Modulation of pain sensitivity by Ascl1- and Lhx6-dependent GABAergic neuronal function in streptozotocin diabetic mice

Authors: Hwang, Sung-Min ¹, Rahman, Md. Mahbubur ¹, Go, Eun Jin ¹, Roh, Jueun ¹, Park, Rayoung ², Lee, Sung-Gwon ³, Nahm, Minyeop ⁴, Berta, Temugin ⁵, Kim, Yong Ho ^{1, ∗}, Park, Chul-Kyu ^{1, ∗∗}

Source: In Molecular Therapy 5 February 2025 33(2):786-804

The LRP1-SHP2 pathway regulates TRPV1 sensitivity in the peripheral nervous system: Insights from amyloid beta 1–42 modulation

Authors: Hwang, Sung-Min ^{a, 1}, Roh, Jueun ^{a, 1}, Go, Eun Jin ^{a, 1}, Pan, Jing-Ying ^b, Park, Jaeik ^a, Rahman, Mahbubur ^a, Jung, YunJae ^c, Lee, Sun-Ho ^d, Han, Inbo ^e, Chung, Gehoon ^f, Lee, Sang Hoon ^g, Berta, Temugin ^g, Park, Chul-Kyu ^{a, c, ⁎}, Kim, Yong Ho ^{a, c, ⁎}

Source: In Journal of Advanced Research March 2025

STING recognition of viral dsDNA by nociceptors mediates pain in mice

Authors: Lee, Sang Hoon, Bonifacio, Fabio, Prudente, Arthur Silveira, Choi, YI, Roh, Jueun, Adjafre, Beatriz Lima, Park, Chul-Kyu, Jung, Sung Jun, Cunha, Thiago M., Berta, Temugin

Source: In Brain Behavior and Immunity October 2024 121:29-42

Microglial STING activation alleviates nerve injury-induced neuropathic pain in male but not female mice

Authors: Silveira Prudente, Arthur, Hoon Lee, Sang, Roh, Jueun, Luckemeyer, Debora D., Cohen, Cinder F., Pertin, Marie, Park, Chul-Kyu, Suter, Marc R., Decosterd, Isabelle, Zhang, Jun-Ming, Ji, Ru-Rong, Berta, Temugin

Source: In Brain Behavior and Immunity March 2024 117:51-65

Single-cell analysis of dorsal root ganglia reveals metalloproteinase signaling in satellite glial cells and pain

Authors: Tonello, Raquel, Silveira Prudente, Arthur, Hoon Lee, Sang, Faith Cohen, Cinder, Xie, Wenrui, Paranjpe, Aditi, Roh, Jueun, Park, Chul-Kyu, Chung, Gehoon, Strong, Judith A., Zhang, Jun-Ming, Berta, Temugin

Source: Brain behavior and immunity. 113:401-414

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Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain: an update

Authors: Berta, Temugin, Strong, Judith A., Zhang, Jun-Ming, Ji, Ru-Rong

Source: Expert opinion on therapeutic targets. 27(8):665-678

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193502395.0x000001&indx=1&recIds=ETOCvdc_100193502395.0x000001

In vivo single microglial cell isolation after intracerebral hemorrhage in mice

Authors: Lei, Beilei, Ho Kim, Yong, Qi, Wenjing, Berta, Temugin, Covington, Anna, Lusk, Jay B., Warner, David S., Ji, Ru-rong, James, Michael L.

Source: In Neuroscience Letters 14 September 2022 787

IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice

Authors: Luo, Xin, Chen, Ouyang, Wang, Zilong, Bang, Sangsu, Ji, Jasmine, Lee, Sang Hoon, Huh, Yul, Furutani, Kenta, He, Qianru, Tao, Xueshu, Ko, Mei-Chuan, Bortsov, Andrey, Donnelly, Christopher R., Chen, Yong, Nackley, Andrea, Berta, Temugin, Ji, Ru-Rong

Source: In Neuron 1 September 2021 109(17):2691-2706

Key role of CCR2-expressing macrophages in a mouse model of low back pain and radiculopathy

Authors: Zhang, Li, Xie, Wenrui, Zhang, Jingdong, Shanahan, Hailey, Tonello, Raquel, Lee, Sang Hoon, Strong, Judith A., Berta, Temugin, Zhang, Jun-Ming

Source: In Brain Behavior and Immunity January 2021 91:556-567

GLP-1 and its derived peptides mediate pain relief through direct TRPV1 inhibition without affecting thermoregulation.

Authors: Go, Eun Jin, Hwang, Sung-Min, Jo, Hyunjung, Rahman, Md. Mahbubur, Park, Jaeik, Lee, Ji Yeon, Jo, Youn Yi, Lee, Byung-Gil, Jung, YunJae, Berta, Temugin, Kim, Yong Ho, Park, Chul-Kyu

Source: Experimental & Molecular Medicine EMM; Nov2024, Vol. 56 Issue 11, p2449-2464, 16p

Sensory Neuron–Expressed TRPC4 Is a Target for the Relief of Psoriasiform Itch and Skin Inflammation in Mice

Authors: Lee, Sang Hoon, Tonello, Raquel, Choi, Youngin, Jung, Sung Jun, Berta, Temugin

Source: In Journal of Investigative Dermatology November 2020 140(11):2221-2229

Monoclonal Antibody Targeting the Matrix Metalloproteinase 9 Prevents and Reverses Paclitaxel-Induced Peripheral Neuropathy in Mice

Authors: Tonello, Raquel, Lee, Sang Hoon, Berta, Temugin

Source: In The Journal of Pain May 2019 20(5):515-527

The inhibition of Kir2.1 potassium channels depolarizes spinal microglial cells, reduces their proliferation, and attenuates neuropathic pain

Authors: Gattlen, Christophe, Deftu, Alexandru‐Florian, Tonello, Raquel, Ling, Yuejuan, Berta, Temugin, Ristoiu, Violeta, Suter, Marc René

Source: Glia. 68(10):2119-2135

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Local Sympathectomy Promotes Anti-inflammatory Responses and Relief of Paclitaxel-induced Mechanical and Cold Allodynia in Mice

Authors: Tonello, Raquel, Xie, Wenrui, Lee, Sang Hoon, Wang, Min, Liu, Xiaojuan, Strong, Judith A., Zhang, Jun-Ming, Berta, Temugin

Source: Anesthesiology. 132(6):1540-1553

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181447501.0x000001&indx=1&recIds=ETOCvdc_100181447501.0x000001

Paclitaxel-activated astrocytes produce mechanical allodynia in mice by releasing tumor necrosis factor-α and stromal-derived cell factor 1

Authors: Liu, Xiaojuan, Tonello, Raquel, Ling, Yuejuan, Gao, Yong-Jing, Berta, Temugin

Source: Journal of neuroinflammation. 16(1):1-14

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190679671.0x000001&indx=1&recIds=ETOCvdc_100190679671.0x000001

Transcriptional profile of spinal dynorphin-lineage interneurons in the developing mouse

Authors: Serafin, Elizabeth K., Chamessian, Alexander, Li, Jie, Zhang, Xiang, McGann, Amanda, Brewer, Chelsie L., Berta, Temugin, Baccei, Mark

Source: Pain. 160(10):2380-2397

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174980651.0x000001&indx=1&recIds=ETOCvdc_100174980651.0x000001

Transcriptional Profiling of Somatostatin Interneurons in the Spinal Dorsal Horn

Authors: Chamessian, Alexander, Young, Michael, Qadri, Yawar, Berta, Temugin, Ji, Ru-Rong, Van de Ven, Thomas

Source: Scientific reports. 8(1):1-16

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135424258.0x000001&indx=1&recIds=ETOCvdc_100135424258.0x000001

High-fat diet exacerbates postoperative pain and inflammation in a sex-dependent manner

Authors: Song, Zongbin, Xie, Wenrui, Strong, Judith A., Berta, Temugin, Ulrich-Lai, Yvonne M., Guo, Qulian, Zhang, Jun-Ming

Source: Pain. 159(9):1731-1741

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174974350.0x000001&indx=1&recIds=ETOCvdc_100174974350.0x000001

SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons

Authors: Han, Qingjian, Kim, Yong Ho, Wang, Xiaoming, Liu, Di, Zhang, Zhi-Jun, Bey, Alexandra L., Lay, Mark, Chang, Wonseok, Berta, Temugin, Zhang, Yan, Jiang, Yong-Hui, Ji, Ru-Rong

Source: In Neuron 21 December 2016 92(6):1279-1293

Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord

Authors: Taves, Sarah, Berta, Temugin, Liu, Da-Lu, Gan, Sophie, Chen, Gang, Kim, Yong Ho, Van de Ven, Thomas, Laufer, Stefan, Ji, Ru-Rong

Source: In Brain Behavior and Immunity July 2016 55:70-81