Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins

Authors: Shirasaki, Ryosuke, Matthews, Geoffrey M., Gandolfi, Sara, de Matos Simoes, Ricardo, Buckley, Dennis L., Raja Vora, Joseline, Sievers, Quinlan L., Brüggenthies, Johanna B., Dashevsky, Olga, Poarch, Haley, Tang, Huihui, Bariteau, Megan A., Sheffer, Michal, Hu, Yiguo, Downey-Kopyscinski, Sondra L., Hengeveld, Paul J., Glassner, Brian J., Dhimolea, Eugen, Ott, Christopher J., Zhang, Tinghu, Kwiatkowski, Nicholas P., Laubach, Jacob P., Schlossman, Robert L., Richardson, Paul G., Culhane, Aedin C., Groen, Richard W.J., Fischer, Eric S., Vazquez, Francisca, Tsherniak, Aviad, Hahn, William C., Levy, Joan, Auclair, Daniel, Licht, Jonathan D., Keats, Jonathan J., Boise, Lawrence H., Ebert, Benjamin L., Bradner, James E., Gray, Nathanael S., Mitsiades, Constantine S.

Source: In Cell Reports 5 January 2021 34(1)

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Use of Olfactory Receptor Genes As Controls for Genome-Scale CRISPR Functional Genomic Studies to Define Treatment Resistance Mechanisms

Authors: Dashevsky, Olga ^*, De Matos Simoes, Ricardo ^*, Shirasaki, Ryosuke ^*, Sheffer, Michal ^*, Dhimolea, Eugen ^*, Gandolfi, Sara ^*, Tang, Huihui ^*, Downey-Kopyscinski, Sondra L. ^*, Bariteau, Megan ^*, Sorrell, Jeffrey ^*, Glassner, Brian ^*, Doench, John ^*, Boise, Larry H., Licht, Jonathan D., Culhane, Aedin ^*, Hahn, William C. ^*, Vazquez, Francisca ^*, Tsherniak, Aviad ^*, Mitsiades, Constantine S.

Source: In Blood 5 November 2020 136 Supplement 1:36-36

Interactions with a “Humanized” Mesenchymal Bone Marrow Stromal Niche In Vivo Modify the Patterns of Essential Genes for Myeloma Cells: Therapeutic Implications

Authors: Shirasaki, Ryosuke ^*, Downey-Kopyscinski, Sondra L. ^*, De Matos Simoes, Ricardo ^*, Dashevsky, Olga ^*, Gandolfi, Sara ^*, Bariteau, Megan ^*, Tsherniak, Aviad ^*, Vazquez, Francisca ^*, Themeli, Maria ^*, Licht, Jonathan D., Boise, Larry H., Groen, Richard W.J., Mitsiades, Constantine S.

Source: In Blood 5 November 2020 136 Supplement 1:40-40

POU2AF1 As a Master Regulator of Oncogenic Transcription Factor Networks in Myeloma

Authors: De Matos Simoes, Ricardo ^*, Shirasaki, Ryosuke ^*, Tang, Huihui ^*, Yamano, Shizuka ^*, Barwick, Benjamin G, Gandolfi, Sara ^*, Dhimolea, Eugen ^*, Downey-Kopyscinski, Sondra L. ^*, Dashevsky, Olga ^*, Glassner, Brian ^*, Sheffer, Michal ^*, Kansara, Dhvanir ^*, Bariteau, Megan ^*, Sorrell, Jeffrey ^*, Gupta, Vikas ^*, Culhane, Aedin ^*, Tsherniak, Aviad ^*, Vazquez, Francisca ^*, Boise, Larry H., Licht, Jonathan D., Mitsiades, Constantine S.

Source: In Blood 5 November 2020 136 Supplement 1:18-19

Systematic Characterization of Genes Representing Preferential Molecular Vulnerabilities for Myeloma Cells Compared to Other Neoplasias - Implications for the Biology and Therapeutic Targeting of Myeloma

Authors: De Matos Simoes, Ricardo ^*, Shirasaki, Ryosuke ^*, Downey-Kopyscinski, Sondra L. ^*, Matthews, Geoffrey ^*, Yiguo, Hu ^*, Sheffer, Michal ^*, Dhimolea, Eugen ^*, Dashevsky, Olga ^*, Gandolfi, Sara ^*, Dempster, Joshua ^*, Meyers, Robin M. ^*, Bryan, Jordan ^*, McFarland, James M. ^*, Brueggenthies, Johanna ^*, Tang, Huihui ^*, Bariteau, Megan ^*, Borah, Minasri ^*, Sievers, Quinlan L ^*, Ebert, Benjamin, Glassner, Brian ^*, Ott, Christopher J., Kwiatkowski, Nicholas P ^*, Doench, John G ^*, Auclair, Daniel ^*, Levy, Joan ^*, Boise, Lawrence H., Keats, Jonathan J, Licht, Jonathan D., Groen, Richard ^*, Gray, Nathanael ^*, Culhane, Aedin ^*, Hahn, William C. ^*, Vazquez, Francisca ^*, Tsherniak, Aviad ^*, Mitsiades, Constantine S.

Source: In Blood 13 November 2019 134 Supplement 1:4407-4407

Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins

Authors: Shirasaki, Ryosuke ^*, Gandolfi, Sara ^*, De Matos Simoes, Ricardo ^*, Matthews, Geoffrey M ^*, Buckley, Dennis ^*, Raja, Joseline ^*, Sievers, Quinlan L ^*, Dashevsky, Olga ^*, Poarch, Haley ^*, Tang, Huihui ^*, Bariteau, Megan ^*, Sheffer, Michal ^*, Downey-Kopyscinski, Sondra L. ^*, Hengeveld, Paul, Glassner, Brian ^*, Dhimolea, Eugen ^*, Ott, Christopher J., Zhang, Tinghu ^*, Kwiatkowski, Nicholas P ^*, Laubach, Jacob P., Schlossman, Robert L., Richardson, Paul G., Culhane, Aedin ^*, Groen, Richard W.J., Fischer, Eric ^*, Ebert, Benjamin L., Vazquez, Francisca ^*, Tsherniak, Aviad ^*, Hahn, William C. ^*, Levy, Joan ^*, Auclair, Daniel ^*, Licht, Jonathan D., Keats, Jonathan J, Boise, Lawrence H., Bradner, James, Gray, Nathanael ^*, Mitsiades, Constantine S.

Source: In Blood 13 November 2019 134 Supplement 1:318-318

Functional Interactions between Transcription Factors Involved in Myeloma Pathogenesis - Biological and Therapeutic Implications

Authors: Downey-Kopyscinski, Sondra L. ^*, De Matos Simoes, Ricardo ^*, Shirasaki, Ryosuke ^*, Tang, Huihui ^*, Glassner, Brian ^*, Dashevsky, Olga ^*, Borah, Minasri ^*, Bariteau, Megan ^*, Groen, Richard ^*, Doench, John G ^*, Mitsiades, Constantine S.

Source: In Blood 13 November 2019 134 Supplement 1:315-315

Functional Characterization of Genes Driving Enhanced Biological Aggressiveness of Myeloma Cells: Identification of Novel and Understudied “Drivers” of Myeloma

Authors: Tang, Huihui ^*, Shirasaki, Ryosuke ^*, De Matos Simoes, Ricardo ^*, Gandolfi, Sara ^*, Dashevsky, Olga ^*, Downey-Kopyscinski, Sondra L. ^*, Glassner, Brian ^*, Sheffer, Michal ^*, Bariteau, Megan ^*, Doench, John G ^*, Mitsiades, Constantine S.

Source: In Blood 13 November 2019 134 Supplement 1:313-313

Pharmacological Perturbation of the Immunoproteasome in Hematologic Neoplasias: Therapeutic Implications

Authors: Downey-Kopyscinski, Sondra L. ^*, De Matos Simoes, Ricardo ^*, Bariteau, Megan ^*, Borah, Minasri L. ^*, Bender, Sam ^*, Foneska, Janaka ^*, Roth, Jennifer ^*, Groen, Richard ^*, Walter, Gina ^*, Friese-Hamim, Manja ^*, Goodstal, Samantha M., Sanderson, Michael ^*, Mitsiades, Constantine S.

Source: In Blood 13 November 2019 134 Supplement 1:1291-1291

Molecular markers of myeloma cell sensitivity vs. resistance to heterobifunctional degraders of oncoproteins: therapeutic implications.

Authors: Shirasaki, Ryosuke, de Matos Simoes, Ricardo, Gandolfi, Sara, Matthews, Geoffrey, Buckley, Dennis, Raja, Joseline, Sievers, Quinlan, Bruggenthies, Johanna, Dashevsky, Olga, Poarch, Haley, Tang, Huihui, Bariteau, Megan, Sheffer, Michal, Hu, Yiguo, Downey-Kopyscinski, Sondra, Hengeveld, Paul, Glassner, Brian J., Dhimolea, Eugen, Ott, Christopher, Zhang, Tinghu, Kwiatkowski, Nicholas, Laubach, Jacob, Schlossman, Robert, Culhane, Aedin, Richardson, Paul G., Groen, Richard, Fischer, Eric, Vazquez, Francisca, Tsherniak, Aviad, Hahn, William, Levy, Joan, Auclair, Daniel, Licht, Jonathan, Keats, Jonathan, Boise, Lawrence, Ebert, Benjamin, Bradner, James, Gray, Nathanael, Mitsiades, Constantine

Source: In Clinical Lymphoma, Myeloma and Leukemia October 2019 19(10) Supplement:e134-e134

CRISPR-based functional genomics landscape of genes recurrently mutated in MM

Authors: de Matos Simoes, Ricardo, Shirasaki, Ryosuke, Tang, Huihui, Sheffer, Michal, Dashevsky, Olga, Downey-Kopyscinski, Sondra, Dhimolea, Eugen, Bariteau, Megan, Licht, Jonathan, Glassner, Brian J., Levy, Joan, Auclair, Daniel, Vazquez, Francisca, Tsherniak, Aviad, Hahn, William, Culhane, Aedin, Mitsiades, Constantine

Source: In Clinical Lymphoma, Myeloma and Leukemia October 2019 19(10) Supplement:e77-e78

Gain-of-function studies with CRISPR-based transcriptional activation at endogenous genomic loci reveals genes with critical roles for myeloma cells

Authors: Tang, Huihui, Shirasaki, Ryosuke, Gandolfi, Sara, de Matos Simoes, Ricardo, Dashevsky, Olga, Glassner, Brian J., Downey-Kopyscinski, Sondra, Sheffer, Michal, Bariteau, Megan, Doench, John, Mitsiades, Constantine

Source: In Clinical Lymphoma, Myeloma and Leukemia October 2019 19(10) Supplement:e49-e49

CRISPR studies identify genes preferentially essential for myeloma cells vs. other neoplasias: implications for future therapies selective against MM

Authors: Shirasaki, Ryosuke, de Matos Simoes, Ricardo, Downey-Kopyscinski, Sondra, Matthews, Geoffrey, Hu, Yiguo, Sheffer, Michal, Dhimolea, Eugen, Dashevsky, Olga, Gandolfi, Sara, Hengeveld, Paul, Dempster, Joshua, Meyers, Robin, Bryan, Jordan, Dharia, Neekesh, McFarland, James, Sarkar, Subhashis, Bruggenthies, Johanna, Tang, Huihui, Bariteau, Megan, Aguirre, Andrew, Borah, Minasri, Sievers, Quinlan, Ebert, Benjamin, Raja, Joseline, Glassner, Brian J., Ott, Christopher, Bradner, James, Kwiatkowski, Nicholas, Auclair, Daniel, Levy, Joan, Poarch, Haley, Zhang, Tinghu, Laubach, Jacob, Buckley, Dennis, Schlossman, Robert, Groen, Richard, Fischer, Eric, Richardson, Paul G., Keats, Jonathan, Boise, Lawrence, Licht, Jonathan, Culhane, Aedin, Gray, Nathanael, Hahn, William, Vazquez, Francisca, Tsherniak, Aviad, Mitsiades, Constantine

Source: In Clinical Lymphoma, Myeloma and Leukemia October 2019 19(10) Supplement:e48-e49

Combinatorial CRISPR-knockout identifies interactions between key genes and regulatory pathways in myeloma

Authors: Downey-Kopyscinski, Sondra, de Matos Simoes, Ricardo, Shirasaki, Ryosuke, Dashevsky, Olga, Gandolfi, Sara, Glassner, Brian J., Bariteau, Megan, Borah, Minasri, Groen, Richard, Doench, John, Mitsiades, Constantine

Source: In Clinical Lymphoma, Myeloma and Leukemia October 2019 19(10) Supplement:e14-e15

CRISPR Activation Screen for HDAC Inhibitor Resistance

Authors: Tang, Huihui ^*, De Matos Simoes, Ricardo ^*, Shirasaki, Ryosuke ^*, Dashevsky, Olga ^*, Glassner, Brian ^*, Downey-Kopyscinski, Sondra L. ^*, Gandolfi, Sara ^*, Sheffer, Michal ^*, Bariteau, Megan ^*, Doench, John G ^*, Mitsiades, Constantine S.

Source: In Blood 29 November 2018 132 Supplement 1:3958-3958

CRISPR Activation Screen for Drivers of MM Cell Proliferation

Authors: Tang, Huihui ^*, De Matos Simoes, Ricardo ^*, Shirasaki, Ryosuke ^*, Dashevsky, Olga ^*, Glassner, Brian ^*, Downey-Kopyscinski, Sondra L. ^*, Gandolfi, Sara ^*, Sheffer, Michal ^*, Bariteau, Megan ^*, Doench, John G ^*, Mitsiades, Constantine S.

Source: In Blood 29 November 2018 132 Supplement 1:3197-3197

Functional Genomic Landscape of Genes with Recurrent Mutations in Multiple Myeloma

Authors: De Matos Simoes, Ricardo ^*, Shirasaki, Ryosuke ^*, Tang, Huihui ^*, Sheffer, Michal ^*, Dashevsky, Olga ^*, Gandolfi, Sara ^*, Dhimolea, Eugen ^*, Bariteau, Megan ^*, Licht, Jonathan D., Glassner, Brian ^*, Groen, Richard WJ, Levy, Joan ^*, Auclair, Daniel ^*, Vazquez, Francisca ^*, Tsherniak, Aviad ^*, Hahn, William C. ^*, Culhane, Aedin ^*, Mitsiades, Constantine S.

Source: In Blood 29 November 2018 132 Supplement 1:189-189

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