Pharmacokinetic and pharmacodynamic properties of the novel basal insulin Fc (insulin efsitora alfa), an insulin fusion protein in development for once‐weekly dosing for the treatment of patients with diabetes

Authors: Heise, Tim, Chien, Jenny, Beals, John M., Benson, Charles, Klein, Oliver, Moyers, Julie S., Haupt, Axel, Pratt, Edward John

Source: Diabetes, obesity & metabolism. 25(4):1080-1090

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Preclinical Characterization of LY3209590, a Novel Weekly Basal Insulin Fc-Fusion Protein

Authors: Moyers, Julie S. ^*, Hansen, Ryan J., Day, Jonathan W., Dickinson, Craig D., Zhang, Chen, Ruan, Xiaoping, Ding, Liyun, Brown, Robin M., Baker, Hana E., Beals, John M.

Source: In The Journal of Pharmacology and Experimental Therapeutics September 2022 382(3):346-355

Photoacoustic imaging reveals mechanisms of rapid-acting insulin formulations dynamics at the injection site

Authors: Khadria, Anjul, Paavola, Chad D., Maslov, Konstantin, Valenzuela, Francisco A., Sperry, Andrea E., Cox, Amy L., Cao, Rui, Shi, Junhui, Brown-Augsburger, Patricia L., Lozano, Emmanuel, Blankenship, Ross L., Majumdar, Ranajoy, Bradley, Scott A., Beals, John M., Oladipupo, Sunday S., Wang, Lihong V.

Source: In Molecular Metabolism August 2022 62

Comprehensive insulin receptor phosphorylation dynamics profiled by mass spectrometry

Authors: Liao, Zhongping, Zhang, Chen, Ding, Liyun, Moyers, Julie S., Tang, Jason X., Beals, John M.

Source: FEBS journal. 289(9):2657-2671

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100153728995.0x000001&indx=1&recIds=ETOCvdc_100153728995.0x000001

The Basis for Weekly Insulin Therapy: Evolving Evidence With Insulin Icodec and Insulin Efsitora Alfa.

Authors: Rosenstock, Julio, Juneja, Rattan, Beals, John M, Moyers, Julie S, Ilag, Liza, McCrimmon, Rory J

Source: Endocrine Reviews; Jun2024, Vol. 45 Issue 3, p379-413, 35p

Subject Terms: INSULIN therapy, HYPOGLYCEMIA, TREATMENT of diabetes

Long‐Duration and Non‐Invasive Photoacoustic Imaging of Multiple Anatomical Structures in a Live Mouse Using a Single Contrast Agent

Authors: Khadria, Anjul, Paavola, Chad D., Zhang, Yang, Davis, Samuel P. X., Grealish, Patrick F., Maslov, Konstantin, Shi, Junhui, Beals, John M., Oladipupo, Sunday S., Wang, Lihong V.

Source: Advanced science. 9(28)

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In Vivo and In Vitro Characterization of Basal Insulin Peglispro: A Novel Insulin Analog

Authors: Owens, Rebecca A., Hansen, Ryan J., Kahl, Steven D., Zhang, Chen, Ruan, Xiaoping, Koester, Anja, Li, Shun, Qian, Hui-Rong, Farmen, Mark W., Michael, M. Dodson, Moyers, Julie S., Cutler, Gordon B., Jr. ¹, Vick, Andrew ², Beals, John M. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics June 2016 357(3):459-465

Concentrated insulins: History and critical reappraisal.

Authors: Heinemann, Lutz¹, Beals, John M.², Malone, James², Anderson, James², Jacobson, Jennie G.², Corrigan, Sheila M.², Sinha, Vikram³

Source: Journal of Diabetes. Apr2019, Vol. 11 Issue 4, p292-300. 9p.

Subject Terms: *INSULIN

p I-shifted insulin analogs with extended in vivo time action and favorable receptor selectivity

Authors: Kohn, Wayne D., Micanovic, Radmila, Myers, Sharon L., Vick, Andrew M., Kahl, Steven D., Zhang, Lianshan, Strifler, Beth A., Li, Shun, Shang, Jing, Beals, John M., Mayer, John P., DiMarchi, Richard D.

Source: In Peptides 2007 28(4):935-948

Enhancing exposure of protein therapeutics

Authors: Beals, John M., Shanafelt, Armen B.

Source: In Drug Discovery Today: Technologies 2006 3(1):87-94

Crystal structure of the obese protein leptin-E100.

Authors: Zhang, Faming, Basinski, Margret B., Beals, John M.

Source: Nature; May 8 1997, Vol. 387, p206-209, 4p

Conformational studies of a peptide corresponding to a region of the C-terminus of ribonuclease A: implications as a potential chain-folding initiation site.

Authors: Beals, John M., Haas, Elisha, Krausz, Sara

Source: Biochemistry; August 6 1991, Vol. 30, p7680-7692, 13p

The Evolution of Insulin and How it Informs Therapy and Treatment Choices.

Authors: Hirsch, Irl B, Juneja, Rattan, Beals, John M, Antalis, Caryl J, Wright, Eugene E

Source: Endocrine Reviews; Oct2020, Vol. 41 Issue 5, p1-23, 23p

Subject Terms: INSULIN, BLOOD sugar

Rational Design of a Fibroblast Growth Factor 21-Based Clinical Candidate, LY2405319.

Authors: Kharitonenkov, Alexei¹ a.kharch@lilly.com, Beals, John M.¹, Micanovic, Radmila¹, Strifler, Beth A.¹, Rathnachalam, Radhakrishnan¹, Wroblewski, Victor J.¹, Li, Shun¹, Koester, Anja¹, Ford, Amy M.¹, Coskun, Tamer¹, Dunbar, James D.¹, Cheng, Christine C.¹, Frye, Christopher C.¹, Bumol, Thomas F.¹, Moller, David E.¹

Source: PLoS ONE. Mar2013, Vol. 8 Issue 3, p1-10. 10p.

Subject Terms: *FIBROBLAST growth factors, *METABOLIC disorders, *GENE expression, *HORMONE regulation, *CARDIOVASCULAR diseases, *RECOMBINANT proteins, *GLYCOSYLATION, *DRUG synergism

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Photoacoustic imaging of the dynamics of a dye-labeled IgG4 monoclonal antibody in subcutaneous tissue reveals a transient decrease in murine blood oxygenation under anesthesia.

Authors: Khadria, Anjul, Paavola, Chad D., Maslov, Konstantin, Brown-Augsburger, Patricia L., Grealish, Patrick F., Lozano, Emmanuel, Blankenship, Ross L., Cao, Rui, Shi, Junhui, Beals, John M., Oladipupo, Sunday S., Wang, Lihong V.

Source: Journal of Biomedical Optics; Nov2023, Vol. 28 Issue 11, p116002-116002, 1p

Subject Terms: ACOUSTIC imaging, MONOCLONAL antibodies, EXTRACELLULAR fluid, OXYGEN in the blood, OXYGEN saturation, ANESTHESIA

Company/Entity: UNITED States. Food & Drug Administration

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Insulin.

Authors: Beals, John M., DeFelippis, Michael R., Kovach, Paul M., Jackson, Jeffrey A.

Source: Pharmaceutical Biotechnology: Fundamentals & Applications; 2013, p255-275, 21p

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IL-1β Epitope Mapping Using Site-Directed Mutagenesis and Hydrogen-Deuterium Exchange Mass Spectrometry Analysis.

Authors: Jirong Lu, Witcher, Derrick R., White, Melissa A., Xiliang Wang, Huang, Lihua, Rathnachalam, Radhakrishnan, Beals, John M., Kuhstoss, Stuart

Source: Biochemistry; 8/23/2005, Vol. 44 Issue 33, p11106-1114, 9p