Alveolar epithelial cells mitigate neutrophilic inflammation in lung injury through regulating mitochondrial fatty acid oxidation

Authors: Kuei-Pin Chung, Chih-Ning Cheng, Yi-Jung Chen, Chia-Lang Hsu, Yen-Lin Huang, Min-Shu Hsieh, Han-Chun Kuo, Ya-Ting Lin, Yi-Hsiu Juan, Kiichi Nakahira, Yen-Fu Chen, Wei-Lun Liu, Sheng-Yuan Ruan, Jung-Yien Chien, Maria Plataki, Suzanne M. Cloonan, Peter Carmeliet, Augustine M. K. Choi, Ching-Hua Kuo, Chong-Jen Yu

Source: Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/5afa0e7fd12540ceb61a70ad3c0d6415

Urine-based multi-omic comparative analysis of COVID-19 and bacterial sepsis-induced ARDS

Authors: Richa Batra, Rie Uni, Oleh M. Akchurin, Sergio Alvarez-Mulett, Luis G. Gómez-Escobar, Edwin Patino, Katherine L. Hoffman, Will Simmons, William Whalen, Kelsey Chetnik, Mustafa Buyukozkan, Elisa Benedetti, Karsten Suhre, Edward Schenck, Soo Jung Cho, Augustine M. K. Choi, Frank Schmidt, Mary E. Choi, Jan Krumsiek

Source: Molecular Medicine, Vol 29, Iss 1, Pp 1-10 (2023)

Subject Terms: COVID-19, Acute respiratory distress syndrome (ARDS), Multi-omic, Mortality signature, Network-based, Computational analysis, Therapeutics. Pharmacology, RM1-950, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1528-3658

Access URL: https://doaj.org/article/73b7e4f3cafd424db0c9cb48062b9e13

Auto-immunoproteomics analysis of COVID-19 ICU patients revealed increased levels of autoantibodies related to the male reproductive system

Authors: Frank Schmidt, Houari B. Abdesselem, Karsten Suhre, Nishant N. Vaikath, Muhammad U. Sohail, Maryam Al-Nesf, Ilham Bensmail, Fathima Mashod, Hina Sarwath, Joerg Bernhardt, Stephanie Schaefer-Ramadan, Ti-Myen Tan, Priscilla E. Morris, Edward J. Schenck, David Price, Vidya Mohamed-Ali, Mohammed Al-Maadheed, Abdelilah Arredouani, Julie Decock, Jonathan M. Blackburn, Augustine M. K. Choi, Omar M. El-Agnaf

Source: Frontiers in Physiology, Vol 14 (2023)

Subject Terms: COVID-19, autoantibodies, immunoproteomics, SPANXN4, Stk25, male reproductive system, Physiology, QP1-981

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphys.2023.1203723/full; https://doaj.org/toc/1664-042X

Access URL: https://doaj.org/article/cafc2cc0758a400281587d6a1c37112f

Lung lymphatic thrombosis and dysfunction caused by cigarette smoke exposure precedes emphysema in mice

Authors: Barbara D. Summers, Kihwan Kim, Cristina C. Clement, Zohaib Khan, Sangeetha Thangaswamy, Jacob McCright, Katharina Maisel, Sofia Zamora, Stephanie Quintero, Alexandra C. Racanelli, David Redmond, Jeanine D’Armiento, Jisheng Yang, Amy Kuang, Laurel Monticelli, Mark L. Kahn, Augustine M. K. Choi, Laura Santambrogio, Hasina Outtz Reed

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/65625e4b867f4e81924ccad4d01752a0

Cytokine signatures of end organ injury in COVID-19

Authors: Luis G. Gómez-Escobar, Katherine L. Hoffman, Justin J. Choi, Alain Borczuk, Steven Salvatore, Sergio L. Alvarez-Mulett, Manuel D. Galvan, Zhen Zhao, Sabrina E. Racine-Brzostek, He S. Yang, Heather W. Stout-Delgado, Mary E. Choi, Augustine M. K. Choi, Soo Jung Cho, Edward J. Schenck

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/de6315cd729b4ccca1809ce8dcb1cf1d

Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort

Authors: William Z. Zhang, Katherine L. Hoffman, Kristen T. Schiffer, Clara Oromendia, Michelle C. Rice, Igor Barjaktarevic, Stephen P. Peters, Nirupama Putcha, Russell P. Bowler, J. Michael Wells, David J. Couper, Wassim W. Labaki, Jeffrey L. Curtis, Meilan K. Han, Robert Paine, Prescott G. Woodruff, Gerard J. Criner, Nadia N. Hansel, Ivan Diaz, Karla V. Ballman, Kiichi Nakahira, Mary E. Choi, Fernando J. Martinez, Augustine M. K. Choi, Suzanne M. Cloonan

Source: Respiratory Research, Vol 22, Iss 1, Pp 1-11 (2021)

Subject Terms: COPD, Mitochondrial dysfunction, mtDNA, SPIROMICS, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: https://doaj.org/toc/1465-993X

Access URL: https://doaj.org/article/fda3f6f536e44b0baee73d681aa4e661

Multi-omic comparative analysis of COVID-19 and bacterial sepsis-induced ARDS

Authors: Richa Batra, William Whalen, Sergio Alvarez-Mulett, Luis G. Gomez-Escobar, Katherine L. Hoffman, Will Simmons, John Harrington, Kelsey Chetnik, Mustafa Buyukozkan, Elisa Benedetti, Mary E. Choi, Karsten Suhre, Edward Schenck, Augustine M. K. Choi, Frank Schmidt, Soo Jung Cho, Jan Krumsiek

Source: PLoS Pathogens, Vol 18, Iss 9 (2022)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484674/?tool=EBI; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/045db0b9a19544b4881ea62a59729541

Identification of Robust Protein Associations With COVID-19 Disease Based on Five Clinical Studies

Authors: Karsten Suhre, Hina Sarwath, Rudolf Engelke, Muhammad Umar Sohail, Soo Jung Cho, William Whalen, Sergio Alvarez-Mulett, Jan Krumsiek, Augustine M. K. Choi, Frank Schmidt

Source: Frontiers in Immunology, Vol 12 (2022)

Subject Terms: COVID-19, Olink proteomics, inflammation and cardiovascular markers, cytokine storm syndrome, CCL16, CXCL10, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.781100/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/4225c005d4cc4dfe8655d4d9aa57ed52

Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis

Authors: Kuei-Pin Chung, Chia-Lang Hsu, Li-Chao Fan, Ziling Huang, Divya Bhatia, Yi-Jung Chen, Shu Hisata, Soo Jung Cho, Kiichi Nakahira, Mitsuru Imamura, Mary E. Choi, Chong-Jen Yu, Suzanne M. Cloonan, Augustine M. K. Choi

Source: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f5f243b5d4f24d84932e8612a7458e3a

Plasma mitochondrial DNA and metabolomic alterations in severe critical illness

Authors: Pär I. Johansson, Kiichi Nakahira, Angela J. Rogers, Michael J. McGeachie, Rebecca M. Baron, Laura E. Fredenburgh, John Harrington, Augustine M. K. Choi, Kenneth B. Christopher

Source: Critical Care, Vol 22, Iss 1, Pp 1-9 (2018)

Subject Terms: Mitochondrial DNA, Metabolite, Metabolomics, Homeostasis, Critical illness, Acylcarnitine, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13054-018-2275-7; https://doaj.org/toc/1364-8535

Access URL: https://doaj.org/article/d8cb2159232f466d89b93403a74890e6

Plasma surfactant protein-D as a diagnostic biomarker for acute respiratory distress syndrome: validation in US and Korean cohorts

Authors: Jinkyeong Park, Maria Pabon, Augustine M. K. Choi, Ilias I. Siempos, Laura E. Fredenburgh, Rebecca M. Baron, Kyeongman Jeon, Chi Ryang Chung, Jeong Hoon Yang, Chi-Min Park, Gee Young Suh

Source: BMC Pulmonary Medicine, Vol 17, Iss 1, Pp 1-7 (2017)

Subject Terms: Acute lung injury, Critical illness, Pulmonary surfactant-associated protein D, Respiratory distress syndrome, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12890-017-0532-1; https://doaj.org/toc/1471-2466

Access URL: https://doaj.org/article/6dec4df974954b1882cb0249243266d1

Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria

Authors: Yohannes A. Mebratu, Ivan Leyva-Baca, Marc G. Wathelet, Neal Lacey, Hitendra S. Chand, Augustine M. K. Choi, Yohannes Tesfaigzi

Source: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/763e7af1c632449592822f6a9fa2b319

Metabolome alterations in severe critical illness and vitamin D status

Authors: Jessica Lasky-Su, Amber Dahlin, Augusto A. Litonjua, Angela J. Rogers, Michael J. McGeachie, Rebecca M. Baron, Lee Gazourian, Diana Barragan-Bradford, Laura E. Fredenburgh, Augustine M. K. Choi, Kris M. Mogensen, Sadeq A. Quraishi, Karin Amrein, Kenneth B. Christopher

Source: Critical Care, Vol 21, Iss 1, Pp 1-10 (2017)

Subject Terms: Vitamin D, Metabolite, Metabolomics, Homeostasis, Critical illness, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13054-017-1794-y; https://doaj.org/toc/1364-8535

Access URL: https://doaj.org/article/17af0c5c27f041abb3960dd5a0033dc0

Comparison of qSOFA and SIRS for predicting adverse outcomes of patients with suspicion of sepsis outside the intensive care unit

Authors: Eli J. Finkelsztein, Daniel S. Jones, Kevin C. Ma, Maria A. Pabón, Tatiana Delgado, Kiichi Nakahira, John E. Arbo, David A. Berlin, Edward J. Schenck, Augustine M. K. Choi, Ilias I. Siempos

Source: Critical Care, Vol 21, Iss 1, Pp 1-10 (2017)

Subject Terms: Infection, Critical care, Organ failure, Severe sepsis, Mortality, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13054-017-1658-5; https://doaj.org/toc/1364-8535

Access URL: https://doaj.org/article/e4419711b9534190882187cf3117dc29

DROSHA-Dependent AIM2 Inflammasome Activation Contributes to Lung Inflammation during Idiopathic Pulmonary Fibrosis

Authors: Soo Jung Cho, Kyoung Sook Hong, Ji Hun Jeong, Mihye Lee, Augustine M. K. Choi, Heather W. Stout-Delgado, Jong-Seok Moon

Source: Cells, Vol 8, Iss 8, p 938 (2019)

Subject Terms: DROSHA, miRNA, AIM2 inflammasome, idiopathic pulmonary fibrosis, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/8/8/938; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/f4b1e5956d75448dae86fd9b45e9a8ab

The Impact of Autophagy on Cell Death Modalities

Authors: Stefan W. Ryter, Kenji Mizumura, Augustine M. K. Choi

Source: International Journal of Cell Biology, Vol 2014 (2014)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1687-8876; https://doaj.org/toc/1687-8884

Access URL: https://doaj.org/article/5bca913972a744e29a65adc7571041e3

Cecal Ligation and Puncture-induced Sepsis as a Model To Study Autophagy in Mice

Authors: Ilias I. Siempos, author^{1, 3}, Hilaire C. Lam, author¹, Yan Ding, author², Mary E. Choi, author², Augustine M. K. Choi, author¹, Stefan W. Ryter, author¹

Source: Journal of Visualized Experiments. (84)

Availability: http://www.jove.com/video/51066

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Mechanisms of Cell Death in Oxidative Stress.

Authors: Stefan W. Ryter, Hong Pyo Kim, Alexander Hoetzel, Jeong W. Park, Kiichi Nakahira, Xue Wang, Augustine M. K. Choi

Source: Antioxidants & Redox Signaling; Jan2007, Vol. 9 Issue 1, p49-89, 41p

Insulin‐like growth factor binding protein 5 induces skin fibrosis: A novel murine model for dermal fibrosis.

Authors: Hidekata Yasuoka, Drazen M. Jukic, Zhihong Zhou, Augustine M. K. Choi, Carol A. Feghali‐Bostwick

Source: Arthritis & Rheumatism; Sep2006, Vol. 54 Issue 9, p3001-3010, 10p

Subject Terms: FIBROSIS, INSULIN-like growth factor-binding proteins, COLLAGEN, FIBRONECTINS, LABORATORY mice