Measurable residual disease monitoring in AML with FLT3-ITD treated with intensive chemotherapy plus midostaurin

Authors: Frank G. Rücker, Lars Bullinger, Sibylle Cocciardi, Sabrina Skambraks, Tamara J. Luck, Daniela Weber, Julia Krzykalla, Ema Pozek, Isabelle Schneider, Andrea Corbacioglu, Verena I. Gaidzik, Annika Meid, Sophia Aicher, Frank Stegelmann, Anika Schrade, Frauke Theis, Walter Fiedler, Helmut R. Salih, Gerald Wulf, Hans Salwender, Thomas Schroeder, Katharina S. Götze, Michael W. M. Kühn, Michael Lübbert, Richard F. Schlenk, Axel Benner, Felicitas Thol, Michael Heuser, Arnold Ganser, Hartmut Döhner, Konstanze Döhner

Source: Blood Advances, Vol 8, Iss 23, Pp 6067-6080 (2024)

Subject Terms: Specialties of internal medicine, RC581-951

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2473952924005792; https://doaj.org/toc/2473-9529

Access URL: https://doaj.org/article/a1ba49620d1d47c78a4a31023fcd9129

Impact of myelodysplasia‐related and additional gene mutations in intensively treated patients with NPM1‐mutated AML

Authors: Sibylle Cocciardi, Maral Saadati, Nina Weiß, Daniela Späth, Silke Kapp‐Schwoerer, Isabelle Schneider, Annika Meid, Verena I. Gaidzik, Sabrina Skambraks, Walter Fiedler, Michael W. M. Kühn, Ulrich Germing, Karin T. Mayer, Michael Lübbert, Elli Papaemmanuil, Felicitas Thol, Michael Heuser, Arnold Ganser, Lars Bullinger, Axel Benner, Hartmut Döhner, Konstanze Döhner

Source: HemaSphere, Vol 9, Iss 1, Pp n/a-n/a (2025)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/3f2b0f6e904f42f29807b454bcc92252

Cytomegalovirus immunoglobulin serology prevalence in patients with newly diagnosed multiple myeloma treated within the GMMG-MM5 phase III trial

Authors: Hans Salwender, Niels Weinhold, Axel Benner, Kaya Miah, Maximilian Merz, Mathias Haenel, Christian Jehn, Elias Mai, Ekaterina Menis, Igor Blau, Christof Scheid, Dirk Hose, Anja Seckinger, Steffen Luntz, Britta Besemer, Markus Munder, Peter Brossart, Bertram Glass, Hans-Walter Lindemann, Katja Weisel, Christine Hanoun, Paul Schnitzler, Sarah Klemm, Hartmut Goldschmidt, Marc Raab, Ahmet Elmaagacli

Source: Hematology, Vol 29, Iss 1 (2024)

Subject Terms: CMV, CMV IgM, multiple myeloma, GMMG-MM5 Phase III Trial, autologous stem cell transplantation, maintenance therapy, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/1607-8454

Access URL: https://doaj.org/article/29275ba759c143408d4a11bc8678e7fb

Outcomes with intensive treatment for acute myeloid leukemia: an analysis of two decades of data from the HARMONY Alliance

Authors: Marta Anna Sobas, Amin T. Turki, Angela Villaverde Ramiro, Alberto Hernández Sánchez, Javier Martinez Elicegui, Teresa González, Raúl Azibeiro Melchor, María Abáigar, Laura Tur, Daniele Dall'Olio, Eric Sträng, Jesse M. Tettero, Gastone Castellani, Axel Benner, Konstanze Döhner, Christian Thiede, Klaus H. Metzeler, Torsten Haferlach, Frederik Damm, Rosa Ayala, Joaquín Martínez-López, Ken I Mills, Jorge Sierra, Sören Lehmann, Matteo G. Della Porta, Jiri Mayer, Dirk Reinhardt, Rubén Villoria Medina, Renate Schulze-Rath, Martje Barbus, Jesús María Hernández-Rivas, Brian J.P Huntly, Gert Ossenkoppele, Hartmut Döhner, Lars Bullinger

Source: Haematologica, Vol 999, Iss 1 (2024)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/11814; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/89bacc8433e84280a3c6e07ffa0f97ee

Refinement of the prognostic impact of somatic CEBPA bZIP domain mutations in acute myeloid leukemia: Results of the AML Study Group (AMLSG)

Authors: Frank G. Rücker, Andrea Corbacioglu, Julia Krzykalla, Sibylle Cocciardi, Claudia Lengerke, Ulrich Germing, Gerald Wulf, Maisun A. Samra, Lino L. Teichmann, Michael Lübbert, Michael W. M. Kühn, Martin Bentz, Jörg Westermann, Lars Bullinger, Verena I. Gaidzik, Annika Meid, Sophia Aicher, Frank Stegelmann, Daniela Weber, Anika Schrade, Felicitas Thol, Michael Heuser, Arnold Ganser, Axel Benner, Hartmut Döhner, Konstanze Döhner, for the German‐Austrian Acute Myeloid Leukemia Study Group (AMLSG)

Source: HemaSphere, Vol 8, Iss 7, Pp n/a-n/a (2024)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/57b77f726894460c9984828c82423457

Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen

Authors: Maximilian Schmutz, Manuela Zucknick, Richard F. Schlenk, Daniel Mertens, Axel Benner, Dieter Weichenhan, Oliver Mücke, Konstanze Döhner, Christoph Plass, Lars Bullinger, Rainer Claus

Source: Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023)

Subject Terms: DNA-methylation, Epigenetics, HMA-treatment, Predictive biomarker, Predictive signature, DNA methylation patterns, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1868-7083

Access URL: https://doaj.org/article/97807982449d429dbc05a64bad75bfbb

Statistical analysis of high-dimensional biomedical data: a gentle introduction to analytical goals, common approaches and challenges

Authors: Jörg Rahnenführer, Riccardo De Bin, Axel Benner, Federico Ambrogi, Lara Lusa, Anne-Laure Boulesteix, Eugenia Migliavacca, Harald Binder, Stefan Michiels, Willi Sauerbrei, Lisa McShane, for topic group “High-dimensional data” (TG9) of the STRATOS initiative

Source: BMC Medicine, Vol 21, Iss 1, Pp 1-54 (2023)

Subject Terms: High-dimensional data, Omics data, STRATOS initiative, Analytical goals, Initial data analysis, Exploratory data analysis, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1741-7015

Access URL: https://doaj.org/article/4341909edf664733b9e0a8f2c0eedbe3

Endothelial Activation and Stress Index (EASIX) to predict mortality after allogeneic stem cell transplantation: a prospective study

Authors: Axel Benner, Peter Dreger, Grzegorz W Basak, Christian Koenecke, Olaf Penack, Christophe Peczynski, Lucia López Corral, Ivan Moiseev, Hélène Schoemans, Zinaida Peric, Thomas Luft, Simona Sica, Mutlu Arat, Maija Itäla-Remes, Nicolaas P M Schaap, Michal Karas, Ludek Raida, Thomas Schroeder, Elisabetta Metafuni, Tulay Ozcelik, Brenda M Sandmaier, Lambros Kordelas

Source: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 1 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/12/1/e007635.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/60017a9b556c4c1eaccc5b562a3da144

Simulation study to evaluate when Plasmode simulation is superior to parametric simulation in estimating the mean squared error of the least squares estimator in linear regression

Authors: Marieke Stolte, Nicholas Schreck, Alla Slynko, Maral Saadati, Axel Benner, Jörg Rahnenführer, Andrea Bommert

Source: PLoS ONE, Vol 19, Iss 5 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11095703/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/e3245a97a1ea44249667c3899c1df8a8

Implications and prognostic impact of mass spectrometry in patients with newly-diagnosed multiple myeloma

Authors: Elias K. Mai, Stefanie Huhn, Kaya Miah, Alexandra M. Poos, Christof Scheid, Katja C. Weisel, Uta Bertsch, Markus Munder, Oscar Berlanga, Dirk Hose, Anja Seckinger, Anna Jauch, Igor W. Blau, Mathias Hänel, Hans J. Salwender, Axel Benner, Marc S. Raab, Hartmut Goldschmidt, Niels Weinhold

Source: Blood Cancer Journal, Vol 13, Iss 1, Pp 1-9 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2044-5385

Access URL: https://doaj.org/article/1275a2059f114b41a54bedff8ec0c75f

P417: GENOMIC LANDSCAPE AND PROGNOSIS IN OLDER ACUTE MYELOID LEUKEMIA PATIENTS NOT ELIGIBLE FOR INTENSIVE CHEMOTHERAPY

Authors: Ekaterina Jahn, Maral Saadati, Pierre Fenaux, Marco Gobbi, Gail Roboz, Lars Bullinger, Pavlo Lutsik, Anna Riedel, Christoph Plass, Nikolaus Jahn, Claudia Walter, Karlheinz Holzmann, Yong Hao, Sue Naim, Nicholas Schreck, Julia Krzykalla, Axel Benner, Harold Keer, Mohammad Azab, Konstanze Döhner, Hartmut Döhner

Source: HemaSphere, Vol 7, p e09006a7 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000968576.09006.a7; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/4c2e871905fb42089d1303d5857af0bd

Fludarabine, cytarabine, and idarubicin with or without venetoclax in patients with relapsed/refractory acute myeloid leukemia

Authors: Rabia Shahswar, Gernot Beutel, Razif Gabdoulline, Adrian Schwarzer, Arnold Kloos, Christian Koenecke, Michael Stadler, Gudrun Gohring, Yvonne Lisa Behrens, Zhixiong Li, Louisa-Kristin Dallmann, Piroska Klement, Catherin Albert, Martin Wichmann, Yasmine Alwie, Axel Benner, Maral Saadati, Arnold Ganser, Felicitas Thol, Michael Heuser

Source: Haematologica, Vol 109, Iss 1 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/11168; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/3e7c9d7e6a4f485a890f7508ac5f6304

Risk factors and characteristics influencing humoral response to COVID-19 vaccination in patients after allogeneic stem cell transplantation

Authors: Marie Luise Hütter-Krönke, Adela Neagoie, Igor Wolfgang Blau, Verena Wais, Lam Vuong, Andrea Gantner, Johann Ahn, Olaf Penack, Jacqueline Schnell, Klaus Axel Nogai, Bettina Eberspächer, Maral Saadati, Axel Benner, Lars Bullinger, Hartmut Döhner, Donald Bunjes, Elisa Sala

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: COVID 19-vaccination, humoral response, allogeneic stem cell transplantation, SARS-CoV-2 antibodies, vaccine, booster, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1174289/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/a381ec357b764032a33b06cba6605847

Palbociclib in Acute Leukemias With KMT2A-rearrangement: Results of AMLSG 23-14 Trial

Authors: Verena I. Gaidzik, Peter Paschka, Richard F. Schlenk, Daniela Weber, Stefan Fröhling, Alwin Krämer, Ralph Wäsch, Jörg Westermann, Karin Mayer, Maike de Wit, Walter Fiedler, Axel Benner, Michael Heuser, Felicitas Thol, Konstanze Döhner, Arnold Ganser, Hartmut Döhner

Source: HemaSphere, Vol 7, Iss 5, p e877 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/HS9.0000000000000877; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/4404753769fb4869903fee2cffeca2b3

Impact of novel agent therapies on immune cell subsets and infectious complications in patients with relapsed/refractory multiple myeloma

Authors: Lukas John, Kaya Miah, Axel Benner, Elias K. Mai, Katharina Kriegsmann, Michael Hundemer, Dorothee Kaudewitz, Carsten Müller-Tidow, Karin Jordan, Hartmut Goldschmidt, Marc S. Raab, Nicola Giesen

Source: Frontiers in Oncology, Vol 13 (2023)

Subject Terms: CD4+-T-cells, infections, relapsed refractory multiple myeloma, novel agents, immune cell subsets, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2023.1078725/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/1187c6ea9da8479ca823052df06d2766

Validation of a proxy‐reported SARC‐F questionnaire for current and retrospective screening of sarcopenia‐related functional impairments

Authors: Johannes Maurus, Tobias Terzer, Axel Benner, Sabine Goisser, Annette Eidam, Anja Roth, Maike Janssen, Sonia Jaramillo, Hannes Martin Lorenz, William Micol, Klaus Hauer, Carsten Müller‐Tidow, Jürgen M. Bauer, Karin Jordan, Nina Rosa Neuendorff

Source: Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 1, Pp 264-275 (2022)

Subject Terms: Sarcopenia, Sarcopenia‐related functional impairments, Patient‐reported outcome, Proxy‐reported outcome, Premorbid condition, SARC‐F, Diseases of the musculoskeletal system, RC925-935, Human anatomy, QM1-695

File Description: electronic resource

Relation: https://doaj.org/toc/2190-5991; https://doaj.org/toc/2190-6009

Access URL: https://doaj.org/article/13d886f9e83244529c3f10f613406c69

Circulating tumour cells in patients with lung cancer universally indicate poor prognosis

Authors: Fukang Jin, Lei Zhu, Jingbo Shao, Mina Yakoub, Lukas Schmitt, Christoph Reißfelder, Sonja Loges, Axel Benner, Sebastian Schölch

Source: European Respiratory Review, Vol 31, Iss 166 (2022)

Subject Terms: Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: http://err.ersjournals.com/content/31/166/220151.full; https://doaj.org/toc/0905-9180; https://doaj.org/toc/1600-0617

Access URL: https://doaj.org/article/178cb9e1d28c43edbbc502a1541179e2

Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia

Authors: Johannes Bloehdorn, Andrejs Braun, Amaro Taylor-Weiner, Billy Michael Chelliah Jebaraj, Sandra Robrecht, Julia Krzykalla, Heng Pan, Adam Giza, Gulnara Akylzhanova, Karlheinz Holzmann, Annika Scheffold, Harvey E. Johnston, Ru-Fang Yeh, Tetyana Klymenko, Eugen Tausch, Barbara Eichhorst, Lars Bullinger, Kirsten Fischer, Martin Weisser, Tadeusz Robak, Christof Schneider, John Gribben, Lekh N. Dahal, Mathew J. Carter, Olivier Elemento, Dan A. Landau, Donna S. Neuberg, Mark S. Cragg, Axel Benner, Michael Hallek, Catherine J. Wu, Hartmut Döhner, Stephan Stilgenbauer, Daniel Mertens

Source: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/fc98052a777c445bb5de9e2a3b17c607

Which patients to sample in clinical cohort studies when the number of events is high and measurement of additional markers is constrained by limited resources

Authors: Dominic Edelmann, Kristin Ohneberg, Natalia Becker, Axel Benner, Martin Schumacher

Source: Cancer Medicine, Vol 9, Iss 20, Pp 7398-7406 (2020)

Subject Terms: case‐cohort, nested case‐control, survival, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2045-7634

Access URL: https://doaj.org/article/8f038705a01947328c81cda22a3c8783

The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution

Authors: Alexej Ballhausen, Moritz Jakob Przybilla, Michael Jendrusch, Saskia Haupt, Elisabeth Pfaffendorf, Florian Seidler, Johannes Witt, Alejandro Hernandez Sanchez, Katharina Urban, Markus Draxlbauer, Sonja Krausert, Aysel Ahadova, Martin Simon Kalteis, Pauline L. Pfuderer, Daniel Heid, Damian Stichel, Johannes Gebert, Maria Bonsack, Sarah Schott, Hendrik Bläker, Toni Seppälä, Jukka-Pekka Mecklin, Sanne Ten Broeke, Maartje Nielsen, Vincent Heuveline, Julia Krzykalla, Axel Benner, Angelika Beate Riemer, Magnus von Knebel Doeberitz, Matthias Kloor

Source: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/a73e02cb910a4f8c83a017a74a1f0a13