MCLA-117, a CLEC12AxCD3 bispecific antibody targeting a leukaemic stem cell antigen, induces T cell-mediated AML blast lysis

Authors: van Loo, Pieter Fokko, Hangalapura, Basav N., Thordardottir, Soley, Gibbins, John D., Veninga, Henrike, Hendriks, Linda J. A., Kramer, Arjen, Roovers, Rob C., Leenders, Marij, de Kruif, John, Doornbos, Robert P., Sirulnik, Andres, Throsby, Mark, Logtenberg, Ton, Dolstra, Harry, Bakker, Alexander B. H.

Source: Expert opinion on biological therapy. 19(7):721-733

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100098595803.0x000001&indx=1&recIds=ETOCvdc_100098595803.0x000001

Translational PK-PD modeling analysis of MCLA-128, a HER2/HER3 bispecific monoclonal antibody, to predict clinical efficacious exposure and dose

Authors: de Vries Schultink, Aurelia H. M., Doornbos, Robert P., Bakker, Alexander B. H., Bol, Kees, Throsby, Mark, Geuijen, Cecile, Maussang, David, Schellens, Jan H. M., Beijnen, Jos H., Huitema, Alwin D. R.

Source: Investigational new drugs. 36(6):1006-1015

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100127315602.0x000001&indx=1&recIds=ETOCvdc_100127315602.0x000001

Comparison of an Anti-Rabies Human Monoclonal Antibody Combination with Human Polyclonal Anti-Rabies Immune Globulin

Authors: Goudsmit, Jaap, Marissen, Wilfred E., Weldon, William C., Niezgoda, Michael, Hanlon, Cathleen A., Rice, Amy B., de Kruif, John, Dietzschold, Bernhard, Bakker, Alexander B. H., Rupprecht, Charles E.

Source: The Journal of Infectious Diseases, 2006 Mar . 193(6), 796-801.

Access URL: https://www.jstor.org/stable/30088330

DAP12 nucleic acids

Binding molecules capable of neutralizing rabies virus and uses thereof

MDL-1 polypeptides

Binding compounds to DAP12 proteins

Antibodies and fragments thereof to MDL-1 protein

A Human Monoclonal Antibody Cocktail as a Novel Component of Rabies Postexposure Prophylaxis.

Authors: Kruif, John de, Bakker, Alexander B. H., Marissen, Wilfred E.

Source: Annual Review of Medicine; 2007, Vol. 58, p359-368, 12p

Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells.

Authors: Bakker, Alexander B. H., Baker, Elizabeth, Sutherland, Grant R.

Source: Proceedings of the National Academy of Sciences of the United States of America; August 17 1999, Vol. 96 Issue 17, p9792-9796, 5p

Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets.

Authors: Meulen, Jan ter, Bakker, Alexander B. H., Brink, Edward N. van den

Source: Lancet; June 26 2004, Vol. 363, p2139-2141, 3p

An activating immunoreceptor complex formed by NKG2D and DAP10.

Authors: Wu, Jun, Song, Yaoli, Bakker, Alexander B. H.

Source: Science; July 30 1999, Vol. 285 Issue 5428, p730-732, 3p

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A Human Monoclonal Antibody Cocktail as a Novel Component of Rabies Postexposure Prophylaxis.

Authors: de Kruif, John¹ j.dekruif@crucell.com, Bakker, Alexander B. H.¹, Marissen, Wilfred E.¹, Kramer, R. Arjen¹, Throsby, Mark¹, Rupprecht, Charles E.², Goudsmit, Jaap¹

Source: Annual Review of Medicine. 2007, Vol. 58 Issue 1, p359-368. 10p. 3 Diagrams, 1 Graph.

Subject Terms: *MONOCLONAL antibodies, *RABIES, *IMMUNOGLOBULINS, *SERUM, *CUSPIDS

The human antibody repertoire specific for rabies virus glycoprotein as selected from immune libraries.

Authors: Kramer, R. Arjen, Marissen, Wilfred E., Goudsmit, Jaap, Visser, Therese J., Clijsters-Van der Horst, Marieke, Bakker, Arjen Q., de Jong, Maureen, Jongeneelen, Mandy, Thijsse, Sandra, Backus, Harold H. J., Rice, Amy B., Weldon, William C., Rupprecht, Charles E., Dietzschold, Bernhard, Bakker, Alexander B. H., de Kruif, John

Source: European Journal of Immunology; Jul2005, Vol. 35 Issue 7, p2131-2145, 15p

Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets.

Authors: ter Meulen, Jan, Bakker, Alexander B H, van den Brink, Edward N, Weverling, Gerrit J, Martina, Byron E E, Haagmans, Bart L, Kuiken, Thijs, de Kruif, John, Preiser, Wolfgang, Spaan, Willy, Gelderblom, Hans R, Goudsmit, Jaap, Osterhaus, Albert DME

Source: Lancet (0099-5355); Jun2004, Vol. 363 Issue 9427, p2139-2141, 3p

Novel Human Monoclonal Antibody Combination Effectively Neutralizing Natural Rabies Virus Variants and Individual In Vitro Escape Mutants.

Authors: Bakker, Alexander B. H.¹, Marissen, Wilfred E.¹, Kramer, R. Arjen¹, Rice, Amy B.², Weldon, William C.³, Niezgoda, Michael³, Hanlon, Cathleen A.³, Thijsse, Sandra¹, Backus, Harold H. J.¹, De Kruif, John¹, Dietzschold, Bernhard², Rupprecht, Charles E.³, Goudsmit, Jaap¹ j.goudsmit@crucell.com

Source: Journal of Virology. Jul2005, Vol. 79 Issue 14, p27-27. 1p.

Subject Terms: *RABIES, *MONOCLONAL antibodies, *IMMUNOGLOBULINS, *GLYCOPROTEINS, *EPITOPES