Automated Synthesis of New Quinoxalinetacrines

Authors: Bautista‐Aguilera, Óscar M., Ismaili, Lhassane, Chioua, Mourad, Iriepa, Isabel, Ángeles Martinez‐Grau, Marìa, Beadle, Christopher D., Vetman, Tatiana, López‐Muñoz, Francisco, Marco‐Contelles, José

Source: ChemistrySelect. 5(21):6491-6493

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107650211.0x000001&indx=1&recIds=ETOCvdc_100107650211.0x000001

The Chemotype of Chromanones as a Privileged Scaffold for Multineurotarget Anti-Alzheimer Agents.

Authors: Keuler, Tim, Lemke, Carina, Elsinghorst, Paul W., Iriepa, Isabel, Chioua, Mourad, Martínez-Grau, María Angeles, Beadle, Christopher D., Vetman, Tatiana, López-Muñoz, Francisco, Wille, Timo, Bartz, Ulrike, Deuther-Conrad, Winnie, Marco-Contelles, José, Gütschow, Michael

Source: ACS Pharmacology & Translational Science; 11/11/2022, Vol. 5 Issue 11, p1097-1108, 12p

Investigation of a Flexible Enantiospecific Approach to Aziridines.

Authors: Jamookeeah, Clare E., Beadle, Christopher D., Jackson, Richard F. W.

Source: Journal of Organic Chemistry; February 1 2008, Vol. 73 Issue 3, p1128-1130, 3p

Chromenones as Multineurotargeting Inhibitors of Human Enzymes.

Authors: Lemke, Carina, Christmann, Joscha, Jiafei Yin, Alonso, José M., Serrano, Estefanía, Chioua, Mourad, Ismaili, Lhassane, Martínez-Grau, María Angeles, Beadle, Christopher D., Vetman, Tatiana, Dato, Florian M., Bartz, Ulrike, Elsinghorst, Paul W., Pietsch, Markus, Müller, Christa E., Iriepa, Isabel, Wille, Timo, Marco-Contelles, José, Gütschow, Michael

Source: ACS Omega; 12/24/2019, Vol. 4 Issue 26, p22161-22168, 8p

Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor

Authors: Hao, Junliang, Beck, James P., Schaus, John M., Krushinski, Joseph H., Chen, Qi, Beadle, Christopher D., Vidal, Paloma, Reinhard, Matthew R., Dressman, Bruce A., Massey, Steven M., Boulet, Serge L., Cohen, Michael P., Watson, Brian M., Tupper, David, Gardinier, Kevin M., Myers, Jason, Johansson, Anette M., Richardson, Jeffery, Richards, Daniel S., Hembre, Erik J., Remick, David M., Coates, David A., Bhardwaj, Rajni M., Diseroad, Benjamin A., Bender, David, Stephenson, Greg, Wolfangel, Craig D., Diaz, Nuria, Getman, Brian G., Wang, Xu-shan, Heinz, Beverly A., Cramer, Jeff W., Zhou, Xin, Maren, Deanna L., Falcone, Julie F., Wright, Rebecca A., Mitchell, Stephen N., Carter, Guy, Yang, Charles R., Bruns, Robert F., Svensson, Kjell A.

Source: Journal of Medicinal Chemistry; October 2019, Vol. 62 Issue: 19 p8711-8732, 22p

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Synthesis and PharmacologicalCharacterization ofC4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate:Identification of a Potent, Selective Metabotropic Glutamate ReceptorAgonist and Determination of Agonist-Bound Human...

Authors: Monn, James A., Prieto, Lourdes, Taboada, Lorena, Pedregal, Concepcion, Junliang Hao, Reinhard, Matt R., Henry, Steven S., Goldsmith, Paul J., Beadle, Christopher D., Walton, Lesley, Man, Teresa, Rudyk, Helene, Clark, Barry, Tupper, David, Baker, S. Richard, Lamas, Carlos, Montero, Carlos, Marcos, Alicia, Blanco, Jaime, Bures, Mark

Source: Journal of Medicinal Chemistry; Feb2015, Vol. 58 Issue 4, p1776-1794, 19p

1-Aryl-3,4-dihydro-1 H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors

Authors: Beadle, Christopher D., Boot, John, Camp, Nicholas P., Dezutter, Nancy, Findlay, Jeremy, Hayhurst, Lorna, Masters, John J., Penariol, Roberta, Walter, Magnus W.

Source: In Bioorganic & Medicinal Chemistry Letters 2005 15(20):4432-4437

Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer's Disease Therapy.

Authors: Bautista-Aguilera, Óscar M., Ismaili, Lhassane, Chioua, Mourad, Andrys, Rudolf, Schmidt, Monika, Bzonek, Petr, Martínez-Grau, María Ángeles, Beadle, Christopher D., Vetman, Tatiana, López-Muñoz, Francisco, Iriepa, Isabel, Refouvelet, Bernard, Musilek, Kamil, Marco-Contelles, José

Source: International Journal of Molecular Sciences; Jun2020, Vol. 21 Issue 11, p3913-3913, 1p

Subject Terms: ALZHEIMER'S disease, QUINOLONE antibacterial agents, ACETYLCHOLINESTERASE, SMALL molecules

ChemInform Abstract: Investigation of a Flexible Enantiospecific Approach to Aziridines.

Authors: Jamookeeah, Clare E., Beadle, Christopher D., Jackson, Richard F. W., Harrity, Joseph P. A.

Source: ChemInform; May2008, Vol. 39 Issue 22, pno-no, 1p

1-Aryl-3,4-dihydro-1H-quinolin-2-one Derivatives, Novel and Selective Norepinephrine Reuptake Inhibitors.

Authors: Beadle, Christopher D., Boot, John, Camp, Nicholas P., Dezutter, Nancy, Findlay, Jeremy, Hayhurst, Lorna, Masters, John J., Penariol, Roberta, Walter, Magnus W.

Source: ChemInform; Jan2006, Vol. 37 Issue 2, pno-no, 1p