Myeloid-T cell interplay and cell state transitions associated with checkpoint inhibitor response in melanoma

Authors: Schlenker, Ramona, Schwalie, Petra C., Dettling, Steffen, Huesser, Tamara, Irmisch, Anja, Mariani, Marisa, Martínez Gómez, Julia M., Ribeiro, Alison, Limani, Florian, Herter, Sylvia, Yángüez, Emilio, Hoves, Sabine, Somandin, Jitka, Siebourg-Polster, Juliane, Kam-Thong, Tony, de Matos, Ines Grazina, Umana, Pablo, Dummer, Reinhard, Levesque, Mitchell P., Bacac, Marina

Source: In Med 12 July 2024 5(7):759-779

CD19-CD28: an affinity-optimized CD28 agonist for combination with glofitamab (CD20-TCB) as off-the-shelf immunotherapy

Authors: Sam, Johannes, Hofer, Thomas, Kuettel, Christine, Claus, Christina, Thom, Jenny, Herter, Sylvia, Georges, Guy, Korfi, Koorosh, Lechmann, Martin, Eigenmann, Miro Julian, Marbach, Daniel, Jamois, Candice, Lechner, Katharina, Krishnan, Sreenath M., Gaillard, Brenda, Marinho, Joana, Kronenberg, Sven, Kunz, Leo, Wilson, Sabine, Briner, Stefanie, Gebhardt, Samuel, Varol, Ahmet, Appelt, Birte, Nicolini, Valeria, Speziale, Dario, Bez, Miriam, Bommer, Esther, Eckmann, Jan, Hage, Carina, Limani, Florian, Jenni, Silvia, Schoenle, Anne, Le Clech, Marine, Vallier, Jean-Baptiste Pierre, Colombetti, Sara, Bacac, Marina, Gasser, Stephan, Klein, Christian, Umaña, Pablo

Source: In Blood 23 May 2024 143(21):2152-2165

The target antigen determines the mechanism of acquired resistance to T cell-based therapies

Authors: Martínez-Sabadell, Alex, Morancho, Beatriz, Rius Ruiz, Irene, Román Alonso, Macarena, Ovejero Romero, Pablo, Escorihuela, Marta, Chicote, Irene, Palmer, Hector G., Nonell, Lara, Alemany-Chavarria, Mercè, Klein, Christian, Bacac, Marina, Arribas, Joaquín, Arenas, Enrique J.

Source: In Cell Reports 18 October 2022 41(3)

Novel in Vivo and in Vitro Pharmacokinetic/Pharmacodynamic-Based Human Starting Dose Selection for Glofitamab

Authors: Frances, Nicolas, Bacac, Marina, Bray-French, Katharine, Christen, François, Hinton, Heather, Husar, Elisabeth, Quackenbush, Elizabeth, Schäfer, Martin, Schick, Eginhard, Vyver, Arthur Van De, Richter, Wolfgang F.

Source: In Journal of Pharmaceutical Sciences April 2022 111(4):1208-1218

Pharmacodynamics and molecular correlates of response to glofitamab in relapsed/refractory non-Hodgkin lymphoma

Authors: Bröske, Ann-Marie E. ^*, Korfi, Koorosh, Belousov, Anton, Wilson, Sabine, Ooi, Chia-Huey, Bolen, Christopher R., Canamero, Marta, Alcaide, Enrique Gomez, James, Ian, Piccione, Emily C., Carlile, David J., Dimier, Natalie, Umaña, Pablo, Bacac, Marina, Weisser, Martin, Dickinson, Michael

Source: In Blood Advances 8 February 2022 6(3):1025-1037

Rationale for combining tyrosine kinase inhibitors and T cell redirecting antibodies to mitigate cytokine release syndrome (CRS)

Authors: Leclercq-cohen, Gabrielle, Bacac, Marina, Klein, Christian

Source: Expert opinion on biological therapy. 23(3):223-225

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100177510203.0x000001&indx=1&recIds=ETOCvdc_100177510203.0x000001

Establishing standardized immune phenotyping of metastatic melanoma by digital pathology

Authors: Sobottka, Bettina ¹, Nowak, Marta ¹, Frei, Anja Laura ¹, Haberecker, Martina ¹, Merki, Samuel ¹, Levesque, Mitchell P. ², Dummer, Reinhard ², Moch, Holger ¹, Koelzer, Viktor Hendrik ¹, Aebersold, Rudolf ³, Ak, Melike ⁴, Al-Quaddoomi, Faisal S. ^{5, 6}, Albinus, Jonas ⁷, Alborelli, Ilaria ⁸, Andani, Sonali ^{6, 9, 10, 11}, Attinger, Per-Olof ¹², Bacac, Marina ¹³, Baumhoer, Daniel ⁸, Beck-Schimmer, Beatrice ¹⁴, Beerenwinkel, Niko ^{6, 15}, Beisel, Christian ¹⁵, Bernasconi, Lara ¹⁶, Bertolini, Anne ^{5, 6}, Bodenmiller, Bernd ^{17, 18}, Bonilla, Ximena ^{6, 9, 10}, Casanova, Ruben ¹⁸, Chevrier, Stéphane ¹⁸, Chicherova, Natalia ^{5, 6}, D'Costa, Maya ¹², Danenberg, Esther ¹⁹, Davidson, Natalie ^{6, 9, 10}, Drăganmoch, Monica-Andreea ¹⁵, Engler, Stefanie ¹⁸, Erkens, Martin ²⁰, Eschbach, Katja ¹⁵, Esposito, Cinzia ¹⁹, Fedier, André ²¹, Ferreira, Pedro ¹⁵, Ficek, Joanna ^{6, 9, 10}, Frey, Bruno ²², Goetze, Sandra ⁷, Grob, Linda ^{5, 6}, Gut, Gabriele ¹⁹, Günther, Detlef ²³, Haeuptle, Pirmin ²⁴, Heinzelmann-Schwarz, Viola ^{21, 25}, Herter, Sylvia ¹³, Holtackers, Rene ¹⁹, Huesser, Tamara ¹³, Irmisch, Anja ⁴, Jacob, Francis ²¹, Jacobs, Andrea ¹⁸, Jaeger, Tim M. ¹², Jahn, Katharina ¹⁵, James, Alva R. ^{6, 9, 10}, Jermann, Philip M. ⁸, Kahles, André ^{6, 9, 10}, Kahraman, Abdullah ^{6, 11}, Kuebler, Werner ²⁶, Kuipers, Jack ^{6, 15}, Kunze, Christian P. ²⁷, Kurzeder, Christian ²⁸, Lehmann, Kjong-Van ^{6, 9, 10}, Lugert, Sebastian ¹², Maass, Gerd ²², Manz, Markus G. ²⁹, Markolin, Philipp ^{6, 9, 10}, Mena, Julien ³, Menzel, Ulrike ¹⁵, Metzler, Julian M. ³⁰, Miglino, Nicola ²⁴, Milani, Emanuela S. ⁷, Muenst, Simone ⁸, Murri, Riccardo ³¹, Ng, Charlotte K.Y. ^{8, 32}, Nicolet, Stefan ⁸, Pedrioli, Patrick G.A. ³³, Pelkmans, Lucas ¹⁹, Piscuoglio, Salvatore ^{8, 21}, Prummer, Michael ^{5, 6}, Ritter, Mathilde ²¹, Rommel, Christian ²⁰, Rosano-González, María L. ^{5, 6}, Rätsch, Gunnar ^{6, 9, 10, 33}, Santacroce, Natascha ¹⁵, del Castillo, Jacobo Sarabia ¹⁹, Schlenker, Ramona ³⁴, Schwalie, Petra C. ²⁰, Schwan, Severin ¹², Schär, Tobias ¹⁵, Senti, Gabriela ¹⁶, Singer, Franziska ^{5, 6}, Sivapatham, Sujana ¹⁸, Snijder, Berend ^{3, 6}, Sreedharan, Vipin T. ^{5, 6}, Stark, Stefan ^{6, 9, 10}, Stekhoven, Daniel J. ^{5, 6}, Theocharides, Alexandre P.A. ²⁹, Thomas, Tinu M. ^{6, 9, 10}, Tolnay, Markus ⁸, Tosevski, Vinko ¹³, Toussaint, Nora C. ^{5, 6}, Tuncel, Mustafa A. ^{6, 15}, Tusup, Marina ⁴, Van Drogen, Audrey ⁷, Vetter, Marcus ³⁵, Vlajnic, Tatjana ⁸, Weber, Sandra ¹⁶, Weber, Walter P. ³⁶, Wegmann, Rebekka ³, Weller, Michael ³⁷, Wendt, Fabian ⁷, Wey, Norbert ¹¹, Wicki, Andreas ^{29, 38}, Wildschut, Mattheus HE ^{3, 29}, Wollscheid, Bernd ⁷, Yu, Shuqing ^{5, 6}, Ziegler, Johanna ⁴, Zimmermann, Marc ^{6, 9, 10}, Zoche, Martin ¹¹, Zuend, Gregor ³⁹

Source: In Laboratory Investigation December 2021 101(12):1561-1570

Engineering therapeutic bispecific antibodies using CrossMab technology

Authors: Klein, Christian, Schaefer, Wolfgang, Regula, Joerg T., Dumontet, Charles, Brinkmann, Ulrich, Bacac, Marina, Umaña, Pablo

Source: In Methods 1 February 2019 154:21-31

An Immune Atlas of Clear Cell Renal Cell Carcinoma

Authors: Chevrier, Stéphane, Levine, Jacob Harrison, Zanotelli, Vito Riccardo Tomaso, Silina, Karina, Schulz, Daniel, Bacac, Marina, Ries, Carola Hermine, Ailles, Laurie, Jewett, Michael Alexander Spencer, Moch, Holger, van den Broek, Maries, Beisel, Christian, Stadler, Michael Beda, Gedye, Craig, Reis, Bernhard, Pe’er, Dana, Bodenmiller, Bernd

Source: In Cell 4 May 2017 169(4):736-749

Novel strategies for the mitigation of cytokine release syndrome induced by T cell engaging therapies with a focus on the use of kinase inhibitors

Authors: Leclercq, Gabrielle, Steinhoff, Nathalie, Haegel, Hélène, De Marco, Donata, Bacac, Marina, Klein, Christian

Source: Oncoimmunology. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168533206.0x000001&indx=1&recIds=ETOCvdc_100168533206.0x000001

Dissecting the mechanism of cytokine release induced by T-cell engagers highlights the contribution of neutrophils

Authors: Leclercq, Gabrielle, Servera, Llucia Alberti, Danilin, Sabrina, Challier, John, Steinhoff, Nathalie, Bossen, Claudia, Odermatt, Alex, Nicolini, Valeria, Umaña, Pablo, Klein, Christian, Bacac, Marina, Giusti, Anna-Maria, Schneider, Anneliese, Haegel, Hélène

Source: Oncoimmunology. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168532736.0x000001&indx=1&recIds=ETOCvdc_100168532736.0x000001

Target Expression, Generation, Preclinical Activity, and Pharmacokinetics of the BCMA-T Cell Bispecific Antibody EM801 for Multiple Myeloma Treatment

Authors: Seckinger, Anja, Delgado, Jose Antonio, Moser, Samuel, Moreno, Laura, Neuber, Brigitte, Grab, Anna, Lipp, Susanne, Merino, Juana, Prosper, Felipe, Emde, Martina, Delon, Camille, Latzko, Melanie, Gianotti, Reto, Lüoend, Remo, Murr, Ramona, Hosse, Ralf J., Harnisch, Lydia Jasmin, Bacac, Marina, Fauti, Tanja, Klein, Christian, Zabaleta, Aintzane, Hillengass, Jens, Cavalcanti-Adam, Elisabetta Ada, Ho, Anthony D., Hundemer, Michael, San Miguel, Jesus F., Strein, Klaus, Umaña, Pablo, Hose, Dirk, Paiva, Bruno, Vu, Minh Diem

Source: In Cancer Cell 13 March 2017 31(3):396-410

The PI3Kδ-Selective Inhibitor Idelalisib Minimally Interferes with Immune Effector Function Mediated by Rituximab or Obinutuzumab and Significantly Augments B Cell Depletion In Vivo

Authors: Palazzo, Adam, Herter, Sylvia, Grosmaire, Laura, Jones, Randy, Frey, Christian R., Limani, Florian, Bacac, Marina, Umana, Pablo, Oldham, Robert J., Marshall, Michael J. E.

Source: Journal of immunology. 200(7):2304-2312

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN615207390&indx=1&recIds=ETOCRN615207390

Ibrutinib-based therapy reinvigorates CD8+ T cells compared to chemoimmunotherapy: immune monitoring from the E1912 trial

Authors: Papazoglou, Despoina, Wang, Xin Victoria, Shanafelt, Tait D., Lesnick, Connie E., Ioannou, Nikolaos, De Rossi, Giulia, Herter, Sylvia, Bacac, Marina, Klein, Christian, Tallman, Martin S., Kay, Neil E., Ramsay, Alan G.

Source: In Blood 4 January 2024 143(1):57-63

Analysis of off-tumour toxicities of T-cell-engaging bispecific antibodies via donor-matched intestinal organoids and tumouroids.

Authors: Harter, Marius F., Recaldin, Timothy, Gerard, Regine, Avignon, Blandine, Bollen, Yannik, Esposito, Cinzia, Guja-Jarosz, Karolina, Kromer, Kristina, Filip, Adrian, Aubert, Julien, Schneider, Anneliese, Bacac, Marina, Bscheider, Michael, Stokar-Regenscheit, Nadine, Piscuoglio, Salvatore, Beumer, Joep, Gjorevski, Nikolche

Source: Nature Biomedical Engineering; Apr2024, Vol. 8 Issue 4, p345-360, 16p

Simlukafusp alfa (FAP-IL2v) immunocytokine is a versatile combination partner for cancer immunotherapy

Authors: Waldhauer, Inja, Gonzalez-Nicolini, Valeria, Freimoser-Grundschober, Anne, Nayak, Tapan K, Fahrni, Linda, Hosse, Ralf J., Gerrits, Danny, Geven, Edwin J. W., Sam, Johannes, Lang, Sabine, Bommer, Esther, Steinhart, Virginie, Husar, Elisabeth, Colombetti, Sara, Van Puijenbroek, Erwin, Neubauer, Markus, Cline, J. Mark, Garg, Pradeep K., Dugan, Gregory, Cavallo, Federica, Acuna, Gonzalo, Charo, Jehad, Teichgräber, Volker, Evers, Stefan, Boerman, Otto C., Bacac, Marina, Moessner, Ekkehard, Umaña, Pablo, Klein, Christian

Source: MAbs. 13(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140347703.0x000001&indx=1&recIds=ETOCvdc_100140347703.0x000001

Combination therapy with the type II anti-CD20 antibody obinutuzumab

Authors: Klein, Christian, Bacac, Marina, Umana, Pablo, Fingerle-Rowson, Günter

Source: Expert opinion on investigational drugs. 26(10):1145-1162

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100048802654.0x000001&indx=1&recIds=ETOCvdc_100048802654.0x000001

XGFR*, a novel affinity-matured bispecific antibody targeting IGF-1R and EGFR with combined signaling inhibition and enhanced immune activation for the treatment of pancreatic cancer

Authors: Schanzer, Juergen M., Wartha, Katharina, Moessner, Ekkehard, Hosse, Ralf J., Moser, Samuel, Croasdale, Rebecca, Trochanowska, Halina, Shao, Cuiying, Wang, Peng, Shi, Lei, Weinzierl, Tina, Rieder, Natascha, Bacac, Marina, Ries, Carola H., Kettenberger, Hubert, Schlothauer, Tilman, Friess, Thomas, Umana, Pablo, Klein, Christian

Source: MAbs. 8(4):811-827

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100030997352.0x000001&indx=1&recIds=ETOCvdc_100030997352.0x000001

Application of a MABEL Approach for a T-Cell-Bispecific Monoclonal Antibody: CEA TCB

Authors: Dudal, Sherri, Hinton, Heather, Giusti, Anna M., Bacac, Marina, Muller, Magali, Fauti, Tanja, Colombetti, Sara, Heckel, Tobias, Giroud, Nicolas, Klein, Christian, Umaña, Pablo, Benincosa, Lisa, Bachl, Juergen, Singer, Thomas, Bray-French, Katharine

Source: Journal of immunotherapy. 39(7):279-289

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100037160723.0x000001&indx=1&recIds=ETOCvdc_100037160723.0x000001

Single-cell characterization of human GBM reveals regional differences in tumor-infiltrating leukocyte activation.

Authors: Schmassmann, Philip, Roux, Julien, Dettling, Steffen, Hogan, Sabrina, Shekarian, Tala, Martins, Tomás A., Ritz, Marie-Françoise, Herter, Sylvia, Bacac, Marina, Hutter, Gregor

Source: eLife; 12/21/2023, p1-26, 26p