A transcriptional atlas of gut-innervating neurons reveals activation of interferon signaling and ferroptosis during intestinal inflammation

Authors: Atreya, Imke, Atreya, Raja, Bacher, Petra, Becker, Christoph, Bojarski, Christian, Britzen-Laurent, Nathalie, Bosch-Voskens, Caroline, Chang, Hyun-Dong, Diefenbach, Andreas, Günther, Claudia, Hegazy, Ahmed N., Hildner, Kai, Klose, Christoph S.N., Koop, Kristina, Krug, Susanne, Kühl, Anja A., Leppkes, Moritz, López-Posadas, Rocío, Ludwig, Leif S.-H., Neufert, Clemens, Neurath, Markus, Patankar, Jay V., Prüß, Magdalena, Radbruch, Andreas, Romagnani, Chiara, Ronchi, Francesca, Sanders, Ashley, Scheffold, Alexander, Schulzke, Jörg-Dieter, Schumann, Michael, Schürmann, Sebastian, Siegmund, Britta, Stürzl, Michael, Trajanoski, Zlatko, Triantafyllopoulou, Antigoni, Waldner, Maximilian, Weidinger, Carl, Wirtz, Stefan, Zundler, Sebastian, Forster, Patrycja M. ^{1, 12}, Jakob, Manuel O. ^{1, 2, 12}, Yusuf, Dilmurat ³, Bubeck, Marvin ^{4, 5}, Limberger, Heidi ^{4, 5}, Luo, Yanjiang ^{6, 7}, Thieme, Paula ¹, Polici, Alexandra ¹, Sterczyk, Nele ¹, Boulekou, Sotiria ¹, Bartel, Laura ¹, Cosovanu, Catalina ¹, Witkowski, Mario ^{1, 8, 9}, González-Acera, Miguel ^{4, 5}, Backofen, Rolf ^{3, 11}

Source: In Neuron 7 May 2025 113(9):1333-1351

TIFA renders intestinal epithelial cells responsive to microbial ADP-heptose and drives colonic inflammation in mice

Authors: Atreya, Imke ^h, Atreya, Raja ^h, Bacher, Petra ^{i, j}, Becker, Christoph ^h, Bojarski, Christian ^k, Britzen-Laurent, Nathalie ^l, Bosch-Voskens, Caroline ^m, Chang, Hyun-Dong ⁿ, Diefenbach, Andreas ^o, Günther, Claudia ^h, Hegazy, Ahmed N. ^k, Hildner, Kai ^h, Klose, Christoph S.N. ^o, Koop, Kristina ^h, Krug, Susanne ^k, Kühl, Anja A. ^k, Leppkes, Moritz ^h, López-Posadas, Rocío ^h, Ludwig, Leif S.-H. ^{p, q}, Neufert, Clemens ^h, Neurath, Markus ^h, Patankar, Jay V. ^h, Plattner, Christina ^r, Prüß, Magdalena ^h, Radbruch, Andreas ⁿ, Romagnani, Chiara ^s, Ronchi, Francesca ^o, Sanders, Ashley ^{k, q}, Scheffold, Alexander ⁱ, Schulzke, Jörg-Dieter ^k, Schumann, Michael ^k, Schürmann, Sebastian ^t, Siegmund, Britta ^k, Stürzl, Michael ^l, Trajanoski, Zlatko ^r, Triantafyllopoulou, Antigoni ⁿ, Waldner, Maximilian ^h, Weidinger, Carl ^k, Wirtz, Stefan ^h, Zundler, Sebastian ^h, Erkert, Lena ^a, Ruder, Barbara ^{a, 1}, Kabisch, Melanie ^a, Gamez Belmonte, Reyes ^a, Gonzalez Acera, Miguel ^a, Schödel, Lena ^a, Chiriac, Mircea T. ^a, Cineus, Roodline ^c, Gnafakis, Stylianos ^d, Leupold, Tamara ^a, Thoma, Oana-Maria ^{a, b}, Stolzer, Iris ^a, Taut, Astrid ^a, Thonn, Veronika ^a, Basic, Marijana ^g, Bleich, André ^g, Neurath, Markus F. ^{a, b}

Source: In Mucosal Immunology April 2025 18(2):453-466

Engineering Therapeutic Regulatory T Cells to Overexpress G Protein-Coupled Receptor 15 Improves Functional Fitness for In Vivo Gut Homing

Authors: Atreya, Imke ¹, Atreya, Raja ¹, Bacher, Petra ^{2, 3}, Becker, Christoph ¹, Bojarski, Christian ⁴, Britzen-Laurent, Nathalie ¹, Bosch-Voskens, Caroline ¹, Chang, Hyun-Dong ⁵, Diefenbach, Andreas ⁶, Günther, Claudia ¹, Hegazy, Ahmed N. ⁴, Hildner, Kai ¹, Klose, Christoph S.N. ⁶, Koop, Kristina ¹, Krug, Susanne ⁴, Kühl, Anja A. ⁴, Leppkes, Moritz ¹, López-Posadas, Rocío ¹, Ludwig, Leif S.-H. ⁷, Neufert, Clemens ¹, Neurath, Markus ¹, Patankar, Jay V. ¹, Plattner, Christina ⁹, Prüß, Magdalena ³, Radbruch, Andreas ⁵, Romagnani, Chiara ³, Ronchi, Francesca ⁶, Sanders, Ashley ^{4, 8}, Scheffold, Alexander ², Schulzke, Jörg-Dieter ⁴, Schumann, Michael ⁴, Schürmann, Sebastian ¹, Siegmund, Britta ⁴, Stürzl, Michael ¹, Trajanoski, Zlatko ⁹, Triantafyllopoulou, Antigoni ^{5, 10}, Waldner, Maximilian ¹, Weidinger, Carl ⁴, Wirtz, Stefan ¹, Zundler, Sebastian ¹, Müller, Tanja M., Liu, Li-Juan, Wiesinger, Manuel, Neurath, Markus F., Voskens, Caroline J. ^§

Source: In Gastroenterology February 2025 168(2):389-392

Multimodal Profiling of Peripheral Blood Identifies Proliferating Circulating Effector CD4+ T Cells as Predictors for Response to Integrin α4β7–Blocking Therapy in Inflammatory Bowel Disease

Authors: Atreya, Imke ¹, Atreya, Raja ¹, Bacher, Petra ^{2, 3}, Becker, Christoph ¹, Bojarski, Christian ⁴, Britzen-Laurent, Nathalie ¹, Bosch-Voskens, Caroline ¹, Chang, Hyun-Dong ⁵, Diefenbach, Andreas ⁶, Günther, Claudia ¹, Hegazy, Ahmed N. ⁴, Hildner, Kai ¹, Klose, Christoph S.N. ⁶, Koop, Kristina ¹, Krug, Susanne ⁴, Kühl, Anja A. ⁷, Leppkes, Moritz ¹, López-Posadas, Rocío ¹, Ludwig, Leif S-H. ^{8, 9}, Neufert, Clemens ¹, Neurath, Markus ¹, Patankar, Jay ¹, Prüß, Magdalena ³, Radbruch, Andreas ⁵, Romagnani, Chiara ³, Ronchi, Francesca ⁶, Sanders, Ashley ^{4, 9}, Scheffold, Alexander ², Schulzke, Jörg-Dieter ⁴, Schumann, Michael ⁴, Schürmann, Sebastian ¹, Siegmund, Britta ⁴, Stürzl, Michael ¹, Trajanoski, Zlatko ¹⁰, Triantafyllopoulou, Antigoni ^{5, 11}, Waldner, Maximilian ¹, Weidinger, Carl ⁴, Wirtz, Stefan ¹, Zundler, Sebastian ¹, Horn, Veronika ^{1, 2, ∗}, Cancino, Camila A. ^{1, 2, ∗}, Steinheuer, Lisa M. ^{3, ∗}, Obermayer, Benedikt ^{4, ∗}, Fritz, Konstantin ^{1, 2}, Nguyen, Anke L. ^{1, 5}, Juhran, Kim Susan ^{1, 2}, Plattner, Christina ⁶, Bösel, Diana ^{1, 2}, Oldenburg, Lotte ⁷, Burns, Marie ², Schulz, Axel Ronald ², Saliutina, Mariia ^{1, 2}, Mantzivi, Eleni ¹, Lissner, Donata ¹, Conrad, Thomas ^{8, 9}, Mashreghi, Mir-Farzin ^{2, 10}, Sonnenberg, Elena ¹, Haag, Lea-Maxie ¹, Beule, Dieter ⁴, Flatz, Lukas ^{12, 13}, D’Haens, Geert ⁷, Mei, Henrik E. ², Thurley, Kevin ^{2, 3, ∗}

Source: In Gastroenterology February 2025 168(2):327-343

Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases

Authors: Saggau, Carina ^{1, 30}, Bacher, Petra ^{1, 2, 30}, Esser, Daniela ³, Rasa, Mahdi ^{1, 4}, Meise, Silja ¹, Mohr, Nicola ¹, Kohlstedt, Nora ¹, Hutloff, Andreas ^{1, 2}, Schacht, Sarah-Sophie ¹, Dargvainiene, Justina ³, Martini, Gabriela Rios ^{1, 2}, Stürner, Klarissa H. ^{3, 5}, Schröder, Ina ³, Markewitz, Robert ³, Hartl, Johannes ⁶, Hastermann, Maria ⁷, Duchow, Ankelien ⁷, Schindler, Patrick ⁷, Becker, Mareike ^{8, 9}, Bautista, Carolin ¹⁰, Gottfreund, Judith ¹¹, Walter, Jörn ¹¹, Polansky, Julia K. ^{12, 13}, Yang, Mingxing ¹², Naghavian, Reza ^{14, 15}, Wendorff, Mareike ^{2, 16}, Schuster, Ev-Marie ¹⁷, Dahl, Andreas ¹⁸, Petzold, Andreas ¹⁸, Reinhardt, Susanne ¹⁸, Franke, Andre ², Wieczorek, Marek ¹⁹, Henschel, Lea ¹⁹, Berger, Daniel ¹⁹, Heine, Guido ²⁰, Holtsche, Maike ²¹, Häußler, Vivien ²², Peters, Christian ¹, Schmidt, Enno ²¹, Fillatreau, Simon ^{23, 24, 25}, Busch, Dirk H. ²⁶, Wandinger, Klaus-Peter ³, Schober, Kilian ^{17, 27}, Martin, Roland ^{14, 15, 28, 29}, Paul, Friedemann ^{7, 30}, Leypoldt, Frank ^{3, 5, 30}, Scheffold, Alexander ^{1, 30, 31, ∗}

Source: In Immunity 8 October 2024 57(10):2416-2432

Primary and secondary anti-viral response captured by the dynamics and phenotype of individual T cell clones

Authors: Minervina, Anastasia A., Pogorelyy, Mikhail V., Komech, Ekaterina A., Karnaukhov, Vadim K., Bacher, Petra, Rosati, Elisa, Franke, Andre, Chudakov, Dmitriy M., Mamedov, Ilgar Z., Lebedev, Yuri B., Mora, Thierry, Walczak, Aleksandra M.

Source: eLife 2020;9:e53704 (2020)

Subject Terms: Quantitative Biology - Genomics

Access URL: http://arxiv.org/abs/1910.11928

Candida albicans-specific Th17 cell-mediated response contributes to alcohol-associated liver disease

Authors: Zeng, Suling, Rosati, Elisa, Saggau, Carina, Messner, Berith, Chu, Huikuan, Duan, Yi, Hartmann, Phillipp, Wang, Yanhan, Ma, Shengyun, Huang, Wendy Jia Men, Lee, Jihyung, Lee, Sung Min, Carvalho-Gontijo, Raquel, Zhang, Vivian, Hoffmann, Joseph P., Kolls, Jay K., Raz, Eyal, Brenner, David A., Kisseleva, Tatiana, LeibundGut-Landmann, Salomé, Bacher, Petra, Stärkel, Peter, Schnabl, Bernd

Source: In Cell Host & Microbe 8 March 2023 31(3):389-404

A Notch/STAT3-driven Blimp-1/c-Maf-dependent molecular switch induces IL-10 expression in human CD4+ T cells and is defective in Crohn´s disease patients

Authors: Ahlers, Jonas, Mantei, Andrej, Lozza, Laura, Stäber, Manuela, Heinrich, Frederik, Bacher, Petra, Hohnstein, Thordis, Menzel, Lutz, Yüz, Simge G., Alvarez-Simon, Daniel, Bickenbach, Anne Rieke, Weidinger, Carl, Mockel-Tenbrinck, Nadine, Kühl, Anja A., Siegmund, Britta, Maul, Jochen, Neumann, Christian, Scheffold, Alexander

Source: In Mucosal Immunology March 2022 15(3):480-490

Nuclear antigen–reactive CD4+ T cells expand in active systemic lupus erythematosus, produce effector cytokines, and invade the kidneys

Authors: Abdirama, Dimas, Tesch, Sebastian, Grießbach, Anna-Sophie, von Spee-Mayer, Caroline, Humrich, Jens Y., Stervbo, Ulrik, Babel, Nina, Meisel, Christian, Alexander, Tobias, Biesen, Robert, Bacher, Petra, Scheffold, Alexander, Eckardt, Kai-Uwe, Hiepe, Falk, Radbruch, Andreas, Burmester, Gerd-Rüdiger, Riemekasten, Gabriela, Enghard, Philipp

Source: In Kidney International January 2021 99(1):238-246

Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19

Authors: Banovich, Nicholas E., Desai, Tushar, Eickelberg, Oliver, Haniffa, Muzlifa, Horvath, Peter, Kropski, Jonathan A., Lafyatis, Robert, Lundeberg, Joakim, Meyer, Kerstin, Nawijn, Martijn C., Nikolic, Marko, Ordovas Montanes, Jose, Pe’er, Dana, Tata, Purushothama Rao, Rawlins, Emma, Regev, Aviv, Reyfman, Paul, Samakovlis, Christos, Schultze, Joachim, Shalek, Alex, Shepherd, Douglas, Spence, Jason, Teichmann, Sarah, Theis, Fabian, Tsankov, Alexander, van den Berge, Maarten, von Papen, Michael, Whitsett, Jeffrey, Zaragosi, Laure Emmanuelle, Angelov, Angel, Bals, Robert, Bartholomäus, Alexander, Becker, Anke, Bezdan, Daniela, Bonifacio, Ezio, Bork, Peer, Clavel, Thomas, Colme-Tatche, Maria, Diefenbach, Andreas, Dilthey, Alexander, Fischer, Nicole, Förstner, Konrad, Frick, Julia-Stefanie, Gagneur, Julien, Goesmann, Alexander, Hain, Torsten, Hummel, Michael, Janssen, Stefan, Kalinowski, Jörn, Kallies, René, Kehr, Birte, Keller, Andreas, Kim-Hellmuth, Sarah, Klein, Christoph, Kohlbacher, Oliver, Korbel, Jan O., Kurth, Ingo, Landthaler, Markus, Li, Yang, Ludwig, Kerstin, Makarewicz, Oliwia, Marz, Manja, McHardy, Alice, Mertes, Christian, Nöthen, Markus, Nürnberg, Peter, Ohler, Uwe, Ossowski, Stephan, Overmann, Jörg, Peter, Silke, Pfeffer, Klaus, Poetsch, Anna R., Pühler, Alfred, Rajewsky, Niklaus, Ralser, Markus, Rieß, Olaf, Ripke, Stephan, Nunes da Rocha, Ulisses, Rosenstiel, Philip, Saliba, Antoine-Emmanuel, Sander, Leif Erik, Sawitzki, Birgit, Schiffer, Philipp, Schulte, Eva-Christina, Schultze, Joachim L., Sczyrba, Alexander, Stegle, Oliver, Stoye, Jens, Vehreschild, Janne, Vogel, Jörg, von Kleist, Max, Walker, Andreas, Walter, Jörn, Wieczorek, Dagmar, Ziebuhr, John, Bernardes, Joana P., Mishra, Neha, Tran, Florian, Bahmer, Thomas, Best, Lena, Blase, Johanna I., Bordoni, Dora, Franzenburg, Jeanette, Geisen, Ulf, Josephs-Spaulding, Jonathan, Köhler, Philipp, Künstner, Axel, Rosati, Elisa, Aschenbrenner, Anna C., Bacher, Petra, Baran, Nathan, Boysen, Teide, Brandt, Burkhard, Bruse, Niklas, Dörr, Jonathan, Dräger, Andreas, Elke, Gunnar, Ellinghaus, David, Fischer, Julia, Forster, Michael, Franke, Andre, Franzenburg, Sören, Frey, Norbert, Friedrichs, Anette, Fuß, Janina, Glück, Andreas, Hamm, Jacob, Hinrichsen, Finn, Hoeppner, Marc P., Imm, Simon, Junker, Ralf, Kaiser, Sina, Kan, Ying H., Knoll, Rainer, Lange, Christoph, Laue, Georg, Lier, Clemens, Lindner, Matthias, Marinos, Georgios, Markewitz, Robert, Nattermann, Jacob, Noth, Rainer, Pickkers, Peter, Rabe, Klaus F., Renz, Alina, Röcken, Christoph, Rupp, Jan, Schaffarzyk, Annika, Scheffold, Alexander, Schulte-Schrepping, Jonas, Schunk, Domagoj, Skowasch, Dirk, Ulas, Thomas, Wandinger, Klaus-Peter, Wittig, Michael, Zimmermann, Johannes, Busch, Hauke, Hoyer, Bimba F., Kaleta, Christoph, Heyckendorf, Jan, Kox, Matthijs, Rybniker, Jan, Schreiber, Stefan

Source: In Immunity 15 December 2020 53(6):1296-1314

Low-Avidity CD4+ T Cell Responses to SARS-CoV-2 in Unexposed Individuals and Humans with Severe COVID-19

Authors: Bacher, Petra, Rosati, Elisa, Esser, Daniela, Martini, Gabriela Rios, Saggau, Carina, Schiminsky, Esther, Dargvainiene, Justina, Schröder, Ina, Wieters, Imke, Khodamoradi, Yascha, Eberhardt, Fabian, Vehreschild, Maria J.G.T., Neb, Holger, Sonntagbauer, Michael, Conrad, Claudio, Tran, Florian, Rosenstiel, Philip, Markewitz, Robert, Wandinger, Klaus-Peter, Augustin, Max, Rybniker, Jan, Kochanek, Matthias, Leypoldt, Frank, Cornely, Oliver A., Koehler, Philipp, Franke, Andre, Scheffold, Alexander

Source: In Immunity 15 December 2020 53(6):1258-1271

T cell immunity to commensal fungi

Authors: Scheffold, Alexander, Bacher, Petra, LeibundGut-Landmann, Salomé

Source: In Current Opinion in Microbiology December 2020 58:116-123

Anti-fungal T cell responses in the lung and modulation by the gut-lung axis

Authors: Scheffold, Alexander, Bacher, Petra

Source: In Current Opinion in Microbiology August 2020 56:67-73

Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans

Authors: Bacher, Petra, Hohnstein, Thordis, Beerbaum, Eva, Röcker, Marie, Blango, Matthew G., Kaufmann, Svenja, Röhmel, Jobst, Eschenhagen, Patience, Grehn, Claudia, Seidel, Kathrin, Rickerts, Volker, Lozza, Laura, Stervbo, Ulrik, Nienen, Mikalai, Babel, Nina, Milleck, Julia, Assenmacher, Mario, Cornely, Oliver A., Ziegler, Maren, Wisplinghoff, Hilmar, Heine, Guido, Worm, Margitta, Siegmund, Britta, Maul, Jochen, Creutz, Petra, Tabeling, Christoph, Ruwwe-Glösenkamp, Christoph, Sander, Leif E., Knosalla, Christoph, Brunke, Sascha, Hube, Bernhard, Kniemeyer, Olaf, Brakhage, Axel A., Schwarz, Carsten, Scheffold, Alexander

Source: In Cell 7 March 2019 176(6):1340-1355

Focus on fungi.

Authors: Iliev, Iliyan D.¹, iliev@med.cornell.edu, Brown, Gordon D.², Bacher, Petra³, Gaffen, Sarah L.⁴, Heitman, Joseph⁵, Klein, Bruce S.⁶, Lionakis, Michail S.⁷

Source: Cell (0092-8674); Sep2024, Vol. 187 Issue 19, p5121-5127, 7p

The effect of regulatory T cells on tolerance to airborne allergens and allergen immunotherapy

Authors: Bacher, Petra, Scheffold, Alexander

Source: In The Journal of Allergy and Clinical Immunology December 2018 142(6):1697-1709

Antigen-specific regulatory T-cell responses against aeroantigens and their role in allergy

Authors: Bacher, Petra, Scheffold, Alexander

Source: In Mucosal Immunology November 2018 11(6):1537-1550

Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans

Authors: Bacher, Petra, Heinrich, Frederik, Stervbo, Ulrik, Nienen, Mikalai, Vahldieck, Marco, Iwert, Christina, Vogt, Katrin, Kollet, Jutta, Babel, Nina, Sawitzki, Birgit, Schwarz, Carsten, Bereswill, Stefan, Heimesaat, Markus M., Heine, Guido, Gadermaier, Gabriele, Asam, Claudia, Assenmacher, Mario, Kniemeyer, Olaf, Brakhage, Axel A., Ferreira, Fátima, Wallner, Michael, Worm, Margitta, Scheffold, Alexander

Source: In Cell 3 November 2016 167(4):1067-1078

Veränderte T-Zell-Reaktion gegen Hefepilze bei chronischer Darmentzündung. (German)

Authors: Martini, Gabriela Rios, Bacher, Petra

Source: BioSpektrum; Mar2024, Vol. 30 Issue 2, p154-157, 4p

Clinical-scale isolation of the total Aspergillus fumigatus–reactive T–helper cell repertoire for adoptive transfer

Authors: Bacher, Petra, Jochheim-Richter, Andrea, Mockel-Tenbrink, Nadine, Kniemeyer, Olaf, Wingenfeld, Eva, Alex, Regina, Ortigao, Alice, Karpova, Darja, Lehrnbecher, Thomas, Ullmann, Andrew J., Hamprecht, Axel, Cornely, Oliver, Brakhage, Axel A., Assenmacher, Mario, Bonig, Halvard, Scheffold, Alexander

Source: In Cytotherapy October 2015 17(10):1396-1405