Differential in vitro cytotoxic effects and metabolomic insights into raw and powdered Manuka honey through UPLC-Q-TOF-MS

Authors: Ienas Idriss, Abdelmoneim H. Ali, Aftab Alam, Maria Fernandez-Cabezudo, Mutamed Ayyash, Basel K. al-Ramadi

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)

Subject Terms: Manuka honey, Cancer, Anti-proliferative effect, Untargeted metabolomics analysis, UPLC-Q-TOF-MS, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/a16e0c4016e34c4ab0e3a7e0f2cd01eb

Azithromycin targets the CD27 pathway to modulate CD27hi T-lymphocyte expansion and type-1 effector phenotype

Authors: Abdul Wahid Ansari, Manju Nidagodu Jayakumar, Fareed Ahmad, Thenmozhi Venkatachalam, Laila Salameh, Hema Unnikannan, Thesni Raheed, Abdul Khader Mohammed, Bassam Mahboub, Basel K. Al-Ramadi, Qutayba Hamid, Martin Steinhoff, Rifat Hamoudi

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: azithromycin, CD27 subset, T-lymphocytes, inflammation, mTOR, type-1 immunity, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1447625/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/3075eeb31b1f45bfb13c54eb0fc50a91

Oral administration of Manuka honey induces IFNγ-dependent resistance to tumor growth that correlates with beneficial modulation of gut microbiota composition

Authors: Razan J. Masad, Ienas Idriss, Yassir A. Mohamed, Ashraf Al-Sbiei, Ghada Bashir, Farah Al-Marzooq, Abeer Altahrawi, Maria J. Fernandez-Cabezudo, Basel K. Al-Ramadi

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: Manuka honey, immunomodulation, type I/II IFN, tumor immunogenicity, colorectal cancer, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1354297/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/70abba4129c04861ae48f149d9676062

Attenuated Salmonella potentiate PD-L1 blockade immunotherapy in a preclinical model of colorectal cancer

Authors: Besan H. Al-Saafeen, Ashraf Al-Sbiei, Ghada Bashir, Yassir A. Mohamed, Razan J. Masad, Maria J. Fernandez-Cabezudo, Basel K. al-Ramadi

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: immune checkpoints inhibitors, PD-L1 blockade, Salmonella typhimurium, immunotherapy, colorectal cancer, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1017780/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/9b47a32fe691425dacb91ccb88ab3977

Characterization of immunomodulatory responses induced by manuka honey

Authors: Razan J. Masad, Rasha A. Nasser, Ghada Bashir, Yassir A. Mohamed, Ashraf Al-Sbiei, Besan H. Al-Saafeen, Maria J. Fernandez-Cabezudo, Basel K. Al-Ramadi

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: manuka honey, TNF-α, inflammatory response, immunomodulation, neutrophil recruitment, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1020574/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/7adf4d7b31744f818bf1e73334f45020

Cis-Nerolidol Inhibits MAP Kinase and NF-κB Signaling Pathways and Prevents Epithelial Tight Junction Dysfunction in Colon Inflammation: In Vivo and In Vitro Studies

Authors: Vishnu Raj, Balaji Venkataraman, Shreesh K. Ojha, Saeeda Almarzooqi, Veedamali S. Subramanian, Basel K. Al-Ramadi, Thomas E. Adrian, Sandeep B. Subramanya

Source: Molecules, Vol 28, Iss 7, p 2982 (2023)

Subject Terms: nerolidol, RAW macrophages, MAPK, DSS colitis, Caco-2 cells, epithelial tight junction, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/7/2982; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/887408d85cb742c9bbc8e453d3dfb411

Editorial: Immunotherapy as an Evolving Approach for the Treatment of Breast Cancer

Authors: Mai F. Tolba, Cesar A. Santa-Maria, Adriana Albini, Emile R. Chimusa, Basel K. Al-Ramadi, Sara M. Tolaney

Source: Frontiers in Oncology, Vol 11 (2021)

Subject Terms: immunotherapy, breast cancer, immune checkpoint inhibitors, combination therapy, biomarker, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.752689/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/c941230005bc480e9524d9065aec0e9e

CD40L modulates transcriptional signatures of neutrophils in the bone marrow associated with development and trafficking

Authors: Tábata Takahashi França, Ashraf Al-Sbiei, Ghada Bashir, Yassir Awad Mohamed, Ranieri Coelho Salgado, Lucila Akune Barreiros, Sarah Maria da Silva Napoleão, Cristina Worm Weber, Janaíra Fernandes Severo Ferreira, Carolina Sanchez Aranda, Carolina Prando, Mayra B. de Barros Dorna, Igor Jurisica, Maria J. Fernandez-Cabezudo, Hans D. Ochs, Antonio Condino-Neto, Basel K. Al-Ramadi, Otavio Cabral-Marques

Source: JCI Insight, Vol 6, Iss 16 (2021)

Subject Terms: Cell biology, Immunology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/5b858107b6654fd692dc899757f40937

GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis

Authors: Otavio Cabral-Marques, Alexandre Marques, Lasse Melvær Giil, Roberta De Vito, Judith Rademacher, Jeannine Günther, Tanja Lange, Jens Y. Humrich, Sebastian Klapa, Susanne Schinke, Lena F. Schimke, Gabriele Marschner, Silke Pitann, Sabine Adler, Ralf Dechend, Dominik N. Müller, Ioana Braicu, Jalid Sehouli, Kai Schulze-Forster, Tobias Trippel, Carmen Scheibenbogen, Annetine Staff, Peter R. Mertens, Madlen Löbel, Justin Mastroianni, Corinna Plattfaut, Frank Gieseler, Duska Dragun, Barbara Elizabeth Engelhardt, Maria J. Fernandez-Cabezudo, Hans D. Ochs, Basel K. al-Ramadi, Peter Lamprecht, Antje Mueller, Harald Heidecke, Gabriela Riemekasten

Source: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ce22418439234ad18d21d372dba2db52

Flow Cytometry Contributions for the Diagnosis and Immunopathological Characterization of Primary Immunodeficiency Diseases With Immune Dysregulation

Authors: Otavio Cabral-Marques, Lena F. Schimke, Edgar Borges de Oliveira, Nadia El Khawanky, Rodrigo Nalio Ramos, Basel K. Al-Ramadi, Gesmar Rodrigues Silva Segundo, Hans D. Ochs, Antonio Condino-Neto

Source: Frontiers in Immunology, Vol 10 (2019)

Subject Terms: flow cytometry, diagnosis, primary immunodeficiency diseases, immune dysregulation, mutation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.02742/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/b5010d21dfc445b48f6e067a3f4cf41c

Involvement of Acetylcholine Receptors in Cholinergic Pathway-Mediated Protection Against Autoimmune Diabetes

Authors: Maria J. Fernández-Cabezudo, Junu A. George, Ghada Bashir, Yassir A. Mohamed, Alreem Al-Mansori, Mohammed M. Qureshi, Dietrich E. Lorke, Georg Petroianu, Basel K. al-Ramadi

Source: Frontiers in Immunology, Vol 10 (2019)

Subject Terms: cholinergic stimulation, acetylcholine, muscarinic AChR, neuroimmunology, type I diabetes, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.01038/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/db802fd2f0254f34bf82fe943fd121f1

Induction of Hypergammaglobulinemia and Autoantibodies by Salmonella Infection in MyD88-Deficient Mice

Authors: Jincy M. Issac, Yassir A. Mohamed, Ghada Hassan Bashir, Ashraf Al-Sbiei, Walter Conca, Taj A. Khan, Asif Iqbal, Gabriela Riemekasten, Katja Bieber, Ralf J. Ludwig, Otavio Cabral-Marques, Maria J. Fernandez-Cabezudo, Basel K. al-Ramadi

Source: Frontiers in Immunology, Vol 9 (2018)

Subject Terms: MyD88 deficiency, autoantibodies, Salmonella typhiumrium, hypergammaglobulinemia, Tfh cells, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2018.01384/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/05e01f401beb45a08dc00dc9a4be7957

Attenuated Bacteria as Immunotherapeutic Tools for Cancer Treatment

Authors: Suneesh Kaimala, Ashraf Al-Sbiei, Otavio Cabral-Marques, Maria J. Fernandez-Cabezudo, Basel K. Al-Ramadi

Source: Frontiers in Oncology, Vol 8 (2018)

Subject Terms: bacterial therapy, attenuated Salmonella, cancer immunotherapy, tumor microenvironment, tumor-infiltrating leukocytes, myeloid-derived suppressor cells, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fonc.2018.00136/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/c739b3f39a4f4849b61afe79d99c0196

Cholinergic Activation Enhances Resistance to Oral Salmonella Infection by Modulating Innate Immune Defense Mechanisms at the Intestinal Barrier

Authors: Ray M. Al-Barazie, Ghada Hassan Bashir, Mohammed M. Qureshi, Yassir A. Mohamed, Ashraf Al-Sbiei, Saeed Tariq, Wim J. Lammers, Basel K. al-Ramadi, Maria J. Fernandez-Cabezudo

Source: Frontiers in Immunology, Vol 9 (2018)

Subject Terms: acetylcholine, cholinergic pathway, Salmonella infection, mucosal innate immunity, antimicrobial peptides, Paneth cells, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fimmu.2018.00551/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/cd0757e3fd294102a0191fadd781b229

The IL-6/STAT3 Signaling Pathway Is an Early Target of Manuka Honey-Induced Suppression of Human Breast Cancer Cells

Authors: Priyanka Aryappalli, Sarah S. Al-Qubaisi, Samir Attoub, Junu A. George, Kholoud Arafat, Khalil B. Ramadi, Yassir A. Mohamed, Mezoon M. Al-Dhaheri, Ashraf Al-Sbiei, Maria J. Fernandez-Cabezudo, Basel K. al-Ramadi

Source: Frontiers in Oncology, Vol 7 (2017)

Subject Terms: triple-negative breast cancer, manuka honey, STAT3, interleukin-6, apoptosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fonc.2017.00167/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/72c6dcf56e5d4972a48eba2af1b82a8b

Evidence for a dual pathway of activation in CD43-stimulated Th2 cells: differential requirement for the Lck tyrosine kinase.

Authors: Maria J. Fernandez-Cabezudo, Camasamudram Vijayasarathy, David L. Pflugh, Alfred L. M. Bothwell, Basel K. al-Ramadi

Source: International Immunology; Aug2004, Vol. 16 Issue 8, p1215-1223, 9p

Correction: Farnesyl pyrophosphate is a new danger signal inducing acute cell death.

Authors: Jing Chen, Xiaochen Zhang, Liping Li, Xianqiang Ma, Chunxiao Yang, Zhaodi Liu, Chenyang Li, Maria J Fernandez-Cabezudo, Basel K Al-Ramadi, Chuan Wu, Weishan Huang, Yong Zhang, Yonghui Zhang, Wanli Liu

Source: PLoS Biology, Vol 21, Iss 11, p e3002414 (2023)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002414&type=printable; https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

Access URL: https://doaj.org/article/137d914d59f14229a65f5892f54b5dfd

Farnesyl pyrophosphate is a new danger signal inducing acute cell death.

Authors: Jing Chen, Xiaochen Zhang, Liping Li, Xianqiang Ma, Chunxiao Yang, Zhaodi Liu, Chenyang Li, Maria J Fernandez-Cabezudo, Basel K Al-Ramadi, Chuan Wu, Weishan Huang, Yong Zhang, Yonghui Zhang, Wanli Liu

Source: PLoS Biology, Vol 19, Iss 4, p e3001134 (2021)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

Access URL: https://doaj.org/article/1e904fc8be45454ab6c7f4bf67617384

Cholinergic stimulation prevents the development of autoimmune diabetes: Evidence for the modulation of Th17 effector cells via an IFNgamma-dependent mechanism

Authors: Junu George, Ghada Bashir, Mohammed M Qureshi, Yassir A Mohamed, Jamil Roumanos Azzi, Basel K al-Ramadi, Maria J Fernandez-Cabezudo

Source: Frontiers in Immunology, Vol 7 (2016)

Subject Terms: Acetylcholine, Th17, IFNg, type I diabetes, Anti-inflammatory pathway, Inhibition of AChE, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00419/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/dd3ed4718ba843c49431a71798eb565b

Intravenous administration of manuka honey inhibits tumor growth and improves host survival when used in combination with chemotherapy in a melanoma mouse model.

Authors: Maria J Fernandez-Cabezudo, Rkia El-Kharrag, Fawaz Torab, Ghada Bashir, Junu A George, Hakam El-Taji, Basel K al-Ramadi

Source: PLoS ONE, Vol 8, Iss 2, p e55993 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3567021?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/78b2ca50a36c420a9b5342167bb42388