MYOD-SKP2 axis boosts tumorigenesis in fusion negative rhabdomyosarcoma by preventing differentiation through p57Kip2 targeting

Authors: Silvia Pomella, Matteo Cassandri, Lucrezia D’Archivio, Antonella Porrazzo, Cristina Cossetti, Doris Phelps, Clara Perrone, Michele Pezzella, Antonella Cardinale, Marco Wachtel, Sara Aloisi, David Milewski, Marta Colletti, Prethish Sreenivas, Zoë S. Walters, Giovanni Barillari, Angela Di Giannatale, Giuseppe Maria Milano, Cristiano De Stefanis, Rita Alaggio, Sonia Rodriguez-Rodriguez, Nadia Carlesso, Christopher R. Vakoc, Enrico Velardi, Beat W. Schafer, Ernesto Guccione, Susanne A. Gatz, Ajla Wasti, Marielle Yohe, Myron Ignatius, Concetta Quintarelli, Janet Shipley, Lucio Miele, Javed Khan, Peter J. Houghton, Francesco Marampon, Berkley E. Gryder, Biagio De Angelis, Franco Locatelli, Rossella Rota

Source: Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/b02d638fdabc4c31acb1630b1acf4c96

Anemia and survival in childhood acute lymphoblastic leukemia

Authors: Oliver Teuffel, Martin Stanulla, Gunnar Cario, Wolf D. Ludwig, Silja Rottgers, Beat W. Schafer, Martin Zimmermann, Martin Schrappe, Felix K. Niggli

Source: Haematologica, Vol 93, Iss 11 (2008)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/5069; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/7b0cfe924ad64d628908d28117d618dc

Single cell transcriptomic profiling identifies tumor-acquired and therapy-resistant cell states in pediatric rhabdomyosarcoma

Authors: Sara G. Danielli, Yun Wei, Michael A. Dyer, Elizabeth Stewart, Heather Sheppard, Marco Wachtel, Beat W. Schäfer, Anand G. Patel, David M. Langenau

Source: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/e29faed2ad884c858ba654d0b6fb5c27

PAX3-FOXO1 uses its activation domain to recruit CBP/P300 and shape RNA Pol2 cluster distribution

Authors: Yaw Asante, Katharina Benischke, Issra Osman, Quy A. Ngo, Jakob Wurth, Dominik Laubscher, Hyunmin Kim, Bhavatharini Udhayakumar, Md Imdadul H. Khan, Diana H. Chin, Jadon Porch, Maharshi Chakraborty, Richard Sallari, Olivier Delattre, Sakina Zaidi, Sarah Morice, Didier Surdez, Sara G. Danielli, Beat W. Schäfer, Berkley E. Gryder, Marco Wachtel

Source: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/8b11c89f44b84a3f89f0cbe46cf89665

CRISPR activation screen identifies TGFβ-associated PEG10 as a crucial tumor suppressor in Ewing sarcoma

Authors: Vadim Saratov, Quy A. Ngo, Gloria Pedot, Semjon Sidorov, Marco Wachtel, Felix K. Niggli, Beat W. Schäfer

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/a89a844999154563b8c8a1db91001c39

BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma

Authors: Dominik Laubscher, Berkley E. Gryder, Benjamin D. Sunkel, Thorkell Andresson, Marco Wachtel, Sudipto Das, Bernd Roschitzki, Witold Wolski, Xiaoli S. Wu, Hsien-Chao Chou, Young K. Song, Chaoyu Wang, Jun S. Wei, Meng Wang, Xinyu Wen, Quy Ai Ngo, Joana G. Marques, Christopher R. Vakoc, Beat W. Schäfer, Benjamin Z. Stanton, Javed Khan

Source: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/3a3e0d79c30a410f82f8195b27c0b538

A combinatorial drug screen in PDX-derived primary rhabdomyosarcoma cells identifies the NOXA - BCL-XL/MCL-1 balance as target for re-sensitization to first-line therapy in recurrent tumors

Authors: Gabriele Manzella, Devmini C. Moonamale, Michaela Römmele, Peter Bode, Marco Wachtel, Beat W. Schäfer

Source: Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 9, Pp 929-938 (2021)

Subject Terms: Rhabdomyosarcoma, PDX-derived primary cells, BCL-2 family proteins, Re-sensitization, Recurrent tumors, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1476558621000555; https://doaj.org/toc/1476-5586

Access URL: https://doaj.org/article/f1fc0a072c4b4d0eba59315f15d35947

Corrigendum to 'Inhibition of HDACs reduces Ewing sarcoma tumor growth through EWS-FLI1 protein destabilization' [Neoplasia volume 27 (2022) pp. 100784/Number C]

Authors: Gloria Pedot, Joana Graça Marques, Philip P. Ambühl, Marco Wachtel, Stephanie Kasper, Quy A. Ngo, Felix K. Niggli, Beat W. Schäfer

Source: Neoplasia: An International Journal for Oncology Research, Vol 31, Iss , Pp 100805- (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S147655862200032X; https://doaj.org/toc/1476-5586

Access URL: https://doaj.org/article/2eafa1ce24fd4896a86e7d22a2679327

YAP/TAZ inhibition reduces metastatic potential of Ewing sarcoma cells

Authors: Lisa Bierbaumer, Anna M. Katschnig, Branka Radic-Sarikas, Maximilian O. Kauer, Jeffrey A. Petro, Sandra Högler, Elisabeth Gurnhofer, Gloria Pedot, Beat W. Schäfer, Raphaela Schwentner, Karin Mühlbacher, Florian Kromp, Dave N. T. Aryee, Lukas Kenner, Aykut Uren, Heinrich Kovar

Source: Oncogenesis, Vol 10, Iss 1, Pp 1-13 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2157-9024

Access URL: https://doaj.org/article/89a3d3215d074d5aa6480f4b4cd974c1

Phenotypic profiling with a living biobank of primary rhabdomyosarcoma unravels disease heterogeneity and AKT sensitivity

Authors: Gabriele Manzella, Leonie D. Schreck, Willemijn B. Breunis, Jan Molenaar, Hans Merks, Frederic G. Barr, Wenyue Sun, Michaela Römmele, Luduo Zhang, Joelle Tchinda, Quy A. Ngo, Peter Bode, Olivier Delattre, Didier Surdez, Bharat Rekhi, Felix K. Niggli, Beat W. Schäfer, Marco Wachtel

Source: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/e1a776112ff34407a13275f886ecd3a9

Inhibition of HDACs reduces Ewing sarcoma tumor growth through EWS-FLI1 protein destabilization

Authors: Gloria Pedot, Joana Graça Marques, Philip P. Ambühl, Marco Wachtel, Stephanie Kasper, Quy A. Ngo, Felix K. Niggli, Beat W. Schäfer

Source: Neoplasia: An International Journal for Oncology Research, Vol 27, Iss , Pp 100784- (2022)

Subject Terms: Ewing sarcoma, EWS-FLI1, Protein stability, Fimepinostat, HDACi, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1476558622000136; https://doaj.org/toc/1476-5586

Access URL: https://doaj.org/article/f24c79f3904c4ff989ef5f1f94d4e53d

Fenretinide Acts as Potent Radiosensitizer for Treatment of Rhabdomyosarcoma Cells

Authors: Eva Brack, Sabine Bender, Marco Wachtel, Martin Pruschy, Beat W. Schäfer

Source: Frontiers in Oncology, Vol 11 (2021)

Subject Terms: rhabdomyosarcoma, childhood cancer, fenretinide, radiation therapy, radiosensitizer, reactive oxygen species, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.664462/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/55c2d2e34cfa4e51b78478eba3aba030

Author Correction: CRISPR activation screen identifies TGFβ-associated PEG10 as a crucial tumor suppressor in Ewing sarcoma

Authors: Vadim Saratov, Quy A. Ngo, Gloria Pedot, Semjon Sidorov, Marco Wachtel, Felix K. Niggli, Beat W. Schäfer

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-1 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/e15d247bc5b94603a306e083c69fd581

USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth

Authors: Maria E. Gierisch, Gloria Pedot, Franziska Walser, Laura A. Lopez-Garcia, Patricia Jaaks, Felix K. Niggli, Beat W. Schäfer

Source: Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/a3adb4d3106e433a8db0de295f5c3477

A Perspective on Polo-Like Kinase-1 Inhibition for the Treatment of Rhabdomyosarcomas

Authors: Susanne A. Gatz, Ewa Aladowicz, Michela Casanova, Julia C. Chisholm, Pamela R. Kearns, Simone Fulda, Birgit Geoerger, Beat W. Schäfer, Janet M. Shipley

Source: Frontiers in Oncology, Vol 9 (2019)

Subject Terms: polo-like kinase 1, PLK1 inhibitors, rhabdomyosarcomas, combination treatment, microtubule disruptors, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fonc.2019.01271/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/4fc4f77910684cc7bfb2bc64c293d211