Exploring 2‑Sulfonylpyrimidine Warheads as Acrylamide Surrogates for Targeted Covalent Inhibition: A BTK Story.

Authors: Moraru, Ruxandra, Valle-Argos, Beatriz, Minton, Annabel, Buermann, Lara, Pan, Suyin, Wales, Thomas E., Joseph, Raji E., Andreotti, Amy H., Strefford, Jonathan C., Packham, Graham, Baud, Matthias G. J.

Source: Journal of Medicinal Chemistry; 8/22/2024, Vol. 671 Issue 6, p13572-13593, 22p

A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes

Authors: Baud, Matthias G. J., Lin-Shiao, Enrique, Cardote, Teresa, Tallant, Cynthia, Pschibul, Annica, Chan, Kwok-Ho, Zengerle, Michael, Garcia, Jordi R., Kwan, Terence T.-L., Ferguson, Fleur M., Ciulli, Alessio

Source: Science, 2014 Oct . 346(6209), 638-641.

Access URL: https://www.jstor.org/stable/24917539

Harnessing Fluorine—Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs

Authors: Bauer, Matthias R., Jones, Rhiannon N., Baud, Matthias G. J., Wilcken, Rainer, Boeckler, Frank M., Fersht, Alan R., Joerger, Andreas C., Spencer, John

Source: ACS chemical biology. 11(8):2265-2274

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN607734020&indx=1&recIds=ETOCRN607734020

Structure–Reactivity Studies of 2‑Sulfonylpyrimidines Allow Selective Protein Arylation.

Authors: Pichon, Maëva M., Drelinkiewicz, Dawid, Lozano, David, Moraru, Ruxandra, Hayward, Laura J., Jones, Megan, McCoy, Michael A., Allstrum-Graves, Samuel, Balourdas, Dimitrios-Ilias, Joerger, Andreas C., Whitby, Richard J., Goldup, Stephen M., Wells, Neil, Langley, Graham J., Herniman, Julie M., Baud, Matthias G. J.

Source: Bioconjugate Chemistry; 9/20/2023, Vol. 34 Issue 9, p1679-1687, 9p

Discovery of Nanomolar-Affinity Pharmacological Chaperones Stabilizing the Oncogenic p53 Mutant Y220C.

Authors: Stephenson Clarke, Joseph R., Douglas, Leon R., Duriez, Patrick J., Balourdas, Dimitrios-Ilias, Joerger, Andreas C., Khadiullina, Raniya, Bulatov, Emil, Baud, Matthias G. J.

Source: ACS Pharmacology & Translational Science; 11/11/2022, Vol. 5 Issue 11, p1169-1180, 12p

Biophysical Survey of Small-Molecule β‑Catenin Inhibitors: A Cautionary Tale.

Authors: McCoy, Michael A., Spicer, Dominique, Wells, Neil, Hoogewijs, Kurt, Fiedler, Marc, Baud, Matthias G. J.

Source: Journal of Medicinal Chemistry; 5/26/2022, Vol. 65 Issue 10, p7246-7261, 16p

Key Players in the Mutant p53 Team: Small Molecules, Gene Editing, Immunotherapy.

Authors: Chasov, Vitaly, Mirgayazova, Regina, Zmievskaya, Ekaterina, Khadiullina, Raniya, Valiullina, Aygul, Stephenson Clarke, Joseph, Rizvanov, Albert, Baud, Matthias G. J., Bulatov, Emil

Source: Frontiers in Oncology; 8/18/2020, Vol. 10, pN.PAG-N.PAG, 10p

Subject Terms: SMALL molecules, GENOME editing, GENETIC mutation, IMMUNOTHERAPY, GENETIC overexpression, T cell receptors, FORKHEAD transcription factors

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