CRISPR-Based Gene Editing Techniques in Pediatric Neurological Disorders

Authors: Chrzanowski, Stephen, Batra, Ranjan

Source: In Pediatric Neurology April 2024 153:166-174

HNRNPA1-induced spliceopathy in a transgenic mouse model of myotonic dystrophy

Authors: Li, Moyi, Zhuang, Yan, Batra, Ranjan, Thomas, James D., Li, Mao, Nutter, Curtis A., Scotti, Marina M., Carter, Helmut A., Wang, Zhan Jun, Huang, Xu-Sheng, Pu, Chuan Qiang, Swanson, Maurice S., Xie, Wei

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Mar 01. 117(10), 5472-5477.

Access URL: https://www.jstor.org/stable/26929260

Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9

Authors: Batra, Ranjan, Nelles, David A., Pirie, Elaine, Blue, Steven M., Marina, Ryan J., Wang, Harrison, Chaim, Isaac A., Thomas, James D., Zhang, Nigel, Nguyen, Vu, Aigner, Stefan, Markmiller, Sebastian, Xia, Guangbin, Corbett, Kevin D., Swanson, Maurice S., Yeo, Gene W.

Source: In Cell 24 August 2017 170(5):899-912

Transcriptome–pathology correlation identifies interplay between TDP-43 and the expression of its kinase CK1E in sporadic ALS

Authors: Krach, Florian, Batra, Ranjan, Wheeler, Emily C., Vu, Anthony Q., Wang, Ruth, Hutt, Kasey, Rabin, Stuart J., Baughn, Michael W., Libby, Ryan T., Diaz-Garcia, Sandra, Stauffer, Jennifer, Pirie, Elaine, Saberi, Shahram, Rodriguez, Maria, Madrigal, Assael A., Kohl, Zacharias, Winner, Beate, Yeo, Gene W., Ravits, John

Source: Acta neuropathologica. 136(3):405-423

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100141526072.0x000001&indx=1&recIds=ETOCvdc_100141526072.0x000001

Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis

Authors: Pereira, Gavin, Sanchez, Laura, Schaughency, Paul, Rubio-Roldán, Alejandro, Choi, Jungbin, Planet, Evarist, Batra, Ranjan, Turelli, Priscilla, Trono, Didier, Ostrow, Lyle, Ravits, John, Kazazian, Haig, Wheelan, Sarah, Heras, Sara, Mayer, Jens, García-Pérez, Jose, Goodier, John

Source: Mobile DNA. 9(1):1-30

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185354109.0x000001&indx=1&recIds=ETOCvdc_100185354109.0x000001

Transcriptional profiling of HERV-K(HML-2) in amyotrophic lateral sclerosis and potential implications for expression of HML-2 proteins

Authors: Mayer, Jens, Harz, Christian, Sanchez, Laura, Pereira, Gavin, Maldener, Esther, Heras, Sara, Ostrow, Lyle, Ravits, John, Batra, Ranjan, Meese, Eckart, García-Pérez, Jose, Goodier, John

Source: Molecular neurodegeneration. 13(1):1-25

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174807359.0x000001&indx=1&recIds=ETOCvdc_100174807359.0x000001

Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System

Authors: Martinez, Fernando J., Pratt, Gabriel A., Van Nostrand, Eric L., Batra, Ranjan, Huelga, Stephanie C., Kapeli, Katannya, Freese, Peter, Chun, Seung J., Ling, Karen, Gelboin-Burkhart, Chelsea, Fijany, Layla, Wang, Harrison C., Nussbacher, Julia K., Broski, Sara M., Kim, Hong Joo, Lardelli, Rea, Sundararaman, Balaji, Donohue, John P., Javaherian, Ashkan, Lykke-Andersen, Jens, Finkbeiner, Steven, Bennett, C. Frank, Ares, Manuel, Jr., Burge, Christopher B., Taylor, J. Paul, Rigo, Frank, Yeo, Gene W.

Source: In Neuron 23 November 2016 92(4):780-795

Exploring effectiveness in brain removal techniques: A comparison of approaches.

Authors: Robertson, Ellen M., Allison, Sara M., Mueller, Caroline M., Ferriby, Andrew C., Roth, Alex R., Batra, Ranjan

Source: Anatomical Sciences Education; Jan/Feb2024, Vol. 17 Issue 1, p147-156, 10p

MBNL Sequestration by Toxic RNAs and RNA Misprocessing in the Myotonic Dystrophy Brain

Authors: Goodwin, Marianne, Mohan, Apoorva, Batra, Ranjan, Lee, Kuang-Yung, Charizanis, Konstantinos, Gómez, Francisco José Fernández, Eddarkaoui, Sabiha, Sergeant, Nicolas, Buée, Luc, Kimura, Takashi, Clark, H. Brent, Dalton, Joline, Takamura, Kenji, Weyn-Vanhentenryck, Sebastien M., Zhang, Chaolin, Reid, Tammy, Ranum, Laura P.W., Day, John W., Swanson, Maurice S.

Source: In Cell Reports 18 August 2015 12(7):1159-1168

RNA-binding proteins in neurodegeneration: Seq and you shall receive

Authors: Nussbacher, Julia K., Batra, Ranjan, Lagier-Tourenne, Clotilde, Yeo, Gene W.

Source: In Trends in Neurosciences April 2015 38(4):226-236

Global insights into alternative polyadenylation regulation

Authors: Batra, Ranjan, Manchanda, Mini, Swanson, Maurice S

Source: RNA biology. 12(6):597-602

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCETOCvdc_100029010226.0x000001&indx=1&recIds=ETOCETOCvdc_100029010226.0x000001

Loss of MBNL Leads to Disruption of Developmentally Regulated Alternative Polyadenylation in RNA-Mediated Disease

Authors: Batra, Ranjan, Charizanis, Konstantinos, Manchanda, Mini, Mohan, Apoorva, Li, Moyi, Finn, Dustin J., Goodwin, Marianne, Zhang, Chaolin, Sobczak, Krzysztof, Thornton, Charles A., Swanson, Maurice S.

Source: In Molecular Cell 23 October 2014 56(2):311-322

Muscleblind-like 2-Mediated Alternative Splicing in the Developing Brain and Dysregulation in Myotonic Dystrophy

Authors: Charizanis, Konstantinos, Lee, Kuang-Yung, Batra, Ranjan, Goodwin, Marianne, Zhang, Chaolin, Yuan, Yuan, Shiue, Lily, Cline, Melissa, Scotti, Marina M., Xia, Guangbin, Kumar, Ashok, Ashizawa, Tetsuo, Clark, H. Brent, Kimura, Takashi, Takahashi, Masanori P., Fujimura, Harutoshi, Jinnai, Kenji, Yoshikawa, Hiroo, Gomes-Pereira, Mário, Gourdon, Geneviève, Sakai, Noriaki, Nishino, Seiji, Foster, Thomas C., Ares, Manuel, Jr., Darnell, Robert B., Swanson, Maurice S.

Source: In Neuron 9 August 2012 75(3):437-450

Aberrant NOVA1 function disrupts alternative splicing in early stages of amyotrophic lateral sclerosis.

Authors: Krach, Florian, Wheeler, Emily C., Regensburger, Martin, Boerstler, Tom, Wend, Holger, Vu, Anthony Q., Wang, Ruth, Reischl, Stephanie, Boldt, Karsten, Batra, Ranjan, Aigner, Stefan, Ravits, John, Winkler, Juergen, Yeo, Gene W., Winner, Beate

Source: Acta Neuropathologica; Sep2022, Vol. 144 Issue 3, p413-435, 23p

Subject Terms: ALTERNATIVE RNA splicing, AMYOTROPHIC lateral sclerosis, MOTOR neuron diseases, RNA-binding proteins, MOTOR neurons, NUCLEAR proteins, CARRIER proteins, FORENSIC pathology

Efficiency in Brain Removal Techniques: A Potentially Novel Approach

Authors: Robertson, Ellen, Klender, Sara, Mueller, Caroline, Ferriby, Andrew, Roth, Alex, Batra, Ranjan

Source: FASEB journal. 34(S1):1-1

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140416217.0x000001&indx=1&recIds=ETOCvdc_100140416217.0x000001

Efferent control of temporal response properties of the Limulus lateral eye.

Authors: Batra, Ranjan, Barlow, Robert B. Jr

Source: Journal of General Physiology; February 1990, Vol. 95, p229-244, 16p

A neuronal population code for sound localization.

Authors: Fitzpatrick, Douglas C., Batra, Ranjan, Stanford, Terrence R.

Source: Nature; August 28 1997, Vol. 388, p871-874, 4p

Visualization and elimination of toxic microsatellite expansion RNA by RNA-targeting Cas9
Eurkarytic mRNA processing (Meeting)

Authors: Batra, Ranjan, Nelles, David, Pirie, Elaine, Blue, Steven, Marina, Ryan, Wang, Harrison, Chaim, Isaac A., Thomas, James D., Zhang, Nigel, Nguyen, Vu

Source: Abstracts of papers presented at the ... meeting on eukaryotic mRNA processing. 2017:213-213

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCCN603358337&indx=1&recIds=ETOCCN603358337

The sustained expression of Cas9 targeting toxic RNAs reverses disease phenotypes in mouse models of myotonic dystrophy type 1.

Authors: Batra, Ranjan, Nelles, David A., Roth, Daniela M., Krach, Florian, Nutter, Curtis A., Tadokoro, Takahiro, Thomas, James D., Sznajder, Łukasz J., Blue, Steven M., Gutierrez, Haydee L., Liu, Patrick, Aigner, Stefan, Platoshyn, Oleksandr, Miyanohara, Atsushi, Marsala, Martin, Swanson, Maurice S., Yeo, Gene W.

Source: Nature Biomedical Engineering; Feb2021, Vol. 5 Issue 2, p157-168, 12p

HNRNPA1-induced spliceopathy in a transgenic mouse model of myotonic dystrophy.

Authors: Moyi Li, Yan Zhuang, Batra, Ranjan, Thomas, James D., Mao Li, Nutter, Curtis A., Scotti, Marina M., Carter, Helmut A., Zhan Jun Wang, Xu-Sheng Huang, Chuan Qiang Pu, Swanson, Maurice S., Wei Xie

Source: Proceedings of the National Academy of Sciences of the United States of America; 3/10/2020, Vol. 117 Issue 10, p5472-5477, 6p

Subject Terms: MYOTONIA atrophica, RNA-binding proteins, TRANSGENIC mice, MUSCLE weakness, SKELETAL muscle