Activated non-neuronal cholinergic system correlates with non-type 2 inflammation and exacerbations in severe asthma

Authors: Huang, Dan ^*, Zhang, Li, Liu, Ying, Wang, Ji ^*, Zhang, Jie, Baines, Katherine J., Liu, Gang, Hsu, Alan Chen-Yu, Wang, Fang, Chen, Zhihong, Oliver, Brian G., Xie, Min, Qin, Ling, Liu, Dan ^*, Wan, Huajing ^*, Luo, Fengming ^*, Li, Weimin ^*, Wang, Gang ^*, Gibson, Peter G.

Source: In Annals of Allergy, Asthma & Immunology July 2024 133(1):64-72

Airway gene expression identifies subtypes of type 2 inflammation in severe asthma

Authors: Frøssing, Laurits, Silberbrandt, Alexander, Von Bülow, Anna, Kjærsgaard Klein, Ditte, Ross Christensen, Marcus, Backer, Vibeke, Baines, Katherine J., Porsbjerg, Celeste

Source: Clinical & experimental allergy. 52(1):59-69

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138804868.0x000001&indx=1&recIds=ETOCvdc_100138804868.0x000001

Relationship between type 2 cytokine and inflammasome responses in obesity-associated asthma

Authors: Pinkerton, James W., Kim, Richard Y., Brown, Alexandra C., Rae, Brittany E., Donovan, Chantal, Mayall, Jemma R., Carroll, Olivia R., Khadem Ali, Md., Scott, Hayley A., Berthon, Bronwyn S., Baines, Katherine J., Starkey, Malcolm R., Kermani, Nazanin Z., Guo, Yi-Ke, Robertson, Avril A.B., O'Neill, Luke A.J., Adcock, Ian M., Cooper, Matthew A., Gibson, Peter G., Wood, Lisa G., Hansbro, Philip M., Horvat, Jay C.

Source: Journal of allergy and clinical immunology. 149(4):1270-1280

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100159043372.0x000001&indx=1&recIds=ETOCvdc_100159043372.0x000001

An altered sputum macrophage transcriptome contributes to the neutrophilic asthma endotype

Authors: Fricker, Michael, Qin, Ling, Sánchez‐Ovando, Stephany, Simpson, Jodie L., Baines, Katherine J., Riveros, Carlos, Scott, Hayley A., Wood, Lisa G., Wark, Peter AB., Kermani, Nazanin Z., Chung, Kian Fan, Gibson, Peter G.

Source: Allergy. 77(4):1204-1215

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100147774805.0x000001&indx=1&recIds=ETOCvdc_100147774805.0x000001

Targeted DNase treatment of obstructive lung disease: a pilot randomised controlled trial.

Authors: Negewo, Netsanet A., Niessen, Natalie M., Baines, Penelope J., Williams, Evan J., Fibbens, Naomi, Simpson, Jodie L., McDonald, Vanessa M., Berthon, Bronwyn S., Gibson, Peter G., Baines, Katherine J.

Source: ERJ Open Research; Jan2025, Vol. 11 Issue 1, p1-13, 13p

Sulforaphane reduces pro-inflammatory response to palmitic acid in monocytes and adipose tissue macrophages

Authors: Williams, Evan J., Guilleminault, Laurent, Berthon, Bronwyn S., Eslick, Shaun, Wright, Timothy, Karihaloo, Constantine, Gately, Mark, Baines, Katherine J., Wood, Lisa G.

Source: In The Journal of Nutritional Biochemistry June 2022 104

Parapneumonic Effusions Are Characterized by Elevated Levels of Neutrophil Extracellular Traps

Authors: Twaddell, Scott H., Gibson, Peter G., Grainge, Christopher, Baines, Katherine J.

Source: In Chest November 2021 160(5):1645-1655

Sputum mast cell/basophil gene expression relates to inflammatory and clinical features of severe asthma

Authors: Winter, Natasha A. ^∗, Qin, Ling ^∗, Gibson, Peter G., McDonald, Vanessa M., Baines, Katherine J., Faulkner, Jack, Evans, Tiffany-Jane, Fricker, Michael

Source: In The Journal of Allergy and Clinical Immunology August 2021 148(2):428-438

Molecular markers of type 2 airway inflammation are similar between eosinophilic severe asthma and eosinophilic chronic obstructive pulmonary disease

Authors: Fricker, Michael, McDonald, Vanessa M., Winter, Natasha A., Baines, Katherine J., Wark, Peter A. B., Simpson, Jodie L., Gibson, Peter G.

Source: Allergy. 76(7):2079-2089

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135937460.0x000001&indx=1&recIds=ETOCvdc_100135937460.0x000001

Sputum TNF markers are increased in neutrophilic and severe asthma and are reduced by azithromycin treatment

Authors: Niessen, Natalie M., Gibson, Peter G., Baines, Katherine J., Barker, Daniel, Yang, Ian A., Upham, John W., Reynolds, Paul N., Hodge, Sandra, James, Alan L., Jenkins, Christine, Peters, Matthew J., Marks, Guy B., Baraket, Melissa, Simpson, Jodie L., Fricker, Michael

Source: Allergy. 76(7):2090-2101

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100134463310.0x000001&indx=1&recIds=ETOCvdc_100134463310.0x000001

Transcriptomics of biopsies identifies novel genes and pathways linked to neutrophilic inflammation in severe asthma

Authors: Sánchez‐Ovando, Stephany, Simpson, Jodie L., Barker, Daniel, Baines, Katherine J., Wark, Peter A. B.

Source: Clinical & experimental allergy. 51(10):1279-1294

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132306077.0x000001&indx=1&recIds=ETOCvdc_100132306077.0x000001

Neutrophilic asthma features increased airway classical monocytes

Authors: Niessen, Natalie M., Baines, Katherine J., Simpson, Jodie L., Scott, Hayley A., Qin, Ling, Gibson, Peter G., Fricker, Michael

Source: Clinical & experimental allergy. 51(2):305-317

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123024614.0x000001&indx=1&recIds=ETOCvdc_100123024614.0x000001

Outcomes of protracted bacterial bronchitis in children: A 5‐year prospective cohort study

Authors: Ruffles, Tom J.C., Marchant, Julie M., Masters, Ian B., Yerkovich, Stephanie T., Wurzel, Danielle F., Gibson, Peter G., Busch, Greta, Baines, Katherine J., Simpson, Jodie L., Smith‐Vaughan, Heidi C., Pizzutto, Susan J., Buntain, Helen M., Hodge, Gregory, Hodge, Sandra, Upham, John W., Chang, Anne B.

Source: Respirology. 26(3):241-248

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115470353.0x000001&indx=1&recIds=ETOCvdc_100115470353.0x000001

The Emerging Role of Neutrophil Extracellular Traps in Respiratory Disease

Authors: Twaddell, Scott H., Baines, Katherine J., Grainge, Christopher, Gibson, Peter G.

Source: In Chest October 2019 156(4):774-782

Soluble fibre supplementation with and without a probiotic in adults with asthma: A 7-day randomised, double blind, three way cross-over trial

Authors: McLoughlin, Rebecca, Berthon, Bronwyn S., Rogers, Geraint B., Baines, Katherine J., Leong, Lex E.X., Gibson, Peter G., Williams, Evan J., Wood, Lisa G.

Source: In eBioMedicine August 2019 46:473-485

A sputum 6-gene signature predicts future exacerbations of poorly controlled asthma

Authors: Fricker, Michael, Gibson, Peter G., Powell, Heather, Simpson, Jodie L., Yang, Ian A., Upham, John W., Reynolds, Paul N., Hodge, Sandra, James, Alan L., Jenkins, Christine, Peters, Matthew J., Marks, Guy B., Baraket, Melissa, Baines, Katherine J.

Source: In The Journal of Allergy and Clinical Immunology July 2019 144(1):51-60

Six gene and TH2 signature expression in endobronchial biopsies of participants with asthma

Authors: Sánchez‐Ovando, Stephany, Baines, Katherine J., Barker, Daniel, Wark, Peter A., Simpson, Jodie L.

Source: Immunity, inflammation and disease. 8(1):40-49

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100109064392.0x000001&indx=1&recIds=ETOCvdc_100109064392.0x000001

Relationship of sputum mast cells with clinical and inflammatory characteristics of asthma

Authors: Fricker, Michael, Qin, Ling, Niessen, Natalie, Baines, Katherine J., McDonald, Vanessa M., Scott, Hayley A., Simpson, Jodie L., Gibson, Peter G.

Source: Clinical & experimental allergy. 50(6):696-707

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107430664.0x000001&indx=1&recIds=ETOCvdc_100107430664.0x000001

Sputum transcriptomics implicates increased p38 signalling activity in severe asthma

Authors: Baines, Katherine J., Fricker, Michael, McDonald, Vanessa M., Simpson, Jodie L., Wood, Lisa G., Wark, Peter A.B., Macdonald, Heather E., Reid, Andrew, Gibson, Peter G.

Source: Respirology. 25(7):709-718

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107639820.0x000001&indx=1&recIds=ETOCvdc_100107639820.0x000001

Saturated fatty acids, obesity, and the nucleotide oligomerization domain–like receptor protein 3 (NLRP3) inflammasome in asthmatic patients

Authors: Wood, Lisa G., Li, Qian, Scott, Hayley A., Rutting, Sandra, Berthon, Bronwyn S., Gibson, Peter G., Hansbro, Philip M., Williams, Evan, Horvat, Jay, Simpson, Jodie L., Young, Paul, Oliver, Brian G., Baines, Katherine J.

Source: In The Journal of Allergy and Clinical Immunology January 2019 143(1):305-315