Gut microbiota-derived imidazole propionate: an emerging target for the prevention and treatment of cardiometabolic diseases

Authors: Yan Zeng, Qi Wu, Man Guo, Fangyuan Teng, Chunxia Jiang, Jiao Chen, Xiaozhen Tan, Chen Zeng, Yang Long, Betty Yuen-Kwan Law, Yong Xu

Source: Frontiers in Endocrinology, Vol 16 (2025)

Subject Terms: imidazole propionate, cardiometabolic disease, diabetes, microbiome, microbial metabolites, biomarker, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2025.1409119/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/140fa59c100e4e558108e68646329c40

Mitophagy and cGAS–STING crosstalk in neuroinflammation

Authors: Xiaogang Zhou, Jing Wang, Lu Yu, Gan Qiao, Dalian Qin, Betty Yuen-Kwan Law, Fang Ren, Jianming Wu, Anguo Wu

Source: Acta Pharmaceutica Sinica B, Vol 14, Iss 8, Pp 3327-3361 (2024)

Subject Terms: Neuroinflammation, Mitophagy, cGAS–STING, Innate immunity, Mitochondrial DNA, Crosstalk, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383524001904; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/1471e72ae72c4e8f9f45471e7ca494cb

MCT4-dependent lactate transport: a novel mechanism for cardiac energy metabolism injury and inflammation in type 2 diabetes mellitus

Authors: Xiu Mei Ma, Kang Geng, Peng Wang, Zongzhe Jiang, Betty Yuen-Kwan Law, Yong Xu

Source: Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-20 (2024)

Subject Terms: MCT4, Lactate, Lipotoxicity, Inflammation, Diabetic cardiomyopathy, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2840

Access URL: https://doaj.org/article/4eacbb6a4f924cb48db92829cff15900

Activation of autophagy by Citri Reticulatae Semen extract ameliorates amyloid-beta-induced cell death and cognition deficits in Alzheimer’s disease

Authors: Yong Tang, Jing Wei, Xiao-Fang Wang, Tao Long, Xiaohong Xiang, Liqun Qu, Xingxia Wang, Chonglin Yu, Xingli Xiao, Xueyuan Hu, Jing Zeng, Qin Xu, Anguo Wu, Jianming Wu, Dalian Qin, Xiaogang Zhou, Betty Yuen-Kwan Law

Source: Neural Regeneration Research, Vol 19, Iss 11, Pp 2467-2479 (2024)

Subject Terms: alzheimer’s disease, amyloid-beta, apoptosis, autophagy, caenorhabditis elegans, citri reticulatae semen, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=11;spage=2467;epage=2479;aulast=; https://doaj.org/toc/1673-5374

Access URL: https://doaj.org/article/47fd4ae8f9814548af6e3edf2a0cae7a

Two 18‐norspirostane steroidal saponins as novel mitophagy enhancers improve Alzheimer's disease

Authors: Wen‐Qiao Qiu, Lu Yu, Chang‐Long He, Jian‐Ming Wu, Betty Yuen‐Kwan Law, Chong‐Lin Yu, Da‐Lian Qin, Xiao‐Gang Zhou, An‐Guo Wu

Source: Clinical and Translational Medicine, Vol 13, Iss 9, Pp n/a-n/a (2023)

Subject Terms: Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2001-1326

Access URL: https://doaj.org/article/366e1b0efe8b4eac82aaf8957c4baab7

Targeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer’s disease

Authors: Xiao-Gang Zhou, Wen-Qiao Qiu, Lu Yu, Rong Pan, Jin-Feng Teng, Zhi-Pei Sang, Betty Yuen-Kwan Law, Ya Zhao, Li Zhang, Lu Yan, Yong Tang, Xiao-Lei Sun, Vincent Kam Wai Wong, Chong-Lin Yu, Jian-Ming Wu, Da-Lian Qin, An-Guo Wu

Source: Inflammation and Regeneration, Vol 42, Iss 1, Pp 1-25 (2022)

Subject Terms: Thonningianin A, NLRP3 inflammasome, Alzheimer’s disease, Autophagy, AMPK/ULK1, Raf/MEK/ERK, Pathology, RB1-214

File Description: electronic resource

Relation: https://doaj.org/toc/1880-8190

Access URL: https://doaj.org/article/18737a8c81c4472581e4f0c99e7cbaf2

High-throughput screening for amyloid-β binding natural small-molecules based on the combinational use of biolayer interferometry and UHPLC−DAD-Q/TOF-MS/MS

Authors: Minsong Guo, Fengdan Zhu, Wenqiao Qiu, Gan Qiao, Betty Yuen-Kwan Law, Lu Yu, Jianming Wu, Yong Tang, Chonglin Yu, Dalian Qin, Xiaogang Zhou, Anguo Wu

Source: Acta Pharmaceutica Sinica B, Vol 12, Iss 4, Pp 1723-1739 (2022)

Subject Terms: Alzheimer's disease, High-throughput screening, Biolayer interferometry, UHPLC−DAD-Q/TOF-MS/MS, Kai-Xin-San, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383521003403; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/be053c1fb28047ccb0c66f356830e655

Microglia autophagy in ischemic stroke: A double-edged sword

Authors: Li Peng, Guangqiang Hu, Qianfang Yao, Jianming Wu, Ziyang He, Betty Yuen-Kwan Law, Guishan Hu, Xiaogang Zhou, Junrong Du, Anguo Wu, Lu Yu

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: ischemic stroke, microglia, autophagy, neuroinflammation, therapy, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1013311/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/e30b69b89c1a438397eff1a4546e5177

Targeting autophagy as a therapeutic strategy for identification of liganans from Peristrophe japonica in Parkinson’s disease

Authors: An-Guo Wu, Rong Pan, Betty Yuen-Kwan Law, Wen-Qiao Qiu, Jian-Ming Wu, Chang-Long He, Vincent Kam-Wai Wong, Chong-Lin Yu, Xiao-Gang Zhou, Da-Lian Qin

Source: Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-3 (2021)

Subject Terms: Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2059-3635

Access URL: https://doaj.org/article/2cc1c54c6dea4a93936eab01c40a4a9b

Transcriptome Analysis of Immune Receptor Activation and Energy Metabolism Reduction as the Underlying Mechanisms in Interleukin-6-Induced Skeletal Muscle Atrophy

Authors: Hualin Sun, Junjie Sun, Ming Li, Lei Qian, Lilei Zhang, Ziwei Huang, Yuntian Shen, Betty Yuen-Kwan Law, Liang Liu, Xiaosong Gu

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: interleukin-6, muscle atrophy, transcription factor, energy metabolism, inflammation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.730070/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/5bbfe0e7a6074b7eba62dddc7dbc4df3

The New Application of UHPLC-DAD-TOF/MS in Identification of Inhibitors on β-Amyloid Fibrillation From Scutellaria baicalensis

Authors: Lu Yu, An-Guo Wu, Vincent Kam-Wai Wong, Li-Qun Qu, Ni Zhang, Da-Lian Qin, Wu Zeng, Bin Tang, Hui-Miao Wang, Qiong Wang, Betty Yuen-Kwan Law

Source: Frontiers in Pharmacology, Vol 10 (2019)

Subject Terms: Alzheimer’s disease, β-amyloid, fibrillation inhibitors, Scutellaria baicalensis, UHPLC-DAD-TOF/MS, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphar.2019.00194/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/06d8b361274d4b22807b138867d9256d

Neferine Attenuates the Protein Level and Toxicity of Mutant Huntingtin in PC-12 Cells via Induction of Autophagy

Authors: Vincent Kam Wai Wong, An Guo Wu, Jing Rong Wang, Liang Liu, Betty Yuen-Kwan Law

Source: Molecules, Vol 20, Iss 3, Pp 3496-3514 (2015)

Subject Terms: autophagy, Nelumbo nucifera, neferine, AMPK, mTOR, a-synuclein, huntingtin, PC-12, bioactivity, natural products, mechanism of action, Organic chemistry, QD241-441

File Description: electronic resource

Relation: http://www.mdpi.com/1420-3049/20/3/3496; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/a11046933fd04509a870988dc18cab1b

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HM30181A, a potent P-glycoprotein inhibitor, potentiates the absorption and in vivo antitumor efficacy of paclitaxel in an orthotopic brain tumor model.

Authors: Wu Zeng¹, Betty Yuen Kwan Law¹, Vincent Kam Wai Wong¹, Denise So Bik Chan², Simon Wing Fai Mok^1,3, Joyce Jia Ying Gao¹, Rebecca Ka Yan Ho³, Xu Liang², Jia Hao Li², Ming Tsung Lee², Weng Li Yoon², Michael P Smolinski⁴, Johnson Yiu Nam Lau², Christopher Wai Kei Lam³ wklam@must.edu.mo, Manson Fok³ manson.fok@gamil.com

Source: Cancer Biology & Medicine. Nov2020, Vol. 17 Issue 4, p986-1001. 16p.

Subject Terms: *BRAIN tumors, *PACLITAXEL, *WEIGHT loss, *P-glycoprotein, *GLIOMAS, *SURVIVAL analysis (Biometry)

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New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy.

Authors: Betty Yuen Kwan Law¹ (AUTHOR) yklaw@must.edu.mo, Simon Wing Fai Mok¹ (AUTHOR) smok55@hotmail.com, An Guo Wu¹ (AUTHOR) wag1114@foxmail.com, Kei Lam, Christopher Wai¹ (AUTHOR) wklam@must.edu.mo, Margaret Xin Yi Yu¹ (AUTHOR) yxyworld@aliyun.com, Vincent Kam Wai Wong¹ (AUTHOR) kawwong@must.edu.mo

Source: Molecules. Mar2016, Vol. 21 Issue 3, p359-403. 45p. 1 Color Photograph, 1 Chart.

Natural small-molecule enhancers of autophagy induce autophagic cell death in apoptosis-defective cells.

Authors: Betty Yuen Kwan Law¹, Wai Kit Chan¹, Su Wei Xu¹, Jing Rong Wang¹, Li Ping Bai¹, Liang Liu¹ lliu@must.edu.mo, Vincent Kam Wai Wong¹ bowaiwong@gmail.com

Source: Scientific Reports. 7/4/2014, p1-14. 14p.

Subject Terms: *AUTOPHAGY, *APOPTOSIS, *CANCER cells, *CANCER chemotherapy, *TUMOR classification

Onjisaponin B Derived from Radix Polygalae Enhances Autophagy and Accelerates the Degradation of Mutant a-Synuclein and Huntingtin in PC-12 Cells.

Authors: An-Guo Wu, Vincent Kam-Wai Wong, Su-Wei Xu, Wai-Kit Chan, Choi-In Ng, Liang Liu, Betty Yuen-Kwan Law

Source: International Journal of Molecular Sciences; Nov2013, Vol. 14 Issue 11, p22618-22641, 24p

Subject Terms: TRITERPENES, POLYGALA, AUTOPHAGY, GENETIC mutation, HUNTINGTIN protein, MITOGEN-activated protein kinases, ALPHA-synuclein

X-chromosome-linked miR-542-5p as a key regulator of sex disparity in rats with adjuvant-induced arthritis by promoting Th17 differentiation

Authors: Jiu Jie Yang, Zhi Li, Lin Na Wang, Bai Xiong Huang, Jerome P. L. Ng, Xiong Fei Xu, Yu Ping Wang, David Wei Zhang, Bo Qin, Ding Qi Zhang, Chang Liu, Wei Dan Luo, Betty Yuen Kwan Law, Hui Miao Wang, Meng Han Liu, Xiao Yun Yun, Joyce Tsz Wai Chan, Wan Yu Wu, Yi Ting Li, Peter Kam Fai Cheung, Man Chon Pou, Kat Sang Ha, Wang Fai Ao Ieong, Chi Hou Leong, Kit Ieng Leong, Chan Wang Lei, Lek Hang Cheang, Vincent Kam Wai Wong

Source: Biomarker Research, Vol 13, Iss 1, Pp 1-15 (2025)

Subject Terms: Rheumatoid arthritis (RA), Sex disparity, Autoimmune disease, X chromosome, X-linked microRNA, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2050-7771

Access URL: https://doaj.org/article/dc431729e23946a0bb96d06e8f270277