Identification of new correctors for traffic-defective ABCB4 variants by a high-content screening approach

Authors: Mounia Lakli, Julie Dumont, Virginie Vauthier, Julie Charton, Veronica Crespi, Manon Banet, Yosra Riahi, Amel Ben Saad, Elodie Mareux, Martine Lapalus, Emmanuel Gonzales, Emmanuel Jacquemin, Florent Di Meo, Benoit Deprez, Florence Leroux, Thomas Falguières

Source: Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/15d3c2a95c39433cb086203c92b4dc08

Drug repurposing and phenotypic screening: innovative strategies for treating ultra-rare disorders

Authors: Adrien Paquot, Benoit Deprez, Terence Beghyn

Source: Frontiers in Medicine, Vol 11 (2024)

Subject Terms: rare diseases, screening, translatability, phenotypic, drug discovery, repurposing, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2024.1489094/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/46041958168d4c79bf0bef7dda33a521

Migration study of phthalates from non-food plastic containers used in food preservation

Authors: Olivier Songue Same, Pierre Nobosse, Guillaume Legrand Ngolong Ngea, Catherine Piveteau, Mohamed Lemdani, Richard Kamga, Benoit Deprez

Source: Heliyon, Vol 9, Iss 9, Pp e20002- (2023)

Subject Terms: PAE, Non-food plastics, Pap, Experimental design, Migration, Kinetic, Science (General), Q1-390, Social sciences (General), H1-99

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844023072109; https://doaj.org/toc/2405-8440

Access URL: https://doaj.org/article/bcfc833372974b26b9fc666da3f469d4

Oral metformin transiently lowers post-prandial glucose response by reducing the apical expression of sodium-glucose co-transporter 1 in enterocytes

Authors: Lorea Zubiaga, Olivier Briand, Florent Auger, Veronique Touche, Thomas Hubert, Julien Thevenet, Camille Marciniak, Audrey Quenon, Caroline Bonner, Simon Peschard, Violeta Raverdy, Mehdi Daoudi, Julie Kerr-Conte, Gianni Pasquetti, Hermann Koepsell, Daniela Zdzieblo, Markus Mühlemann, Bernard Thorens, Nathalie D. Delzenne, Laure B. Bindels, Benoit Deprez, Marie C. Vantyghem, Blandine Laferrère, Bart Staels, Damien Huglo, Sophie Lestavel, François Pattou

Source: iScience, Vol 26, Iss 4, Pp 106057- (2023)

Subject Terms: Drugs, Molecular physiology, Endocrinology, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004223001347; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/a2d8b736d8cd49a09e2f84d1fd3fac11

Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps

Authors: Coline Plé, Heng-Keat Tam, Anais Vieira Da Cruz, Nina Compagne, Juan-Carlos Jiménez-Castellanos, Reinke T. Müller, Elizabeth Pradel, Wuen Ee Foong, Giuliano Malloci, Alexia Ballée, Moritz A. Kirchner, Parisa Moshfegh, Adrien Herledan, Andrea Herrmann, Benoit Deprez, Nicolas Willand, Attilio Vittorio Vargiu, Klaas M. Pos, Marion Flipo, Ruben C. Hartkoorn

Source: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/2d5e83c99b5c4265bf969d47fed84ba5

Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice.

Authors: Sandrine Belouzard, Arnaud Machelart, Valentin Sencio, Thibaut Vausselin, Eik Hoffmann, Nathalie Deboosere, Yves Rouillé, Lowiese Desmarets, Karin Séron, Adeline Danneels, Cyril Robil, Loic Belloy, Camille Moreau, Catherine Piveteau, Alexandre Biela, Alexandre Vandeputte, Séverine Heumel, Lucie Deruyter, Julie Dumont, Florence Leroux, Ilka Engelmann, Enagnon Kazali Alidjinou, Didier Hober, Priscille Brodin, Terence Beghyn, François Trottein, Benoit Deprez, Jean Dubuisson

Source: PLoS Pathogens, Vol 18, Iss 5, p e1010498 (2022)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/ef24a1fe221949deb66833f87060787b

High-Throughput Quantitative Screening of Glucose-Stimulated Insulin Secretion and Insulin Content Using Automated MALDI-TOF Mass Spectrometry

Authors: Clément Philippe Delannoy, Egon Heuson, Adrien Herledan, Frederik Oger, Bryan Thiroux, Mickaël Chevalier, Xavier Gromada, Laure Rolland, Philippe Froguel, Benoit Deprez, Sébastien Paul, Jean-Sébastien Annicotte

Source: Cells, Vol 12, Iss 6, p 849 (2023)

Subject Terms: insulin secretion, pancreatic beta cell, high-throughput screening, MALDI-TOF mass spectrometry, type 2 diabetes, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/6/849; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/8713886262774b1a8af08dcc746eafc0

Rapid and Efficient Access to Novel Bio-Inspired 3-Dimensional Tricyclic SpiroLactams as Privileged Structures via Meyers’ Lactamization

Authors: Salia Tangara, Léo Faïon, Catherine Piveteau, Frédéric Capet, Romain Godelier, Marion Michel, Marion Flipo, Benoit Deprez, Nicolas Willand, Baptiste Villemagne

Source: Pharmaceuticals, Vol 16, Iss 3, p 413 (2023)

Subject Terms: focused chemical library, natural-like products, tricyclic spirolactams, Fsp3-rich compounds, privileged scaffolds, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/16/3/413; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/457540ee79dc4ef9b38bd6f202d0cd9c

Exploring the Antitubercular Activity of Anthranilic Acid Derivatives: From MabA (FabG1) Inhibition to Intrabacterial Acidification

Authors: Léo Faïon, Kamel Djaout, Catalin Pintiala, Catherine Piveteau, Florence Leroux, Alexandre Biela, Stéphanie Slupek, Rudy Antoine, Monika Záhorszká, Francois-Xavier Cantrelle, Xavier Hanoulle, Jana Korduláková, Benoit Deprez, Nicolas Willand, Alain R. Baulard, Marion Flipo

Source: Pharmaceuticals, Vol 16, Iss 3, p 335 (2023)

Subject Terms: MabA inhibitors, anthranilic acid, FabG1, tuberculosis, mycolic acids, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/16/3/335; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/8f8af7ff2c8049dca93bfab59dd0da06

Farnesoid X Receptor Activation in Brain Alters Brown Adipose Tissue Function via the Sympathetic System

Authors: Benjamin Deckmyn, Dorothée Domenger, Chloé Blondel, Sarah Ducastel, Emilie Nicolas, Emilie Dorchies, Emilie Caron, Julie Charton, Emmanuelle Vallez, Benoit Deprez, Jean-Sébastien Annicotte, Sophie Lestavel, Anne Tailleux, Christophe Magnan, Bart Staels, Kadiombo Bantubungi

Source: Frontiers in Molecular Neuroscience, Vol 14 (2022)

Subject Terms: FXR, brain, hypothalamus, energy homeostasis, brown adipose tissue, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnmol.2021.808603/full; https://doaj.org/toc/1662-5099

Access URL: https://doaj.org/article/a3af6d005d634d79ae9036c03fc6ed79

Insulin-Degrading Enzyme, an Under-Estimated Potential Target to Treat Cancer?

Authors: Laetitia Lesire, Florence Leroux, Rebecca Deprez-Poulain, Benoit Deprez

Source: Cells, Vol 11, Iss 7, p 1228 (2022)

Subject Terms: insulin-degrading enzyme, cancer, target, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/11/7/1228; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/ce739b9228324f75854e29e553800e2a

Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles

Authors: Joana Costa-Gouveia, Elisabetta Pancani, Samuel Jouny, Arnaud Machelart, Vincent Delorme, Giuseppina Salzano, Raffaella Iantomasi, Catherine Piveteau, Christophe J. Queval, Ok-Ryul Song, Marion Flipo, Benoit Deprez, Jean-Paul Saint-André, José Hureaux, Laleh Majlessi, Nicolas Willand, Alain Baulard, Priscille Brodin, Ruxandra Gref

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/b72ffe20c51947b68f1019be57e2cb02

Molecular Design in Practice: A Review of Selected Projects in a French Research Institute That Illustrates the Link between Chemical Biology and Medicinal Chemistry

Authors: Benoit Deprez, Damien Bosc, Julie Charton, Cyril Couturier, Rebecca Deprez-Poulain, Marion Flipo, Florence Leroux, Baptiste Villemagne, Nicolas Willand

Source: Molecules, Vol 26, Iss 19, p 6083 (2021)

Subject Terms: drug discovery, hit to lead optimization, target engagement, target validation, kinetic target guided synthesis, fragment, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/26/19/6083; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/3139cdf061794c5db887520979edb00b

ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease

Authors: Florent Letronne, Geoffroy Laumet, Anne-Marie Ayral, Julien Chapuis, Florie Demiautte, Mathias Laga, Michel E. Vandenberghe, Nicolas Malmanche, Florence Leroux, Fanny Eysert, Yoann Sottejeau, Linda Chami, Amandine Flaig, Charlotte Bauer, Pierre Dourlen, Marie Lesaffre, Charlotte Delay, Ludovic Huot, Julie Dumont, Elisabeth Werkmeister, Franck Lafont, Tiago Mendes, Franck Hansmannel, Bart Dermaut, Benoit Deprez, Anne-Sophie Hérard, Marc Dhenain, Nicolas Souedet, Florence Pasquier, David Tulasne, Claudine Berr, Jean-Jacques Hauw, Yves Lemoine, Philippe Amouyel, David Mann, Rebecca Déprez, Frédéric Checler, David Hot, Thierry Delzescaux, Kris Gevaert, Jean-Charles Lambert

Source: EBioMedicine, Vol 9, Iss C, Pp 278-292 (2016)

Subject Terms: Alzheimer, APP, ADAM30, Amyloid, Metabolism, LTP, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396416302468; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/b6a220c6a95c4d56a4492c3f25a412a8

Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme

Authors: Zhening Zhang, Wenguang G Liang, Lucas J Bailey, Yong Zi Tan, Hui Wei, Andrew Wang, Mara Farcasanu, Virgil A Woods, Lauren A McCord, David Lee, Weifeng Shang, Rebecca Deprez-Poulain, Benoit Deprez, David R Liu, Akiko Koide, Shohei Koide, Anthony A Kossiakoff, Sheng Li, Bridget Carragher, Clinton S Potter, Wei-Jen Tang

Source: eLife, Vol 7 (2018)

Subject Terms: insulin, amyloid peptide, insulin degrading enzyme, proteostasis, cryoEM, integrative structural biology, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/33572; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/bdf640b40b944a06bfcc72ce62dd4071

Publisher Correction: Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles

Authors: Joana Costa-Gouveia, Elisabetta Pancani, Samuel Jouny, Arnaud Machelart, Vincent Delorme, Giuseppina Salzano, Raffaella Iantomasi, Catherine Piveteau, Christophe J. Queval, Ok-Ryul Song, Marion Flipo, Benoit Deprez, Jean-Paul Saint-André, José Hureaux, Laleh Majlessi, Nicolas Willand, Alain Baulard, Priscille Brodin, Ruxandra Gref

Source: Scientific Reports, Vol 8, Iss 1, Pp 1-1 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/b18214c8b972422fbd41c9543e4edc14

Designing focused chemical libraries enriched in protein-protein interaction inhibitors using machine-learning methods.

Authors: Christelle Reynès, Hélène Host, Anne-Claude Camproux, Guillaume Laconde, Florence Leroux, Anne Mazars, Benoit Deprez, Robin Fahraeus, Bruno O Villoutreix, Olivier Sperandio

Source: PLoS Computational Biology, Vol 6, Iss 3, p e1000695 (2010)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2832677?pdf=render; https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

Access URL: https://doaj.org/article/d53d63284ed141c0ba809fd78c0a202c

Evaluation of the exposure to bisphenols from baby bottles and non-food containers used for food preservation in Cameroon.

Authors: Olivier, SONGUE-SAME, Catherine, PIVETEAU, Alexandre, BIELA, Richard, KAMGA, Benoit, DEPREZ

Source: In Journal of Hazardous Materials Advances February 2023 9

High-Throughput DNA Plasmid Multiplexing and Transfection Using Acoustic Nanodispensing Technology

Authors: Béatrice Colin, author¹, Nicolas Rocq, author², Benoit Deprez, author¹, Cyril Couturier, author¹

Source: Journal of Visualized Experiments. (150)

Availability: http://www.jove.com/video/59570

Modulators of hERAP2 discovered by high-throughput screening

Authors: Laura, Medve, Ronan, Gealageas, Vy, Lam Bao, Valentin, Guillaume, Omar, Castillo-Aguilera, Virgyl, Camberlein, Piveteau, Catherine, Melissa, Rosell, Charlotte, Fleau, Sandrine, Warenghem, Julie, Charton, Julie, Dumont-Ryckembusch, Damien, Bosc, Florence, Leroux, Peter, van Endert, Benoit, Deprez, Rebecca, Deprez-Poulain

Source: European journal of medicinal chemistry. 211

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100127030413.0x000001&indx=1&recIds=ETOCvdc_100127030413.0x000001