DrugMap: A quantitative pan-cancer analysis of cysteine ligandability

Authors: Takahashi, Mariko, Chong, Harrison B., Zhang, Siwen, Yang, Tzu-Yi, Lazarov, Matthew J., Harry, Stefan, Maynard, Michelle, Hilbert, Brendan, White, Ryan D., Murrey, Heather E., Tsou, Chih-Chiang, Vordermark, Kira, Assaad, Jonathan, Gohar, Magdy, Dürr, Benedikt R., Richter, Marianne, Patel, Himani, Kryukov, Gregory, Brooijmans, Natasja, Alghali, Aliyu Sidi Omar, Rubio, Karla, Villanueva, Antonio, Zhang, Junbing, Ge, Maolin, Makram, Farah, Griesshaber, Hanna, Harrison, Drew, Koglin, Ann-Sophie, Ojeda, Samuel, Karakyriakou, Barbara, Healy, Alexander, Popoola, George, Rachmin, Inbal, Khandelwal, Neha, Neil, Jason R., Tien, Pei-Chieh, Chen, Nicholas, Hosp, Tobias, van den Ouweland, Sanne, Hara, Toshiro, Bussema, Lillian, Dong, Rui, Shi, Lei, Rasmussen, Martin Q., Domingues, Ana Carolina, Lawless, Aleigha, Fang, Jacy, Yoda, Satoshi, Nguyen, Linh Phuong, Reeves, Sarah Marie, Wakefield, Farrah Nicole, Acker, Adam, Clark, Sarah Elizabeth, Dubash, Taronish, Kastanos, John, Oh, Eugene, Fisher, David E., Maheswaran, Shyamala, Haber, Daniel A., Boland, Genevieve M., Sade-Feldman, Moshe, Jenkins, Russell W., Hata, Aaron N., Bardeesy, Nabeel M., Suvà, Mario L., Martin, Brent R., Liau, Brian B., Ott, Christopher J., Rivera, Miguel N., Lawrence, Michael S., Bar-Peled, Liron

Source: In Cell 9 May 2024 187(10):2536-2556

Chemical proteomics to study metabolism, a reductionist approach applied at the systems level

Authors: Ali, Md Yousuf, Bar-Peled, Liron

Source: In Cell Chemical Biology 21 March 2024 31(3):446-451

Reductive stress in cancer: coming out of the shadows

Authors: Ge, Maolin, Papagiannakopoulos, Thales, Bar-Peled, Liron

Source: In Trends in Cancer February 2024 10(2):103-112

Chemical biology approaches to uncovering nuclear ROS control

Authors: Zhang, Junbing, Bar-Peled, Liron

Source: In Current Opinion in Chemical Biology October 2023 76

Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway

Authors: Zhang, Junbing, Simpson, Claire M., Berner, Jacqueline, Chong, Harrison B., Fang, Jiafeng, Ordulu, Zehra, Weiss-Sadan, Tommy, Possemato, Anthony P., Harry, Stefan, Takahashi, Mariko, Yang, Tzu-yi, Richter, Marianne, Patel, Himani, Smith, Abby E., Carlin, Alexander D., Hubertus de Groot, Adriaan F., Wolf, Konstantin, Shi, Lei, Wei, Ting-Yu, Dürr, Benedikt R., Chen, Nicholas J., Vornbäumen, Tristan, Wichmann, Nina O., Mahamdeh, Mohammed S., Pooladanda, Venkatesh, Matoba, Yusuke, Kumar, Shaan, Kim, Eugene, Bouberhan, Sara, Oliva, Esther, Rueda, Bo R., Soberman, Roy J., Bardeesy, Nabeel, Liau, Brian B., Lawrence, Michael, Stokes, Matt P., Beausoleil, Sean A., Bar-Peled, Liron

Source: In Cell 25 May 2023 186(11):2361-2379

NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer

Authors: Weiss-Sadan, Tommy, Ge, Maolin, Hayashi, Makiko, Gohar, Magdy, Yao, Cong-Hui, de Groot, Adriaan, Harry, Stefan, Carlin, Alexander, Fischer, Hannah, Shi, Lei, Wei, Ting-Yu, Adelmann, Charles H., Wolf, Konstantin, Vornbäumen, Tristan, Dürr, Benedikt R., Takahashi, Mariko, Richter, Marianne, Zhang, Junbing, Yang, Tzu-Yi, Vijay, Vindhya, Fisher, David E., Hata, Aaron N., Haigis, Marcia C., Mostoslavsky, Raul, Bardeesy, Nabeel, Papagiannakopoulos, Thales, Bar-Peled, Liron

Source: In Cell Metabolism 7 March 2023 35(3):487-503

UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors

Authors: Yeo, Megan J. R., Zhang, Olivia, Xie, Xiaowen, Nam, Eunju, Payne, N. Connor, Gosavi, Pallavi M., Kwok, Hui Si, Iram, Irtiza, Lee, Ceejay, Li, Jiaming, Chen, Nicholas J., Nguyen, Khanh, Jiang, Hanjie, Wang, Zhipeng A., Lee, Kwangwoon, Mao, Haibin, Harry, Stefan A., Barakat, Idris A., Takahashi, Mariko, Waterbury, Amanda L., Barone, Marco, Mattevi, Andrea, Carr, Steven A., Udeshi, Namrata D., Bar-Peled, Liron, Cole, Philip A., Mazitschek, Ralph, Liau, Brian B., Zheng, Ning

Source: Nature; March 2025, Vol. 639 Issue: 8053 p232-240, 9p

An MXD1-derived repressor peptide identifies noncoding mediators of MYC-driven cell proliferation

Authors: Raffeiner, Philipp, Hart, Jonathan R., García-Caballero, Daniel, Bar-Peled, Liron, Weinberg, Marc S., Vogt, Peter K.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Mar . 117(12), 6571-6579.

Access URL: https://www.jstor.org/stable/26929573

ABHD12 and LPCAT3 Interplay Regulates a Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network Implicated in Neurological Disease

Authors: Ichu, Taka-Aki, Reed, Alex, Ogasawara, Daisuke, Ulanovskaya, Olesya, Roberts, Amanda, Aguirre, Carlos A., Bar-Peled, Liron, Gao, Jie, Germain, Jason, Barbas, Sabrina

Source: Biochemistry. 59(19):1793-1799

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN623902997&indx=1&recIds=ETOCRN623902997

C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly

Authors: Rasheed, Nadia, Lima, Tatiani B., Mercaldi, Gustavo F., Nascimento, Andrey F.Z., Silva, Ana L.S., Righetto, Germanna L., Bar‐Peled, Liron, Shen, Kuang, Sabatini, David M., Gozzo, Fabio C., Aparicio, Ricardo, Smetana, Juliana H.C.

Source: FEBS open bio. 9(9):1589-1602

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100092055860.0x000001&indx=1&recIds=ETOCvdc_100092055860.0x000001

Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan

Authors: Chen, Alice, Lum, Kenneth, Lara-Gonzalez, Pablo, Ogasawara, Daisuke, Cognetta, Armand, To, Alan, Parsons, William, Simon, Gabriel, Desai, Arshad, Petrascheck, Michael, Bar-Peled, Liron, Cravatt, Benjamin

Source: Nature chemical biology. 15(5):453-462

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132430449.0x000001&indx=1&recIds=ETOCvdc_100132430449.0x000001

Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer

Authors: Bar-Peled, Liron, Kemper, Esther K., Suciu, Radu M., Vinogradova, Ekaterina V., Backus, Keriann M., Horning, Benjamin D., Paul, Thomas A., Ichu, Taka-Aki, Svensson, Robert U., Olucha, Jose, Chang, Max W., Kok, Bernard P., Zhu, Zhou, Ihle, Nathan T., Dix, Melissa M., Jiang, Ping, Hayward, Matthew M., Saez, Enrique, Shaw, Reuben J., Cravatt, Benjamin F.

Source: In Cell 19 October 2017 171(3):696-709

Tweaking the NRF2 signaling cascade in human myelogenous leukemia cells by artificial nano-organelles.

Authors: Wolf, Konstantin M. P., Maffeis, Viviana, Schoenenberger, Cora-Ann, Zünd, Tamara, Bar-Peled, Liron, Palivan, Cornelia G., Vogel, Viola

Source: Proceedings of the National Academy of Sciences of the United States of America; 5/28/2024, Vol. 121 Issue 22, p1-12, 33p

Subject Terms: MYELOID leukemia, ARTIFICIAL cells, NUCLEAR factor E2 related factor, MONONUCLEAR leukocytes, REACTIVE oxygen species

Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1

Authors: Schweitzer, Lawrence D., Comb, William C., Bar-Peled, Liron, Sabatini, David M.

Source: In Cell Reports 1 September 2015 12(9):1445-1455

Regulation of mTORC1 by amino acids

Authors: Bar-Peled, Liron, Sabatini, David M.

Source: In Trends in Cell Biology July 2014 24(7):400-406

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

Authors: Wang, Shuyu, Tsun, Zhi-Yang, Wolfson, Rachel L., Shen, Kuang, Wyant, Gregory A., Plovanich, Molly E., Yuan, Elizabeth D., Jones, Tony D., Chantranupong, Lynne, Comb, William, Wang, Tim, Bar-Peled, Liron, Zoncu, Roberto, Straub, Christoph, Kim, Choah, Park, Jiwon, Sabatini, Bernardo L., Sabatini, David M.

Source: Science, 2015 Jan 01. 347(6218), 188-194.

Access URL: http://www.jstor.org/stable/24745741

Size does matter: Lysosome-based signaling machine regulates cell growth

Authors: Bar-Peled, Liron

Source: Science, 2014 Dec 01. 346(6214), 1191-1192.

Access URL: http://www.jstor.org/stable/24745593

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

Authors: Tsun, Zhi-Yang, Bar-Peled, Liron, Chantranupong, Lynne, Zoncu, Roberto, Wang, Tim, Kim, Choah, Spooner, Eric, Sabatini, David M.

Source: In Molecular Cell 21 November 2013 52(4):495-505

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

Authors: Bar-Peled, Liron, Chantranupong, Lynne, Cherniack, Andrew D., Chen, Walter W., Ottina, Kathleen A., Grabiner, Brian C., Spear, Eric D., Carter, Scott L, Meyerson, Matthew, Sabatini, David M.

Source: Science, 2013 May . 340(6136), 1100-1106.

Access URL: http://dx.doi.org/10.1126/science.1232044

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

Authors: Bar-Peled, Liron, Schweitzer, Lawrence D., Zoncu, Roberto, Sabatini, David M.

Source: In Cell 14 September 2012 150(6):1196-1208