Clostridium difficile toxins induce VEGF-A and vascular permeability to promote disease pathogenesis

Authors: Huang, Jun, Kelly, Ciarán, Bakirtzi, Kyriaki, Villafuerte Gálvez, Javier, Lyras, Dena, Mileto, Steven, Larcombe, Sarah, Xu, Hua, Yang, Xiaotong, Shields, Kelsey, Zhu, Weishu, Zhang, Yi, Goldsmith, Jeffrey, Patel, Ishan, Hansen, Joshua, Huang, Meijin, Yla-Herttuala, Seppo, Moss, Alan, Paredes-Sabja, Daniel, Pothoulakis, Charalabos, Shah, Yatrik, Wang, Jianping, Chen, Xinhua

Source: Nature microbiology. 4(2):269-279

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Clostridium difficile toxins induce VEGF-A and vascular permeability to promote disease pathogenesis

Authors: Huang, Jun, Kelly, Ciarán P., Bakirtzi, Kyriaki, Villafuerte Gálvez, Javier A., Lyras, Dena, Mileto, Steven J., Larcombe, Sarah, Xu, Hua, Yang, Xiaotong, Shields, Kelsey S., Zhu, Weishu, Zhang, Yi, Goldsmith, Jeffrey D., Patel, Ishan J., Hansen, Joshua, Huang, Meijin, Yla-Herttuala, Seppo, Moss, Alan C., Paredes-Sabja, Daniel, Pothoulakis, Charalabos, Shah, Yatrik M., Wang, Jianping, Chen, Xinhua

Source: Nature microbiology. 4(2):269-279

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130017459.0x000001&indx=1&recIds=ETOCvdc_100130017459.0x000001

Identification of a Novel Substance P–Neurokinin-1 Receptor MicroRNA-221-5p Inflammatory Network in Human Colonic Epithelial Cells

Authors: Fang, Kai, Sideri, Aristea, Law, Ivy Ka Man, Bakirtzi, Kyriaki, Polytarchou, Christos, Iliopoulos, Dimitrios, Pothoulakis, Charalabos

Source: In Cellular and Molecular Gastroenterology and Hepatology September 2015 1(5):503-515

Substance P Mediates Proinflammatory Cytokine Release From Mesenteric Adipocytes in Inflammatory Bowel Disease Patients

Authors: Sideri, Aristea, Bakirtzi, Kyriaki, Shih, David Q., Koon, Hon Wai, Fleshner, Phillip, Arsenescu, Razvan, Arsenescu, Violeta, Turner, Jerrold R., Karagiannides, Iordanes, Pothoulakis, Charalabos

Source: In Cellular and Molecular Gastroenterology and Hepatology July 2015 1(4):420-432

Antifibrogenic Effects of the Antimicrobial Peptide Cathelicidin in Murine Colitis-Associated Fibrosis

Authors: Yoo, Jun Hwan, Ho, Samantha, Tran, Deanna Hoang-Yen, Cheng, Michelle, Bakirtzi, Kyriaki, Kubota, Yuzu, Ichikawa, Ryan, Su, Bowei, Tran, Diana Hoang-Ngoc, Hing, Tressia C., Chang, Irene, Shih, David Q., Issacson, Richard E., Gallo, Richard L., Fiocchi, Claudio, Pothoulakis, Charalabos, Koon, Hon Wai

Source: In Cellular and Molecular Gastroenterology and Hepatology January 2015 1(1):55-74

The Neurotensin–HIF-1α–VEGFα Axis Orchestrates Hypoxia, Colonic Inflammation, and Intestinal Angiogenesis

Authors: Bakirtzi, Kyriaki, West, Gail, Fiocchi, Claudio, Law, Ivy Ka Man, Iliopoulos, Dimitrios, Pothoulakis, Charalabos

Source: In The American Journal of Pathology December 2014 184(12):3405-3414

Neurotensin Promotes the Development of Colitis and Intestinal Angiogenesis via Hif-1α-miR-210 Signaling

Authors: Bakirtzi, Kyriaki, Law, Ivy Ka Man, Xue, Xiang, Iliopoulos, Dimitrios, Shah, Yatrik M., Pothoulakis, Charalabos

Source: Journal of immunology. 196(10):4311-4321

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Neurotensin-induced Proinflammatory Signaling in Human Colonocytes Is Regulated by β-Arrestins and Endothelin-converting Enzyme-1-dependent Endocytosis and Resensitization of Neurotensin Receptor 1

Authors: Law, Ivy Ka Man, Murphy, Jane E., Bakirtzi, Kyriaki, Bunnett, Nigel W., Pothoulakis, Charalabos

Source: In Journal of Biological Chemistry 27 April 2012 287(18):15066-15075

Neurotensin Signaling Activates MicroRNAs-21 and -155 and Akt, Promotes Tumor Growth in Mice, and Is Increased in Human Colon Tumors

Authors: Bakirtzi, Kyriaki, Hatziapostolou, Maria, Karagiannides, Iordanes, Polytarchou, Christos, Jaeger, Savina, Iliopoulos, Dimitrios, Pothoulakis, Charalabos

Source: In Gastroenterology November 2011 141(5):1749-1761

Cathelicidin Signaling via the Toll-like Receptor Protects Against Colitis in Mice

Authors: Koon, Hon Wai, Shih, David Q., Chen, Jeremy, Bakirtzi, Kyriaki, Hing, Tressia C., Law, Ivy, Ho, Samantha, Ichikawa, Ryan, Zhao, Dezheng, Xu, Hua, Gallo, Richard, Dempsey, Paul, Cheng, Genhong, Targan, Stephan R., Pothoulakis, Charalabos

Source: In Gastroenterology November 2011 141(5):1852-1863

Insulin-like Growth Factor-1 Receptor Transactivation Modulates the Inflammatory and Proliferative Responses of Neurotensin in Human Colonic Epithelial Cells

Authors: Zhao, Dezheng, Bakirtzi, Kyriaki, Zhan, Yanai, Zeng, Huiyan, Koon, Hon Wai, Pothoulakis, Charalabos

Source: In Journal of Biological Chemistry 25 February 2011 286(8):6092-6099

Silence Please!

Authors: Bakirtzi, Kyriaki, Hoffman, Jill M., Pothoulakis, Charalabos

Source: American journal of pathology. 183(6):1700-1702

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100066142736.0x000001&indx=1&recIds=ETOCvdc_100066142736.0x000001

Cellugyrin Induces Biogenesis of Synaptic-like Microvesicles in PC12 Cells

Authors: Belfort, Gabriel M., Bakirtzi, Kyriaki, Kandror, Konstantin V. ^‡

Source: In Journal of Biological Chemistry 25 February 2005 280(8):7262-7272

MiR-21 in Substance P-induced exosomes promotes cell proliferation and migration in human colonic epithelial cells.

Authors: Bakirtzi, Kyriaki¹, Law, Ivy Ka Man¹, Kai Fang¹, Iliopoulos, Dimitrios², Pothoulakis, Charalabos¹ cpothoulakis@mednet.ucla.edu

Source: American Journal of Physiology: Gastrointestinal & Liver Physiology. Dec2019, Vol. 317 Issue 6, pG802-G810. 9p.

Subject Terms: *CELL migration, *CELL communication, *CELL proliferation, *EPITHELIAL cells, *EXOSOMES, *SUBSTANCE P, *CULTURE media (Biology)

Substance P-Induced Colonic Epithelial Cell-Secreted Exosomes Exacerbate Experimental Colitis and Regulate Cell Proliferation and Migration via Exosomal MIR-21

Authors: Bakirtzi, Kyriaki, Iliopoulos, Dimitrios, Pothoulakis, Charalabos

Source: Gastroenterology. 152(5):S103-S103

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100054021002.0x000001&indx=1&recIds=ETOCvdc_100054021002.0x000001

Silence Please!: siRNA Approaches to Tighten the Intestinal Barrier in Vivo

Authors: Bakirtzi, Kyriaki, Hoffman, Jill M., Pothoulakis, Charalabos

Source: In The American Journal of Pathology December 2013 183(6):1700-1702

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435 - Substance P-Induced Colonic Epithelial Cell-Secreted Exosomes Exacerbate Experimental Colitis and Regulate Cell Proliferation and Migration via Exosomal MIR-21

Authors: Bakirtzi, Kyriaki, Iliopoulos, Dimitrios, Pothoulakis, Charalabos

Source: In Gastroenterology April 2017 152(5) Supplement 1:S103-S103

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