Safety, immunogenicity and effect on viral rebound of HTI vaccines combined with a TLR7 agonist in early-treated HIV-1 infection: a randomized, placebo-controlled phase 2a trial

Authors: Lucia Bailón, José Moltó, Adrian Curran, Julen Cadiñanos, Juan Carlos Lopez Bernaldo de Quirós, Ignacio de Los Santos, Juan Ambrosioni, Arkaitz Imaz, Susana Benet, Paula Suanzes, Jordi Navarro, Juan González-García, Carmen Busca, Leire Pérez-Latorre, Juan Berenguer, Lucio Jesús García-Fraile, Gina Mejía-Abril, Jose M. Miró, Sofía Scévola, Santiago Moreno, Pere Domingo, Yuan Tian, Michelle Frankot, Daina Lim, Yanhui Cai, Elena Vendrame, Susan Guo, Jeffrey J. Wallin, Romas Geleziunas, Devi SenGupta, Yovaninna Alarcón-Soto, Isabel Leal, Alvaro Aranguen, Margarida Garcia-Garcia, Ian McGowan, Christian Brander, Jose Ramón Arribas, Beatriz Mothe, On behalf of the AELIX-003 Study Group

Source: Nature Communications, Vol 16, Iss 1, Pp 1-16 (2025)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/8610988418d24db6ac8cd6fd153b534c

Time to HIV viral rebound and frequency of post-treatment control after analytical interruption of antiretroviral therapy: an individual data-based meta-analysis of 24 prospective studies

Authors: Jesper D. Gunst, Jesal Gohil, Johanthan Z. Li, Ronald J. Bosch, Andrea White, Catherine Seamon, Tae-Wook Chun, Beatriz Mothe, Kathleen Gittens, Lauren Praiss, Marie-Angélique De Scheerder, Linos Vandekerckhove, Kevin Escandón, Ann Thorkelson, Timothy Schacker, Devi SenGupta, Christian Brander, Emmanouil Papasavvas, Luis J. Montaner, Javier Martinez-Picado, Ruxandra Calin, Antonella Castagna, Camilla Muccini, Wesley de Jong, Lorna Leal, Felipe Garcia, Rob A. Gruters, Timothy Tipoe, John Frater, Ole S. Søgaard, Sarah Fidler

Source: Nature Communications, Vol 16, Iss 1, Pp 1-13 (2025)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/5f9f778bf57f41fb8a0d588a9b6dc7f7

Relationship between HLA genetic variations, COVID-19 vaccine antibody response, and risk of breakthrough outcomes

Authors: Junqing Xie, Beatriz Mothe, Marta Alcalde Herraiz, Chunxiao Li, Yu Xu, Annika M. Jödicke, Yaqing Gao, Yunhe Wang, Shuo Feng, Jia Wei, Zhuoyao Chen, Shenda Hong, Yeda Wu, Binbin Su, Xiaoying Zheng, Catherine Cohet, Raghib Ali, Nick Wareham, Daniel Prieto Alhambra

Source: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f5c1a6aafc9b4ee18cd32bbbff208828

The impact of analytical treatment interruptions and trial interventions on time to viral re‐suppression in people living with HIV restarting ART in cure‐related clinical studies: a systematic review and meta‐analysis

Authors: Ming Jie Lee, Miles Eason, Antonella Castagna, Galli Laura, Marie‐Angelique De Scheerder, James Riley, Pablo Tebas, Jesper Gunst, Ole Søgaard, Eric Florence, Eugene Kroon, Mark De Souza, Beatriz Mothe, Marina Caskey, Sarah Fidler

Source: Journal of the International AIDS Society, Vol 27, Iss 8, Pp n/a-n/a (2024)

Subject Terms: antiretroviral therapy, ATI, HIV, HIV cure, treatment interruption, viral suppression, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/1758-2652

Access URL: https://doaj.org/article/248624d98f04464b807c1ffc49fa3d38

Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8+ T cell immunity

Authors: Miriam Rosás-Umbert, Jesper D. Gunst, Marie H. Pahus, Rikke Olesen, Mariane Schleimann, Paul W. Denton, Victor Ramos, Adam Ward, Natalie N. Kinloch, Dennis C. Copertino, Tuixent Escribà, Anuska Llano, Zabrina L. Brumme, R. Brad Jones, Beatriz Mothe, Christian Brander, Julie Fox, Michel C. Nussenzweig, Sarah Fidler, Marina Caskey, Martin Tolstrup, Ole S. Søgaard

Source: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ef639b4a891643dcb296cca780fd13c0

Plasma proteomic profiling identifies CD33 as a marker of HIV control in natural infection and after therapeutic vaccinationResearch in context

Authors: Clara Duran-Castells, Anna Prats, Bruna Oriol-Tordera, Anuska Llano, Cristina Galvez, Javier Martinez-Picado, Ester Ballana, Edurne Garcia-Vidal, Bonaventura Clotet, Jose A. Muñoz-Moreno, Thomas Hanke, José Moltó, Beatriz Mothe, Christian Brander, Marta Ruiz-Riol

Source: EBioMedicine, Vol 95, Iss , Pp 104732- (2023)

Subject Terms: Control of HIV-1 infection, Plasma proteomics, Inflammation, Neurological function, Siglec-3/CD33, Kick and kill HIV cure strategy, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396423002979; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/3b80065fccfc4b748f1b0fc22a58d62a

Impact of ChAdOx1 or DNA Prime Vaccination on Magnitude, Breadth, and Focus of MVA-Boosted Immunogen-Specific T Cell Responses

Authors: Alex Olvera, Luis Romero-Martin, Bruna Oriol-Tordera, Miriam Rosas-Umbert, Tuixent Escribà, Beatriz Mothe, Christian Brander

Source: Vaccines, Vol 12, Iss 3, p 279 (2024)

Subject Terms: T-cell vaccine, HIV, immunodominance, immune memory, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-393X/12/3/279; https://doaj.org/toc/2076-393X

Access URL: https://doaj.org/article/3e38dbd850c44131bf763791e9e2d017

Gut microbiome signatures linked to HIV-1 reservoir size and viremia control

Authors: Alessandra Borgognone, Marc Noguera-Julian, Bruna Oriol, Laura Noël-Romas, Marta Ruiz-Riol, Yolanda Guillén, Mariona Parera, Maria Casadellà, Clara Duran, Maria C. Puertas, Francesc Català-Moll, Marlon De Leon, Samantha Knodel, Kenzie Birse, Christian Manzardo, José M. Miró, Bonaventura Clotet, Javier Martinez-Picado, José Moltó, Beatriz Mothe, Adam Burgener, Christian Brander, Roger Paredes, the BCN02 Study Group

Source: Microbiome, Vol 10, Iss 1, Pp 1-15 (2022)

Subject Terms: HIV-1 post-treatment control, Gut microbiome, Therapeutic HIV-1 vaccine, Viral reservoir size, Microbiome-based predictive biomarker, Microbial ecology, QR100-130

File Description: electronic resource

Relation: https://doaj.org/toc/2049-2618

Access URL: https://doaj.org/article/f4eb4630f5eb4505a01baefcff14f0eb

Disruption of the HLA-E/NKG2X axis is associated with uncontrolled HIV infections

Authors: Luis Romero-Martín, Clara Duran-Castells, Mireia Olivella, Míriam Rosás-Umbert, Marta Ruiz-Riol, Jorge Sanchez, Dennis Hartigan-O´Connor, Beatriz Mothe, Àlex Olvera, Christian Brander

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: HIV, Natural Killer cells, HLA-E, NKG2A, NKG2C, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1027855/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/032ba9aefb4844fcbbac0f5a8c7312e7

Kinetics of immune responses elicited after three mRNA COVID-19 vaccine doses in predominantly antibody-deficient individuals

Authors: Erola Ainsua-Enrich, Núria Pedreño-Lopez, Carmen Bracke, Carlos Ávila-Nieto, María Luisa Rodríguez de la Concepción, Edwards Pradenas, Benjamin Trinité, Silvia Marfil, Cristina Miranda, Sandra González, Ruth Toledo, Marta Font, Susana Benet, Tuixent Escribà, Esther Jimenez-Moyano, Ruth Peña, Samandhy Cedeño, Julia G. Prado, Beatriz Mothe, Christian Brander, Nuria Izquierdo-Useros, Julia Vergara-Alert, Joaquim Segalés, Marta Massanella, Rosa María Benitez, Alba Romero, Daniel Molina-Morant, Julià Blanco, Bonaventura Clotet, Lourdes Mateu, María Luisa Pedro-Botet, Jorge Carrillo

Source: iScience, Vol 25, Iss 11, Pp 105455- (2022)

Subject Terms: Immunology, Virology, Immune response, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004222017278; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/073012793b3643598393de5b4241a3fc

Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection

Authors: Anna Prats, Ignacio Martínez-Zalacaín, Beatriz Mothe, Eugènia Negredo, Núria Pérez-Álvarez, Maite Garolera, Sira Domènech-Puigcerver, Pep Coll, Michael Meulbroek, Anna Chamorro, Carmina R. Fumaz, Maria J. Ferrer, Bonaventura Clotet, Carles Soriano-Mas, Jose A. Muñoz-Moreno

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/b686a287e1084a619c984d1749a54ecd

T-Follicular-Like CD8+ T Cell Responses in Chronic HIV Infection Are Associated With Virus Control and Antibody Isotype Switching to IgG

Authors: Luis Romero-Martín, Ferran Tarrés-Freixas, Núria Pedreño-López, Maria L. Rodríguez de la Concepción, Francesc Cunyat, Dennis Hartigan-O'Connor, Jorge Carrillo, Beatriz Mothe, Julià Blanco, Marta Ruiz-Riol, Christian Brander, Alex Olvera

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: HIV, humoral immune response, human immunodeficiency virus (HIV) control, T-follicular cytotoxic (Tfc) cells, viral control, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.928039/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/52de45fb5dc940a49cc527d71d8abd4f

Epigenetic landscape in the kick-and-kill therapeutic vaccine BCN02 clinical trial is associated with antiretroviral treatment interruption (ATI) outcome

Authors: Bruna Oriol-Tordera, Anna Esteve-Codina, María Berdasco, Míriam Rosás-Umbert, Elena Gonçalves, Clara Duran-Castells, Francesc Català-Moll, Anuska Llano, Samandhy Cedeño, Maria C. Puertas, Martin Tolstrup, Ole S. Søgaard, Bonaventura Clotet, Javier Martínez-Picado, Tomáš Hanke, Behazine Combadiere, Roger Paredes, Dennis Hartigan-O'Connor, Manel Esteller, Michael Meulbroek, María Luz Calle, Alex Sanchez-Pla, José Moltó, Beatriz Mothe, Christian Brander, Marta Ruiz-Riol

Source: EBioMedicine, Vol 78, Iss , Pp 103956- (2022)

Subject Terms: HIV-1 vaccine, Epigenetics, DNA methylation, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396422001402; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/9f3d6a37e4e5465486ac479f3e27ef6c

iHIVARNA phase IIa, a randomized, placebo-controlled, double-blinded trial to evaluate the safety and immunogenicity of iHIVARNA-01 in chronically HIV-infected patients under stable combined antiretroviral therapy

Authors: Wesley de Jong, Joeri Aerts, Sabine Allard, Christian Brander, Jozefien Buyze, Eric Florence, Eric van Gorp, Guido Vanham, Lorna Leal, Beatriz Mothe, Kris Thielemans, Montse Plana, Félipe Garcia, Rob Gruters, on behalf of the iHIVARNA consortium

Source: Trials, Vol 20, Iss 1, Pp 1-10 (2019)

Subject Terms: HIV-1, Therapeutic vaccine, Functional cure, Immunotherapy, Reservoir, Lymph node, Medicine (General), R5-920

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13063-019-3409-1; https://doaj.org/toc/1745-6215

Access URL: https://doaj.org/article/abecefcfd3194ea2927807cc24cfb71f

Therapeutic Vaccination Refocuses T-cell Responses Towards Conserved Regions of HIV-1 in Early Treated Individuals (BCN 01 study)

Authors: Beatriz Mothe, Christian Manzardo, Alvaro Sanchez-Bernabeu, Pep Coll, Sara Morón-López, Maria C. Puertas, Miriam Rosas-Umbert, Patricia Cobarsi, Roser Escrig, Núria Perez-Alvarez, Irene Ruiz, Cristina Rovira, Michael Meulbroek, Alison Crook, Nicola Borthwick, Edmund G. Wee, Hongbing Yang, Jose M. Miró, Lucy Dorrell, Bonaventura Clotet, Javier Martinez-Picado, Christian Brander, Tomáš Hanke

Source: EClinicalMedicine, Vol 11, Iss , Pp 65-80 (2019)

Subject Terms: Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589537019300872; https://doaj.org/toc/2589-5370

Access URL: https://doaj.org/article/9525071b69b242ee8ae52281b8baa3b5

Does Antigen Glycosylation Impact the HIV-Specific T Cell Immunity?

Authors: Alex Olvera, Samandhy Cedeño, Anuska Llano, Beatriz Mothe, Jorge Sanchez, Gemma Arsequell, Christian Brander

Source: Frontiers in Immunology, Vol 11 (2021)

Subject Terms: virus, human immunodeficiency virus, T cell, cytotoxic T lymphocyte, epitope, glycosylation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2020.573928/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/23c54ad9610a4a3c989409f31581faf6

Immune Profiles Identification by Vaccinomics After MVA Immunization in Randomized Clinical Study

Authors: Jorge Sanchez, Elena Gonçalves, Anuska Llano, Pedro Gonzáles, María Fernández-Maldonado, Annika Vogt, Angele Soria, Susana Perez, Samandhy Cedeño, Marco Antonio Fernández, Julien Nourikyan, Simon de Bernard, Carmela Ganoza, Eric Pedruzzi, Olivia Bonduelle, Beatriz Mothe, Carmen E. Gòmez, Mariano Esteban, Felipe Garcia, Javier R. Lama, Christian Brander, Behazine Combadiere

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: immunogenicity, cutaneous vaccination, intramuscular route, vaccinia virus vector, transcriptome, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2020.586124/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/7de6587d92de4cdd98f362c26b6bf00a

Methylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control.

Authors: Bruna Oriol-Tordera, Maria Berdasco, Anuska Llano, Beatriz Mothe, Cristina Gálvez, Javier Martinez-Picado, Jorge Carrillo, Julià Blanco, Clara Duran-Castells, Carmela Ganoza, Jorge Sanchez, Bonaventura Clotet, Maria Luz Calle, Alex Sánchez-Pla, Manel Esteller, Christian Brander, Marta Ruiz-Riol

Source: PLoS Pathogens, Vol 16, Iss 8, p e1008678 (2020)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/932994bc041b404db54d93aecb303cb6

HIVconsv Vaccines and Romidepsin in Early-Treated HIV-1-Infected Individuals: Safety, Immunogenicity and Effect on the Viral Reservoir (Study BCN02)

Authors: Beatriz Mothe, Miriam Rosás-Umbert, Pep Coll, Christian Manzardo, Maria C. Puertas, Sara Morón-López, Anuska Llano, Cristina Miranda, Samandhy Cedeño, Miriam López, Yovaninna Alarcón-Soto, Guadalupe Gómez Melis, Klaus Langohr, Ana M. Barriocanal, Jessica Toro, Irene Ruiz, Cristina Rovira, Antonio Carrillo, Michael Meulbroek, Alison Crook, Edmund G. Wee, Jose M. Miró, Bonaventura Clotet, Marta Valle, Javier Martinez-Picado, Tomáš Hanke, Christian Brander, José Moltó, The BCN02 Study Investigators

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: romidepsin, HDAC inhibitor, kick&kill strategy, HIVconsv, early-treatment, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2020.00823/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/488e5500178f4b47bb1f5b03a865f708

In vivo Effects of Romidepsin on T-Cell Activation, Apoptosis and Function in the BCN02 HIV-1 Kick&Kill Clinical Trial

Authors: Miriam Rosás-Umbert, Marta Ruiz-Riol, Marco A. Fernández, Marta Marszalek, Pep Coll, Christian Manzardo, Samandhy Cedeño, José M. Miró, Bonaventura Clotet, Tomáš Hanke, José Moltó, Beatriz Mothe, Christian Brander, the BCN02 study group, Susana Benet, Anuksa Llano, Javier Martinez-Picado, Sara Morón-López, Roger Paredes, Maria C. Puertas, Roser Escrig, Silvia Gel, Miriam López, Cristina Miranda, Jose Muñoz, Nuria Perez-Alvarez, Jordi Puig, Boris Revollo, Jessica Toro, Ana Maria Barriocanal, Magi Farré, Cristina Perez-Reche, Marta Valle, Juan Ambrosioni, Irene Ruiz, Cristina Rovira, Carmen Ligero, Jose M. Miro, Antonio Carrillo, Michael Meulbroek, Ferran Pujol, Jorge Saz, Nicola Borthwick, Alison Crook, Edmund G. Wee

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: romidepsin, HDAC inhibitor, kick&kill strategy, therapeutic vaccine, latency reversing agent (LRA), Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2020.00418/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/7ff34c69a231482fa4c4bba2e9a493f3