G protein selectivity profile of GPR56/ADGRG1 and its effect on downstream effectors.

Authors: Jallouli, Raida, Moreno-Salinas, Ana L., Laniel, Andréanne, Holleran, Brian, Avet, Charlotte, Jacob, Joan, Hoang, Trang, Lavoie, Christine, Carmon, Kendra S., Bouvier, Michel, Leduc, Richard

Source: Cellular & Molecular Life Sciences; 9/4/2024, Vol. 81 Issue 1, p1-18, 18p

Subject Terms: G proteins, LIGANDS (Biochemistry), TRAFFIC signs & signals, CANCER cells, BREAST cancer, G protein coupled receptors

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Conformation- and activation-based BRET sensors differentially report on GPCR–G protein coupling.

Authors: Wright, Shane C., Avet, Charlotte, Gaitonde, Supriya A., Muneta-Arrate, Itziar, Le Gouill, Christian, Hogue, Mireille, Breton, Billy, Koutsilieri, Stefania, Alarcia, Rebeca Diez, Héroux, Madeleine, Lauschke, Volker M., Bouvier, Michel

Source: Science Signaling; 6/18/2024, Vol. 17 Issue 841, p1-8, 8p

Subject Terms: G protein coupled receptors, FLUORESCENCE resonance energy transfer, MUSCARINIC receptors, G proteins, CELL communication, BIOLUMINESCENCE

Use of Novel ebBRET Biosensors for Comprehensive Signaling Profiling of One Hundred Therapeutically Relevant Human GPCRs

Authors: Mancini, Arturo, Avet, Charlotte, Breton, Billy, Le Gouill, Christian, Hauser, Alexander, Normand, Claire, Gross, Florence, Lukasheva, Viktoriya, Hogue, Mireille, Morissette, Sandra, Fauman, Eric, Fortin, Jean‐Philippe, Schann, Stephan, Leroy, Xavier, Gloriam, David, Bouvier, Michel

Source: FASEB journal. 35

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123844006.0x000001&indx=1&recIds=ETOCvdc_100123844006.0x000001

The PAR2 inhibitor I-287 selectively targets Gαq and Gα12/13 signaling and has anti-inflammatory effects

Authors: Avet, Charlotte, Sturino, Claudio, Grastilleur, Sébastien, Gouill, Christian Le, Semache, Meriem, Gross, Florence, Gendron, Louis, Bennani, Youssef, Mancini, Joseph A., Sayegh, Camil E., Bouvier, Michel

Source: Communications biology. 3(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190769539.0x000001&indx=1&recIds=ETOCvdc_100190769539.0x000001

SET Protein Interacts with Intracellular Domains of the Gonadotropin-releasing Hormone Receptor and Differentially Regulates Receptor Signaling to cAMP and Calcium in Gonadotrope Cells

Authors: Avet, Charlotte, Garrel, Ghislaine, Denoyelle, Chantal, Laverrière, Jean-Noël, Counis, Raymond, Cohen-Tannoudji, Joëlle, Simon, Violaine

Source: In Journal of Biological Chemistry 25 January 2013 288(4):2641-2654

GnRH regulates the expression of its receptor accessory protein SET in pituitary gonadotropes.

Authors: Avet, Charlotte¹, Denoyelle, Chantal¹, L’Hôte, David¹, Petit, Florence¹, Guigon, Céline J.¹, Cohen-Tannoudji, Joëlle¹, Simon, Violaine¹ violaine.simon@univ-paris-diderot.fr

Source: PLoS ONE. 7/27/2018, Vol. 13 Issue 7, p1-19. 19p.

Subject Terms: *GONADOTROPIN releasing hormone, *G protein coupled receptors, *CELLULAR signal transduction, *GAMETOGENESIS, *PROTEASOMES

Common coupling map advances GPCR-G protein selectivity.

Authors: Hauser, Alexander S.¹, Avet, Charlotte², Normand, Claire³, Mancini, Arturo³, Asuka Inoue⁴, Bouvier, Michel² michel.bouvier@umontreal.ca, Gloriam, David E.¹ david.gloriam@sund.ku.dk

Source: eLife. 4/12/2022, p1-22. 22p.

Subject Terms: *G proteins, *G protein coupled receptors, *CELL communication, *PROTEINS, *DRUG design

Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs.

Authors: Avet, Charlotte¹, Mancini, Arturo², Breton, Billy^2,3, Le Gouill, Christian¹, Hauser, Alexander S.⁴, Normand, Claire², Hiroyuki Kobayashi¹, Gross, Florence², Hogue, Mireille¹, Lukasheva, Viktoriya¹, St-Onge, Stéphane¹, Carrier, Marilyn¹, Héroux, Madeleine¹, Morissette, Sandra², Fauman, Eric B.⁵, Fortin, Jean-Philippe⁶, Schann, Stephan⁷, Leroy, Xavier⁷ xleroy@domaintherapeutics.com, Gloriam, David E.⁴ david.gloriam@sund.ku.dk, Bouvier, Michel¹ michel.bouvier@umontreal.ca

Source: eLife. 4/12/2022, p1-34. 34p.

Subject Terms: *G proteins, *G protein coupled receptors, *BIOSENSORS, *CELL membranes, *CELLULAR signal transduction

Profiling the Signaling Repertoire of One Hundred Therapeutically‐Relevant Human GPCRs

Authors: Mancini, Arturo, Avet, Charlotte, Breton, Billy, Normand, Claire, Gross, Florence, Lukasheva, Viktoriya, Hogue, Mireille, Morissette, Sandra, Fauman, Eric, Fortin, Jean-Philippe, Schann, Stephan, Gouill, Christian Le, Bouvier, Michel

Source: FASEB journal. 34(S1):1-1

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140407861.0x000001&indx=1&recIds=ETOCvdc_100140407861.0x000001

Carbon Black Nanoparticles Selectively Alter Follicle-Stimulating Hormone Expression in vitro and in vivo in Female Mice.

Authors: Avet, Charlotte, Paul, Emmanuel N., Garrel, Ghislaine, Grange-Messent, Valérie, L'Hôte, David, Denoyelle, Chantal, Corre, Raphaël, Dupret, Jean-Marie, Lanone, Sophie, Boczkowski, Jorge, Simon, Violaine, Cohen-Tannoudji, Joëlle

Source: Frontiers in Neuroscience; 12/6/2021, Vol. 15, p1-15, 15p

Subject Terms: CARBON-black, FOLLICLE-stimulating hormone, GONADOTROPIN releasing hormone, CELL culture, NANOPARTICLES, GONADOTROPIN

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Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor.

Authors: Fink, Elissa A., Jun Xu, Hübner, Harald, Braz, Joao M., Seemann, Philipp, Avet, Charlotte, Craik, Veronica, Weikert, Dorothee, Schmidt, Maximilian F., Webb, Chase M., Tolmachova, Nataliya A., Moroz, Yurii S., Xi-Ping Huang, Kalyanaraman, Chakrapani, Gahbauer, Stefan, Geng Chen, Zheng Liu, Jacobson, Matthew P., Irwin, John J., Bouvier, Michel, michel.bouvier@umontreal.ca

Source: Science; 9/30/2022, Vol. 377 Issue 6614, p1509-1509, 1p, 1 Diagram

Decoding high gonadotropin-releasing hormone pulsatility: a role for GnRH receptor coupling to the cAMP pathway?

Authors: Cohen-Tannoudji, Joëlle, Avet, Charlotte, Garrel, Ghislaine, Counis, Raymond, Simon, Violaine

Source: Frontiers in Endocrinology; Aug2012, Vol. 3, p1-6, 6p

Subject Terms: GONADOTROPIN releasing hormone, LUTEINIZING hormone releasing hormone receptors, CYCLIC adenylic acid, CELLULAR signal transduction, NITRIC-oxide synthases, FOLLISTATIN

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The PAR2 inhibitor I-287 selectively targets Gαq and Gα12/13 signaling and has anti-inflammatory effects.

Authors: Avet, Charlotte¹, Sturino, Claudio^2,3, Grastilleur, Sébastien⁴, Gouill, Christian Le¹, Semache, Meriem^1,5, Gross, Florence^1,5, Gendron, Louis⁴, Bennani, Youssef^2,6, Mancini, Joseph A.^2,7, Sayegh, Camil E.^2,8, Bouvier, Michel¹ michel.bouvier@umontreal.ca

Source: Communications Biology. 11/27/2020, Vol. 3 Issue 1, pN.PAG-N.PAG. 1p.

Subject Terms: *PROTEASE-activated receptors, *INFLAMMATION, *ALLOSTERIC regulation, *LIABILITIES (Accounting), *THERAPEUTICS