Quiescent cells maintain active degradation-mediated protein quality control requiring proteasome, autophagy, and nucleus-vacuole junctions

Authors: Franić, Dina ^{1, ‡}, Pravica, Mihaela ^{1, ‡}, Zubčić, Klara ¹, Miles, Shawna ², Bedalov, Antonio ^{2, 3}, Boban, Mirta ^{1, ∗}

Source: In Journal of Biological Chemistry January 2025 301(1)

Donor bone marrow–derived macrophage engraftment into the central nervous system of patients following allogeneic transplantation

Authors: Loeb, Anisha M., Pattwell, Siobhan S., Meshinchi, Soheil, Bedalov, Antonio, Loeb, Keith R.

Source: In Blood Advances 10 October 2023 7(19):5851-5859

Ribosomal DNA replication time coordinates completion of genome replication and anaphase in yeast

Authors: Kwan, Elizabeth X., Alvino, Gina M., Lynch, Kelsey L., Levan, Paula F., Amemiya, Haley M., Wang, Xiaobin S., Johnson, Sarah A., Sanchez, Joseph C., Miller, Madison A., Croy, Mackenzie, Lee, Seung-been, Naushab, Maria, Bedalov, Antonio, Cuperus, Josh T., Brewer, Bonita J., Queitsch, Christine, Raghuraman, M.K.

Source: In Cell Reports 28 March 2023 42(3)

Sir2 and Fun30 regulate ribosomal DNA replication timing via MCM helicase positioning and nucleosome occupancy.

Authors: Lichauco, Carmina, Foss, Eric J., Gatbonton-Schwager, Tonibelle, Athow, Nelson F., Lofts, Brandon, Acob, Robin, Taylor, Erin, Marquez, James J., Lao, Uyen, Miles, Shawna, Bedalov, Antonio

Source: eLife; 1/20/2025, p1-23, 23p

Bone marrow stromal cells enhance differentiation of acute myeloid leukemia induced by pyrimidine synthesis inhibitors.

Authors: Smoljo, Tomislav, Lalic, Hrvoje, Dembitz, Vilma, Tomic, Barbara, Batinic, Josip, Vrhovac, Radovan, Bedalov, Antonio, Visnjic, Dora

Source: American Journal of Physiology: Cell Physiology; Nov2024, Vol. 327 Issue 5, pC1202-C1218, 17p

Subject Terms: MESENCHYMAL stem cells, CHECKPOINT kinase 1, DIHYDROOROTATE dehydrogenase, ACUTE myeloid leukemia, STROMAL cells

The ribonucleoside AICAr induces differentiation of myeloid leukemia by activating the ATR/Chk1 via pyrimidine depletion

Alternate Title: AICAr induces differentiation by activating the ATR/Chk1 (English)

Authors: Dembitz, Vilma, Tomic, Barbara, Kodvanj, Ivan, Simon, Julian A., Bedalov, Antonio, Visnjic, Dora

Source: In Journal of Biological Chemistry 18 October 2019 294(42):15257-15270

Application of simultaneous selective pressures slows adaptation

Authors: Merlo, Lauren M. F., Sprouffske, Kathleen, Howard, Taylor C., Gardiner, Kristin L., Caulin, Aleah F., Blum, Steven M., Evans, Perry, Bedalov, Antonio, Sniegowski, Paul D., Maley, Carlo C.

Source: Evolutionary applications. 13(7):1615-1625

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108174703.0x000001&indx=1&recIds=ETOCvdc_100108174703.0x000001

Identification of a Small Molecule Inhibitor of Sir2p

Authors: Bedalov, Antonio, Gatbonton, Tonibelle, Irvine, William P., Gottschling, Daniel E., Simon, Julian A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2001 Dec . 98(26), 15113-15118.

Access URL: https://www.jstor.org/stable/3057419

Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-β superfamily as a regulator of XIST expression

Authors: Sripathy, Smitha, Leko, Vid, Adrianse, Robin L., Loe, Taylor, Foss, Eric J., Dalrymple, Emily, Lao, Uyen, Gatbonton-Schwager, Tonibelle, Carter, Kelly T., Payer, Bernhard, Paddison, Patrick J., Grady, William M., Lee, Jeannie T., Bartolomei, Marisa S., Bedalov, Antonio

Source: Proceedings of the National Academy of Sciences of the United States of America, 2017 Feb . 114(7), 1619-1624.

Access URL: https://www.jstor.org/stable/26479390

SIR2 suppresses replication gaps and genome instability by balancing replication between repetitive and unique sequences

Authors: Foss, Eric J., Lao, Uyen, Dalrymple, Emily, Adrianse, Robin L., Loe, Taylor, Bedalov, Antonio

Source: Proceedings of the National Academy of Sciences of the United States of America, 2017 Jan . 114(3), 552-557.

Access URL: https://www.jstor.org/stable/26478991

A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation

Authors: Lessing, Derek, Dial, Thomas O., Wei, Chunyao, Payer, Bernhard, Carrette, Lieselot L. G., Kesner, Barry, Szanto, Attila, Jadhav, Ajit, Maloney, David J., Simeonov, Anton, Theriault, Jimmy, Hasaka, Thomas, Bedalov, Antonio, Bartolomei, Marisa S., Lee, Jeannie T.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2016 Dec . 113(50), 14366-14371.

Access URL: https://www.jstor.org/stable/26472844

Identification of 1600 replication origins in S. cerevisiae.

Authors: Foss, Eric J., Lichauco, Carmina, Gatbonton-Schwager, Tonibelle, Gonske, Sara J., Lofts, Brandon, Lao, Uyen, Bedalov, Antonio

Source: eLife; 2/5/2024, p1-21, 21p

Inositol pyrophosphates modulate cell cycle independently of alteration in telomere length

Authors: Banfic, Hrvoje, Crljen, Vladiana, Lukinovic-Skudar, Vesna, Dembitz, Vilma, Lalic, Hrvoje, Bedalov, Antonio, Visnjic, Dora

Source: Advances in biological regulation. 60:22-28

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193581173.0x000001&indx=1&recIds=ETOCvdc_100193581173.0x000001

Bone marrow stromal cells reduce low-dose cytarabine-induced differentiation of acute myeloid leukemia.

Authors: Smoljo, Tomislav, Tomic, Barbara, Lalic, Hrvoje, Dembitz, Vilma, Batinic, Josip, Bedalov, Antonio, Visnjic, Dora

Source: Frontiers in Pharmacology; 2023, p1-18, 18p

Subject Terms: MESENCHYMAL stem cells, ACUTE myeloid leukemia, MYELODYSPLASTIC syndromes, STROMAL cells, CELL cycle, DNA damage

5-aminoimidazole-4-carboxamide ribonucleoside induces differentiation in a subset of primary acute myeloid leukemia blasts

Authors: Dembitz, Vilma, Lalic, Hrvoje, Kodvanj, Ivan, Tomic, Barbara, Batinic, Josip, Dubravcic, Klara, Batinic, Drago, Bedalov, Antonio, Visnjic, Dora

Source: BMC cancer. 20(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186555689.0x000001&indx=1&recIds=ETOCvdc_100186555689.0x000001

Inositol Pyrophosphates Modulate S Phase Progression after Pheromone-induced Arrest in Saccharomyces cerevisiae

Authors: Banfic, Hrvoje, Bedalov, Antonio, York, John D., Visnjic, Dora

Source: In Journal of Biological Chemistry 18 January 2013 288(3):1717-1725

Conditioning with Treosulfan and Fludarabine followed by Allogeneic Hematopoietic Cell Transplantation for High-Risk Hematologic Malignancies

Authors: Nemecek, Eneida R., Guthrie, Katherine A., Sorror, Mohamed L., Wood, Brent L., Doney, Kristine C., Hilger, Ralf A., Scott, Bart L., Kovacsovics, Tibor J., Maziarz, Richard T., Woolfrey, Ann E., Bedalov, Antonio, Sanders, Jean E., Pagel, John M., Sickle, Eileen J., Witherspoon, Robert, Flowers, Mary E., Appelbaum, Frederick R., Deeg, H. Joachim

Source: In Biology of Blood and Marrow Transplantation 2011 17(3):341-350

Chromosomal Mcm2-7 distribution and the genome replication program in species from yeast to humans.

Authors: Foss, Eric J.¹, Sripathy, Smitha¹, Gatbonton-Schwager, Tonibelle¹, Kwak, Hyunchang¹, Thiesen, Adam H.¹, Lao, Uyen¹, Bedalov, Antonio^1,2, abedalov@fredhutch.org

Source: PLoS Genetics; 9/2/2021, Vol. 17 Issue 9, p1-36, 36p

Differential Utilization of Regulatory Domains within the α1(I) Collagen Promoter in Osseous and Fibroblastic Cells

Authors: Pavlin, Dubravko, Lichtler, Alexander C., Bedalov, Antonio, Kream, Barbara E., Harrison, John R., Thomas, Huw F., Gronowicz, Gloria A., Clark, Stephen H., Woody, Charles O., Rowe, David W.

Source: The Journal of Cell Biology, 1992 Jan 01. 116(1), 227-236.

Access URL: https://www.jstor.org/stable/1614943

Perturbed maintenance of transcriptional repression on the inactive X-chromosome in the mouse brain after Xist deletion

Authors: Adrianse, Robin L., Smith, Kaleb, Gatbonton-Schwager, Tonibelle, Sripathy, Smitha P., Lao, Uyen, Foss, Eric J., Boers, Ruben G., Boers, Joachim B., Gribnau, Joost, Bedalov, Antonio

Source: Epigenetics & chromatin. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130328916.0x000001&indx=1&recIds=ETOCvdc_100130328916.0x000001