Pharmacological inhibition of MutT homolog 1 (MTH1) in allergic airway inflammation as a novel treatment strategy.

Authors: Adler, Anna, Bergwik, Jesper, Padra, Médea, Papareddy, Praveen, Schmidt, Tobias, Dahlgren, Madelene, Kahn, Robin, Berglund, Ulrika Warpman, Egesten, Arne

Source: Respiratory Research; 3/14/2025, Vol. 26 Issue 1, p1-12, 12p

Subject Terms: ASTHMA, THERAPEUTICS, ANTI-inflammatory agents, INTERLEUKIN-2, ENZYMES, IMMUNE response, APOPTOSIS

NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir

Authors: Zhang, Si Min, Rehling, Daniel, Jemth, Ann-Sofie, Throup, Adam, Landázuri, Natalia, Almlöf, Ingrid, Göttmann, Mona, Valerie, Nicholas C.K., Borhade, Sanjay R., Wakchaure, Prasad, Page, Brent D.G., Desroses, Matthieu, Homan, Evert J., Scobie, Martin, Rudd, Sean G., Berglund, Ulrika Warpman, Söderberg-Nauclér, Cecilia, Stenmark, Pål, Helleday, Thomas

Source: In Cell Chemical Biology 16 December 2021 28(12):1693-1702

Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity

Authors: Rehling, Daniel, Zhang, Si Min, Jemth, Ann-Sofie, Koolmeister, Tobias, Throup, Adam, Wallner, Olov, Scaletti, Emma, Moriyama, Takaya, Nishii, Rina, Davies, Jonathan, Desroses, Matthieu, Rudd, Sean G., Scobie, Martin, Homan, Evert, Berglund, Ulrika Warpman, Yang, Jun J., Helleday, Thomas, Stenmark, Pål

Source: In Journal of Biological Chemistry January-June 2021 296

TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model

Authors: Moukengue, Brice, Brown, Hannah K, Charrier, Céline, Battaglia, Séverine, Baud'huin, Marc, Quillard, Thibaut, Pham, Therese M, Pateras, Ioannis S, Gorgoulis, Vassilis G, Helleday, Thomas, Heymann, Dominique, Berglund, Ulrika Warpman, Ory, Benjamin, Lamoureux, Francois

Source: In EBioMedicine March 2020 53

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

Authors: Visnes, Torkild, Cázares-Körner, Armando, Hao, Wenjing, Wallner, Olov, Masuyer, Geoffrey, Loseva, Olga, Mortusewicz, Oliver, Wiita, Elisée, Sarno, Antonio, Manoilov, Aleksandr, Astorga-Wells, Juan, Jemth, Ann-Sofie, Pan, Lang, Sanjiv, Kumar, Karsten, Stella, Gokturk, Camilla, Grube, Maurice, Homan, Evert J., Hanna, Bishoy M. F., Paulin, Cynthia B. J., Pham, Therese, Rasti, Azita, Berglund, Ulrika Warpman, von Nicolai, Catharina, Benitez-Buelga, Carlos, Koolmeister, Tobias, Ivanic, Dag, Iliev, Petar, Scobie, Martin, Krokan, Hans E., Baranczewski, Pawel, Artursson, Per, Altun, Mikael, Jensen, Annika Jenmalm, Kalderén, Christina, Ba, Xueqing, Zubarev, Roman A., Stenmark, Pål, Boldogh, Istvan, Helleday, Thomas

Source: Science, 2018 Nov . 362(6416), 834-839.

Access URL: https://www.jstor.org/stable/26569336

Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity

Authors: Narwal, Mohit, Jemth, Ann-Sofie, Gustafsson, Robert, Almlöf, Ingrid, Berglund, Ulrika Warpman, Helleday, Thomas, Stenmark, Pål

Source: Biochemistry. 57(5):593-603

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN614784244&indx=1&recIds=ETOCRN614784244

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

Authors: Sanjiv, Kumar, Hagenkort, Anna, Calderón-Montaño, José Manuel, Koolmeister, Tobias, Reaper, Philip M., Mortusewicz, Oliver, Jacques, Sylvain A., Kuiper, Raoul V., Schultz, Niklas, Scobie, Martin, Charlton, Peter A., Pollard, John R., Berglund, Ulrika Warpman, Altun, Mikael, Helleday, Thomas

Source: In Cell Reports 12 January 2016 14(2):298-309

Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma.

Authors: Oksvold, Morten P.^1,2, Berglund, Ulrika Warpman³, Gad, Helge^3,4, Bai, Baoyan^1,2, Stokke, Trond⁵, Rein, Idun Dale⁵, Pham, Therese³, Sanjiv, Kumar³, Øy, Geir Frode⁶, Norum, Jens Henrik⁷, Smeland, Erlend B.^1,2, Myklebust, June H.^1,2, Helleday, Thomas^3,4, Våtsveen, Thea Kristin^1,2 thea.kristin.vatsveen@rr-research.no

Source: Scientific Reports. 3/18/2021, Vol. 11 Issue 1, p1-13. 13p.

Subject Terms: *ANTINEOPLASTIC agents, *LYMPHOMAS, *CANCER immunotherapy, *CANCER chemotherapy, *DISEASE relapse

Correction: A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma

Authors: Einarsdottir, Berglind O., Karlsson, Joakim, Söderberg, Elin M. V., Lindberg, Mattias F., Funck-Brentano, Elisa, Jespersen, Henrik, Brynjolfsson, Siggeir F., Bagge, Roger Olofsson, Carstam, Louise, Scobie, Martin, Koolmeister, Tobias, Wallner, Olof, Stierner, Ulrika, Berglund, Ulrika Warpman, Ny, Lars, Nilsson, Lisa M., Larsson, Erik, Helleday, Thomas, Nilsson, Jonas A.

Source: Cell death and disease. 11(2)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161846795.0x000001&indx=1&recIds=ETOCvdc_100161846795.0x000001

A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma

Authors: Einarsdottir, Berglind O., Karlsson, Joakim, Söderberg, Elin M. V., Lindberg, Mattias F., Funck-Brentano, Elisa, Jespersen, Henrik, Brynjolfsson, Siggeir F., Olofsson Bagge, Roger, Carstam, Louise, Scobie, Martin, Koolmeister, Tobias, Wallner, Olof, Stierner, Ulrika, Berglund, Ulrika Warpman, Ny, Lars, Nilsson, Lisa M., Larsson, Erik, Helleday, Thomas, Nilsson, Jonas A.

Source: Cell death and disease. 9(8)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131008237.0x000001&indx=1&recIds=ETOCvdc_100131008237.0x000001

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Development of a chemical probe against NUDT15

Authors: Zhang, Si Min, Desroses, Matthieu, Hagenkort, Anna, Valerie, Nicholas C. K., Rehling, Daniel, Carter, Megan, Wallner, Olov, Koolmeister, Tobias, Throup, Adam, Jemth, Ann-Sofie, Almlöf, Ingrid, Loseva, Olga, Lundbäck, Thomas, Axelsson, Hanna, Regmi, Shruti, Sarno, Antonio, Krämer, Andreas, Pudelko, Linda, Bräutigam, Lars, Rasti, Azita, Göttmann, Mona, Wiita, Elisée, Kutzner, Juliane, Schaller, Torsten, Kalderén, Christina, Cázares-Körner, Armando, Page, Brent D. G., Krimpenfort, Rosa, Eshtad, Saeed, Altun, Mikael, Rudd, Sean G., Knapp, Stefan, Scobie, Martin, Homan, Evert J., Berglund, Ulrika Warpman, Stenmark, Pål, Helleday, Thomas

Source: Nature Chemical Biology; October 2020, Vol. 16 Issue: 10 p1120-1128, 9p

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Ex vivo culture of cells derived from circulating tumour cell xenograft to support small cell lung cancer research and experimental therapeutics.

Authors: Lallo, Alice, Gulati, Sakshi, Schenk, Maximilian W, Khandelwal, Garima, Berglund, Ulrika Warpman, Pateras, Ioannis S, Chester, Christopher P E, Pham, Therese M, Kalderen, Christina, Frese, Kristopher K, Gorgoulis, Vassilis G, Miller, Crispin, Blackhall, Fiona, Helleday, Thomas, Dive, Caroline

Source: British Journal of Pharmacology; Feb2019, Vol. 176 Issue 3, p436-450, 15p, 3 Color Photographs, 3 Graphs

Subject Terms: SMALL cell lung cancer, CANCER cell culture, XENOGRAFTS, NEUROENDOCRINE tumors, GENE expression, TUMOR treatment, TRANSCRIPTOMES, PHENOTYPES

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