Proteomic Analysis of Spatial Heterogeneity Identifies HMGB2 as Putative Biomarker of Tumor Progression in Adult-Type Diffuse Astrocytomas.

Authors: Becker, Aline P.¹ (AUTHOR) aline.becker@osumc.edu, Becker, Valesio¹ (AUTHOR) valesio.becker@osumc.edu, McElroy, Joseph² (AUTHOR) joseph.mcelroy@osumc.edu, Webb, Amy³ (AUTHOR) amy.hite@osumc.edu, Han, Chunhua¹ (AUTHOR) chunhua.han@osumc.edu, Guo, Yingshi¹ (AUTHOR) yingshi.guo@osumc.edu, Bell, Erica H.⁴ (AUTHOR) erica.bell@osumc.edu, Fleming, Jessica¹ (AUTHOR) jessica.fleming@osumc.edu, Popp, Ilinca⁵ (AUTHOR) ilinca.popp@uniklinik-freiburg.de, Staszewski, Ori⁶ (AUTHOR) ori.staszewski@uks.eu, Prinz, Marco^7,8 (AUTHOR) marco.prinz@uniklinik-freiburg.de, Otero, Jose J.⁹ (AUTHOR) jose.otero@osumc.edu, Haque, Saikh Jaharul¹ (AUTHOR) jahar.haque@osumc.edu, Grosu, Anca-Ligia⁵ (AUTHOR) anca.grosu@uniklinik-freiburg.de, Chakravarti, Arnab¹ (AUTHOR) arnab.chakravarti@osumc.edu

Source: Cancers. Apr2024, Vol. 16 Issue 8, p1516. 19p.

Subject Terms: *RISK assessment, *GLIOMAS, *LIQUID chromatography-mass spectrometry, *GENOMICS, *RESEARCH funding, *CELL proliferation, *TUMOR markers, *CANCER patients, *DESCRIPTIVE statistics, *DNA methylation, *IMMUNOHISTOCHEMISTRY, *KAPLAN-Meier estimator, *LOG-rank test, *PROTEOMICS, *GENE expression profiling, *STAINS & staining (Microscopy), *DATA analysis software, *FACTOR analysis, *DISEASE progression, *OVERALL survival, *ADULTS

Geographic Terms: OHIO

Evaluation of the prognostic potential of EGFL7 in pilocytic astrocytomas

Authors: Brunhara, Bruno B., Becker, Aline P., Neder, Luciano, Gonçalves, Paola G., Oliveira, Cristiane, Clara, Carlos A., Reis, Rui M., Bidinotto, Lucas T.

Source: Neuropathology. 41(1):21-28

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115845031.0x000001&indx=1&recIds=ETOCvdc_100115845031.0x000001

Neuropathology of Pituitary Adenomas and Sellar Lesions

Authors: Kobalka, Peter J, Huntoon, Kristin, Becker, Aline P

Source: Neurosurgery. 88(5):900-918

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100122501851.0x000001&indx=1&recIds=ETOCvdc_100122501851.0x000001

Correspondence comprehensive characterization of a brainstem aggregoma (light and heavy chain deposition disease)

Authors: Becker, Aline P., Osorio, Diana S., Bell, Erica H., Giglio, Pierre, Fleming, Jessica L., Cottrell, Catherine E., Mardis, Elaine R., Miller, Katherine E., Schieffer, Kathleen M., Kelly, Benjamin J., Makary, Mina S., Slone, Wayne, Benson, Don, Leonard, Jeffrey, Kahwash, Samir B., Boué, Daniel R., Chakravarti, Arnab

Source: Brain pathology. 33(5)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191750219.0x000001&indx=1&recIds=ETOCvdc_100191750219.0x000001

The T‐box transcription factor brachyury behaves as a tumor suppressor in gliomas

Authors: Pinto, Filipe, Costa, Ângela M, Santos, Gisele C, Matsushita, Marcus M, Costa, Sandra, Silva, Viviane AO, Miranda‐Gonçalves, Vera, Lopes, Celeste M, Clara, Carlos A, Becker, Aline P, Neder, Luciano, Hajj, Glaucia NM, Cunha, Isabela W, Jones, Chris, Andrade, Raquel P, Reis, Rui M

Source: Journal of pathology. 251(1):87-99

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100111125446.0x000001&indx=1&recIds=ETOCvdc_100111125446.0x000001

2100: HMGB2 KD shortens G2/M, reduces cell, proliferation, and radio-sensitizes TP53wt and mutant GBM cells

Authors: Becker, Aline P., Becker, Valesio, Sebastian, Ebin, Haque, S. Jaharul, McElroy, Joseph, Webb, Amy, Fleming, Jessica, Singh, Karnika, Han, Chunhua, Summers, Matthew K., Venere, Monica, Chakravarti, Arnab

Source: In Radiotherapy and Oncology May 2024 194 Supplement 1:S5400-S5402

PATH-15. PROTEOMIC SIGNATURES PREDICT GRADE IN PEDIATRIC AND YOUNG ADULT INFILTRATIVE ASTROCYTOMAS

Authors: Graham, Richard T, Sells, Blake E, Fleming, Jessica, McElroy, Joseph P, Bell, Erica H, Haque, S Jaharul, Becker, Aline P, Boué, Daniel R, Finlay, Jonathan L, Chakravarti, Arnab

Source: Neuro-oncology. 22(Supplement 3):iii427-iii427

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112164316.0x000001&indx=1&recIds=ETOCvdc_100112164316.0x000001

The Carbonic Anhydrase Inhibitor E7070 Sensitizes Glioblastoma Cells to Radio- and Chemotherapy and Reduces Tumor Growth.

Authors: Teixeira, Silvia A., Viapiano, Mariano S., Andrade, Augusto F., Nandhu, Mohan S., Pezuk, Julia A., Bidinotto, Lucas T., Suazo, Veridiana K., Neder, Luciano, Carlotti, Carlos G., Becker, Aline P., Tone, Luiz Gonzaga, Scrideli, Carlos A.

Source: Molecular Neurobiology; Sep2021, Vol. 58 Issue 9, p4520-4534, 15p

Long-Term Report of a Comprehensive Molecular and Genomic Analysis in NRG Oncology/RTOG 0424: A Phase II Study of Radiation and Temozolomide in High-Risk Grade II Glioma.

Authors: Fleming, Jessica L., Pugh, Stephanie L., Fisher, Barbara J., Lesser, Glenn J., Macdonald, David R., Bell, Erica H., McElroy, Joseph P., Becker, Aline P., Timmers, Cynthia D., Aldape, Kenneth D., Rogers, C. Leland, Doyle, Thomas J., Werner-Wasik, Maria, Bahary, Jean-Paul, Yu, Hsiang-Hsuan Michael, D'Souza, David P., Laack, Nadia N., Sneed, Penny K., Kwok, Young, Won, Minhee

Source: JCO Precision Oncology; 8/1/2021, Vol. 5, p1397-1407, 11p

Subject Terms: GENOMICS, PROPORTIONAL hazards models, OVERALL survival, TEMOZOLOMIDE, GLIOMAS

Combinatorial targeting of glutamine metabolism and lysosomal-based lipid metabolism effectively suppresses glioblastoma

Authors: Zhong, Yaogang, Geng, Feng, Mazik, Logan, Yin, Xinmin, Becker, Aline Paixao, Mohammed, Shabber, Su, Huali, Xing, Enming, Kou, Yongjun, Chiang, Cheng-Yao, Fan, Yunzhou, Guo, Yongchen, Wang, Qiang, Li, Pui-Kai, Mo, Xiaokui, Lefai, Etienne, He, Liqing, Cheng, Xiaolin, Zhang, Xiang, Chakravarti, Arnab, Guo, Deliang

Source: Cell Reports Medicine; September 2024, Vol. 5 Issue: 9

Comprehensive Genomic Analysis in NRG Oncology/RTOG 9802: A Phase III Trial of Radiation Versus Radiation Plus Procarbazine, Lomustine (CCNU), and Vincristine in High-Risk Low-Grade Glioma.

Authors: Bell, Erica H., Zhang, Peixin, Shaw, Edward G., Buckner, Jan C., Barger, Geoffrey R., Bullard, Dennis E., Mehta, Minesh P., Gilbert, Mark R., Brown, Paul D., Stelzer, Keith J., McElroy, Joseph P., Fleming, Jessica l., Timmers, Cynthia D., Becker, Aline P., Salavaggione, Andrea L., Liu, Ziyan, Aldape, Kenneth, Brachman, David G., Gertler, Stanley Z., Murtha, Albert D.

Source: Journal of Clinical Oncology; 10/10/2020, Vol. 38 Issue 29, p3407-3417, 12p

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Tumor Heterogeneity in Glioblastomas: From Light Microscopy to Molecular Pathology.

Authors: Becker, Aline P.¹ (AUTHOR) Aline.Becker@osumc.edu, Sells, Blake E.² (AUTHOR) blake.sells@wustl.edu, Haque, S. Jaharul¹ (AUTHOR) Arnab.Chakravarti@osumc.edu, Chakravarti, Arnab¹ (AUTHOR), Schönthal, Axel H. (AUTHOR)

Source: Cancers. 2/15/2021, Vol. 13 Issue 4, p761-761. 1p.

Subject Terms: *CELL differentiation, *DNA, *MICROSCOPY, *CANCER invasiveness, *CARCINOGENESIS, *GLIOMAS, *MOLECULAR pathology, *CELL physiology, *RNA, *INDIVIDUALIZED medicine, *STEM cells

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miR-4516 predicts poor prognosis and functions as a novel oncogene via targeting PTPN14in human glioblastoma

Authors: Cui, Tiantian, Bell, Erica H., McElroy, Joseph, Becker, Aline Paixao, Gulati, Pooja Manchanda, Geurts, Marjolein, Mladkova, Nikol, Gray, Ashley, Liu, Kevin, Yang, Linlin, Liu, Ziyan, Fleming, Jessica L., Haque, S. Jaharul, Barnholtz-Sloan, Jill S., Ligon, Keith L., Beroukhim, Rameen, Robe, Pierre, Chakravarti, Arnab

Source: Oncogene; April 2019, Vol. 38 Issue: 16 p2923-2936, 14p