Are all measures of liver Kpuu a function of FH, as determined following oral dosing, or have we made a critical error in defining hepatic drug clearance?

Authors: Benet, L.Z., Sodhi, J.K.

Source: In European Journal of Pharmaceutical Sciences 1 May 2024 196

An examination of protein binding and protein-facilitated uptake relating to in vitro-in vivo extrapolation

Authors: Bowman, C.M., Benet, L.Z.

Source: In European Journal of Pharmaceutical Sciences 15 October 2018 123:502-514

Distinguishing between the Permeability Relationships with Absorption and Metabolism To Improve BCS and BDDCS Predictions in Early Drug Discovery

Authors: Larregieu, C.A., Benet, L.Z.

Source: MOLECULAR PHARMACEUTICS. 11(4):1335-1344

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN353273253&indx=1&recIds=ETOCRN353273253

Prevalence of Acid-Reducing Agents (ARA) in Cancer Populations and ARA Drug-Drug Interaction Potential for Molecular Targeted Agents in Clinical Development

Authors: Smelick, G.S., Heffron, T.P., Chu, L., Dean, B., West, D.A., DuVall, S.L., Lum, B.L., Budha, N., Holden, S.N., Benet, L.Z.

Source: MOLECULAR PHARMACEUTICS. 10(11):4055-4062

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN342568050&indx=1&recIds=ETOCRN342568050

Effect of P-Glycoprotein on the Rat Intestinal Permeability and Metabolism of the BDDCS Class 1 Drug Verapamil

Authors: Estudante, M., Maya, M., Morais, J.G., Soveral, G., Benet, L.Z.

Source: MOLECULAR PHARMACEUTICS. 10(11):4038-4045

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN342568036&indx=1&recIds=ETOCRN342568036

Gastric Reacidification with Betaine HCl in Healthy Volunteers with Rabeprazole-Induced Hypochlorhydria

Authors: Yago, M.R., Frymoyer, A.R., Smelick, G.S., Frassetto, L.A., Budha, N.R., Dresser, M.J., Ware, J.A., Benet, L.Z.

Source: MOLECULAR PHARMACEUTICS. 10(11):4032-4037

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN342568024&indx=1&recIds=ETOCRN342568024

Introduction to biopharmaceutics drug disposition classification system (BDDCS)

Authors: Liu, W., Yang, L., Benet, L.Z., Zhai, S.D.

Source: CHINESE JOURNAL OF NEW DRUGS AND CLINICAL REMEDIES. 32(4):265-271

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN335331106&indx=1&recIds=ETOCRN335331106

Characterization of the Acyl-Adenylate Linked Metabolite of Mefenamic Acid

Authors: Horng, H., Benet, L.Z.

Source: CHEMICAL RESEARCH IN TOXICOLOGY. 26(3):465-476

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN329939945&indx=1&recIds=ETOCRN329939945

BDDCS Class Prediction for New Molecular Entities

Authors: Broccatelli, F., Cruciani, G., Benet, L.Z., Oprea, T.I.

Source: MOLECULAR PHARMACEUTICS. 9(3):570-580

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN310537352&indx=1&recIds=ETOCRN310537352

Impact of a Hospitalwide Increase in Empiric Pediatric Vancomycin Dosing on Initial Trough Concentrations

Authors: Frymoyer, A., Guglielmo, B.J., Wilson, S.D., Scarpace, S.B., Benet, L.Z., Hersh, A.L.

Source: PHARMACOTHERAPY. 31(9):871-876

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN298152782&indx=1&recIds=ETOCRN298152782

Stereoselective Flunoxaprofen-S-acyl-glutathione Thioester Formation Mediated by Acyl-CoA Formation in Rat Hepatocytes

Authors: Grillo, M.P., Wait, J.C.M., Lohr, M.T., Khera, S., Benet, L.Z.

Source: DRUG METABOLISM AND DISPOSITION -BETHESDA-. 38(1):133-142

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN263504197&indx=1&recIds=ETOCRN263504197

The Drug Transporter-Metabolism Alliance: Uncovering and Defining the Interplay

Authors: Benet, L.Z.

Source: MOLECULAR PHARMACEUTICS. 6(6):1631-1643

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN263391560&indx=1&recIds=ETOCRN263391560

Pharmacy Education: The Driving Force for Change, Stature and Influence of Our Profession

Authors: Benet, L.Z.

Source: JOURNAL OF MEDICAL SCIENCES -TAIPEI. 29(4):159-166

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN256756879&indx=1&recIds=ETOCRN256756879

Current Recommended Dosing of Vancomycin for Children With Invasive Methicillin-Resistant Staphylococcus aureus Infections Is Inadequate

Authors: Frymoyer, A., Hersh, A.L., Benet, L.Z., Guglielmo, B.J.

Source: PEDIATRIC INFECTIOUS DISEASE JOURNAL. 28(5):398-402

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN250265761&indx=1&recIds=ETOCRN250265761

Nonnucleoside Reverse Transcriptase Inhibitor Pharmacokinetics in a Large Unselected Cohort of HIV-Infected Women

Authors: Gandhi, M., Benet, L.Z., Bacchetti, P., Kalinowski, A., Anastos, K., Wolfe, A.R., Young, M., Cohen, M., Minkoff, H., Gange, S.J.

Source: JAIDS -HAGERSTOWN MD-. 50(5):482-491

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN248008979&indx=1&recIds=ETOCRN248008979

gamma -Glutamyltranspeptidase-Mediated Degradation of Diclofenac-S-acyl-glutathione in Vitro and in Vivo in Rat

Authors: Grillo, M.P., Hua, F., March, K.L., Benet, L.Z., Knutson, C.G., Ware, J.A.

Source: CHEMICAL RESEARCH IN TOXICOLOGY. 21(10):1933-1938

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN239109729&indx=1&recIds=ETOCRN239109729

Differential Effects of Fibrates on the Metabolic Activation of 2-Phenylpropionic Acid in Rats

Authors: Li, C., Grillo, M.P., Badagnani, I., Fife, K.L., Benet, L.Z.

Source: DRUG METABOLISM AND DISPOSITION -BETHESDA-. 36(4):682-687

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN226587561&indx=1&recIds=ETOCRN226587561

HIV-Infected Liver and Kidney Transplant Recipients: 1- and 3-Year Outcomes

Authors: Roland, M.E. ^*, Barin, B., Carlson, L., Frassetto, L.A., Terrault, N.A., Hirose, R., Freise, C.E., Benet, L.Z., Ascher, N.L., Roberts, J.P., Murphy, B., Keller, M.J., Olthoff, K.M., Blumberg, E.A., Brayman, K.L., Bartlett, S.T., Davis, C.E., McCune, J.M., Bredt, B.M., Stablein, D.M., Stock, P.G.

Source: In American Journal of Transplantation February 2008 8(2):355-365

Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery

Authors: Benet, L.Z., Izumi, T., Zhang, Y., Silverman, J.A., Wacher, V.J.

Source: JOURNAL OF CONTROLLED RELEASE. 62(1-2):25-31

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN068464158&indx=1&recIds=ETOCRN068464158

Pharmacokinetic Differences Corroborate Observed Low Tacrolimus Dosage in Native American Renal Transplant Patients

Authors: Grover, A., Frassetto, L.A., Benet, L.Z., Chakkera, H.A.

Source: DRUG METABOLISM AND DISPOSITION -BETHESDA-. 39(11):2017-2019

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN301391905&indx=1&recIds=ETOCRN301391905