PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilization

Authors: Ito, Junya, Nakamura, Toshitaka, Toyama, Takashi, Chen, Deng, Berndt, Carsten, Poschmann, Gereon, Mourão, André Santos Dias, Doll, Sebastian, Suzuki, Mirai, Zhang, Weijia, Zheng, Jiashuo, Trümbach, Dietrich, Yamada, Naoya, Ono, Koya, Yazaki, Masana, Kawai, Yasutaka, Arisawa, Mieko, Ohsaki, Yusuke, Shirakawa, Hitoshi, Wahida, Adam, Proneth, Bettina, Saito, Yoshiro, Nakagawa, Kiyotaka, Mishima, Eikan, Conrad, Marcus

Source: In Molecular Cell 5 December 2024 84(23):4629-4644

Ferroptosis in health and disease

Authors: Berndt, Carsten, Alborzinia, Hamed, Amen, Vera Skafar, Ayton, Scott, Barayeu, Uladzimir, Bartelt, Alexander, Bayir, Hülya, Bebber, Christina M., Birsoy, Kivanc, Böttcher, Jan P., Brabletz, Simone, Brabletz, Thomas, Brown, Ashley R., Brüne, Bernhard, Bulli, Giorgia, Bruneau, Alix, Chen, Quan, DeNicola, Gina M., Dick, Tobias P., Distéfano, Ayelén, Dixon, Scott J., Engler, Jan B., Esser-von Bieren, Julia, Fedorova, Maria, Friedmann Angeli, José Pedro, Friese, Manuel A., Fuhrmann, Dominic C., García-Sáez, Ana J., Garbowicz, Karolina, Götz, Magdalena, Gu, Wei, Hammerich, Linda, Hassannia, Behrouz, Jiang, Xuejun, Jeridi, Aicha, Kang, Yun Pyo, Kagan, Valerian E., Konrad, David B., Kotschi, Stefan, Lei, Peng, Le Tertre, Marlène, Lev, Sima, Liang, Deguang, Linkermann, Andreas, Lohr, Carolin, Lorenz, Svenja, Luedde, Tom, Methner, Axel, Michalke, Bernhard, Milton, Anna V., Min, Junxia, Mishima, Eikan, Müller, Sebastian, Motohashi, Hozumi, Muckenthaler, Martina U., Murakami, Shohei, Olzmann, James A., Pagnussat, Gabriela, Pan, Zijan, Papagiannakopoulos, Thales, Pedrera Puentes, Lohans, Pratt, Derek A., Proneth, Bettina, Ramsauer, Lukas, Rodriguez, Raphael, Saito, Yoshiro, Schmidt, Felix, Schmitt, Carina, Schulze, Almut, Schwab, Annemarie, Schwantes, Anna, Soula, Mariluz, Spitzlberger, Benedikt, Stockwell, Brent R., Thewes, Leonie, Thorn-Seshold, Oliver, Toyokuni, Shinya, Tonnus, Wulf, Trumpp, Andreas, Vandenabeele, Peter, Vanden Berghe, Tom, Venkataramani, Vivek, Vogel, Felix C.E., von Karstedt, Silvia, Wang, Fudi, Westermann, Frank, Wientjens, Chantal, Wilhelm, Christoph, Wölk, Michele, Wu, Katherine, Yang, Xin, Yu, Fan, Zou, Yilong, Conrad, Marcus

Source: In Redox Biology September 2024 75

Systemic and strict regulation of the glutathione redox state in mitochondria and cytosol is needed for zebrafish ontogeny

Authors: Hamre, Kristin, Zhang, Wuxiao, Austgulen, Maren Hoff, Mykkeltvedt, Eva, Yin, Peng, Berntssen, Marc, Espe, Marit, Berndt, Carsten

Source: In BBA - General Subjects June 2024 1868(6)

Glutaredoxin 2 promotes SP-1-dependent CSPG4 transcription and migration of wound healing NG2 glia and glioma cells: Enzymatic Taoism

Authors: Wilms, Christina, Lepka, Klaudia, Häberlein, Felix, Edwards, Steven, Felsberg, Jörg, Pudelko, Linda, Lindenberg, Tobias T., Poschmann, Gereon, Qin, Nan, Volbracht, Katrin, Prozorovski, Tim, Meuth, Sven G., Kahlert, Ulf D., Remke, Marc, Aktas, Orhan, Reifenberger, Guido, Bräutigam, Lars, Odermatt, Benjamin, Berndt, Carsten

Source: In Redox Biology February 2022 49

Deficiency of the Two-Pore Potassium Channel KCNK9 Impairs Intestinal Epithelial Cell Survival and Aggravates Dextran Sodium Sulfate-Induced Colitis

Authors: Pfeuffer, Steffen, Müntefering, Thomas, Rolfes, Leoni, Straeten, Frederike Anne, Eichler, Susann, Gruchot, Joel, Dobelmann, Vera, Prozorovski, Tim, Görg, Boris, Vucur, Mihael, Berndt, Carsten, Küry, Patrick, Ruck, Tobias, Bittner, Stefan, Bettenworth, Dominik, Budde, Thomas, Lüdde, Tom, Meuth, Sven G.

Source: In Cellular and Molecular Gastroenterology and Hepatology 2022 14(6):1199-1211

Glutaredoxins with iron-sulphur clusters in eukaryotes - Structure, function and impact on disease

Authors: Berndt, Carsten, Christ, Loïck, Rouhier, Nicolas, Mühlenhoff, Ulrich

Source: In BBA - Bioenergetics 1 January 2021 1862(1)

Muscarinic receptor drug trihexyphenidyl can alter growth of mesenchymal glioblastoma in vivo.

Authors: Du, Renfei, Sanin, Ahmed Y., Shi, Wenjie, Huang, Bing, Nickel, Ann-Christin, Vargas-Toscano, Andres, Huo, Shuran, Nickl-Jockschat, Thomas, Dumitru, Claudia A., Hu, Wei, Duan, Siyu, Sandalcioglu, I. Erol, Croner, Roland S., Alcaniz, Joshua, Walther, Wolfgang, Berndt, Carsten, Kahlert, Ulf D.

Source: Frontiers in Pharmacology; 2024, p1-12, 12p

Subject Terms: BRAIN tumors, DRUG receptors, DRUG repositioning, TUMOR classification, GLIOBLASTOMA multiforme, MUSCARINIC receptors

Muscarinic receptor drug trihexyphenidyl can alter growth of mesenchymal glioblastoma in vivo.

Authors: Renfei Du, Sanin, Ahmed Y., Wenjie Shi, Bing Huang, Nickel, Ann-Christin, Vargas-Toscano, Andres, Shuran Huo, Nickl-Jockschat, Thomas, Dumitru, Claudia A., Wei Hu, Siyu Duan, Sandalcioglu, I. Erol, Croner, Roland S., Alcaniz, Joshua, Walther, Wolfgang, Berndt, Carsten, Kahlert, Ulf D.

Source: Frontiers in Pharmacology; 2024, p1-12, 12p

Subject Terms: BRAIN tumors, DRUG receptors, DRUG repositioning, TUMOR classification, GLIOBLASTOMA multiforme, MUSCARINIC receptors

Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells

Authors: Prozorovski, Tim, Ingwersen, Jens, Lukas, Denise, Göttle, Peter, Koop, Barbara, Graf, Jonas, Schneider, Reiner, Franke, Kristin, Schumacher, Stefan, Britsch, Stefan, Hartung, Hans-Peter, Küry, Patrick, Berndt, Carsten, Aktas, Orhan

Source: In Neuroscience Letters 21 June 2019 704:116-125

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

Authors: Ingold, Irina, Berndt, Carsten, Schmitt, Sabine, Doll, Sebastian, Poschmann, Gereon, Buday, Katalin, Roveri, Antonella, Peng, Xiaoxiao, Porto Freitas, Florencio, Seibt, Tobias, Mehr, Lisa, Aichler, Michaela, Walch, Axel, Lamp, Daniel, Jastroch, Martin, Miyamoto, Sayuri, Wurst, Wolfgang, Ursini, Fulvio, Arnér, Elias S.J., Fradejas-Villar, Noelia, Schweizer, Ulrich, Zischka, Hans, Friedmann Angeli, José Pedro, Conrad, Marcus

Source: In Cell 25 January 2018 172(3):409-422

Characterization of Human Glutaredoxin 2 as Iron-Sulfur Protein: A Possible Role as Redox Sensor

Authors: Lillig, Christopher Horst, Berndt, Carsten, Vergnolle, Olivia, Lönn, Maria Elisabet, Hudemann, Christoph, Bill, Eckhard, Holmgren, Arne, Lerner, Richard A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2005 Jun 01. 102(23), 8168-8173.

Access URL: https://www.jstor.org/stable/3375811

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

Authors: Egea, Javier, Fabregat, Isabel, Frapart, Yves M., Ghezzi, Pietro, Görlach, Agnes, Kietzmann, Thomas, Kubaichuk, Kateryna, Knaus, Ulla G., Lopez, Manuela G., Olaso-Gonzalez, Gloria, Petry, Andreas, Schulz, Rainer, Vina, Jose, Winyard, Paul, Abbas, Kahina, Ademowo, Opeyemi S., Afonso, Catarina B., Andreadou, Ioanna, Antelmann, Haike, Antunes, Fernando, Aslan, Mutay, Bachschmid, Markus M., Barbosa, Rui M., Belousov, Vsevolod, Berndt, Carsten, Bernlohr, David, Bertrán, Esther, Bindoli, Alberto, Bottari, Serge P., Brito, Paula M., Carrara, Guia, Casas, Ana I., Chatzi, Afroditi, Chondrogianni, Niki, Conrad, Marcus, Cooke, Marcus S., Costa, João G., Cuadrado, Antonio, My-Chan Dang, Pham, De Smet, Barbara, Debelec–Butuner, Bilge, Dias, Irundika H.K., Dunn, Joe Dan, Edson, Amanda J., El Assar, Mariam, El-Benna, Jamel, Ferdinandy, Péter, Fernandes, Ana S., Fladmark, Kari E., Förstermann, Ulrich, Giniatullin, Rashid, Giricz, Zoltán, Görbe, Anikó, Griffiths, Helen, Hampl, Vaclav, Hanf, Alina, Herget, Jan, Hernansanz-Agustín, Pablo, Hillion, Melanie, Huang, Jingjing, Ilikay, Serap, Jansen-Dürr, Pidder, Jaquet, Vincent, Joles, Jaap A., Kalyanaraman, Balaraman, Kaminskyy, Danylo, Karbaschi, Mahsa, Kleanthous, Marina, Klotz, Lars-Oliver, Korac, Bato, Korkmaz, Kemal Sami, Koziel, Rafal, Kračun, Damir, Krause, Karl-Heinz, Křen, Vladimír, Krieg, Thomas, Laranjinha, João, Lazou, Antigone, Li, Huige, Martínez-Ruiz, Antonio, Matsui, Reiko, McBean, Gethin J., Meredith, Stuart P., Messens, Joris, Miguel, Verónica, Mikhed, Yuliya, Milisav, Irina, Milković, Lidija, Miranda-Vizuete, Antonio, Mojović, Miloš, Monsalve, María, Mouthuy, Pierre-Alexis, Mulvey, John, Münzel, Thomas, Muzykantov, Vladimir, Nguyen, Isabel T.N., Oelze, Matthias, Oliveira, Nuno G., Palmeira, Carlos M., Papaevgeniou, Nikoletta, Pavićević, Aleksandra, Pedre, Brandán, Peyrot, Fabienne, Phylactides, Marios, Pircalabioru, Gratiela G., Pitt, Andrew R., Poulsen, Henrik E., Prieto, Ignacio, Rigobello, Maria Pia, Robledinos-Antón, Natalia, Rodríguez-Mañas, Leocadio, Rolo, Anabela P., Rousset, Francis, Ruskovska, Tatjana, Saraiva, Nuno, Sasson, Shlomo, Schröder, Katrin, Semen, Khrystyna, Seredenina, Tamara, Shakirzyanova, Anastasia, Smith, Geoffrey L., Soldati, Thierry, Sousa, Bebiana C., Spickett, Corinne M., Stancic, Ana, Stasia, Marie José, Steinbrenner, Holger, Stepanić, Višnja, Steven, Sebastian, Tokatlidis, Kostas, Tuncay, Erkan, Turan, Belma, Ursini, Fulvio, Vacek, Jan, Vajnerova, Olga, Valentová, Kateřina, Van Breusegem, Frank, Varisli, Lokman, Veal, Elizabeth A., Yalçın, A. Suha, Yelisyeyeva, Olha, Žarković, Neven, Zatloukalová, Martina, Zielonka, Jacek, Touyz, Rhian M., Papapetropoulos, Andreas, Grune, Tilman, Lamas, Santiago, Schmidt, Harald H.H.W., Di Lisa, Fabio, Daiber, Andreas

Source: In Redox Biology October 2017 13:94-162

The metalloprotease ADAMTS4 generates N-truncated Aβ4–x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease

Authors: Walter, Susanne, Jumpertz, Thorsten, Hüttenrauch, Melanie, Ogorek, Isabella, Gerber, Hermeto, Storck, Steffen E., Zampar, Silvia, Dimitrov, Mitko, Lehmann, Sandra, Lepka, Klaudia, Berndt, Carsten, Wiltfang, Jens, Becker-Pauly, Christoph, Beher, Dirk, Pietrzik, Claus U., Fraering, Patrick C., Wirths, Oliver, Weggen, Sascha

Source: Acta neuropathologica. 137(2):239-257

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100141525964.0x000001&indx=1&recIds=ETOCvdc_100141525964.0x000001

Early alpha-lipoic acid therapy protects from degeneration of the inner retinal layers and vision loss in an experimental autoimmune encephalomyelitis-optic neuritis model

Authors: Dietrich, Michael, Helling, Niklas, Hilla, Alexander, Heskamp, Annemarie, Issberner, Andrea, Hildebrandt, Thomas, Kohne, Zippora, Küry, Patrick, Berndt, Carsten, Aktas, Orhan, Fischer, Dietmar, Hartung, Hans-Peter, Albrecht, Philipp

Source: Journal of neuroinflammation. 15(1):1-13

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161462615.0x000001&indx=1&recIds=ETOCvdc_100161462615.0x000001

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

Authors: Gascón, Sergio, Murenu, Elisa, Masserdotti, Giacomo, Ortega, Felipe, Russo, Gianluca L., Petrik, David, Deshpande, Aditi, Heinrich, Christophe, Karow, Marisa, Robertson, Stephen P., Schroeder, Timm, Beckers, Johannes, Irmler, Martin, Berndt, Carsten, Angeli, José P. Friedmann, Conrad, Marcus, Berninger, Benedikt, Götz, Magdalena

Source: In Cell Stem Cell 3 March 2016 18(3):396-409

Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design.

Authors: Funk, Lisa-Marie, Poschmann, Gereon, Rabe von Pappenheim, Fabian, Chari, Ashwin, Stegmann, Kim M., Dickmanns, Antje, Wensien, Marie, Eulig, Nora, Paknia, Elham, Heyne, Gabi, Penka, Elke, Pearson, Arwen R., Berndt, Carsten, Fritz, Tobias, Bazzi, Sophia, Uranga, Jon, Mata, Ricardo A., Dobbelstein, Matthias, Hilgenfeld, Rolf, Curth, Ute

Source: Nature Communications; 1/9/2024, Vol. 15 Issue 1, p1-18, 18p

Subject Terms: DRUG design, SARS-CoV-2, OXIDATION-reduction reaction, COVID-19 pandemic, DRUG target, PROTEOLYTIC enzymes

Redox-regulated fate of neural stem progenitor cells

Authors: Prozorovski, Tim, Schneider, Reiner, Berndt, Carsten, Hartung, Hans-Peter, Aktas, Orhan

Source: In BBA - General Subjects August 2015 1850(8):1543-1554

Redox regulation of cytoskeletal dynamics during differentiation and de-differentiation

Authors: Gellert, Manuela, Hanschmann, Eva-Maria, Lepka, Klaudia, Berndt, Carsten, Lillig, Christopher Horst

Source: In BBA - General Subjects August 2015 1850(8):1575-1587

The mitochondrial monothiol glutaredoxin S15 is essential for iron-sulfur protein maturation in Arabidopsis thaliana

Authors: Moseler, Anna, Aller, Isabel, Wagner, Stephan, Nietzel, Thomas, Przybyla-Toscano, Jonathan, Mühlenhoff, Ulrich, Lill, Roland, Berndt, Carsten, Rouhier, Nicolas, Schwarzländer, Markus, Meyer, Andreas J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2015 Nov 01. 112(44), 13735-13740.

Access URL: https://www.jstor.org/stable/26465682

Arabidopsis Glutaredoxin S17 and Its Partner, the Nuclear Factor Y Subunit C11/Negative Cofactor 2 α , Contribute to Maintenance of the Shoot Apical Meristem under Long-Day Photoperiod

Authors: Knuesting, Johannes, Riondet, Christophe, Maria, Carlos, Kruse, Inga, Bécuwe, Noëlle, König, Nicolas, Berndt, Carsten, Tourrette, Sébastien, Guilleminot-Montoya, Jocelyne, Herrero, Enrique, Gaymard, Frédéric, Balk, Janneke, Belli, Gemma, Scheibe, Renate, Reichheld, Jean-Philippe, Rouhier, Nicolas, Rey, Pascal

Source: Plant Physiology, 2015 Apr 01. 167(4), 1643-1658.

Access URL: https://www.jstor.org/stable/24801856