Polθ Inhibitor (ART558) Demonstrates a Synthetic Lethal Effect with PARP and RAD52 Inhibitors in Glioblastoma Cells.

Authors: Barszczewska-Pietraszek, Gabriela¹ (AUTHOR) gabriela.barszczewska.pietraszek@edu.uni.lodz.pl, Czarny, Piotr² (AUTHOR), Drzewiecka, Małgorzata¹ (AUTHOR), Błaszczyk, Maciej³ (AUTHOR), Radek, Maciej³ (AUTHOR), Synowiec, Ewelina¹ (AUTHOR), Wigner-Jeziorska, Paulina¹ (AUTHOR), Sitarek, Przemysław⁴ (AUTHOR), Szemraj, Janusz² (AUTHOR), Skorski, Tomasz⁵ (AUTHOR), Śliwiński, Tomasz¹ (AUTHOR) tomasz.sliwinski@biol.uni.lodz.pl

Source: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 17, p9134. 17p.

Subject Terms: *DNA damage, *DNA polymerases, *CELL cycle, *GENE expression, *CELL analysis, *POLY ADP ribose

Class I HDAC Inhibition Leads to a Downregulation of FANCD2 and RAD51, and the Eradication of Glioblastoma Cells.

Authors: Drzewiecka, Małgorzata, Jaśniak, Dominika, Barszczewska-Pietraszek, Gabriela, Czarny, Piotr, Kobrzycka, Anna, Wieczorek, Marek, Radek, Maciej, Szemraj, Janusz, Skorski, Tomasz, Śliwiński, Tomasz

Source: Journal of Personalized Medicine; Sep2023, Vol. 13 Issue 9, p1315, 14p

Subject Terms: METHYLGUANINE, ALKYLATING agents, GLIOBLASTOMA multiforme, VALPROIC acid, DNA repair, DOWNREGULATION

Histone Deacetylases (HDAC) Inhibitor—Valproic Acid Sensitizes Human Melanoma Cells to Dacarbazine and PARP Inhibitor.

Authors: Drzewiecka, Małgorzata, Gajos-Michniewicz, Anna, Hoser, Grażyna, Jaśniak, Dominika, Barszczewska-Pietraszek, Gabriela, Sitarek, Przemysław, Czarny, Piotr, Piekarski, Janusz, Radek, Maciej, Czyż, Małgorzata, Skorski, Tomasz, Śliwiński, Tomasz

Source: Genes; Jun2023, Vol. 14 Issue 6, p1295, 12p

Subject Terms: DACARBAZINE, VALPROIC acid, DOUBLE-strand DNA breaks, MICROPHTHALMIA-associated transcription factor, DEACETYLASES, ALKYLATING agents, HISTONE deacetylase inhibitors

Polθ Inhibition: An Anticancer Therapy for HR-Deficient Tumours.

Authors: Barszczewska-Pietraszek, Gabriela¹ (AUTHOR), Drzewiecka, Małgorzata¹ (AUTHOR), Czarny, Piotr² (AUTHOR), Skorski, Tomasz³ (AUTHOR), Śliwiński, Tomasz¹ (AUTHOR) tomasz.sliwinski@biol.uni.lodz.pl

Source: International Journal of Molecular Sciences. Jan2023, Vol. 24 Issue 1, p319. 16p.

Subject Terms: *DOUBLE-strand DNA breaks, *DNA repair, *SMALL molecules, *DNA ligases, *DNA polymerases

Synthetic Lethality Targeting Polθ.

Authors: Drzewiecka, Małgorzata¹ (AUTHOR) mal.drzewiecka@gmail.com, Barszczewska-Pietraszek, Gabriela¹ (AUTHOR) gabriela.barszczewska.pietraszek@edu.uni.lodz.pl, Czarny, Piotr² (AUTHOR) piotr.czarny@umed.lodz.pl, Skorski, Tomasz³ (AUTHOR) tskorski@temple.edu, Śliwiński, Tomasz¹ (AUTHOR) tskorski@temple.edu

Source: Genes. Jun2022, Vol. 13 Issue 6, p1101-1101. 16p.

Subject Terms: *DOUBLE-strand DNA breaks, *DNA polymerases, *TREATMENT effectiveness, *TUMOR treatment, *DNA repair, *PATIENT safety, *DNA mismatch repair