Transporter-Enzyme Interplay in the Pharmacokinetics of PF-06835919, a First-In-Class Ketohexokinase Inhibitor for Metabolic Disorders and Nonalcoholic Fatty Liver Disease

Authors: Weng, Yan, Fonseca, Kari R., Bi, Yi-an, Mathialagan, Sumathy, Riccardi, Keith, Tseng, Elaine, Bessire, Andrew J., Cerny, Mathew A., Tess, David A., Rodrigues, A. David, Kalgutkar, Amit S., Litchfield, John, Di, Li, Varma, Manthena V.S. ^*

Source: In Drug Metabolism and Disposition September 2022 50(9):1312-1321

Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948.

Authors: Filipski, Kevin J., Martinez-Alsina, Luis A., Reese, Matthew R., Evrard, Edelweiss, Buzon, Leanne M., Cameron, Kimberly O., Zhang, Yuan, Coffman, Karen J., Bradow, James, Kormos, Bethany L., Liu, Shenping, Knafels, John D., Sahasrabudhe, Parag V., Chen, Jie, Kalgutkar, Amit S., Bessire, Andrew J., Orozco, Christine C., Balesano, Amanda, Cerny, Matthew A., Bollinger, Eliza

Source: Journal of Medicinal Chemistry; 2/13/2025, Vol. 68 Issue 3, p2466-2482, 17p

LC/MS Methods for Studying Lysosomal ADC Catabolism

Authors: Bessire, Andrew J., Subramanyam, Chakrapani

Source: Methods in molecular biology. 2078:341-352

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN622106230&indx=1&recIds=ETOCRN622106230

Development of Fluorophore-Labeled Thailanstatin Antibody-Drug Conjugates for Cellular Trafficking Studies

Authors: Kulkarni, Chethana, Finley, James E., Bessire, Andrew J., Zhong, Xiaotian, Musto, Sylvia, Graziani, Edmund I.

Source: Bioconjugate chemistry. 28(4):1041-1047

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631357839&indx=1&recIds=ETOCRN631357839

Determination of Antibody—Drug Conjugate Released Payload Species Using Directed in Vitro Assays and Mass Spectrometric Interrogation

Authors: Bessire, Andrew J., Ballard, T. Eric, Charati, Manoj, Cohen, Justin, Green, Michael, Lam, My-Hanh, Loganzo, Frank, Nolting, Birte, Pierce, Betsy, Puthenveetil, Sujiet

Source: Bioconjugate chemistry. 27(7):1645-1654

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631258577&indx=1&recIds=ETOCRN631258577

Linkage isomerization equilibria in (chloranilato)palladium(II) complexes with amine ligands. Crystal structure of (chloranilato)bis(acetonitrile)palladium(II)

Authors: Bessire, Andrew J., Whittlesey, Bruce R., Holwerda, Robert A.

Source: Inorganic Chemistry; February 1 1995, Vol. 34, p622-627, 6p

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Dirlotapide as a model substrate to refine structure-based drug design strategies on CYP3A4-catalyzed metabolism

Authors: Sun, Hao, Bessire, Andrew J., Vaz, Alfin

Source: In Bioorganic & Medicinal Chemistry Letters 1 January 2012 22(1):371-376

Nonclinical characterization of the pharmacokinetics and disposition of inotuzumab ozogamicin, a calicheamicin-containing antibody-drug conjugate

Authors: Johnson, Theodore R., Bessire, Andrew J., Gleave, Michelle, Nedderman, Angus N.R., Kavosi, Mania, Ballard, T. Eric

Source: In Drug Metabolism and Pharmacokinetics January 2018 33(1) Supplement:S40-S40

Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide

Authors: Robinson, Ralph P., Bartlett, Jeremy A., Bertinato, Peter, Bessire, Andrew J., Cosgrove, Judith, Foley, Patrick M., Manion, Tara B., Minich, Martha L., Ramos, Brenda, Reese, Matthew R., Schmahai, Theodore J., Swick, Andrew G., Tess, David A., Vaz, Alfin, Wolford, Angela

Source: In Bioorganic & Medicinal Chemistry Letters 2011 21(14):4150-4154

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Deconstruction of Activity-Dependent Covalent Modification of Heme in Human Neutrophil Myeloperoxidase by Multistage Mass Spectrometry (MS⁴).

Authors: Geoghegan, Kieran F.¹, kieran.f.geoghegan@pfizer.com, Varghese, Alison H.¹, Xidong Feng¹, Bessire, Andrew J.¹, Conboy, James J.¹, Ruggeri, Roger B.¹, Ahn, Kay¹, Spath, Samantha N.¹, Filippov, Sergey V.¹, Conrad, Steven J.¹, Carpino, Philip A.¹, Guimarães, Cristiano R. W.¹, Vajdos, Felix F.¹

Source: Biochemistry; 3/13/2012, Vol. 51 Issue 10, p2065-2077, 13p

Deconstruction of Activity-Dependent Covalent Modification of Heme in Human Neutrophil Myeloperoxidase by Multistage Mass Spectrometry (MS⁴).

Authors: Geoghegan, Kieran F., Varghese, Alison H., Xidong Feng, Bessire, Andrew J., Conboy, James J., Ruggeri, Roger B., Ahn, Kay, Spath, Samantha N., Filippov, Sergey V., Conrad, Steven J., Carpino, Philip A., Guimarães, Cristiano R. W., Vajdos, Felix F.

Source: Biochemistry; 3/13/2012, Vol. 51 Issue 10, p2065-2077, 13p

The use of ¹⁸O-exchange and base-catalyzed N-dealkylation with liquid chromatography/tandem mass spectrometry to identify carbinolamide metabolites.

Authors: Bessire, Andrew J., Vaz, Alfin D. N., Walker, Gregory S., Wang, Wei Wei, Sharma, Raman

Source: Rapid Communications in Mass Spectrometry: RCM; Jul2010, Vol. 24 Issue 14, p2151-2161, 11p

Deconstruction of Activity-Dependent Covalent Modification of Heme in Human Neutrophil Myeloperoxidase by Multistage Mass Spectrometry (MS⁴).

Authors: Geoghegan, Kieran F.¹, kieran.f.geoghegan@pfizer.com, Varghese, Alison H.¹, Xidong Feng¹, Bessire, Andrew J.¹, Conboy, James J.¹, Ruggeri, Roger B.¹, Ahn, Kay¹, Spath, Samantha N.¹, Filippov, Sergey V.¹, Conrad, Steven J.¹, Carpino, Philip A.¹, Guimarães, Cristiano R. W.¹, Vajdos, Felix F.¹

Source: Biochemistry; 3/13/2012, Vol. 51 Issue 10, p2065-2077, 13p

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Redox reactivity of azathiaferrocenophane complexes with copper(II) and palladium(II)

Authors: Kim, Jong Seung, Bessire, Andrew J., Bartsch, Richard A., Holwerda, Robert A., Czech, Bronislaw P.

Source: In Journal of Organometallic Chemistry 1994 484(1):47-51