Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4

Authors: Myers, Stephanie M., Miller, Duncan C., Molyneux, Lauren, Arasta, Mercedes, Bawn, Ruth H., Blackburn, Timothy J., Cook, Simon J., Edwards, Noel, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Hammonds, Tim, Hardcastle, Ian R., Harnor, Suzannah J., Heptinstall, Amy B., Lochhead, Pamela A., Martin, Mathew P., Martin, Nick C., Newell, David R., Owen, Paul J., Pang, Leon C., Reuillon, Tristan, Rigoreau, Laurent J.M., Thomas, Huw D., Tucker, Julie A., Wang, Lan-Zhen, Wong, Ai-Ching, Noble, Martin E.M., Wedge, Stephen R., Cano, Celine

Source: In European Journal of Medicinal Chemistry 15 September 2019 178:530-543

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Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction

Authors: Chessari, Gianni, Hardcastle, Ian R., Ahn, Jong Sook, Anil, Burcu, Anscombe, Elizabeth, Bawn, Ruth H., Bevan, Luke D., Blackburn, Timothy J., Buck, Ildiko, Cano, Celine, Carbain, Benoit, Castro, Juan, Cons, Ben, Cully, Sarah J., Endicott, Jane A., Fazal, Lynsey, Golding, Bernard T., Griffin, Roger J., Haggerty, Karen, Harnor, Suzannah J., Hearn, Keisha, Hobson, Stephen, Holvey, Rhian S., Howard, Steven, Jennings, Claire E., Johnson, Christopher N., Lunec, John, Miller, Duncan C., Newell, David R., Noble, Martin E. M., Reeks, Judith, Revill, Charlotte H., Riedinger, Christiane, St. Denis, Jeffrey D., Tamanini, Emiliano, Thomas, Huw, Thompson, Neil T., Vinković, Mladen, Wedge, Stephen R., Williams, Pamela A., Wilsher, Nicola E., Zhang, Bian, Zhao, Yan

Source: Journal of Medicinal Chemistry; 20210101, Issue: Preprints

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