Synthesis, potent anti-TB activity against M. tuberculosis ATTC 27294, crystal structures and complex formation of selected 2-arylidenehydrazinylbenzothiazole derivatives

Authors: Pinheiro, Alessandra.C., de Souza, Marcus.V.N., Lourenço, Maria.C.S., da Costa, Cristiane F., Baddeley, Thomas C., Low, John N., Wardell, Solange.M.S.V., Wardell, James L.

Source: In Journal of Molecular Structure 15 February 2019 1178:655-668

Crystal structures and Hirshfeld surface analyses of the di- and tri-hydrates of (5α,17E)-17-hydrazonoandrostan-3-ol: Significant differences in the hydrogen bonding patterns and supramolecular arrangements

Authors: Gomes, Ligia R., Low, John N., Turner, Alan B., Baddeley, Thomas C., Wardell, James L.

Source: In Steroids December 2018 140:92-103

Cysteine-Independent Inhibition of Alzheimer's Disease-like Paired Helical Filament Assembly by Leuco-Methylthioninium (LMT)

Authors: Al-Hilaly, Youssra K., Pollack, Saskia J., Rickard, Janet E., Simpson, Michael, Raulin, Ana-Caroline, Baddeley, Thomas, Schellenberger, Pascale, Storey, John M.D., Harrington, Charles R., Wischik, Claude M., Serpell, Louise C.

Source: In Journal of Molecular Biology 19 October 2018 430(21):4119-4131

Crystal structures of four 1-(aryl)-[1,2,4]triazolo[4,3-a]quinoxaline derivatives

Authors: Nogueira, Thais C.M., Pinheiro, Alessandra C., de Souza, Marcus V.N., Baddeley, Thomas C., Wardell, James L., Wardell, Solange M.S.V.

Source: In Journal of Molecular Structure 15 January 2017 1128:579-589

Complex Disposition of Methylthioninium Redox Forms Determines Efficacy in Tau Aggregation Inhibitor Therapy for Alzheimer’s Disease

Authors: Baddeley, Thomas C., McCaffrey, Jennifer, M. D. Storey, John, Cheung, John K.S., Melis, Valeria, Horsley, David, Harrington, Charles R., Wischik, Claude M. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics January 2015 352(1):110-118

Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice.

Authors: Kondak, Constantin, Leith, Michael, Baddeley, Thomas C., Santos, Renato X., Harrington, Charles R., Wischik, Claude M., Riedel, Gernot, Klein, Jochen

Source: International Journal of Molecular Sciences; Jul2023, Vol. 24 Issue 13, p10810, 15p

Subject Terms: OXYGEN consumption, RIVASTIGMINE, MEMANTINE, MITOCHONDRIA, MICRODIALYSIS, ALZHEIMER'S disease

Variation in supramolecular arrangements of hydrazones, o-H2NC6H4CMe[dbnd]NNHC6H4X (X[dbnd]H, o-, m- and p-NO2), derived from o-aminoacetophenone and phenylhydrazines

Authors: Alan Howie, R., Baddeley, Thomas C., Wardell, James L., Wardell, Solange M.S.V.

Source: In Journal of Molecular Structure 8 August 2012 1020:16-22

Phenothiazine diaminium salts and their use

3,7-diamino-10H-phenothiazine salts and their use

Studies of distannylated-1,2-dithiolato compounds: Synthesis of 4,5-bis[(triorganostannylmethyl)thiolato]-1,3-dithiole-2-thiones, (R 3SnCH 2) 2(dmit), and 4,5-bis[(triorganostannylmethyl)thiolato]-1,3-dithiole-2-ones, (R 3SnCH 2) 2(dmio) – Crystal structures of (Ph 3SnCH 2) 2(dmit) and (Ph 3SnCH 2) 2(dmio)

Authors: Baddeley, Thomas C., Bordinhão, Jairo, Comerlato, Nadia M., de Castro Cortás, Laila, Ferreira, Glaucio B., Howie, R. Alan, Wardell, James L.

Source: In Journal of Organometallic Chemistry 2007 692(25):5583-5588

METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS

3,7-DIAMINO-10H-PHINOTHIAZINE SALTS AND THEIR USE

METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS

3,7-DIAMINO-10H-PHENOTHIAZINE SALTS AND THEIR USE

Novel Method of Analysis for the Determination of Residual Formaldehyde by High-Performance Liquid Chromatography.

Authors: Delbono, Vittoria, Larch, Christopher P., Newlands, Katrina Carol, Rhydderch, Shona, Baddeley, Thomas Craven, Storey, John Mervyn David

Source: International Journal of Analytical Chemistry; 9/6/2022, p1-10, 10p

Subject Terms: HIGH performance liquid chromatography, FORMALDEHYDE, CURRENT good manufacturing practices, CARBONYL group, ALKYLATING agents

Geographic Terms: UNITED Kingdom

A homologous series of eunicellin-based diterpenes from Acalycigorgia sp. characterised by tandem mass spectrometry

Authors: Kyeremeh, Kwaku, Baddeley, Thomas C., Stein, Bridget K., Jaspars, Marcel

Source: In Tetrahedron 2006 62(37):8770-8778

HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine.

Authors: Santos, Renato X., Melis, Valeria, Goatman, Elizabeth A., Leith, Michael, Baddeley, Thomas C., Storey, John M. D., Riedel, Gernot, Wischik, Claude M., Harrington, Charles R.

Source: Biomedicines; Apr2022, Vol. 10 Issue 4, p867, 21p

Subject Terms: RIVASTIGMINE, BIOENERGETICS, LABORATORY mice, CHOLINESTERASE inhibitors, CEREBRAL atrophy

Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia.

Authors: Shiells, Helen, Schelter, Bjoern O, Bentham, Peter, Baddeley, Thomas C, Rubino, Christopher M, Ganesan, Harish, Hammel, Jeffrey, Vuksanovic, Vesna, Staff, Roger T, Murray, Alison D, Bracoud, Luc, Wischik, Damon J, Riedel, Gernot, Gauthier, Serge, Jia, Jianping, Moebius, Hans J, Hardlund, Jiri, Kipps, Christopher M, Kook, Karin, Storey, John M D

Source: Journal of Alzheimer's Disease; 2020, Vol. 75 Issue 2, p501-519, 19p

Subject Terms: BRAIN, DISEASE progression, RESEARCH, RESEARCH methodology, MAGNETIC resonance imaging, MEDICAL cooperation, EVALUATION research, ATROPHY, TREATMENT effectiveness, COMPARATIVE studies, RANDOMIZED controlled trials, DOSE-effect relationship in pharmacology, BLIND experiment, QUESTIONNAIRES, STATISTICAL sampling, FRONTOTEMPORAL dementia, METHYLENE blue, PHARMACODYNAMICS

Supramolecular structures of substituted a,a'-trehalose derivatives.

Authors: Baddeley, Thomas C.¹, Davidson, Lain G.², Glidewell, Christopher³ cg@st-andrews.ac.uk, Low, John N.¹, Skakle, Janet M. S.¹, Wardella, James L.^1,4

Source: Acta Crystallographica: Section B (Wiley-Blackwell). Aug2004, Vol. 60 Issue 4, p461-471. 11p. 18 Diagrams, 3 Charts.

Subject Terms: *HYDROGEN bonding, *PHYSICAL & theoretical chemistry, *CRYSTALS, *CRYSTALLOGRAPHY, *PHYSICAL sciences

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