Co-occurring mutations identify prognostic subgroups of microsatellite stable colorectal cancer

Authors: Luís Nunes, Jakob Mørkved Stenersen, Kushtrim Kryeziu, Tobias Sjöblom, Bengt Glimelius, Ragnhild A. Lothe, Anita Sveen

Source: Molecular Cancer, Vol 23, Iss 1, Pp 1-7 (2024)

Subject Terms: CRC, Locoregional, Metastatic, MSS, Survival, Prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1476-4598

Access URL: https://doaj.org/article/77059ecf6491416ab78186162728bb5b

Total neoadjuvant treatment using short-course radiotherapy and four CAPOX cycles in locally advanced rectal cancer with high-risk criteria for recurrence: a Swedish nationwide cohort study (LARCT-US)Research in context

Authors: Bengt Glimelius, Tanweera Khan, Karin Adolfsson, Eva Angenete, Åke Berglund, Kristina Bonde, Nils Elander, Tone Fokstuen, Johan Haux, Israa Imam, Cecilia Lagerbäck, Ingrid Ljuslinder, Andrzej Piwowar, Marie Zajicova, Per J. Nilsson

Source: EClinicalMedicine, Vol 75, Iss , Pp 102771- (2024)

Subject Terms: Locally advanced rectal cancer, Total neoadjuvant treatment, Complete response, Population observational cohort, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S258953702400350X; https://doaj.org/toc/2589-5370

Access URL: https://doaj.org/article/e883f34623c44a3b9ec58bd2e18a9b0d

Single-cell AI-based detection and prognostic and predictive value of DNA mismatch repair deficiency in colorectal cancer

Authors: Marta Nowak, Faiz Jabbar, Ann-Katrin Rodewald, Luciana Gneo, Tijana Tomasevic, Andrea Harkin, Tim Iveson, Mark Saunders, Rachel Kerr, Karin Oein, Noori Maka, Jennifer Hay, Joanne Edwards, Ian Tomlinson, Owen Sansom, Caroline Kelly, Francesco Pezzella, David Kerr, Alistair Easton, Enric Domingo, Viktor H. Koelzer, David N. Church, Bengt Glimelius, Ismail Gogenur, Emma Jaeger, Hannah Morgan, Clare Orange, Claire Palles, Campbell Roxburgh

Source: Cell Reports Medicine, Vol 5, Iss 9, Pp 101727- (2024)

Subject Terms: colorectal cancer, mismatch repair deficiency, microsatellite instability, AI, digital pathology, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666379124004543; https://doaj.org/toc/2666-3791

Access URL: https://doaj.org/article/0addef455aaa46a896ad776bd6ad5c75

Recent advances in rectal cancer treatment – are we on the right track?

Authors: Bengt Glimelius

Source: Upsala Journal of Medical Sciences, Vol 129, Pp 1-13 (2024)

Subject Terms: locally advanced rectal cancer, organ preservation, watch and wait, total neoadjuvant treatment, Medicine

File Description: electronic resource

Relation: https://ujms.net/index.php/ujms/article/view/10537/16941; https://doaj.org/toc/0300-9734; https://doaj.org/toc/2000-1967

Access URL: https://doaj.org/article/2fa8cb6be39e43cca65a66f68082cbe8

Results of a diagnostic imaging audit in a randomised clinical trial in rectal cancer highlight the importance of careful planning and quality control

Authors: Ilaria Prata, Martina Eriksson, Jasenko Krdzalic, Elma Meershoek-Klein Kranenbarg, Annet G. H. Roodvoets, Regina Beets-Tan, Cornelis J. H. van de Velde, Boudewijn van Etten, Geke A. P. Hospers, Bengt Glimelius, Per J. Nilsson, Corrie A. M. Marijnen, Koen C. M. J. Peeters, Lennart K. Blomqvist

Source: Insights into Imaging, Vol 14, Iss 1, Pp 1-12 (2023)

Subject Terms: Rectal cancer, Magnetic resonance imaging, Image acquisition protocol, Audit, Medical physics. Medical radiology. Nuclear medicine, R895-920

File Description: electronic resource

Relation: https://doaj.org/toc/1869-4101

Access URL: https://doaj.org/article/5ee9bb25dacb4bb7b809aee0c198cc65

Detailed analysis of metastatic colorectal cancer patients who developed cardiotoxicity on another fluoropyrimidine and switched to S-1 treatment (subgroup analysis of the CardioSwitch-study)

Authors: Sampsa Kinos, Helga Hagman, Päivi Halonen, Leena-Maija Soveri, Mary O'Reilly, Per Pfeiffer, Jan-Erik Frödin, Halfdan Sorbye, Eetu Heervä, Gabor Liposits, Raija Kallio, Annika Ålgars, Raija Ristamäki, Tapio Salminen, Maarit Bärlund, Carl-Henrik Shah, Ray McDermott, Rebecka Röckert, Petra Flygare, Johannes Kwakman, Arco Teske, Cornelis Punt, Bengt Glimelius, Pia Österlund

Source: Acta Oncologica, Vol 63, Iss 1 (2024)

Subject Terms: metastatic colorectal cancer, fluoropyrimidines, S-1, cardiotoxicity, capecitabine, 5-fluorouracil, metastasectomy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://medicaljournalssweden.se/actaoncologica/article/view/24023; https://doaj.org/toc/1651-226X

Access URL: https://doaj.org/article/340dd2f28c5441ddaf0adaf8e0022afa

Low‐dose aspirin use and colorectal cancer survival in 32,195 patients—A national cohort study

Authors: Mehrnoosh Shahrivar, Caroline E. Weibull, Karin Ekström Smedby, Bengt Glimelius, Ingvar Syk, Peter Matthiessen, Caroline Nordenvall, Anna Martling

Source: Cancer Medicine, Vol 12, Iss 1, Pp 315-324 (2023)

Subject Terms: aspirin, colorectal cancer, pharmacoepidemiology, survival, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2045-7634

Access URL: https://doaj.org/article/55d35f0ba0e24b62b6635101111c46e7

Hospital factors and metastatic surgery in colorectal cancer patients, a population-based cohort study

Authors: Malin Ljunggren, Caroline E. Weibull, Emma Rosander, Gabriella Palmer, Bengt Glimelius, Anna Martling, Caroline Nordenvall

Source: BMC Cancer, Vol 22, Iss 1, Pp 1-12 (2022)

Subject Terms: Colorectal neoplasms, High-volume hospitals, Low-volume hospitals, Neoplasm metastasis, Secondary, Surgery, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/727ac0b792af4e2199b0f02d08bd892f

An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancersResearch in context

Authors: Artur Mezheyeuski, Max Backman, Johanna Mattsson, Alfonso Martín-Bernabé, Chatarina Larsson, Ina Hrynchyk, Klara Hammarström, Simon Ström, Joakim Ekström, Siarhei Mauchanski, Salome Khelashvili, Amanda Lindberg, Margrét Agnarsdóttir, Per-Henrik Edqvist, Jutta Huvila, Ulrika Segersten, Per-Uno Malmström, Johan Botling, Björn Nodin, Charlotta Hedner, David Borg, Jenny Brändstedt, Hanna Sartor, Karin Leandersson, Bengt Glimelius, Anna Portyanko, Fredrik Ponten, Karin Jirström, Patrick Micke, Tobias Sjöblom

Source: EBioMedicine, Vol 88, Iss , Pp 104452- (2023)

Subject Terms: Tumour immunology, Macrophages, Immunoscore, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396423000178; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/21d6bb4dde9a4bcc8ada77b8353d03fb

Quality of life assessments in clinical practice using either the EORTC-QLQ-C30 or the SEIOQL-DW: a randomized study

Authors: Åsa Kettis, Hanna Fagerlind, Jan-Erik Frödin, Bengt Glimelius, Lena Ring

Source: Journal of Patient-Reported Outcomes, Vol 5, Iss 1, Pp 1-27 (2021)

Subject Terms: Oncology, Clinical practice, EORTC-QLQ-C30, SEIQOL-DW, Individualized quality of life, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://doaj.org/toc/2509-8020

Access URL: https://doaj.org/article/9f2f6767a6ab45a98a45d47a12e717c6

KRAS-G12C Mutation in One Real-Life and Three Population-Based Nordic Cohorts of Metastatic Colorectal Cancer

Authors: Emerik Osterlund, Ari Ristimäki, Soili Kytölä, Teijo Kuopio, Eetu Heervä, Timo Muhonen, Päivi Halonen, Raija Kallio, Leena-Maija Soveri, Jari Sundström, Mauri Keinänen, Annika Ålgars, Raija Ristamäki, Halfdan Sorbye, Per Pfeiffer, Luís Nunes, Tapio Salminen, Annamarja Lamminmäki, Markus J. Mäkinen, Tobias Sjöblom, Helena Isoniemi, Bengt Glimelius, Pia Osterlund

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: colorectal cancer, metastatic, KRAS mutation, KRAS-G12C mutation, population-based, real-world, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.826073/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/decb120b6a4a470ea68f4e7d8f7c7d6d

Consequences of a high incidence of microsatellite instability and BRAF‐mutated tumors: A population‐based cohort of metastatic colorectal cancer patients

Authors: Kristine Ø. Aasebø, Anca Dragomir, Magnus Sundström, Artur Mezheyeuski, Per‐Henrik Edqvist, Geir Egil Eide, Fredrik Ponten, Per Pfeiffer, Bengt Glimelius, Halfdan Sorbye

Source: Cancer Medicine, Vol 8, Iss 7, Pp 3623-3635 (2019)

Subject Terms: colorectal neoplasm, microsatellite instability, proto‐oncogene proteins, B‐raf, prognosis, neoplasm metastasis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2045-7634

Access URL: https://doaj.org/article/4afffda008d14f09a49e47ab6b689b3a

The prognostic impact of the tumour stroma fraction: A machine learning-based analysis in 16 human solid tumour types

Authors: Patrick Micke, Carina Strell, Johanna Mattsson, Alfonso Martín-Bernabé, Hans Brunnström, Jutta Huvila, Malin Sund, Fredrik Wärnberg, Fredrik Ponten, Bengt Glimelius, Ina Hrynchyk, Siarhei Mauchanski, Salome Khelashvili, Gemma Garcia-Vicién, David G. Molleví, Per-Henrik Edqvist, Aine O´Reilly, Sara Corvigno, Hanna Dahlstrand, Johan Botling, Ulrika Segersten, Agnieszka Krzyzanowska, Anders Bjartell, Jacob Elebro, Margareta Heby, Sebastian Lundgren, Charlotta Hedner, David Borg, Jenny Brändstedt, Hanna Sartor, Per-Uno Malmström, Martin Johansson, Björn Nodin, Max Backman, Cecilia Lindskog, Karin Jirström, Artur Mezheyeuski

Source: EBioMedicine, Vol 65, Iss , Pp 103269- (2021)

Subject Terms: Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396421000621; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/26bb87848f8f441298d6b26084798ea5

Two high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenström macroglobulinemia

Authors: Mary L. McMaster, Sonja I. Berndt, Jianqing Zhang, Susan L. Slager, Shengchao Alfred Li, Claire M. Vajdic, Karin E. Smedby, Huihuang Yan, Brenda M. Birmann, Elizabeth E. Brown, Alex Smith, Geffen Kleinstern, Mervin M. Fansler, Christine Mayr, Bin Zhu, Charles C. Chung, Ju-Hyun Park, Laurie Burdette, Belynda D. Hicks, Amy Hutchinson, Lauren R. Teras, Hans-Olov Adami, Paige M. Bracci, James McKay, Alain Monnereau, Brian K. Link, Roel C. H. Vermeulen, Stephen M. Ansell, Ann Maria, W. Ryan Diver, Mads Melbye, Akinyemi I. Ojesina, Peter Kraft, Paolo Boffetta, Jacqueline Clavel, Edward Giovannucci, Caroline M. Besson, Federico Canzian, Ruth C. Travis, Paolo Vineis, Elisabete Weiderpass, Rebecca Montalvan, Zhaoming Wang, Meredith Yeager, Nikolaus Becker, Yolanda Benavente, Paul Brennan, Lenka Foretova, Marc Maynadie, Alexandra Nieters, Silvia de Sanjose, Anthony Staines, Lucia Conde, Jacques Riby, Bengt Glimelius, Henrik Hjalgrim, Nisha Pradhan, Andrew L. Feldman, Anne J. Novak, Charles Lawrence, Bryan A. Bassig, Qing Lan, Tongzhang Zheng, Kari E. North, Lesley F. Tinker, Wendy Cozen, Richard K. Severson, Jonathan N. Hofmann, Yawei Zhang, Rebecca D. Jackson, Lindsay M. Morton, Mark P. Purdue, Nilanjan Chatterjee, Kenneth Offit, James R. Cerhan, Stephen J. Chanock, Nathaniel Rothman, Joseph Vijai, Lynn R. Goldin, Christine F. Skibola, Neil E. Caporaso

Source: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4f8f4ed337f247598d7a3f86722ba590

KRAS and BRAF mutations in circulating tumour DNA from locally advanced rectal cancer

Authors: Francesco Sclafani, Ian Chau, David Cunningham, Jens C. Hahne, George Vlachogiannis, Zakaria Eltahir, Andrea Lampis, Chiara Braconi, Eleftheria Kalaitzaki, David Gonzalez De Castro, Andrew Wotherspoon, Jaume Capdevila, Bengt Glimelius, Noelia Tarazona, Ruwaida Begum, Hazel Lote, Sanna Hulkki Wilson, Giulia Mentrasti, Gina Brown, Diana Tait, Jacqueline Oates, Nicola Valeri

Source: Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/2003b11877bd4935942baabe372bee21

Prognostic factors in patients with loco-regionally advanced gastric cancer

Authors: Bo Hultman, Ulf Gunnarsson, Peter Nygren, Magnus Sundbom, Bengt Glimelius, Haile Mahteme

Source: World Journal of Surgical Oncology, Vol 15, Iss 1, Pp 1-8 (2017)

Subject Terms: Surgery, Gastric cancer, Peritoneal, Metastases, Prognostic factor, Loco-regionally advanced cancer, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12957-017-1243-z; https://doaj.org/toc/1477-7819

Access URL: https://doaj.org/article/9212da760ca046fc888ecd103a42b30a

Randomized study comparing full dose monotherapy (S-1 followed by irinotecan) and reduced dose combination therapy (S-1/oxaliplatin followed by S-1/irinotecan) as initial therapy for older patients with metastatic colorectal cancer: NORDIC 9

Authors: Stine Braendegaard Winther, Pia Österlund, Åke Berglund, Bengt Glimelius, Camilla Qvortrup, Halfdan Sorbye, Per Pfeiffer, on behalf of the Academy of Geriatric Cancer Research (AgeCare)

Source: BMC Cancer, Vol 17, Iss 1, Pp 1-7 (2017)

Subject Terms: Randomized phase II, Non-intensive, SOX, IRIS, Oral, Geriatric assessment, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12885-017-3526-8; https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/99c67e463c064c20bf3675724a4d4f49

CDX2: A Prognostic Marker in Metastatic Colorectal Cancer Defining a Better BRAF Mutated and a Worse KRAS Mutated Subgroup

Authors: Kristine Aasebø, Anca Dragomir, Magnus Sundström, Artur Mezheyeuski, Per-Henrik Edqvist, Geir Egil Eide, Fredrik Ponten, Per Pfeiffer, Bengt Glimelius, Halfdan Sorbye

Source: Frontiers in Oncology, Vol 10 (2020)

Subject Terms: caudal type homeobox transcription factor, CDX2, colorectal cancer, metastatic disease, stage 4 colorectal cancer, prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fonc.2020.00008/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/b837c69e9b124f41bf850ea28727f6ad

Genetically Determined Height and Risk of Non-hodgkin Lymphoma

Authors: Amy Moore, Eleanor Kane, Zhaoming Wang, Orestis A. Panagiotou, Lauren R. Teras, Alain Monnereau, Nicole Wong Doo, Mitchell J. Machiela, Christine F. Skibola, Susan L. Slager, Gilles Salles, Nicola J. Camp, Paige M. Bracci, Alexandra Nieters, Roel C. H. Vermeulen, Joseph Vijai, Karin E. Smedby, Yawei Zhang, Claire M. Vajdic, Wendy Cozen, John J. Spinelli, Henrik Hjalgrim, Graham G. Giles, Brian K. Link, Jacqueline Clavel, Alan A. Arslan, Mark P. Purdue, Lesley F. Tinker, Demetrius Albanes, Giovanni M. Ferri, Thomas M. Habermann, Hans-Olov Adami, Nikolaus Becker, Yolanda Benavente, Simonetta Bisanzi, Paolo Boffetta, Paul Brennan, Angela R. Brooks-Wilson, Federico Canzian, Lucia Conde, David G. Cox, Karen Curtin, Lenka Foretova, Susan M. Gapstur, Hervé Ghesquières, Martha Glenn, Bengt Glimelius, Rebecca D. Jackson, Qing Lan, Mark Liebow, Marc Maynadie, James McKay, Mads Melbye, Lucia Miligi, Roger L. Milne, Thierry J. Molina, Lindsay M. Morton, Kari E. North, Kenneth Offit, Marina Padoan, Alpa V. Patel, Sara Piro, Vignesh Ravichandran, Elio Riboli, Silvia de Sanjose, Richard K. Severson, Melissa C. Southey, Anthony Staines, Carolyn Stewart, Ruth C. Travis, Elisabete Weiderpass, Stephanie Weinstein, Tongzhang Zheng, Stephen J. Chanock, Nilanjan Chatterjee, Nathaniel Rothman, Brenda M. Birmann, James R. Cerhan, Sonja I. Berndt

Source: Frontiers in Oncology, Vol 9 (2020)

Subject Terms: non-Hodgkin lymphoma, height, genetics, chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fonc.2019.01539/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/faeb08a523c64b9eb6ce56166d471af3

3-month versus 6-month adjuvant chemotherapy for patients with high-risk stage II and III colorectal cancer: 3-year follow-up of the SCOT non-inferiority RCT

Authors: Timothy Iveson, Kathleen A Boyd, Rachel S Kerr, Jose Robles-Zurita, Mark P Saunders, Andrew H Briggs, Jim Cassidy, Niels Henrik Hollander, Josep Tabernero, Andrew Haydon, Bengt Glimelius, Andrea Harkin, Karen Allan, John McQueen, Sarah Pearson, Ashita Waterston, Louise Medley, Charles Wilson, Richard Ellis, Sharadah Essapen, Amandeep S Dhadda, Mark Harrison, Stephen Falk, Sherif Raouf, Charlotte Rees, Rene K Olesen, David Propper, John Bridgewater, Ashraf Azzabi, David Farrugia, Andrew Webb, David Cunningham, Tamas Hickish, Andrew Weaver, Simon Gollins, Harpreet Wasan, James Paul

Source: Health Technology Assessment, Vol 23, Iss 64 (2019)

Subject Terms: oxaliplatin, capecitabine, disease-free survival, chemotherapy, adjuvant, quality-adjusted life-years, colorectal neoplasms, fluorouracil, randomised controlled trial, Medical technology, R855-855.5

File Description: electronic resource

Relation: https://doaj.org/toc/1366-5278; https://doaj.org/toc/2046-4924

Access URL: https://doaj.org/article/4215111445164519a465163178fd46e0