Molecular subclusters of follicular lymphoma: a report from the United Kingdom’s Haematological Malignancy Research Network

Authors: Crouch, Simon ^{∗, ∗}, Painter, Daniel ^∗, Barrans, Sharon L. ^∗, Roman, Eve, Beer, Philip A. ^∗, Cooke, Susanna L., Glover, Paul, Van Hoppe, Suzan J.L., Webster, Nichola, Lacy, Stuart E., Ruiz, Camilo, Campbell, Peter J., Hodson, Daniel J., Patmore, Russell, Burton, Cathy, Smith, Alexandra, Tooze, Reuben M.

Source: In Blood Advances 8 November 2022 6(21):5716-5731

Cancer Biomarkers in the era of precision oncology: Addressing the needs of patients and health systems

Authors: Normanno, Nicola, Apostolidis, Kathi, de Lorenzo, Francesco, Beer, Philip A., Henderson, Raymond, Sullivan, Richard, Biankin, Andrew V., Horgan, Denis, Lawler, Mark

Source: Seminars in cancer biology. 84:293-301

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100166608465.0x000001&indx=1&recIds=ETOCvdc_100166608465.0x000001

Genomic characterization of hepatoid tumors: context matters

Authors: Lawlor, Rita T., Mafficini, Andrea, Sciammarella, Concetta, Cantù, Cinzia, Rusev, Borislav C., Piredda, Maria L., Antonello, Davide, Grimaldi, Sonia, Bonizzato, Giada, Sperandio, Nicola, Marchegiani, Giovanni, Malleo, Giuseppe, Pea, Antonio, Salvia, Roberto, Mombello, Aldo, Mazzoleni, Guido, Nottegar, Alessia, Hanspeter, Esther, Riva, Giulio, Tomezzoli, Anna, Bencivenga, Maria, de Manzoni, Giovanni, Pedron, Serena, Paolino, Gaetano, Mattiolo, Paola, Brosens, Lodewijk A., Silvestris, Nicola, Fassan, Matteo, Cooke, Susanna L., Beer, Philip A., Milella, Michele, Adsay, Volkan N., Cheng, Liang, Scarpa, Aldo, Luchini, Claudio

Source: In Human Pathology December 2021 118:30-41

Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis

Authors: Gong, Chun, Krupka, Joanna A., Gao, Jie, Grigoropoulos, Nicholas F., Giotopoulos, George, Asby, Ryan, Screen, Michael, Usheva, Zelvera, Cucco, Francesco, Barrans, Sharon, Painter, Daniel, Zaini, Nurmahirah Binte Mohammed, Haupl, Björn, Bornelöv, Susanne, Ruiz De Los Mozos, Igor, Meng, Wei, Zhou, Peixun, Blain, Alex E., Forde, Sorcha, Matthews, Jamie, Khim Tan, Michelle Guet, Burke, G.A. Amos, Sze, Siu Kwan, Beer, Philip, Burton, Cathy, Campbell, Peter, Rand, Vikki, Turner, Suzanne D., Ule, Jernej, Roman, Eve, Tooze, Reuben, Oellerich, Thomas, Huntly, Brian J., Turner, Martin, Du, Ming-Qing, Samarajiwa, Shamith A., Hodson, Daniel J.

Source: In Molecular Cell 7 October 2021 81(19):4059-4075

Application of the LymphGen classification tool to 928 clinically and genetically‐characterised cases of diffuse large B cell lymphoma (DLBCL)

Authors: Runge, Hendrik F. P., Lacy, Stuart, Barrans, Sharon, Beer, Philip A, Painter, Daniel, Smith, Alexandra, Roman, Eve, Burton, Cathy, Crouch, Simon, Tooze, Reuben, Hodson, Daniel J.

Source: British journal of haematology. 192(1):216-220

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112477397.0x000001&indx=1&recIds=ETOCvdc_100112477397.0x000001

Preclinical and phase I studies of KA2237, a selective and potent inhibitor of PI3K β/δ in relapsed refractory B cell lymphoma

Authors: Nastoupil, Loretta J., Neelapu, Sattva S., Davis, Richard Eric, Samaniego, Felipe, Fowler, Nathan H., Westin, Jason, Lee, Hun Ju, Wang, Michael, Hagemeister, Fredrick, Cecil, Alexander R. L., Dow, James, Haque, Kemal, Silva, Franck A., Whale, Andrew, Lensun, Letitia, Bone, Elisabeth A., McElwaine-Johnn, Hilary, Beer, Philip A.

Source: Leukemia & lymphoma. 62(14):3452-3462

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100136544505.0x000001&indx=1&recIds=ETOCvdc_100136544505.0x000001

Combined inhibition of CTPS1 and ATR is a metabolic vulnerability in p53‐deficient myeloma cells.

Authors: Durand, Romane, Bellanger, Céline, Descamps, Géraldine, Dousset, Christelle, Maïga, Sophie, Derrien, Jennifer, Thirouard, Laura, Bouard, Louise, Asnagli, Hélène, Beer, Philip, Parker, Andrew, Gomez‐Bougie, Patricia, Devilder, Marie‐Claire, Moreau, Philippe, Touzeau, Cyrille, Moreau‐Aubry, Agnès, Chiron, David, Pellat‐Deceunynck, Catherine

Source: HemaSphere; Oct2024, Vol. 8 Issue 10, p1-16, 16p

MYC-induced human acute myeloid leukemia requires a continuing IL-3/GM-CSF costimulus

Authors: Bulaeva, Elizabeth, Pellacani, Davide, Nakamichi, Naoto, Hammond, Colin A., Beer, Philip A., Lorzadeh, Alireza, Moksa, Michelle, Carles, Annaïck, Bilenky, Misha, Lefort, Sylvain, Shu, Jeremy, Wilhelm, Brian T., Weng, Andrew P., Hirst, Martin, Eaves, Connie J. ^*

Source: In Blood 10 December 2020 136(24):2764-2773

Defining the clinical genomic landscape for real-world precision oncology

Authors: Beer, Philip A., Cooke, Susanna L., Chang, David K., Biankin, Andrew V.

Source: In Genomics November 2020 112(6):5324-5330

Targeted sequencing in DLBCL, molecular subtypes, and outcomes: a Haematological Malignancy Research Network report

Authors: Lacy, Stuart E. ^{1, *}, Barrans, Sharon L. ^{2, *}, Beer, Philip A. ^{3, *}, Painter, Daniel ¹, Smith, Alexandra G. ¹, Roman, Eve ¹, Cooke, Susanna L. ⁴, Ruiz, Camilo ³, Glover, Paul ², Van Hoppe, Suzan J.L. ², Webster, Nichola ², Campbell, Peter J. ³, Tooze, Reuben M. ⁵, Patmore, Russell ⁶, Burton, Cathy ^{2, †}, Crouch, Simon ^{1, 1, †}, Hodson, Daniel J. ^{7, †}

Source: In Blood 14 May 2020 135(20):1759-1771

A topological view of human CD34+ cell state trajectories from integrated single-cell output and proteomic data

Authors: Knapp, David J.H.F. ^*, Hammond, Colin A. ^*, Wang, Fangwu, Aghaeepour, Nima, Miller, Paul H., Beer, Philip A., Pellacani, Davide, VanInsberghe, Michael, Hansen, Carl, Bendall, Sean C., Nolan, Garry P., Eaves, Connie J. ^*

Source: In Blood 28 February 2019 133(9):927-939

Immuno-oncology from the perspective of somatic evolution

Authors: González, Santiago, Volkova, Nadezda, Beer, Philip, Gerstung, Moritz

Source: In Seminars in Cancer Biology October 2018 52 Part 2:75-85

Precision medicine and a molecular tumour board for pancreatic cancer in the UK national health service

Authors: Froeling, Fieke E.M., Bradley, Sarah, Dixon, Judith, Upstill-Goddard, Rosie, Grimwood, Paul, Westwood, Paul, Biankin, Andrew V., Beer, Philip A., Graham, Janet, Valle, Juan, Chang, David K.

Source: Pancreatology. 23(4):e4-e5

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191524607.0x000001&indx=1&recIds=ETOCvdc_100191524607.0x000001

Targeting MEK in vemurafenib-resistant hairy cell leukemia

Authors: Caeser, Rebecca, Collord, Grace, Yao, Wen-Qing, Chen, Zi, Vassiliou, George, Beer, Philip, Du, Ming-Qing, Scott, Mike, Follows, George, Hodson, Daniel

Source: Leukemia. 33(2):541-545

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112261904.0x000001&indx=1&recIds=ETOCvdc_100112261904.0x000001

Assays for functionally defined normal and malignant mammary stem cells

Authors: Aalam, Syed Mohammed Musheer, Beer, Philip Anthony, Kannan, Nagarajan

Source: Advances in cancer research. 141:129-174

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN619010617&indx=1&recIds=ETOCRN619010617

Genetic modification of primary human B cells to model high-grade lymphoma

Authors: Caeser, Rebecca, Di Re, Miriam, Krupka, Joanna, Gao, Jie, Lara-Chica, Maribel, Dias, João, Cooke, Susanna, Fenner, Rachel, Usheva, Zelvera, Runge, Hendrik, Beer, Philip, Eldaly, Hesham, Pak, Hyo-Kyung, Park, Chan-Sik, Vassiliou, George, Huntly, Brian, Mupo, Annalisa, Bashford-Rogers, Rachael, Hodson, Daniel

Source: Nature communications. 10(1):1-16

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190822476.0x000001&indx=1&recIds=ETOCvdc_100190822476.0x000001

Societal challenges of precision medicine: Bringing order to chaos

Authors: Becker, Robert, Beer, Philip, Bergh, Jonas, Bogaerts, Jan, Dovedi, Simon, Fojo, Antonio T., Gerstung, Moritz, Golfinopoulos, Vassilis, Hewitt, Stephen, Hochhauser, Daniel, Juhl, Hartmut, Kinders, Robert, Lillie, Thomas, Herbert, Kim Lyerly, Maheswaran, Shyamala, Mesri, Mehdi, Nagai, Sumimasa, Norstedt, Irene, O'Connor, Daniel, Oliver, Kathy, Oyen, Wim J.G., Pignatti, Francesco, Polley, Eric, Rosenfeld, Nitzan, Schellens, Jan, Schilsky, Richard, Schneider, Erasmus, Senderowicz, Adrian, Tenhunen, Olli, van Dongen, Augustinus, Vietz, Christine, Wilking, Nils, Salgado, Roberto, Moore, Helen, Martens, John W.M., Lively, Tracy, Malik, Shakun, McDermott, Ultan, Michiels, Stefan, Moscow, Jeffrey A., Tejpar, Sabine, McKee, Tawnya, Lacombe, Denis

Source: In European Journal of Cancer October 2017 84:325-334

Analysis of parameters that affect human hematopoietic cell outputs in mutant c-kit-immunodeficient mice

Authors: Miller, Paul H., Rabu, Gabrielle, MacAldaz, Margarita, Knapp, David J.H.F., Cheung, Alice M.S., Dhillon, Kiran, Nakamichi, Naoto, Beer, Philip A., Shultz, Leonard D., Humphries, R. Keith, Eaves, Connie J.

Source: In Experimental Hematology April 2017 48:41-49

Interpreting and integrating genomic tests results in clinical cancer care: Overview and practical guidance.

Authors: Casolino, Raffaella, Beer, Philip A., Chakravarty, Debyani, Davis, Melissa B., Malapelle, Umberto, Mazzarella, Luca, Normanno, Nicola, Pauli, Chantal, Subbiah, Vivek, Turnbull, Clare, Westphalen, C. Benedikt, Biankin, Andrew V.

Source: CA: A Cancer Journal for Clinicians; May2024, Vol. 74 Issue 3, p264-285, 22p

Subject Terms: TUMOR risk factors, TUMOR genetics, MEDICAL protocols, RISK assessment, GENOMICS, CLINICAL medicine research, CANCER patient medical care, DECISION making in clinical medicine, GENETIC mutation, INDIVIDUALIZED medicine, TUMORS, GENETIC testing, SEQUENCE analysis

Distinct signaling programs control human hematopoietic stem cell survival and proliferation

Authors: Knapp, David J.H.F., Hammond, Colin A., Aghaeepour, Nima, Miller, Paul H., Pellacani, Davide, Beer, Philip A., Sachs, Karen, Qiao, Wenlian, Wang, WeiJia, Humphries, R.Keith, Sauvageau, Guy, Zandstra, Peter W., Bendall, Sean C., Nolan, Garry P., Hansen, Carl, Eaves, Connie J.

Source: In Blood 19 January 2017 129(3):307-318