NOD2 protects against allergic lung inflammation in obese female mice

Authors: Rodrigues e-Lacerda, Rodrigo ^{1, 2}, Barra, Nicole G. ¹, Fang, Han ¹, Anhê, Gabriel Forato ², Schertzer, Jonathan D. ^{1, 3, ∗}

Source: In iScience 15 November 2024 27(11)

Microbiota protect against frailty and loss of skeletal muscle, and maintain inflammatory tone during aging in mice.

Authors: Conn, Meghan O., DeJong, Erica N., Marko, Daniel M., Fayyazi, Russta, Zada, Dana Kukje, Foley, Kevin P., Barra, Nicole G., Bowdish, Dawn M. E., Schertzer, Jonathan D.

Source: American Journal of Physiology: Cell Physiology; Mar2025, Vol. 328 Issue 3, pC887-C894, 8p

Postbiotic Impact on Host Metabolism and Immunity Provides Therapeutic Potential in Metabolic Disease.

Authors: Fang, Han, e-Lacerda, Rodrigo Rodrigues, Barra, Nicole G, Zada, Dana Kukje, Robin, Nazli, Mehra, Alina, Schertzer, Jonathan D

Source: Endocrine Reviews; Feb2025, Vol. 46 Issue 1, p60-79, 20p

Subject Terms: BACTERIAL cell walls, METABOLIC regulation, SHORT-chain fatty acids, METABOLIC disorders, BACTERIAL metabolites

Gut microbiota-based vaccination engages innate immunity to improve blood glucose control in obese mice

Authors: Duggan, Brittany M., Tamrakar, Akhilesh K., Barra, Nicole G., Anhê, Fernando F., Paniccia, Gabriella, Wallace, Jessica G., Stacey, Hannah D., Surette, Michael G., Miller, Matthew S., Sloboda, Deborah M., Schertzer, Jonathan D.

Source: In Molecular Metabolism January 2022 55

Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota

Authors: Ahmed, Basma A., Ong, Frank J., Barra, Nicole G., Blondin, Denis P., Gunn, Elizabeth, Oreskovich, Stephan M., Szamosi, Jake C., Syed, Saad A., Hutchings, Emily K., Konyer, Norman B., Singh, Nina P., Yabut, Julian M., Desjardins, Eric M., Anhê, Fernando F., Foley, Kevin P., Holloway, Alison C., Noseworthy, Michael D., Haman, Francois, Carpentier, Andre C., Surette, Michael G., Schertzer, Jonathan D., Punthakee, Zubin, Steinberg, Gregory R., Morrison, Katherine M.

Source: In Cell Reports Medicine 21 September 2021 2(9)

Metabolic endotoxemia is dictated by the type of lipopolysaccharide

Authors: Anhê, Fernando F., Barra, Nicole G., Cavallari, Joseph F., Henriksbo, Brandyn D., Schertzer, Jonathan D.

Source: In Cell Reports 14 September 2021 36(11)

Inflammation promotes adipocyte lipolysis via IRE1 kinase

Authors: Foley, Kevin P., Chen, Yong, Barra, Nicole G., Heal, Mark, Kwok, Kieran, Tamrakar, Akhilesh K., Chi, Wendy, Duggan, Brittany M., Henriksbo, Brandyn D., Liu, Yong, Schertzer, Jonathan D.

Source: In Journal of Biological Chemistry January-June 2021 296

Gut microbiota impairs insulin clearance in obese mice

Authors: Foley, Kevin P., Zlitni, Soumaya, Duggan, Brittany M., Barra, Nicole G., Anhê, Fernando F., Cavallari, Joseph F., Henriksbo, Brandyn D., Chen, Cassandra Y., Huang, Michael, Lau, Trevor C., Plante, Roxanne, Schwab, Michael, Marette, André, Schertzer, Jonathan D.

Source: In Molecular Metabolism December 2020 42

Bruton's tyrosine kinase (BTK) inhibitors alter blood glucose and insulin in obese mice but reduce inflammation independent of BTK.

Authors: Chan, Darryl Y.¹ (AUTHOR), Barra, Nicole G.^1,2,3 (AUTHOR), Fang, Han^1,2,3 (AUTHOR), e-Lacerda, Rodrigo Rodrigues^1,2,3 (AUTHOR), Schertzer, Jonathan D.^1,2,3 (AUTHOR) schertze@mcmaster.ca

Source: American Journal of Physiology: Endocrinology & Metabolism. Sep2024, Vol. 327 Issue 3, pE271-E278. 8p.

Subject Terms: *BRUTON tyrosine kinase, *PYRIN (Protein), *PROTEIN-tyrosine kinase inhibitors, *BLOOD sugar, *METABOLIC regulation, *INSULIN

Wearable Aptalyzer Integrates Microneedle and Electrochemical Sensing for In Vivo Monitoring of Glucose and Lactate in Live Animals.

Authors: Bakhshandeh, Fatemeh, Zheng, Hanjia, Barra, Nicole G., Sadeghzadeh, Sadegh, Ausri, Irfani, Sen, Payel, Keyvani, Fatemeh, Rahman, Fasih, Quadrilatero, Joe, Liu, Juewen, Schertzer, Jonathan D., Soleymani, Leyla, Poudineh, Mahla

Source: Advanced Materials; 8/28/2024, Vol. 36 Issue 35, p1-14, 14p

Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity

Authors: Yao, Yushi, Jeyanathan, Mangalakumari, Haddadi, Siamak, Barra, Nicole G., Vaseghi-Shanjani, Maryam, Damjanovic, Daniela, Lai, Rocky, Afkhami, Sam, Chen, Yonghong, Dvorkin-Gheva, Anna, Robbins, Clinton S., Schertzer, Jonathan D., Xing, Zhou

Source: In Cell 29 November 2018 175(6):1634-1650

Life‐long exercise training and inherited aerobic endurance capacity produce converging gut microbiome signatures in rodents

Authors: Anhê, Fernando F., Zlitni, Soumaya, Barra, Nicole G., Foley, Kevin P., Nilsson, Mats I., Nederveen, Joshua P., Koch, Lauren G., Britton, Steven L., Tarnopolsky, Mark A., Schertzer, Jonathan D.

Source: Physiological reports. 10(5)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100163880967.0x000001&indx=1&recIds=ETOCvdc_100163880967.0x000001

Immunometabolism of T cells and NK cells: metabolic control of effector and regulatory function

Authors: Poznanski, Sophie M., Barra, Nicole G., Ashkar, Ali A., Schertzer, Jonathan D.

Source: Inflammation research. 67(10):813-828

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125186112.0x000001&indx=1&recIds=ETOCvdc_100125186112.0x000001

Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection

Authors: Lee, Amanda J., Chen, Branson, Chew, Marianne V., Barra, Nicole G., Shenouda, Mira M., Nham, Tina, van Rooijen, Nico, Jordana, Manel, Mossman, Karen L., Schreiber, Robert D.

Source: Journal of experimental medicine. 214(4):1153-1168

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN610653647&indx=1&recIds=ETOCRN610653647

Defective NOD2 peptidoglycan sensing promotes diet‐induced inflammation, dysbiosis, and insulin resistance

Authors: Denou, Emmanuel, Lolmède, Karine, Garidou, Lucile, Pomie, Celine, Chabo, Chantal, Lau, Trevor C, Fullerton, Morgan D, Nigro, Giulia, Zakaroff‐Girard, Alexia, Luche, Elodie, Garret, Céline, Serino, Matteo, Amar, Jacques, Courtney, Michael, Cavallari, Joseph F, Henriksbo, Brandyn D, Barra, Nicole G, Foley, Kevin P, McPhee, Joseph B, Duggan, Brittany M, O'Neill, Hayley M, Lee, Amanda J, Sansonetti, Philippe, Ashkar, Ali A, Khan, Waliul I, Surette, Michael G, Bouloumié, Anne, Steinberg, Gregory R, Burcelin, Rémy, Schertzer, Jonathan D

Source: EMBO molecular medicine. 7(3):259-274

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186098692.0x000001&indx=1&recIds=ETOCvdc_100186098692.0x000001

Critical Role of Natural Killer Cells in Lung Immunopathology During Influenza Infection in Mice

Authors: Abdul-Careem, Mohamed F., Mian, M. Firoz, Yue, Geoffry, Gillgrass, Amy, Chenoweth, Meghan J., Barra, Nicole G., Chew, Marianne V., Chan, Tiffany, Al-Garawi, Amal A., Jordana, Manel, Ashkar, Ali A.

Source: The Journal of Infectious Diseases, 2012 Jul . 206(2), 167-177.

Access URL: http://dx.doi.org/10.1093/infdis/jis340

FimH, a TLR4 ligand, induces innate antiviral responses in the lung leading to protection against lethal influenza infection in mice

Authors: Abdul-Careem, Mohamed F., Firoz Mian, M., Gillgrass, Amy E., Chenoweth, Meghan J., Barra, Nicole G., Chan, Tiffany, Al-Garawi, Amal A., Chew, Marianne V., Yue, Geoffry, Roojen, Nico van, Xing, Zhou, Ashkar, Ali A.

Source: In Antiviral Research 2011 92(2):346-355

Innate and adaptive immunity against herpes simplex virus type 2 in the genital mucosa

Authors: Chan, Tiffany, Barra, Nicole G., Lee, Amanda J., Ashkar, Ali A.

Source: In Journal of Reproductive Immunology 2011 88(2):210-218

Is it safe to use smoking cessation therapeutics during pregnancy?

Authors: De Long, Nicole E, Barra, Nicole G, Hardy, Daniel B, Holloway, Alison C

Source: Expert opinion on drug safety. 13(12):1721-1731

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103349535.0x000001&indx=1&recIds=ETOCvdc_100103349535.0x000001

Human gut microbiota after bariatric surgery alters intestinal morphology and glucose absorption in mice independently of obesity.

Authors: Anhê, Fernando F., Zlitni, Soumaya, Song-Yang Zhang, Choi, Béatrice So-Yun, Chen, Cassandra Y., Foley, Kevin P., Barra, Nicole G., Surette, Michael G., Biertho, Laurent, Richard, Denis, Tchernof, André, Lam, Tony K. T., Marette, Andre, Schertzer, Jonathan

Source: Gut; Mar2023, Vol. 72 Issue 3, p460-471, 12p

Subject Terms: GASTRIC bypass, FECAL microbiota transplantation, GUT microbiome, BARIATRIC surgery, HUMAN microbiota, WEIGHT loss, GLUCOSE