced Small Intestinal Mucositis by Pectins is Dependent on Pectin's Methyl‐Ester Number and Distribution

Authors: Beukema, Martin, Jermendi, Éva, Koster, Taco, Kitaguchi, Kohji, Haan, Bart J., Berg, Marco Alexander, Faas, Marijke M., Schols, Henk A., Vos, Paul

Source: Molecular nutrition & food research. 65(18)

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Prolonging the delivery of influenza virus vaccine improves the quantity and quality of the induced immune responses in mice.

Authors: Beukema, Martin, Gong, Shuran, Al-Jaawni, Kasem, de Vries-Idema, Jacqueline J., Krammer, Florian, Fan Zhou, Cox, Rebecca Jane, Huckriede, Anke

Source: Frontiers in Immunology; 2023, p1-12, 12p

Subject Terms: INFLUENZA vaccines, IMMUNE response, FLU vaccine efficacy, ANTIBODY formation, VIRUS diseases

Pectin Interaction with Immune Receptors is Modulated by Ripening Process in Papayas.

Authors: Prado, Samira B. R.^1,2, Beukema, Martin³, Jermendi, Eva⁴, Schols, Henk A.⁴, de Vos, Paul³, Fabi, João Paulo^1,2,5 jpfabi@usp.br

Source: Scientific Reports. 2/3/2020, Vol. 10 Issue 1, p1-11. 11p.

Subject Terms: *PECTINS, *PATTERN perception receptors, *TOLL-like receptors, *DIETARY fiber, *GALACTURONAN