Pegvaliase treatment normalizes blood neurotransmitter metabolites in adults with phenylketonuria

Authors: Sigg, Monika A., Wilson, Christopher, Clague, Gillian E., Zhou, Huiyu, Su, Cheng, Berguig, Geoffrey Y.

Source: In Molecular Genetics and Metabolism November 2024 143(3)

Haploinsufficiency underlies the neurodevelopmental consequences of SLC6A1 variants

Authors: Silva, Dina Buitrago, Trinidad, Marena, Ljungdahl, Alicia, Revalde, Jezrael L., Berguig, Geoffrey Y., Wallace, William, Patrick, Cory S., Bomba, Lorenzo, Arkin, Michelle, Dong, Shan, Estrada, Karol, Hutchinson, Keino, LeBowitz, Jonathan H., Schlessinger, Avner, Johannesen, Katrine M., Møller, Rikke S., Giacomini, Kathleen M., Froelich, Steven, Sanders, Stephan J., Wuster, Arthur

Source: In The American Journal of Human Genetics 6 June 2024 111(6):1222-1238

Application of in-vitro-cultured primary hepatocytes to evaluate species translatability and AAV transduction mechanisms of action

Authors: Liu, Su, Razon, Lisa, Ritchie, Olivia, Sihn, Choong-Ryoul, Handyside, Britta, Berguig, Geoffrey, Woloszynek, Jill, Zhang, Lening, Batty, Paul, Lillicrap, David, Agrawal, Vishal, Cortesio, Christa, Gebretsadik, Kahsay, Akeefe, Hassibullah, Colosi, Peter, Kim, Benjamin, Bunting, Stuart, Fong, Sylvia

Source: In Molecular Therapy - Methods & Clinical Development 8 September 2022 26:61-71

Of mice and men: Plasma phenylalanine reduction in PKU corrects neurotransmitter pathways in the brain

Authors: Berguig, Geoffrey Y., Martin, Nathan T., Creer, Athena Y., Xie, Lin, Zhang, Lening, Murphy, Ryan, Pacheco, Glenn, Bullens, Sherry, Olbertz, Joy, Weng, Haoling H.

Source: In Molecular Genetics and Metabolism December 2019 128(4):422-430

Cellular Uptake and Delivery of Myeloperoxidase to Lysosomes Promote Lipofuscin Degradation and Lysosomal Stress in Retinal Cells

Alternate Title: MPO-mediated Lipofuscin Degradation and Lysosomal Stress (English)

Authors: Yogalingam, Gouri, Lee, Amanda R., Mackenzie, Donald S., Maures, Travis J., Rafalko, Agnes, Prill, Heather, Berguig, Geoffrey Y., Hague, Chuck, Christianson, Terri, Bell, Sean M., LeBowitz, Jonathan H.

Source: In Journal of Biological Chemistry 10 March 2017 292(10):4255-4265

Intracellular Delivery System for Antibody–Peptide Drug Conjugates

Authors: Berguig, Geoffrey Y, Convertine, Anthony J, Frayo, Shani, Kern, Hanna B, Procko, Erik, Roy, Debashish, Srinivasan, Selvi, Margineantu, Daciana H, Booth, Garrett, Palanca-Wessels, Maria Corinna, Baker, David, Hockenbery, David, Press, Oliver W, Stayton, Patrick S

Source: In Molecular Therapy May 2015 23(5):907-917

Comprehensive characterization and quantification of adeno associated vectors by size exclusion chromatography and multi angle light scattering

Authors: McIntosh, Nicole L., Berguig, Geoffrey Y., Karim, Omair A., Cortesio, Christa L., De Angelis, Rolando, Khan, Ayesha A., Gold, Daniel, Maga, John A., Bhat, Vikas S.

Source: Scientific reports. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194111873.0x000001&indx=1&recIds=ETOCvdc_100194111873.0x000001

A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells

Authors: Procko, Erik, Berguig, Geoffrey Y., Shen, Betty W., Song, Yifan, Frayo, Shani, Convertine, Anthony J., Margineantu, Daciana, Booth, Garrett, Correia, Bruno E., Cheng, Yuanhua, Schief, William R., Hockenbery, David M., Press, Oliver W., Stoddard, Barry L., Stayton, Patrick S., Baker, David

Source: In Cell 19 June 2014 157(7):1644-1656

A bioactive elastin-like recombinamer reduces unspecific protein adsorption and enhances cell response on titanium surfaces

Authors: Salvagni, Emiliano, Berguig, Geoffrey, Engel, Elisabeth, Rodriguez-Cabello, J. Carlos, Coullerez, Geraldine, Textor, Marcus, Planell, Josep A., Gil, F. Javier, Aparicio, Conrado

Source: In Colloids and Surfaces B: Biointerfaces 1 February 2014 114:225-233

Anti-CD22 Antibody Targeting of pH-responsive Micelles Enhances Small Interfering RNA Delivery and Gene Silencing in Lymphoma Cells

Authors: Palanca-Wessels, Maria C, Convertine, Anthony J, Cutler-Strom, Richelle, Booth, Garrett C, Lee, Fan, Berguig, Geoffrey Y, Stayton, Patrick S, Press, Oliver W

Source: In Molecular Therapy August 2011 19(8):1529-1537

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Glycosylation independent lysosomal targeting of alpha-n-acetylglucosaminidase confers highly efficient enzyme uptake into critical cellular targets of disease pathogenesis in mucopolysaccharidosis type IIIB

Authors: Yogalingam, Gouri, Prill, Heather, Lee, Amanda, Christianson, Terri, Tiger, Pascale M.N., Yip, Bryan K., Lo, Melanie J., Holtzinger, John, Berguig, Geoffrey, Aoyagi-Scharber, Mika, Fitzpatrick, Paul, Lawrence, Roger, Crawford, Brett, LeBowitz, Jonathan H.

Source: In Molecular Genetics and Metabolism February 2016 117(2):S122-S122

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Synthesis and characterization of transferrin-targeted chemotherapeutic delivery systems prepared via RAFT copolymerization of high molecular weight PEG macromonomers.

Authors: Roy, Debashish, Berguig, Geoffrey Y., Ghosn, Bilal, Lane, Daniel D., Braswell, Scott, Stayton, Patrick S., Convertine, Anthony J.

Source: Polymer Chemistry; 2014, Vol. 5 Issue 5, p1791-1799, 9p

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