Intricate interplay of CRISPR-Cas systems, anti-CRISPR proteins, and antimicrobial resistance genes in a globally successful multi-drug resistant Klebsiella pneumoniae clone

Authors: Jianping Jiang, Astrid V. Cienfuegos-Gallet, Tengfei Long, Gisele Peirano, Tingyu Chu, Johann D. D. Pitout, Barry N. Kreiswirth, Liang Chen

Source: Genome Medicine, Vol 17, Iss 1, Pp 1-21 (2025)

Subject Terms: Klebsiella pneumoniae, CG147, CRISPR-Cas, Anti-CRISPR, Genomic epidemiology, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/c23296d21a2547699ac696de8be40bbe

Use of epigenetically modified bacteriophage and dual beta-lactams to treat a Mycobacterium abscessus sternal wound infection

Authors: Madison Cristinziano, Elena Shashkina, Liang Chen, Jaime Xiao, Melissa B. Miller, Christina Doligalski, Raymond Coakley, Leonard Jason Lobo, Brent Footer, Luther Bartelt, Lawrence Abad, Daniel A. Russell, Rebecca Garlena, Michael J. Lauer, Maggie Viland, Ari Kaganovsky, Emily Mowry, Deborah Jacobs-Sera, David van Duin, Barry N. Kreiswirth, Graham F. Hatfull, Anne Friedland

Source: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/6fa1002d493542e3abaa7dee551e3d04

Correction: Intricate interplay of CRISPR-Cas systems, anti-CRISPR proteins, and antimicrobial resistance genes in a globally successful multi-drug resistant Klebsiella pneumoniae clone

Authors: Jianping Jiang, Astrid V Cienfuegos-Gallet, Tengfei Long, Gisele Peirano, Tingyu Chu, Johann D. D. Pitout, Barry N. Kreiswirth, Liang Chen

Source: Genome Medicine, Vol 17, Iss 1, Pp 1-1 (2025)

Subject Terms: Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/8140ab588a39482b92fcc58b6ceb7dbf

Insights into the molecular basis of reduced vancomycin susceptibility among three prominent Staphylococcus aureus clonal complexes

Authors: Natalia Malachowa, Daniel E. Sturdevant, Adeline R. Porter, Grant Martin, Craig Martens, Vinod Nair, Bryan Hansen, Stacy Ricklefs, Stephen G. Jenkins, Liang Chen, Barry N. Kreiswirth, Frank R. DeLeo

Source: Microbiology Spectrum, Vol 12, Iss 8 (2024)

Subject Terms: MRSA, VRSA, VISA, antibiotic resistance, transcriptome, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/8cbaf093e0154a78bdd7d09c1332d7ee

Klebsiella pneumoniae clinical isolates with features of both multidrug-resistance and hypervirulence have unexpectedly low virulence

Authors: Travis J. Kochan, Sophia H. Nozick, Aliki Valdes, Sumitra D. Mitra, Bettina H. Cheung, Marine Lebrun-Corbin, Rachel L. Medernach, Madeleine B. Vessely, Jori O. Mills, Christopher M. R. Axline, Julia A. Nelson, Ethan M. VanGosen, Timothy J. Ward, Egon A. Ozer, David van Duin, Liang Chen, Barry N. Kreiswirth, S. Wesley Long, James M. Musser, Zackery P. Bulman, Richard G. Wunderink, Alan R. Hauser

Source: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/28f7799f087c454c9e785b199d23c81d

Differential mucosal tropism and dissemination of classical and hypervirulent Klebsiella pneumoniae infection

Authors: Teck-Hui Teo, Nurul N. Ayuni, Michelle Yin, Jun Hao Liew, Jason Q. Chen, Natalia Kurepina, Ravisankar Rajarethinam, Barry N. Kreiswirth, Liang Chen, Pablo Bifani

Source: iScience, Vol 27, Iss 2, Pp 108875- (2024)

Subject Terms: Medical microbiology, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004224000968; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/b9f9486cddbb4a01860c5cd5a53c92f6

CRISPR-Cas9-mediated IncF plasmid curing in extraintestinal pathogenic Escherichia coli

Authors: Liang Chen, Gisele Peirano, Kelly Yen, Bingjie Wang, Austin Terlecky, Rebekah DeVinney, Barry N. Kreiswirth, Johann D. D. Pitout

Source: Microbiology Spectrum, Vol 12, Iss 1 (2024)

Subject Terms: extraintestinal pathogenic Escherichia coli, plasmid, CRISPR, pCasCure, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/9a1a24ed801d4298aa6fafe427db4ba0

Interaction of multidrug-resistant hypervirulent Klebsiella pneumoniae with components of human innate host defense

Authors: Frank R. DeLeo, Adeline R. Porter, Scott D. Kobayashi, Brett Freedman, Mingju Hao, Jianping Jiang, Yi-Tsung Lin, Barry N. Kreiswirth, Liang Chen

Source: mBio, Vol 14, Iss 5 (2023)

Subject Terms: Klebsiella, hypervirulence, innate host defense, antibiotic resistance, multidrug resistance, neutrophils, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/0c5715eb42e348358c2c4a49984d9718

Genomic Epidemiology of Global Carbapenemase-Producing Escherichia coli, 2015–2017

Authors: Gisele Peirano, Liang Chen, Diego Nobrega, Thomas J. Finn, Barry N. Kreiswirth, Rebekah DeVinney, Johann D.D. Pitout

Source: Emerging Infectious Diseases, Vol 28, Iss 5, Pp 924-931 (2022)

Subject Terms: E. coli, surveillance, carbapenemases, molecular epidemiology, whole-genome sequencing, Escherichia coli, Medicine, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://wwwnc.cdc.gov/eid/article/28/5/21-2535_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059

Access URL: https://doaj.org/article/c1eb3df6e1b047f2b5061b42c7ecce75

Ceftazidime-avibactam based combinations against carbapenemase producing Klebsiella pneumoniae harboring hypervirulence plasmids

Authors: Zackery P. Bulman, Xing Tan, Ting-Yu Chu, Yanqin Huang, Amisha P. Rana, Nidhi Singh, Stephanie A. Flowers, Yasuhiro Kyono, Barry N. Kreiswirth, Liang Chen

Source: Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 3946-3954 (2022)

Subject Terms: Carbapenem-resistant, Klebsiella pneumoniae, Hypervirulent, Transcriptomic, Antibiotic tolerance, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2001037022002975; https://doaj.org/toc/2001-0370

Access URL: https://doaj.org/article/dd27c42644c74bf7ae1ab07415bac37e

Exploiting a conjugative endogenous CRISPR-Cas3 system to tackle multidrug-resistant Klebsiella pneumoniaeResearch in context

Authors: Ying Zhou, Yang Yang, Xiaobin Li, Dongxing Tian, Wenxiu Ai, Weiwen Wang, Bingjie Wang, Barry N. Kreiswirth, Fangyou Yu, Liang Chen, Xiaofei Jiang

Source: EBioMedicine, Vol 88, Iss , Pp 104445- (2023)

Subject Terms: IncFII plasmid, CRISPR-Cas system, K. pneumoniae, Antimicrobial resistance, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396423000105; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/b95d2e32fef84662b423b5295efd554d

Pre-epidemic evolution of the MRSA USA300 clade and a molecular key for classification

Authors: Colleen M. Bianco, Ahmed M. Moustafa, Kelsey O’Brien, Michael A. Martin, Timothy D. Read, Barry N. Kreiswirth, Paul J. Planet

Source: Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)

Subject Terms: USA300, SNPs, phylogenetic, epidemics, molecular key, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2023.1081070/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/b9402ef493aa45ddbfba5c1cf45b759b

Within-Host Genotypic and Phenotypic Diversity of Contemporaneous Carbapenem-Resistant Klebsiella pneumoniae from Blood Cultures of Patients with Bacteremia

Authors: Shaoji Cheng, Giuseppe Fleres, Liang Chen, Guojun Liu, Binghua Hao, Anthony Newbrough, Eileen Driscoll, Ryan K. Shields, Kevin M. Squires, Ting-yu Chu, Barry N. Kreiswirth, M. Hong Nguyen, Cornelius J. Clancy

Source: mBio, Vol 13, Iss 6 (2022)

Subject Terms: Klebsiella pneumoniae, sequence type 258, carbapenem resistance, within-host diversity, bloodstream infection, blood culture, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/8bba3d1e7b134705bbfe1806872b7622

Subinhibitory Concentrations of Antibiotics Alter the Response of Klebsiella pneumoniae to Components of Innate Host Defense

Authors: Clement Opoku-Temeng, Brett Freedman, Adeline R. Porter, Scott D. Kobayashi, Liang Chen, Barry N. Kreiswirth, Frank R. DeLeo

Source: Microbiology Spectrum, Vol 10, Iss 6 (2022)

Subject Terms: Klebsiella, antibiotic resistance, capsular polysaccharide, serum resistance, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/e6821ac3fdb142899e410a6c0850d165

Genomic Epidemiology and Serology Associated with a SARS-CoV-2 R.1 Variant Outbreak in New Jersey

Authors: Barun Mathema, Liang Chen, Pengfei Wang, Marcus H. Cunningham, Jose R. Mediavilla, Kar Fai Chow, Yang Luo, Yanan Zhao, Kaelea Composto, Jerry Zuckerman, Michael C. Zody, Nancy Wilson, Annie Lee, Dayna M. Oschwald, Lihong Liu, Sho Iketani, Soren Germer, Samantha Fennessey, Maple Wang, Yael Kramer, Patricia Toole, Tom Maniatis, David D. Ho, David S. Perlin, Barry N. Kreiswirth

Source: mBio, Vol 13, Iss 5 (2022)

Subject Terms: SARS-CoV-2, variants of concern, spike protein, vaccine, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/3a7ee6d3a8124173bbb10105a3c49990

Genetic composition and evolution of the prevalent Mycobacterium tuberculosis lineages 2 and 4 in the Chinese and Zhejiang Province populations

Authors: Beibei Wu, Wenlong Zhu, Yue Wang, Qi Wang, Lin Zhou, Zhengwei Liu, Lijun Bi, Mathema Barun, Barry N. Kreiswirth, Liang Chen, Songhua Chen, Xiaomeng Wang, Weibing Wang

Source: Cell & Bioscience, Vol 11, Iss 1, Pp 1-15 (2021)

Subject Terms: Mycobacterium tuberculosis, Whole-genome sequencing, Phylogenetic analysis, Bayesian evolutionary analysis, Transmission, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/2045-3701

Access URL: https://doaj.org/article/1ab4eee6e0774baf826d34dd8bc4e050

Molecular and Clinical Epidemiology of SARS-CoV-2 Infection among Vaccinated and Unvaccinated Individuals in a Large Healthcare Organization from New Jersey

Authors: José R. Mediavilla, Tara Lozy, Annie Lee, Justine Kim, Veronica W. Kan, Elizabeth Titova, Ashish Amin, Michael C. Zody, André Corvelo, Dayna M. Oschwald, Amy Baldwin, Samantha Fennessey, Jerry M. Zuckerman, Thomas Kirn, Liang Chen, Yanan Zhao, Kar Fai Chow, Tom Maniatis, David S. Perlin, Barry N. Kreiswirth

Source: Viruses, Vol 15, Iss 8, p 1699 (2023)

Subject Terms: SARS-CoV-2, COVID-19, pandemic, variants, RT-PCR, sequencing, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/15/8/1699; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/5345b6fc7daf45348ca77a969c9d9ca6

A novel diagnostic test to screen SARS-CoV-2 variants containing E484K and N501Y mutations

Authors: Yanan Zhao, Annie Lee, Kaelea Composto, Marcus H. Cunningham, Jose R. Mediavilla, Samantha Fennessey, André Corvelo, Kar Fai Chow, Michael Zody, Liang Chen, Barry N. Kreiswirth, David S. Perlin

Source: Emerging Microbes and Infections, Vol 10, Iss 1, Pp 994-997 (2021)

Subject Terms: SARS-CoV-2, variants, E484K, N501Y, screening, molecular assay, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/f856030969c94e6fac0bae8acb464770

Genetic diversity and characteristics of high-level tigecycline resistance Tet(X) in Acinetobacter species

Authors: Chong Chen, Chao-Yue Cui, Jun-Jun Yu, Qian He, Xiao-Ting Wu, Yu-Zhang He, Ze-Hua Cui, Cang Li, Qiu-Lin Jia, Xiang-Guang Shen, Ruan-Yang Sun, Xi-Ran Wang, Min-Ge Wang, Tian Tang, Yan Zhang, Xiao-Ping Liao, Barry N. Kreiswirth, Shi-Dan Zhou, Bin Huang, Hong Du, Jian Sun, Liang Chen, Ya-Hong Liu

Source: Genome Medicine, Vol 12, Iss 1, Pp 1-13 (2020)

Subject Terms: tet(X), bla NDM-1, Tigecycline resistance, ISCR2, Acinetobacter species, Flavobacteriaceae bacteria, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/3f4569410a96470a80daeb2dc6a8cd85

Accessory Genomes Drive Independent Spread of Carbapenem-Resistant Klebsiella pneumoniae Clonal Groups 258 and 307 in Houston, TX

Authors: William C. Shropshire, An Q. Dinh, Michelle Earley, Lauren Komarow, Diana Panesso, Kirsten Rydell, Sara I. Gómez-Villegas, Hongyu Miao, Carol Hill, Liang Chen, Robin Patel, Bettina C. Fries, Lilian Abbo, Eric Cober, Sara Revolinski, Courtney L. Luterbach, Henry Chambers, Vance G. Fowler, Robert A. Bonomo, Samuel A. Shelburne, Barry N. Kreiswirth, David van Duin, Blake M. Hanson, Cesar A. Arias

Source: mBio, Vol 13, Iss 2 (2022)

Subject Terms: CG258, CG307, carbapenem-resistant Klebsiella pneumoniae, divergent evolution, genomic surveillance, mobile genetic elements, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/e43cc0d1ce2e4e04b01dd6cff6b21d51