Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations

Authors: Nasrallah, Chady, Cannone, Giuseppe, Briot, Julie, Rottier, Karine, Berizzi, Alice E., Huang, Chia-Ying, Quast, Robert B., Hoh, Francois, Banères, Jean-Louis, Malhaire, Fanny, Berto, Ludovic, Dumazer, Anaëlle, Font-Ingles, Joan, Gómez-Santacana, Xavier, Catena, Juanlo, Kniazeff, Julie, Goudet, Cyril, Llebaria, Amadeu, Pin, Jean-Philippe, Vinothkumar, Kutti R., Lebon, Guillaume

Source: In Cell Reports 31 August 2021 36(9)

Conformational diversity in class C GPCR positive allosteric modulation.

Authors: Cannone, Giuseppe, Berto, Ludovic, Malhaire, Fanny, Ferguson, Gavin, Fouillen, Aurelien, Balor, Stéphanie, Font-Ingles, Joan, Llebaria, Amadeu, Goudet, Cyril, Kotecha, Abhay, K.R., Vinothkumar, Lebon, Guillaume

Source: Nature Communications; 1/13/2025, Vol. 16 Issue 1, p1-17, 17p

Subject Terms: TRANSMEMBRANE domains, GLUTAMATE receptors, ALLOSTERIC regulation, LIFE sciences, MEDICAL sciences, G protein coupled receptors

Les avancées récentes dans le domaine de la biologie structurale des récepteurs couplés aux protéines G de la classe C : Le récepteur métabotropique du glutamate 5. (French)

Alternate Title: Recent advances in the structural biology of the class C G protein-coupled receptors: The metabotropic Glutamate receptor 5. (English)

Authors: Berto, Ludovic, Dumazer, Anaëlle, Malhaire, Fanny, Cannone, Giuseppe, Kutti Ragunath, Vinothkumar, Goudet, Cyril, Lebon, Guillaume

Source: Biologie Aujourd'hui; 2021, Vol. 215 Issue 3/4, p85-94, 10p

Subject Terms: G protein coupled receptors, GLUTAMATE receptors, MICROSCOPY