Aptamer sgc8-Modified PAMAM Nanoparticles for Targeted siRNA Delivery to Inhibit BCL11B in T-Cell Acute Lymphoblastic Leukemia

Authors: Zeng X, Nie D, Liu Z, Peng X, Wang X, Qiu K, Zhong S, Liao Z, Zha X, Li Y, Zeng C

Source: International Journal of Nanomedicine, Vol Volume 19, Pp 12297-12309 (2024)

Subject Terms: bcl11b, t-all, aptamer, sgc8, sibcl11b, pamam, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.dovepress.com/aptamer-sgc8-modified-pamam-nanoparticles-for-targeted-sirna-delivery--peer-reviewed-fulltext-article-IJN; https://doaj.org/toc/1178-2013

Access URL: https://doaj.org/article/cac9b44f350c4d5faefb9891e09f723f

T and NK cell functionality in a patient harboring heterozygous novel BCL11B p.Asp632fsAla∗91 and STX11 p.R129P mutations

Authors: Lorenzo Erra, Ana Colado, Franco Gino Brunello, Emma Prieto, Verónica Goris, Mariana Villa, Matías Oleastro, Marcelo Martí, Roberto Gabriel Pozner, Mercedes Borge, María Belén Almejun

Source: Heliyon, Vol 11, Iss 4, Pp e42636- (2025)

Subject Terms: BCL11B, STX11, Autoimmunity, Science (General), Q1-390, Social sciences (General), H1-99

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844025010163; https://doaj.org/toc/2405-8440

Access URL: https://doaj.org/article/50a0c30c7f514175820597f9d3bb0d17

DNA-binding affinity and specificity determine the phenotypic diversity in BCL11B-related disorders

Authors: Lessel, Ivana ^{1, 2, 86}, Baresic, Anja ^{3, 86}, Chinn, Ivan K. ^{4, 5}, May, Jonathan ⁶, Goenka, Anu ^{7, 8}, Chandler, Kate E. ^{7, 8}, Posey, Jennifer E. ⁹, Afenjar, Alexandra ¹⁰, Averdunk, Luisa ^{11, 12}, Bedeschi, Maria Francesca ¹³, Besnard, Thomas ^{14, 15}, Brager, Rae ¹⁶, Brick, Lauren ¹⁷, Brugger, Melanie ^{18, 19}, Brunet, Theresa ¹⁸, Byrne, Susan ²⁰, Calle-Martín, Oscar de la ²¹, Capra, Valeria ²², Cardenas, Paul ²³, Chappé, Céline ²⁴, Chong, Hey J. ²⁵, Cogne, Benjamin ^{14, 15}, Conboy, Erin ²⁶, Cope, Heidi ²⁷, Courtin, Thomas ²⁸, Deb, Wallid ^{14, 15}, Dilena, Robertino ²⁹, Dubourg, Christèle ^{30, 31}, Elgizouli, Magdeldin ³², Fernandes, Erica ³³, Fitzgerald, Kristi K. ³⁴, Gangi, Silvana ³⁵, George-Abraham, Jaya K. ^{36, 37}, Gucsavas-Calikoglu, Muge ³⁸, Haack, Tobias B. ³⁹, Hadonou, Medard ⁴⁰, Hanker, Britta ⁴¹, Hüning, Irina ⁴¹, Iascone, Maria ⁴², Isidor, Bertrand ^{14, 15}, Järvelä, Irma ⁴³, Jin, Jay J. ⁴⁴, Jorge, Alexander A.L. ^{45, 46}, Josifova, Dragana ⁴⁷, Kalinauskiene, Ruta ⁴⁷, Kamsteeg, Erik-Jan ⁴⁸, Keren, Boris ²⁸, Kessler, Elena ⁴⁹, Kölbel, Heike ⁵⁰, Kozenko, Mariya ¹⁷, Kubisch, Christian ¹, Kuechler, Alma ³², Leal, Suzanne M. ^{51, 52}, Leppälä, Juha ⁵³, Luu, Sharon M. ²⁶, Lyon, Gholson J. ^{54, 55, 56}, Madan-Khetarpal, Suneeta ⁵⁷, Mancardi, Margherita ⁵⁸, Marchi, Elaine ⁵⁴, Mehta, Lakshmi ⁵⁹, Menendez, Beatriz ⁶⁰, Morel, Chantal F. ⁶¹, Harasink, Sue Moyer ³³, Nevay, Dayna-Lynn ⁶¹, Nigro, Vincenzo ^{62, 63}, Odent, Sylvie ^{64, 65}, Oegema, Renske ⁶⁶, Pappas, John ⁶⁷, Pastore, Matthew T. ^{68, 69}, Perilla-Young, Yezmin ³⁸, Platzer, Konrad ⁷⁰, Powell-Hamilton, Nina ⁷¹, Rabin, Rachel ⁶⁷, Rekab, Aisha ⁵⁹, Rezende, Raissa C. ⁴⁶, Robert, Leema ⁴⁷, Romano, Ferruccio ²², Scala, Marcello ^{72, 73}, Poths, Karin ³⁹, Schrauwen, Isabelle ⁷⁴, Sebastian, Jessica ⁵⁷, Short, John ⁴⁰, Sidlow, Richard ⁷⁵, Sullivan, Jennifer ²⁷, Szakszon, Katalin ⁷⁶, Tan, Queenie K.G. ²⁷, Wagner, Matias ^{18, 78, 79}, Wieczorek, Dagmar ¹¹, Yuan, Bo ^{9, 80}, Maeding, Nicole ⁸¹, Strunk, Dirk ⁸¹, Begtrup, Amber ⁸², Banka, Siddharth ^{7, 8}, Lupski, James R. ^{4, 9, 80, 83}, Tolosa, Eva ^{6, 84}, Lessel, Davor ^{1, 2, 85, ∗}

Source: In The American Journal of Human Genetics 6 February 2025 112(2):394-413

Targeting BCL11B in CAR-engineered lymphoid progenitors drives NK-like cell development with prolonged anti-leukemic activity

Authors: Baatz, Franziska ¹, Ghosh, Arnab ², Herbst, Jessica ¹, Polten, Saskia ³, Meyer, Johann ⁴, Rhiel, Manuel ⁵, Maetzig, Tobias ⁴, Geffers, Robert ⁶, Rothe, Michael ⁴, Bastone, Antonella Lucia ⁴, John-Neek, Philipp ^{4, 7}, Frühauf, Jörg ⁸, Eiz-Vesper, Britta ⁹, Bonifacius, Agnes ⁹, Falk, Christine S. ¹⁰, Kaisenberg, Constantin v. ¹¹, Cathomen, Toni ^{5, 12, 13}, Schambach, Axel ^{4, 14}, van den Brink, Marcel R.M. ¹⁵, Hust, Michael ³, Sauer, Martin G. ^{1, ∗}

Source: In Molecular Therapy February 2025

Advances in the molecular mechanisms of zinc-finger transcription factors in neurodevelopmental disorders

Authors: Wang, Hailin ^a, Yang, Ying ^{b, c, 1}, Ni, Ziwei ^a, Qiao, Xiaoting ^a, Guo, Yaqian ^a, Wang, Xiaomin ^a, Cao, Duo ^{d, 2}, Wang, Yayun ^{e, 2}, Ruan, Cailian ^{a, f, ⁎}

Source: In IBRO Neuroscience Reports June 2025 18:409-413

Analysis of the Transcriptional Control of Bcl11b in Chicken: IRF1 and GATA1 as Negative Regulators

Authors: Lingling Qiu, Haojie Wang, Wenhao Li, Ting Yang, Hao Bai, Guobin Chang

Source: Animals, Vol 15, Iss 5, p 665 (2025)

Subject Terms: Bcl11b, promoter, transcriptional regulation, ALV-J, chicken, Veterinary medicine, SF600-1100, Zoology, QL1-991

File Description: electronic resource

Relation: https://www.mdpi.com/2076-2615/15/5/665; https://doaj.org/toc/2076-2615

Access URL: https://doaj.org/article/b5f7996ef84a4819b0a5eca909b8065d

BCL11B expression in hepatocellular carcinoma relates to chemosensitivity and clinical prognosis

Authors: Hiroyuki Abe, Kenya Kamimura, Shujiro Okuda, Yu Watanabe, Jun Inoue, Yutaka Aoyagi, Toshifumi Wakai, Ryo Kominami, Shuji Terai

Source: Cancer Medicine, Vol 12, Iss 14, Pp 15650-15663 (2023)

Subject Terms: BCL11B, drug sensitivity, GATA6, hepatocellular carcinoma, prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2045-7634

Access URL: https://doaj.org/article/b28136d80b664370b096168307a180cc

A Bcl11bN797K variant isolated from an immunodeficient patient inhibits early thymocyte development in mice

Authors: Kazuaki Matsumoto, Kazuki Okuyama, Tom Sidwell, Motoi Yamashita, Takaho Endo, Naoko Satoh-Takayama, Hiroshi Ohno, Tomohiro Morio, Ellen V. Rothenberg, Ichiro Taniuchi

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: IEIS, immune deficiency, BCL11B, mis-sense variant, T cell, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1363704/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/83c8db04a2b14d88adbf03ead9999ff0

BCL11B Is Involved in Stress-Induced Differentiation of Keratinocytes and Has A Potential Role in Psoriasis Pathogenesis

Authors: Sara Parsa, Zahra-Soheila Soheili, Hamidreza Alizadeh Otaghvar, Elham Behrangi, Parvin Mansouri, Erik Lubberts, Seyed Javad Mowla

Source: Cell Journal, Vol 25, Iss 5, Pp 300-306 (2023)

Subject Terms: bcl11b, keratinocyte, psoriasis, stress-induced differentiation, transcription factor, Medicine, Science

File Description: electronic resource

Relation: https://www.celljournal.org/article_701676_f2314ccfe063d10b510a9fd703c91e50.pdf; https://doaj.org/toc/2228-5806; https://doaj.org/toc/2228-5814

Access URL: https://doaj.org/article/697450cc49d34a738c2e256dd56af2d6

Advance in the Treatment of Pediatric Leukemia

Contributors: Handgretinger, Rupert

Subject Terms: acute lymphoblastic leukemia, pediatric, advances, diagnosis, treatment, immunotherapy, bispecific T-cell engager (BiTE), BCP-ALL, leukemia, TRAIL, antibody, Fc-engineering, xenograft, CD19, juvenile myelomonocytic leukemia, RAS signaling, hematopoietic stem cell transplantation, 5-azacitidine, myelodysplastic/myeloproliferative disorders, targeted therapy, ADC, antibody–drug conjugate, pediatric leukemia, ALL, AML, allogeneic stem cell transplantation, acute myeloid leukemia, minimal residual disease, conditioning regimen, alternative donors, B-ALL, DUX4, IKZF1, PAX5, Ph-like, ZNF384, NUTM1, T-ALL, NOTCH1, BCL11B, transcriptome, genome, chronic myeloid leukemia, CML, tyrosine kinase inhibitor, immunizations, COVID-19, childhood acute lymphoblastic leukemia, low-risk ALL, risk-stratified treatment, treatment related toxicity, L-asparaginase, acute pancreatitis, polymorphism, SNV, ABCC4, CFTR, other extramedullary relapse, lymphoblastic leukemia, children, prognosis, evolution of CAR T cells, FDA-approved CAR products, TcR versus CAR, limitations and complications of CAR T cell therapy, future directions of CAR T cell therapy, Research and information: general, Chemistry

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/84555
https://mdpi.com/books/pdfview/book/5539

The Role of Bcl11 Transcription Factors in Neurodevelopmental Disorders

Authors: Franziska Anna Seigfried, Stefan Britsch

Source: Biology, Vol 13, Iss 2, p 126 (2024)

Subject Terms: Ctip1, Ctip2, Bcl11a, Bcl11b, brain development, neurodevelopment, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2079-7737/13/2/126; https://doaj.org/toc/2079-7737

Access URL: https://doaj.org/article/fcd58377da3541b1bdf8556cbcd1e270

A novel variant in BCL11B in an individual with neurodevelopmental delay: A case report

Authors: Yonglin Yu, Xiaoyi Jia, Hongwei Yin, Hongfang Jiang, Yu Du, Fan Yang, Zuozhen Yang, Haifeng Li

Source: Molecular Genetics & Genomic Medicine, Vol 11, Iss 4, Pp n/a-n/a (2023)

Subject Terms: BCL11B, cerebral palsy, developmental delay, whole‐exome sequencing, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/2324-9269

Access URL: https://doaj.org/article/172754fe8f2d4d7d9d6ca72f5d166b38

Human induced-T-to-natural killer cells have potent anti-tumour activities

Authors: Zhiwu Jiang, Le Qin, Yuou Tang, Rui Liao, Jingxuan Shi, Bingjia He, Shanglin Li, Diwei Zheng, Yuanbin Cui, Qiting Wu, Youguo Long, Yao Yao, Zhihui Wei, Qilan Hong, Yi Wu, Yuanbang Mai, Shixue Gou, Xiaoping Li, Robert Weinkove, Sam Norton, Wei Luo, Weineng Feng, Hongsheng Zhou, Qifa Liu, Jiekai Chen, Liangxue Lai, Xinwen Chen, Duanqing Pei, Thomas Graf, Xingguo Liu, Yangqiu Li, Pentao Liu, Zhenfeng Zhang, Peng Li

Source: Biomarker Research, Vol 10, Iss 1, Pp 1-22 (2022)

Subject Terms: BCL11B, CRISPR/Cas9, T cells, Immunotherapy, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2050-7771

Access URL: https://doaj.org/article/05d264f1064e4fdda9f2bdf26d6a951c

BCL11B depletion induces the development of highly cytotoxic innate T cells out of IL-15 stimulated peripheral blood αβ CD8+ T cells

Authors: Hannes Forkel, Piotr Grabarczyk, Maren Depke, Sascha Troschke-Meurer, Stefan Simm, Elke Hammer, Stephan Michalik, Christian Hentschker, Björn Corleis, Lucie Loyal, Maxi Zumpe, Nikolai Siebert, Anca Dorhoi, Andreas Thiel, Holger Lode, Uwe Völker, Christian A. Schmidt

Source: OncoImmunology, Vol 11, Iss 1 (2022)

Subject Terms: BCL11B, knock-out, IL-15, innateness, AICC, ADCC, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/38c9a1f16c6741208dbf26b7a38a18f3

Case report: A novel truncating variant of BCL11B associated with rare feature of craniosynostosis and global developmental delay

Authors: Xuemei Zhao, Bingbing Wu, Huiyao Chen, Ping Zhang, Yanyan Qian, Xiaomin Peng, Xinran Dong, Yaqiong Wang, Gang Li, Chenbin Dong, Huijun Wang

Source: Frontiers in Pediatrics, Vol 10 (2022)

Subject Terms: BCL11B, truncating variation, pediatrics, craniosynostosis, developmental delay, Pediatrics, RJ1-570

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fped.2022.982361/full; https://doaj.org/toc/2296-2360

Access URL: https://doaj.org/article/3c6fcf775a444fd8be659cb0ec23b0eb

Using i-GONAD for Cell-Type-Specific and Systematic Analysis of Developmental Transcription Factors In Vivo

Authors: Christoph Wiegreffe, Simon Ehricke, Luisa Schmid, Jacqueline Andratschke, Stefan Britsch

Source: Biology, Vol 12, Iss 9, p 1236 (2023)

Subject Terms: transcription factors, i-GONAD, FLBIO tag, Bcl11a, Bcl11b, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2079-7737/12/9/1236; https://doaj.org/toc/2079-7737

Access URL: https://doaj.org/article/663a0c41ac384e9c88ce5e8e323449ab

Lower BCL11B expression is associated with adverse clinical outcome for patients with myelodysplastic syndrome

Authors: Xin Huang, Cunte Chen, Mengjun Zhong, Suxia Geng, Yujie Zhao, Minming Li, Chenxin Deng, Lingji Zeng, Ping Wu, Zesheng Lu, Jianyu Weng, Xin Du, Yangqiu Li

Source: Biomarker Research, Vol 9, Iss 1, Pp 1-5 (2021)

Subject Terms: BCL11B, prognosis, myelodysplastic syndrome, immune cell, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2050-7771

Access URL: https://doaj.org/article/fe401c4529e047ea846b89e606435bc8

Decreased TCF1 and BCL11B expression predicts poor prognosis for patients with chronic lymphocytic leukemia

Authors: Taotao Liang, Xiaojiao Wang, Yanyan Liu, Hao Ai, Qian Wang, Xianwei Wang, Xudong Wei, Yongping Song, Qingsong Yin

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: chronic lymphocytic leukemia, T cell immune, TCF1, BCL11B, TTFT, prognosis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.985280/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/fe86b95a797a4473ad99334201b4a31d

Identification of two novel variants of the BCL11B gene in two Chinese pedigrees associated with neurodevelopmental disorders

Authors: Fengyu Che, Xiaoling Tie, Hong Lei, Xi Zhang, Mingyue Duan, Liyu Zhang, Ying Yang

Source: Frontiers in Molecular Neuroscience, Vol 15 (2022)

Subject Terms: BCL11B gene, neurodevelopmental disorders (NDD), intellectual disorder, minigene, immunodeficiency, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnmol.2022.927357/full; https://doaj.org/toc/1662-5099

Access URL: https://doaj.org/article/25709b689c8c4dd2a4fba109ae6a5ba4

Case Report and Review of the Literature: Congenital Diaphragmatic Hernia and Craniosynostosis, a Coincidence or Common Cause?

Authors: Linda Gaillard, Anne Goverde, Quincy C. C. van den Bosch, Fernanda S. Jehee, Erwin Brosens, Danielle Veenma, Frank Magielsen, Annelies de Klein, Irene M. J. Mathijssen, Marieke F. van Dooren

Source: Frontiers in Pediatrics, Vol 9 (2021)

Subject Terms: case report, craniosynostosis, congenital diaphragmatic hernia (CDH), BCL11B, craniosynostosis syndromes, Pediatrics, RJ1-570

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fped.2021.772800/full; https://doaj.org/toc/2296-2360

Access URL: https://doaj.org/article/0e39453c73344b71ac8d697ccb435594