Super‐killer CTLs are generated by single gene deletion of Bach2

Authors: Barton, Philippa R., Davenport, Alexander J., Hukelmann, Jens, Cantrell, Doreen A., Stinchcombe, Jane C., Richard, Arianne C., Griffiths, Gillian M

Source: European journal of immunology. 52(11):1776-1788

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100163912752.0x000001&indx=1&recIds=ETOCvdc_100163912752.0x000001

High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation

Authors: Abeler-Dörner, Lucie, Laing, Adam G., Lorenc, Anna, Ushakov, Dmitry S., Clare, Simon, Speak, Anneliese O., Duque-Correa, Maria A., White, Jacqueline K., Ramirez-Solis, Ramiro, Saran, Namita, Bull, Katherine R., Morón, Belén, Iwasaki, Jua, Barton, Philippa R., Caetano, Susana, Hng, Keng I., Cambridge, Emma, Forman, Simon, Crockford, Tanya L., Griffiths, Mark, Kane, Leanne, Harcourt, Katherine, Brandt, Cordelia, Notley, George, Babalola, Kolawole O., Warren, Jonathan, Mason, Jeremy C., Meeniga, Amrutha, Karp, Natasha A., Melvin, David, Cawthorne, Eleanor, Weinrick, Brian, Rahim, Albina, Drissler, Sibyl, Meskas, Justin, Yue, Alice, Lux, Markus, Song-Zhao, George X., Chan, Anna, Ballesteros Reviriego, Carmen, Abeler, Johannes, Wilson, Heather, Przemska-Kosicka, Agnieszka, Edmans, Matthew, Strevens, Natasha, Pasztorek, Markus, Meehan, Terrence F., Powrie, Fiona, Brinkman, Ryan, Dougan, Gordon, Jacobs, William, Lloyd, Clare M., Cornall, Richard J., Maloy, Kevin J., Grencis, Richard K., Griffiths, Gillian M., Adams, David J., Hayday, Adrian C.

Source: Nature immunology. 21(1):86-100

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193494124.0x000001&indx=1&recIds=ETOCvdc_100193494124.0x000001

The receptor protein tyrosine phosphatase PTPRK promotes intestinal repair and catalysis-independent tumour suppression.

Authors: Young, Katherine A., Wojdyla, Katarzyna, Lai, Tiffany, Mulholland, Katie E., Casanova, Silvia Aldaz, Antrobus, Robin, Andrews, Simon R., Biggins, Laura, Mahler-Araujo, Betania, Barton, Philippa R., Anderson, Keith R., Fearnley, Gareth W., Sharpe, Hayley J.

Source: Journal of Cell Science; 7/15/2024, Vol. 137 Issue 14, p1-19, 19p

Subject Terms: PROTEIN-tyrosine phosphatase, EPITHELIAL-mesenchymal transition, PHOSPHOPROTEIN phosphatases, CANCER cell migration, REGULATION of growth

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Mitochondrial translation is required for sustained killing by cytotoxic T cells.

Authors: Lisci, Miriam, Barton, Philippa R., Randzavola, Lyra O., Ma, Claire Y., Marchingo, Julia M., Cantrell, Doreen A., Paupe, Vincent, Prudent, Julien, Stinchcombe, Jane C., Griffiths, Gillian M. gg305@cam.ac.uk

Source: Science. 10/15/2021, Vol. 374 Issue 6565, p299-299. 1p. 1 Diagram.

Subject Terms: *CYTOTOXIC T cells, *IMMUNE system, *PERFORINS, *GRANZYMES, *GLYCOLYSIS