The dynamics of thrombolysis over time in acute immunologic reactions

Authors: Calvin Lukas Kienbacher, Christian Schörgenhofer, Gerhard Ruzicka, Jürgen Grafeneder, Christine Hufnagl, Bernd Jilma, Michael Schwameis, Harald Herkner

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-7 (2025)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/e9c47932878b4efba411e60918fb8232

Very low doses of rituximab in autoimmune hemolytic anemia—an open-label, phase II pilot trial

Authors: Miriam M. Moser, Renate Thalhammer, Christian Sillaber, Ulla Derhaschnig, Christa Firbas, Ulrich Jäger, Bernd Jilma, Christian Schoergenhofer

Source: Frontiers in Medicine, Vol 11 (2024)

Subject Terms: rituximab, CD20+ B cells, autoimmune hemolytic anemia (AIHA), cold agglutinin disease, warm autoimmune hemolytic anemia, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2024.1481333/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/f5078ed6523a4ce0bc9992e69c004e1b

Efficacy and safety of asunercept, a CD95L-selective inhibitor, in hospitalised patients with moderate-to-severe COVID-19: ASUNCTIS, a multicentre, randomised, open-label, controlled, phase 2 trialResearch in context

Authors: Maria Pilar Ruiz Seco, José Ramón Paño Pardo, Christian Schoergenhofer, Christiane Dings, Thorsten Lehr, Felix Herth, Andriy Krendyukov, Carola Straub, Martin Kappler, Bernd Jilma, Harald Fricke, Julian Pardo, Diego de Miguel, Meinolf Thiemann, Michael Bergmann, Henning Walczak, Thomas Hoeger

Source: EClinicalMedicine, Vol 77, Iss , Pp 102879- (2024)

Subject Terms: Asunercept, CD95L (FasL), COVID-19, Phase 2 clinical trial, Lymphocytopenia, Apoptosis, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589537024004589; https://doaj.org/toc/2589-5370

Access URL: https://doaj.org/article/f34a85026187404385bbd167989aeaf9

Association of prediabetes with clinical outcomes in patients with chronic coronary syndrome: a post hoc analysis of the ISCHEMIA and ISCHEMIA-CKD trials

Authors: Anselm Jorda, Christian Hengstenberg, Irene M. Lang, Alexandra Kautzky-Willer, Jürgen Harreiter, Markus Zeitlinger, Bernd Jilma, Georg Gelbenegger

Source: Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-10 (2024)

Subject Terms: Impaired glucose tolerance, Stable coronary artery disease, Mortality, Prediabetes, Cardiovascular risk, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2840

Access URL: https://doaj.org/article/60ca539e3ee548b0929bec0d6d6fdf0c

Long-term efficacy and safety of continued complement C1s inhibition with sutimlimab in cold agglutinin disease: CADENZA study Part BResearch in context

Authors: Alexander Röth, Sigbjørn Berentsen, Wilma Barcellini, Shirley D’Sa, Bernd Jilma, Marc Michel, Ilene C. Weitz, Masaki Yamaguchi, Jun-ichi Nishimura, Josephine M.I. Vos, Joan Cid, Michael Storek, Nancy Wong, Ronnie Yoo, Deepthi Jayawardene, Shruti Srivastava, Marek Wardęcki, Frank Shafer, Michelle Lee, Catherine M. Broome

Source: EClinicalMedicine, Vol 74, Iss , Pp 102733- (2024)

Subject Terms: Autoimmune haemolytic anaemia, Cold agglutinin disease, Classical complement pathway, Complement C1s, Sutimlimab, Haemolysis, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589537024003122; https://doaj.org/toc/2589-5370

Access URL: https://doaj.org/article/3d87b23487004a108e8a911cd7c2cb67

Pharmacokinetics and pharmacodynamics of low doses of recombinant tissue plasminogen activator to establish a model for biosimilarity comparisons

Authors: Ulla Derhaschnig, Nina Buchtele, Margarete M. Steiner, Christa Drucker, Christa Firbas, Christian Schörgenhofer, Georg Gelbenegger, Franz König, Bernd Jilma, Katarina D. Kovacevic Miljevic

Source: Research and Practice in Thrombosis and Haemostasis, Vol 8, Iss 6, Pp 102518- (2024)

Subject Terms: pharmacodynamics, pharmacokinetics, tissue plasminogen activator, clinical trial, thrombolytic therapy, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2475037924002139; https://doaj.org/toc/2475-0379

Access URL: https://doaj.org/article/320aceae17f847ab935a975f45d5f00f

A randomized, double-blind study on the safety and immunogenicity of rTSST-1 variant vaccine: phase 2 resultsResearch in context

Authors: Christian Schoergenhofer, Georg Gelbenegger, Dzenita Hasanacevic, Léa Schöner, Margarete M. Steiner, Christa Firbas, Nina Buchtele, Ulla Derhaschnig, Andreas Tanzmann, Nina Model, Julian Larcher-Senn, Manuel Drost, Martha M. Eibl, Andreas Roetzer, Bernd Jilma

Source: EClinicalMedicine, Vol 67, Iss , Pp 102404- (2024)

Subject Terms: Staphylococcus aureus, Toxic shock syndrome, Superantigen, TSST-1, Vaccine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589537023005813; https://doaj.org/toc/2589-5370

Access URL: https://doaj.org/article/c5ad4265a94d4108997a1f30384cf6b2

Immunoglobulin G production in COVID-19 - associations with age, outcome, viral persistence, inflammation and pro-thrombotic markers

Authors: Anita Pirabe, Waltraud C. Schrottmaier, Stefan Heber, Anna Schmuckenschlager, Sonja Treiber, David Pereyra, Jonas Santol, Erich Pawelka, Marianna Traugott, Christian Schörgenhofer, Tamara Seitz, Mario Karolyi, Bernd Jilma, Ulrike Resch, Alexander Zoufaly, Alice Assinger

Source: Journal of Infection and Public Health, Vol 16, Iss 3, Pp 384-392 (2023)

Subject Terms: COVID-19, Immune response, Age, Immunoglobulins, Spike protein, Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1876034123000266; https://doaj.org/toc/1876-0341

Access URL: https://doaj.org/article/e03f979a9ae44b3197cba2120bc207e5

A multicentre, patient- and assessor-blinded, non-inferiority, randomised and controlled phase II trial to compare standard and torque teno virus-guided immunosuppression in kidney transplant recipients in the first year after transplantation: TTVguideIT

Authors: Frederik Haupenthal, Jette Rahn, Fabrizio Maggi, Fanny Gelas, Philippe Bourgeois, Christian Hugo, Bernd Jilma, Georg A. Böhmig, Harald Herkner, Michael Wolzt, Konstantin Doberer, Matthias Vossen, Daniele Focosi, Hannes Neuwirt, Miriam Banas, Bernhard Banas, Klemens Budde, Ondrej Viklicky, Paolo Malvezzi, Lionel Rostaing, Joris I. Rotmans, Stephan J. L. Bakker, Kathrin Eller, Daniel Cejka, Alberto Molina Pérez, David Rodriguez-Arias, Franz König, Gregor Bond, the TTVguideTX consortium partners

Source: Trials, Vol 24, Iss 1, Pp 1-22 (2023)

Subject Terms: Kidney transplantation, Torque teno virus, Immunosuppression, Tacrolimus, Immunological monitoring, Personalised medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1745-6215

Access URL: https://doaj.org/article/20431b7dfd564fe1995fc701d439b0ab

COVID-19 vaccine-associated myocarditis: Analysis of the suspected cases reported to the EudraVigilance and a systematic review of the published literature

Authors: Vikash Jaiswal, Dattatreya Mukherjee, Song Peng Ang, Tejasvi Kainth, Sidra Naz, Abhigan Babu Shrestha, Vibhor Agrawal, Saloni Mitra, Jia Ee Chia, Bernd Jilma, Mamas A. Mamas, Catherine Gebhard, Marek Postula, Jolanta M. Siller-Matula

Source: International Journal of Cardiology: Heart & Vasculature, Vol 49, Iss , Pp 101280- (2023)

Subject Terms: COVID-19 vaccine, mRNA vaccine, Myocarditis, Myopericarditis, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352906723001112; https://doaj.org/toc/2352-9067

Access URL: https://doaj.org/article/165c5673102f4441a112fdea5dc7cbe2

Population-based incidence of all-cause anaphylaxis and its development over time: a systematic review and meta-analysis

Authors: Vanessa Pühringer, Bernd Jilma, Harald Herkner

Source: Frontiers in Allergy, Vol 4 (2023)

Subject Terms: anaphylaxis, epidemiology, incidence, meta-analysis, systematic review, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/falgy.2023.1249280/full; https://doaj.org/toc/2673-6101

Access URL: https://doaj.org/article/e72ed0cd6e7042c9b81f515a044b3443

Renin-angiotensin system inhibitor discontinuation in COVID-19 did not modify systemic ACE2 in a randomized controlled trial

Authors: Vincent Rathkolb, Marianna T. Traugott, Andreas Heinzel, Marko Poglitsch, Judith Aberle, Farsad Eskandary, Agnes Abrahamowicz, Martin Mueller, Petra Knollmueller, Tarik Shoumariyeh, Jasmin Stuflesser, Ivan Seeber, Georg Gibas, Hannah Mayfurth, Viktoria Tinhof, Lukas Schmoelz, Markus Zeitlinger, Christian Schoergenhofer, Bernd Jilma, Bernd Genser, Wolfgang Hoepler, Sara Omid, Mario Karolyi, Christoph Wenisch, Rainer Oberbauer, Alexander Zoufaly, Manfred Hecking, Roman Reindl-Schwaighofer

Source: iScience, Vol 26, Iss 11, Pp 108146- (2023)

Subject Terms: Virology, Human metabolism, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S258900422302223X; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/cde4c1a923a34b2a9fa80a213f0e9c8c

The systemic renin-angiotensin system in COVID-19

Authors: Roman Reindl-Schwaighofer, Sebastian Hödlmoser, Oliver Domenig, Katharina Krenn, Farsad Eskandary, Simon Krenn, Christian Schörgenhofer, Benedikt Rumpf, Mario Karolyi, Marianna T. Traugott, Agnes Abrahamowicz, Viktoria Tinhof, Hannah Mayfurth, Vincent Rathkolb, Sebastian Mußnig, Lukas Schmölz, Roman Ullrich, Andreas Heinzel, Franz König, Christina Binder, Diana Bonderman, Robert Strassl, Elisabeth Puchhammer-Stöckl, Gregor Gorkiewicz, Judith H. Aberle, Bernd Jilma, Christoph Wenisch, Marko Poglitsch, Rainer Oberbauer, Alexander Zoufaly, Manfred Hecking

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/43989e90444c4d55a24f4a4230dbb5a8

P1471: SUSTAINED EFFICACY OF SUTIMLIMAB, A COMPLEMENT C1S INHIBITOR, IN PATIENTS WITH COLD AGGLUTININ DISEASE: RESULTS FROM PART B OF THE PHASE 3 CADENZA STUDY

Authors: Alexander Röth, Sigbjørn Berentsen, Wilma Barcellini, Shirley D’sa, Bernd Jilma, Marc Michel, Ilene C Weitz, Masaki Yamaguchi, Jun-Ichi Nishimura, Josephine Vos, Joan Cid, Michael Storek, Nancy Wong, Ronnie Yoo, Deepthi Jayawardene, Shruti Srivastava, Marek Wardęcki, Frank Shafer, Michelle Lee, Catherine M Broome

Source: HemaSphere, Vol 7, p e83270db (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000972768.83270.db; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/34c6141f83354a40a8c76a7bba4fdcb6

P1469: INHIBITION OF COMPLEMENT C1S WITH SUTIMLIMAB IN PATIENTS WITH COLD AGGLUTININ DISEASE (CAD): RESULTS FOLLOWING 9-WEEK OFF-TREATMENT PERIOD (WASHOUT) IN THE PHASE 3 CADENZA STUDY

Authors: Alexander Röth, Sigbjørn Berentsen, Wilma Barcellini, Shirley D’sa, Bernd Jilma, Marc Michel, Ilene C Weitz, Masaki Yamaguchi, Jun-Ichi Nishimura, Josephine Vos, Joan Cid, Michael Storek, Nancy Wong, Ronnie Yoo, Deepthi Jayawardene, Katarina Kralova, Marek Wardęcki, Frank Shafer, Michelle Lee, Catherine M Broome

Source: HemaSphere, Vol 7, p e3331235 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000972760.33312.35; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/bec69a5d1b2b4ad8afba22ee30dce3db

P1486: SERUM BIOMARKERS AS PREDICTORS OF RESPONSE TO SUTIMLIMAB IN COLD AGGLUTININ DISEASE (CAD): A POST-HOC ANALYSIS OF PHASE 3 CARDINAL AND CADENZA STUDY DATA

Authors: Wilma Barcellini, Catherine M Broome, Bernd Jilma, Yasutaka Ueda, Josephine Vos, Shirley D’sa, Umer Khan, Ronnie Yoo, Marek Wardęcki, Alexander Röth

Source: HemaSphere, Vol 7, p e0644617 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000972828.06446.17; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/c7f083034a3443c0939394294a79a5ea

P1675: SUTIMLIMAB PROVIDES SUSTAINED IMPROVEMENTS IN PATIENT-REPORTED OUTCOMES AND QUALITY OF LIFE IN PATIENTS WITH COLD AGGLUTININ DISEASE: OPEN-LABEL EXTENSION OF THE PHASE 3 CADENZA STUDY

Authors: Alexander Röth, Catherine M Broome, Wilma Barcellini, Bernd Jilma, Quentin A Hill, David Cella, Tor Henrik Anderson Tvedt, Masaki Yamaguchi, Irina Murakhovskaya, Michelle Lee, Frank Shafer, Marek Wardęcki, Deepthi Jayawardene, Ronnie Yoo, Jerome Msihid, Ilene C Weitz

Source: HemaSphere, Vol 7, p e715321f (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000973572.71532.1f; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/527214c958cf4a5b9152c4944cc811ce

Drug–Drug Interactions in Patients with Acute Respiratory Distress Syndrome

Authors: Thorsten Bischof, Christoph Schaller, Nina Buchtele, Thomas Staudinger, Roman Ullrich, Felix Kraft, Marine L. Andersson, Bernd Jilma, Christian Schoergenhofer

Source: Pharmaceutics, Vol 16, Iss 3, p 303 (2024)

Subject Terms: potential drug–drug interactions, intensive care unit, acute respiratory distress syndrome, extracorporeal membrane oxygenation, coronavirus disease 2019, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/16/3/303; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/661d2258d793457cab61bbd1f23aa5ef

First-in-human phase I clinical trial of a TLR4-binding DNA aptamer, ApTOLL: Safety and pharmacokinetics in healthy volunteers

Authors: Macarena Hernández-Jiménez, Samuel Martín-Vílchez, Dolores Ochoa, Gina Mejía-Abril, Manuel Román, Paola Camargo-Mamani, Sergio Luquero-Bueno, Bernd Jilma, María A. Moro, Gerónimo Fernández, David Piñeiro, Marc Ribó, Víctor M. González, Ignacio Lizasoain, Francisco Abad-Santos

Source: Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 124-135 (2022)

Subject Terms: MT: oligonucleotides, MT: therapies and applications, aptamer, TLR4, inflammation, antagonist, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253122000543; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/1d6415b299c844c7bc5d3c6a71847c5b

Safety, tolerability, and efficacy of monoclonal CD38 antibody felzartamab in late antibody-mediated renal allograft rejection: study protocol for a phase 2 trial

Authors: Katharina A. Mayer, Klemens Budde, Philip F. Halloran, Konstantin Doberer, Lionel Rostaing, Farsad Eskandary, Anna Christamentl, Markus Wahrmann, Heinz Regele, Sabine Schranz, Sarah Ely, Christa Firbas, Christian Schörgenhofer, Alexander Kainz, Alexandre Loupy, Stefan Härtle, Rainer Boxhammer, Bernd Jilma, Georg A. Böhmig

Source: Trials, Vol 23, Iss 1, Pp 1-15 (2022)

Subject Terms: Antibody-mediated rejection, CD38, Donor-specific antibody, Felzartamab, Kidney transplantation, Monoclonal antibody, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1745-6215

Access URL: https://doaj.org/article/4f8aa02fcc984a15b6ec9bd5b10aa1db