Modeling incomplete penetrance in arrhythmogenic cardiomyopathy by human induced pluripotent stem cell derived cardiomyocytes

Authors: De Bortoli, Marzia, Meraviglia, Viviana, Mackova, Katarina, Frommelt, Laura S., König, Eva, Rainer, Johannes, Volani, Chiara, Benzoni, Patrizia, Schlittler, Maja, Cattelan, Giada, Motta, Benedetta M., Volpato, Claudia, Rauhe, Werner, Barbuti, Andrea, Zacchigna, Serena, Pramstaller, Peter P., Rossini, Alessandra

Source: In Computational and Structural Biotechnology Journal 2023 21:1759-1773

Caveolin-3 and Caveolin-1 Interaction Decreases Channel Dysfunction Due to Caveolin-3 Mutations.

Authors: Benzoni, Patrizia¹ (AUTHOR) patrizia.benzoni@unimi.it, Gazzerro, Elisabetta² (AUTHOR), Fiorillo, Chiara³ (AUTHOR), Baratto, Serena⁴ (AUTHOR), Bartolucci, Chiara⁵ (AUTHOR), Severi, Stefano⁵ (AUTHOR), Milanesi, Raffaella¹ (AUTHOR), Lippi, Melania¹ (AUTHOR), Langione, Marianna¹ (AUTHOR), Murano, Carmen¹ (AUTHOR), Meoni, Clarissa¹ (AUTHOR), Popolizio, Vera¹ (AUTHOR), Cospito, Alessandro¹ (AUTHOR), Baruscotti, Mirko¹ (AUTHOR), Bucchi, Annalisa¹ (AUTHOR), Barbuti, Andrea¹ (AUTHOR) patrizia.benzoni@unimi.it

Source: International Journal of Molecular Sciences. Jan2024, Vol. 25 Issue 2, p980. 18p.

Subject Terms: *CAVEOLINS, *HEART, *ION channels, *CHO cell, *MUSCULAR dystrophy, *CAVEOLAE, *HETEROZYGOSITY, *HEART diseases

The funny current: Even funnier than 40 years ago. Uncanonical expression and roles of HCN/f channels all over the body

Authors: Benzoni, Patrizia, Bertoli, Giorgia, Giannetti, Federica, Piantoni, Chiara, Milanesi, Raffaella, Pecchiari, Matteo, Barbuti, Andrea, Baruscotti, Mirko, Bucchi, Annalisa

Source: In Progress in Biophysics and Molecular Biology November 2021 166:189-204

PCSK9 deficiency rewires heart metabolism and drives heart failure with preserved ejection fraction

Authors: Da Dalt, Lorenzo, Castiglioni, Laura, Baragetti, Andrea, Audano, Matteo, Svecla, Monika, Bonacina, Fabrizia, Pedretti, Silvia, Uboldi, Patrizia, Benzoni, Patrizia, Giannetti, Federica, Barbuti, Andrea, Pellegatta, Fabio, Indino, Serena, Donetti, Elena, Sironi, Luigi, Mitro, Nico, Catapano, Alberico Luigi, Norata, Giuseppe Danilo

Source: European heart journal. 42(32):3078-3090

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128948337.0x000001&indx=1&recIds=ETOCvdc_100128948337.0x000001

NOD-1 activation increases the spontaneous activity and the I(f) current of murine sinoatrial node cells

Authors: Canzolino, Serena, Bertoli, Giorgia, Bakhouba, Samira, Molla, David, Benzoni, Patrizia, Barbuti, Andrea, Baruscotti, Mirko, Fernández-Velasco, Maria, Bucchi, Annalisa

Source: In Vascular Pharmacology June 2024 155

A gain of function mutation in PITX2c gene linked to atrial fibrillation alters mitochondrial function and membrane excitability

Authors: Benzoni, Patrizia, Da Dalt, Lorenzo, Cospito, Alessandro, Popolizio, Vera, Giannetti, Federica, Ruberti, Cristina, Baruscotti, Mirko, Bucchi, Annalisa, Norata, Giuseppe Danilo, Barbuti, Andrea

Source: In Vascular Pharmacology June 2024 155

Generation of human induced pluripotent stem cells (EURACi001-A, EURACi002-A, EURACi003-A) from peripheral blood mononuclear cells of three patients carrying mutations in the CAV3 gene

Authors: Meraviglia, Viviana, Benzoni, Patrizia, Landi, Sara, Murano, Carmen, Langione, Marianna, Motta, Benedetta M., Baratto, Serena, Silipigni, Rosamaria, Di Segni, Marina, Pramstaller, Peter P., DiFrancesco, Dario, Gazzerro, Elisabetta, Barbuti, Andrea, Rossini, Alessandra

Source: Stem cell research. 27:25-29

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100055815965.0x000001&indx=1&recIds=ETOCvdc_100055815965.0x000001

Biomanufacturing of a Chitosan/Collagen Scaffold to Drive Adhesion and Alignment of Human Cardiomyocyte Derived from Stem Cells

Authors: Benzoni, Patrizia, Ginestra, Paola, Altomare, Lina, Fiorentino, Antonio, De Nardo, Luigi, Ceretti, Elisabetta, Dell’Era, Patrizia

Source: In Procedia CIRP 2016 49:113-120

Ion channel dysfunction and fibrosis in atrial fibrillation: Two sides of the same coin.

Authors: Arabia, Gianmarco, Bellicini, Maria Giulia, Cersosimo, Angelica, Memo, Maurizio, Mazzarotto, Francesco, Inciardi, Riccardo Maria, Cerini, Manuel, Chen, Lin Yee, Aboelhassan, Mohamed, Benzoni, Patrizia, Mitacchione, Gianfranco, Bontempi, Luca, Curnis, Antonio

Source: Pacing & Clinical Electrophysiology; Mar2024, Vol. 47 Issue 3, p417-428, 12p

Subject Terms: ATRIAL fibrillation risk factors, RISK assessment, EPIGENOMICS, FIBROSIS, HEART conduction system, GENES, ATRIAL fibrillation, MYOCARDIUM, PATHOGENESIS, ION channels, HEART cells, MYOCARDIAL depressants, ELECTROPHYSIOLOGY, MEMBRANE proteins, DISEASE complications

PITX2 gain-of-function mutation associated with atrial fibrillation alters mitochondrial activity in human iPSC atrial-like cardiomyocytes.

Authors: Benzoni, Patrizia, Da Dalt, Lorenzo, Elia, Noemi, Popolizio, Vera, Cospito, Alessandro, Giannetti, Federica, Dell'Era, Patrizia, Olesen, Morten S., Bucchi, Annalisa, Baruscotti, Mirko, Norata, Giuseppe Danilo, Barbuti, Andrea

Source: Frontiers in Physiology; 2023, p01-11, 11p

Subject Terms: GAIN-of-function mutations, ATRIAL fibrillation, MITOCHONDRIA, MELAS syndrome, ARRHYTHMIA, ENERGY consumption, TRANSCRIPTION factors

Lack of the transcription factor Nfix causes tachycardia in mice sinus node and rats neonatal cardiomyocytes.

Authors: Landi, Sara, Giannetti, Federica, Benzoni, Patrizia, Campostrini, Giulia, Rossi, Giuliana, Piantoni, Chiara, Bertoli, Giorgia, Bonfanti, Chiara, Carnevali, Luca, Bucchi, Annalisa, Baruscotti, Mirko, Careccia, Giorgia, Messina, Graziella, Barbuti, Andrea

Source: Acta Physiologica; Oct2023, Vol. 239 Issue 2, p1-13, 13p, 1 Color Photograph, 1 Diagram, 6 Charts, 5 Graphs

Subject Terms: SINOATRIAL node, TRANSCRIPTION factors, TACHYCARDIA, MICE, HEART beat

Induced Pluripotent Stem Cell-Based Studies of Parkinson's Disease: Challenges and Promises

Authors: Sanchez-Danes, Adriana, Benzoni, Patrizia, Memo, Maurizio, Dell'Era, Patrizia, Raya, Angel, Consiglio, Antonella

Source: CNS & neurological disorders drug targets. 12(8):1114-1127

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCETOCvdc_100027175135.0x000001&indx=1&recIds=ETOCETOCvdc_100027175135.0x000001

Generation of the induced human pluripotent stem cell lines CSSi009-A from a patient with a GNB5 pathogenic variant, and CSSi010-A from a CRISPR/Cas9 engineered GNB5 knock-out human cell line

Authors: Malerba, Natascia, Benzoni, Patrizia, Squeo, Gabriella Maria, Milanesi, Raffaella, Giannetti, Federica, Sadleir, Lynette G., Poke, Gemma, Augello, Bartolomeo, Croce, Anna Irma, Barbuti, Andrea, Merla, Giuseppe

Source: Stem cell research. 40

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100098032277.0x000001&indx=1&recIds=ETOCvdc_100098032277.0x000001

PCSK9 deficiency rewires heart metabolism and drives heart failure with preserved ejection fraction.

Authors: Dalt, Lorenzo Da, Castiglioni, Laura, Baragetti, Andrea, Audano, Matteo, Svecla, Monika, Bonacina, Fabrizia, Pedretti, Silvia, Uboldi, Patrizia, Benzoni, Patrizia, Giannetti, Federica, Barbuti, Andrea, Pellegatta, Fabio, Indino, Serena, Donetti, Elena, Sironi, Luigi, Mitro, Nico, Catapano, Alberico Luigi, Norata, Giuseppe Danilo

Source: European Heart Journal; 8/21/2021, Vol. 42 Issue 32, p3078-3090, 13p

Subject Terms: LOW density lipoproteins, BLOOD lipoproteins, HEART metabolism, HEART failure, HEART diseases

A detailed characterization of the hyperpolarization-activated "funny" current (If) in human-induced pluripotent stem cell (iPSC)–derived cardiomyocytes with pacemaker activity.

Authors: Giannetti, Federica¹ (AUTHOR), Benzoni, Patrizia¹ (AUTHOR), Campostrini, Giulia^1,2 (AUTHOR), Milanesi, Raffaella^1,3 (AUTHOR), Bucchi, Annalisa¹ (AUTHOR), Baruscotti, Mirko¹ (AUTHOR), Dell'Era, Patrizia⁴ (AUTHOR), Rossini, Alessandra⁵ (AUTHOR), Barbuti, Andrea¹ (AUTHOR) andrea.barbuti@unimi.it

Source: Pflügers Archiv: European Journal of Physiology. Jul2021, Vol. 473 Issue 7, p1009-1021. 13p.

Subject Terms: *SINOATRIAL node, *PLURIPOTENT stem cells, *ADRENERGIC agonists, *PACEMAKER cells, *MUSCARINIC agonists, *ISOPROTERENOL

Loss of Dystrophin Alters Calcium-Handling Maturation in Response to Microenvironment in Hipsc-Cardiomyocytes from Duchenne Muscular Dystrophy Patients

Authors: Pioner, J. Manuel, Coppini, Raffaele, Santini, Lorenzo, Palandri, Chiara, Lupi, Flavia, Langione, Marianna, Benzoni, Patrizia, Landi, Sara, Barbuti, Andrea, Tesi, Chiara, Mack, David L., Regnier, Michael, Parmeggiani, Camilla, Poggesi, Corrado, Ferrantini, Cecilia

Source: Biophysical journal. 116(S1):95a-95a

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100076353255.0x000001&indx=1&recIds=ETOCvdc_100076353255.0x000001

Human iPSC modelling of a familial form of atrial fibrillation reveals a gain of function of If and ICaL in patient-derived cardiomyocytes.

Authors: Benzoni, Patrizia¹ (AUTHOR), Campostrini, Giulia¹ (AUTHOR), Landi, Sara¹ (AUTHOR), Bertini, Valeria² (AUTHOR), Marchina, Eleonora² (AUTHOR), Iascone, Maria³ (AUTHOR), Ahlberg, Gustav⁴ (AUTHOR), Olesen, Morten Salling⁴ (AUTHOR), Crescini, Elisabetta² (AUTHOR), Mora, Cristina² (AUTHOR), Bisleri, Gianluigi⁵ (AUTHOR), Muneretto, Claudio⁶ (AUTHOR), Ronca, Roberto² (AUTHOR), Presta, Marco² (AUTHOR), Poliani, Pier Luigi² (AUTHOR), Piovani, Giovanna² (AUTHOR), Verardi, Rosanna⁷ (AUTHOR), Pasquale, Elisa Di⁸ (AUTHOR), Consiglio, Antonella^2,9,10 (AUTHOR), Raya, Angel^11,12,13 (AUTHOR)

Source: Cardiovascular Research. May2020, Vol. 116 Issue 6, p1147-1160. 14p.

Subject Terms: *ATRIAL fibrillation, *INDUCED pluripotent stem cells, *ARRHYTHMIA, *CARDIOVASCULAR diseases, *ELECTROPHYSIOLOGY, *ATRIAL arrhythmias

Phage Displayed Peptides/Antibodies Recognizing Growth Factors and Their Tyrosine Kinase Receptors as Tools for Anti-Cancer Therapeutics.

Authors: Ronca, Roberto¹ ronca@med.unibs.it, Benzoni, Patrizia² patrizia.benzoni@med.unibs.it, De Luca, Angela² angela.deluca@med.unibs.it, Crescini, Elisabetta² elisabetta.crescini@med.unibs.it, Dell'Era, Patrizia² dellera@med.unibs.it

Source: International Journal of Molecular Sciences. Apr2012, Vol. 13 Issue 4, p5254-5277. 24p.

Subject Terms: *PEPTIDE biotechnology, *BACTERIAL antibodies, *CANCER chemotherapy, *PROTEIN-tyrosine kinases, *BACTERIOPHAGES, *FIBROBLAST growth factor receptors

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