Damage sensing through TLR9 regulates inflammatory and antiviral responses during influenza infection

Authors: Kim, Jooyoung ^{a, b, 1}, Yuan, Yifan ^{b, c, 1}, Agaronyan, Karen ^{b, d}, Zhao, Amy ^b, Wang, Victoria D ^a, Gau, David ^{e, f}, Toosi, Nicholas ^f, Gupta, Gayatri ^b, Essayas, Heran ^b, Kaminski, Ayelet ^b, McGovern, John ^b, Yu, Sheeline ^b, Woo, Samuel ^b, Lee, Chris J. ^b, Gandhi, Shifa ^b, Saber, Tina ^b, Saleh, Tayebeh ^a, Hu, Buqu ^b, Sun, Ying ^b, Ishikawa, Genta ^b, Bain, William ^{a, g}, Evankovich, John ^a, Chen, Lujia ^h, Yun, HongDuck ^a, Herzog, Erica L. ^b, Dela Cruz, Charles S. ^{a, b, g}, Ryu, Changwan ^{b, ⁎}, Sharma, Lokesh ^{a, b, ⁎}

Source: In Mucosal Immunology January 2025

'Now We Got Bad Blood': Beyond Phenotype Labels in an 'Era' of Meta-omics in Critical Illness

Authors: Kitsios, Georgios D., Bain, William

Source: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 209(7):772-774

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632811281&indx=1&recIds=ETOCRN632811281

Impact of enzymatic digestion on single cell suspension yield from peripheral human lung tissue

Authors: Bondonese, Anna, Craig, Andrew, Fan, Li, Valenzi, Eleanor, Bain, William, Lafyatis, Robert, Sembrat, John, Chen, Kong, Snyder, Mark E.

Source: Cytometry.Part A. 103(10):777-785

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195886138.0x000001&indx=1&recIds=ETOCvdc_100195886138.0x000001

A common single nucleotide polymorphism is associated with inflammation and critical illness outcomes

Authors: El-Dehaibi, Fayten ^{1, 6}, Zamora, Ruben ^{1, 6}, Radder, Josiah ^{2, 6}, Yin, Jinling ^{1, 6}, Shah, Ashti M. ³, Namas, Rami A. ¹, Situ, Michelle ¹, Zhao, Yanwu ², Bain, William ², Morris, Alison ², McVerry, Bryan J. ², Barclay, Derek A. ¹, Billiar, Timothy R. ^{1, 7}, Zhang, Yingze ^{2, 7}, Kitsios, Georgios D. ^{2, 7}, Vodovotz, Yoram ^{1, 4, 5, 7, 8, ∗}

Source: In iScience 15 December 2023 26(12)

Trajectories of Host-Response Subphenotypes in Patients With COVID-19 Across the Spectrum of Respiratory Support

Authors: Lu, Michael, Drohan, Callie, Bain, William, Shah, Faraaz A., Bittner, Matthew, Evankovich, John, Prendergast, Niall T., Hensley, Matthew, Suber, Tomeka L., Fitzpatrick, Meghan, Ramanan, Raj, Murray, Holt, Schaefer, Caitlin, Qin, Shulin, Wang, Xiaohong, Zhang, Yingze, Nouraie, Seyed M., Gentry, Heather, Murray, Cathy, Patel, Asha, Macatangay, Bernard J., Jacobs, Jana, Mellors, John W., Lee, Janet S., Ray, Prabir, Ray, Anuradha, Methé, Barbara, Morris, Alison, McVerry, Bryan J., Kitsios, Georgios D.

Source: In CHEST Critical Care December 2023 1(3)

Noninvasive diagnosis of secondary infections in COVID-19 by sequencing of plasma microbial cell-free DNA

Authors: Lisius, Grace, Duttagupta, Radha, Ahmed, Asim A., Hensley, Matthew, Al-Yousif, Nameer, Lu, Michael, Bain, William, Shah, Faraaz, Blauwkamp, Timothy A., Bercovici, Sivan, Schaefer, Caitlin, Qin, Shulin, Wang, Xiaohong, Zhang, Yingze, Mitchell, Kevin J., Hughes, Ellen K., Jacobs, Jana L., Naqvi, Asma, Haidar, Ghady, Mellors, John W., Methé, Barbara, McVerry, Bryan J., Morris, Alison, Kitsios, Georgios D.

Source: In iScience 17 November 2023 26(11)

The upper and lower respiratory tract microbiome in severe aspiration pneumonia

Authors: Kitsios, Georgios D. ^{1, 2, 3, 4, 15, 17, ∗}, Nguyen, Vi D. ^{2, 5, 15}, Sayed, Khaled ^{6, 7}, Al-Yousif, Nameer ⁸, Schaefer, Caitlin ^{1, 4}, Shah, Faraaz A. ^{1, 2, 4, 9}, Bain, William ^{1, 2, 4, 9}, Yang, Haopu ^{2, 10}, Fitch, Adam ³, Li, Kelvin ³, Wang, Xiaohong ¹, Qin, Shulin ^{1, 3}, Gentry, Heather ¹, Zhang, Yingze ^{1, 4}, Varon, Jack ¹¹, Arciniegas Rubio, Antonio ¹¹, Englert, Joshua A. ¹², Baron, Rebecca M. ¹¹, Lee, Janet S. ¹³, Methé, Barbara ^{1, 3}, Benos, Panayiotis V. ⁷, Morris, Alison ^{1, 2, 3, 14, 16}, McVerry, Bryan J. ^{1, 2, 3, 4, 16}

Source: In iScience 16 June 2023 26(6)

Therapeutic JAK inhibition does not impact lung injury during viral or bacterial pneumonia in male mice.

Authors: Sharma, Lokesh, Singh, Ravineel B., Ngeow, Caden, van der Geest, Rick, Duray, Alexis M., Tolman, Nathanial J., McVerry, Bryan J., Dela Cruz, Charles S., Alcorn, John F., Bain, William, Robinson, Keven M.

Source: Physiological Reports; Feb2025, Vol. 13 Issue 3, p1-14, 14p

Political Theology and International Relations: From History to Emancipation.

Authors: Bain, William¹ (AUTHOR) polbww@nus.edu.sg

Source: International Studies Quarterly. Dec2023, Vol. 67 Issue 4, p1-12. 12p.

Subject Terms: *POLITICAL theology, *LIBERTY, *INTERNATIONAL relations, *HISTORICAL sociology, *DIPLOMATIC history

Elastase Activity From Pseudomonas aeruginosa Respiratory Isolates and ICU Mortality

Authors: Zupetic, Jill, Peñaloza, Hernán F., Bain, William, Hulver, Mei, Mettus, Roberta, Jorth, Peter, Doi, Yohei, Bomberger, Jennifer, Pilewski, Joseph, Nouraie, Mehdi, Lee, Janet S.

Source: In Chest November 2021 160(5):1624-1633

Rationale and design of the Prone Position and Respiratory Outcomes in Non-intubated COVID-19 PatiEnts: The “PRONE” Study

Authors: Friedman, Eugene, Franzone, John, Ko, Emily R., Corey, Kristin, Mock, Jason, Alavian, Naseem, Schwartz, Adam, Drummond, M. Bradley, Suber, Tomeka, Linstrum, Kelsey, Bain, William, Castiblanco, Saramaria Afanador, Zak, Martin, Zaeh, Sandra, Gupta, Ishaan, Damarla, Mahendra, Punjabi, Naresh M.

Source: In Contemporary Clinical Trials October 2021 109

Lower Respiratory Tract Myeloid Cells Harbor SARS-Cov-2 and Display an Inflammatory Phenotype

Authors: Bain, William G., Peñaloza, Hernán F., Ladinsky, Mark S., van der Geest, Rick, Sullivan, Mara, Ross, Mark, Kitsios, Georgios D., Methé, Barbara A., McVerry, Bryan J., Morris, Alison, Watson, Alan M., Watkins, Simon C., St Croix, Claudette M., Stolz, Donna B., Bjorkman, Pamela J., Lee, Janet S.

Source: Chest. 159(3):963-966

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100136872252.0x000001&indx=1&recIds=ETOCvdc_100136872252.0x000001

Oxidized phospholipid and transcriptomic signatures of THC-related vaping associated lung injury.

Authors: Suber, Tomeka L., Tabary, Mohammadreza, Bain, William, Olonisakin, Tolani, Lockwood, Karina, Xiong, Zeyu, Zhang, Yingze, Kohli, Naina, Furguiele, Lauren, Peñaloza, Hernán, McVerry, Bryan J., Rose, Jason J., Shah, Faraaz, Methé, Barbara, Li, Kelvin, Mallampalli, Rama K., Chen, Kong, Fan, Li, Morris, Alison, Tyurin, Vladimir A.

Source: Scientific Reports; 12/30/2024, Vol. 14 Issue 1, p1-15, 15p

Subject Terms: LUNG injuries, E-cigarette or vaping product use-associated lung injuries, PHYSIOLOGICAL oxidation, ARACHIDONIC acid, OLEIC acid

Clinical and biologic profiles of patients with acute respiratory distress syndrome by prevalence of chronic obstructive pulmonary disease or emphysema; a cohort study.

Authors: Nath, Sridesh, Qurashi, Hafiz, Kitsios, Georgios D., Bain, William, Aneis, Hamam, Suber, Tomeka, Prendergast, Niall, Hensley, Matthew, Schaefer, Caitlin, Zhang, Yingze, Bon, Jessica, McVerry, Bryan J., Evankovich, John, Shah, Faraaz Ali

Source: Respiratory Research; 11/8/2024, Vol. 25 Issue 1, p1-11, 11p

Subject Terms: PULMONARY emphysema, ADULT respiratory distress syndrome, CHRONIC obstructive pulmonary disease, CONGESTIVE heart failure, INTENSIVE care units

Context‐specific anti‐inflammatory roles of type III interferon signaling in the lung in nonviral injuries.

Authors: Feng, Jingjing, Kim, Jooyoung, Wang, Victoria D., Chang, De, Liu, Hongbo, Bain, William G., Robinson, Keven M., Jie, Zhijun, Kotenko, Sergei V., Dela Cruz, Charles S., Sharma, Lokesh

Source: Physiological Reports; Oct2024, Vol. 12 Issue 20, p1-10, 10p

Subject Terms: LUNG injuries, INTERFERONS, PULMONARY fibrosis, KNOCKOUT mice, BLEOMYCIN

The evolution of radiographic edema in ARDS and its association with clinical outcomes: A prospective cohort study in adult patients

Authors: Kotok, Daniel, Yang, Libing, Evankovich, John W., Bain, William, Dunlap, Daniel G., Shah, Faraaz, Zhang, Yingze, Manatakis, Dimitris V., Benos, Panayiotis V., Barbash, Ian J., Rapport, Sarah F., Lee, Janet S., Morris, Alison, McVerry, Bryan J., Kitsios, Georgios D.

Source: In Journal of Critical Care April 2020 56:222-228

Respiratory Tract Dysbiosis Is Associated with Worse Outcomes in Mechanically Ventilated Patients

Authors: Kitsios, Georgios D., Yang, Haopu, Yang, Libing, Qin, Shulin, Fitch, Adam, Wang, Xiao-Hong, Fair, Katherine, Evankovich, John, Bain, William, Shah, Faraaz

Source: American journal of respiratory and critical care medicine. 202(12):1666-1677

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN625660865&indx=1&recIds=ETOCRN625660865

Increased Alternative Complement Pathway Function and Improved Survival during Critical Illness

Authors: Bain, William, Li, Huihua, van der Geest, Rick, Moore, Sara R., Olonisakin, Tolani F., Ahn, Brian, Papke, Erin, Moghbeli, Kaveh, DeSensi, Rebecca, Rapport, Sarah

Source: American journal of respiratory and critical care medicine. 202(2):230-240

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN624295102&indx=1&recIds=ETOCRN624295102

Inflammatory Subphenotype Is Associated with Acute Brain Dysfunction in Mechanically Ventilated Patients.

Authors: Prendergast, Niall T., Franz, Christopher A., Schaefer, Caitlin, Covell, Nicole Bensen, Balish, Kelsey, Onyemekwu, Chukwudi A., Potter, Kelly M., Zhang, Yingze, Bain, William G., Shah, Faraaz A., Nouraie, S. Mehdi, McVerry, Bryan J., Kitsios, Georgios D., Girard, Timothy D.

Source: Annals of the American Thoracic Society; Sep2024, Vol. 21 Issue 9, p1329-1333, 5p

Subject Terms: LUNGS, ADULT respiratory distress syndrome

In Vivo Evolution of a Klebsiella pneumoniae Capsule Defect With wcaJ Mutation Promotes Complement-Mediated Opsonophagocytosis During Recurrent Infection.

Authors: Bain, William^1,2 (AUTHOR), Ahn, Brian³ (AUTHOR), Peñaloza, Hernán F¹ (AUTHOR), McElheny, Christi L⁴ (AUTHOR), Tolman, Nathanial¹ (AUTHOR), van der Geest, Rick¹ (AUTHOR), Gonzalez-Ferrer, Shekina¹ (AUTHOR), Chen, Nathalie⁴ (AUTHOR), An, Xiaojing¹ (AUTHOR), Hosuru, Ria¹ (AUTHOR), Tabary, Mohammadreza¹ (AUTHOR), Papke, Erin¹ (AUTHOR), Kohli, Naina¹ (AUTHOR), Farooq, Nauman⁵ (AUTHOR), Bachman, William⁴ (AUTHOR), Olonisakin, Tolani F¹ (AUTHOR), Xiong, Zeyu¹ (AUTHOR), Griffith, Marissa P⁴ (AUTHOR), Sullivan, Mara⁶ (AUTHOR), Franks, Jonathan⁶ (AUTHOR)

Source: Journal of Infectious Diseases. 7/15/2024, Vol. 230 Issue 1, p209-220. 12p.

Subject Terms: *PHAGOCYTIC function tests, *WHOLE genome sequencing, *ENZYME-linked immunosorbent assay, *LUNG infections, *POLYSACCHARIDES, *KLEBSIELLA infections, *KLEBSIELLA pneumoniae