Hepatic arterial infusion of autologous CD34+ cells for hepatitis C virus-related decompensated cirrhosis: A multicenter, open-label, exploratory randomized controlled trial

Authors: Toru Nakamura, Atsutaka Masuda, Makoto Kako, Hirayuki Enomoto, Masaki Kaibori, Yasuyuki Fujita, Kyoko Tanizawa, Tetsuya Ioji, Yoshihiro Fujimori, Kei Fukami, Takuma Hazama, Hideki Iwamoto, Yasukazu Kako, Kaoru Kobayashi, Hironori Koga, Koji Nagafuji, Takayasu Ohtake, Hiroyuki Suzuki, Tomoyuki Takashima, Toshitaka Tsukiyama, Haruki Uojima, Kenichi Yamahara, Koichiro Yamakado, Hidekazu Yamamoto, Kazunori Yoh, Satoshi Yoshihara, Atsuhiko Kawamoto, Shuhei Nishiguchi, Shuzo Kobayashi, Takuji Torimura, Takumi Kawaguchi

Source: Regenerative Therapy, Vol 27, Iss , Pp 455-463 (2024)

Subject Terms: CD34 antigens, Cell therapy, Clinical trial, Cirrhosis, Medicine (General), R5-920, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352320424000804; https://doaj.org/toc/2352-3204

Access URL: https://doaj.org/article/b19699346ecd4bd1940b165cd426aae3

Phase III clinical trial of autologous CD34 + cell transplantation to accelerate fracture nonunion repair

Authors: Ryosuke Kuroda, Takahiro Niikura, Tomoyuki Matsumoto, Tomoaki Fukui, Keisuke Oe, Yutaka Mifune, Hironobu Minami, Hiroshi Matsuoka, Kimikazu Yakushijin, Yoshiharu Miyata, Shinichiro Kawamoto, Tatsuo Kagimura, Yasuyuki Fujita, Atsuhiko Kawamoto

Source: BMC Medicine, Vol 21, Iss 1, Pp 1-16 (2023)

Subject Terms: Clinical trial, Phase III, CD34 + cell, Transplantation, Fracture nonunion, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1741-7015

Access URL: https://doaj.org/article/ea3ea946858643d39d493415861b4c62

A phase I/IIa clinical trial of third-generation autologous chondrocyte implantation (IK-01) for focal cartilage injury of the knee

Authors: Takehiko Matsushita, Tomoyuki Matsumoto, Daisuke Araki, Kanto Nagai, Yuichi Hoshino, Takahiro Niikura, Atsuhiko Kawamoto, Masahiro J. Go, Shin Kawamata, Masanori Fukushima, Ryosuke Kuroda

Source: Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology, Vol 28, Iss , Pp 6-12 (2022)

Subject Terms: Autologous chondrocyte implantation, Third-generation, Knee, Sports medicine, RC1200-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2214687322000061; https://doaj.org/toc/2214-6873

Access URL: https://doaj.org/article/87fd56079a1e45fe9e51e24192c5e4b5

Intravenous injection of adult human bone marrow mesenchymal stromal cells attenuates spinal cord ischemia/reperfusion injury in a murine aortic arch crossclamping modelCentral MessagePerspective

Authors: Hidekazu Nakai, MD, Yasuyuki Fujita, MD, PhD, Satoru Masuda, MT, Miki Komatsu, MT, Ayumi Tani, MT, Yutaka Okita, MD, PhD, Kenji Okada, MD, PhD, Atsuhiko Kawamoto, MD, PhD

Source: JTCVS Open, Vol 7, Iss , Pp 23-40 (2021)

Subject Terms: paraplegia, spinal cord ischemia, spinal cord reperfusion injury, human bone marrow mesenchymal stromal cells, thoracic aortic surgery, Diseases of the circulatory (Cardiovascular) system, RC666-701, Surgery, RD1-811

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666273621001571; https://doaj.org/toc/2666-2736

Access URL: https://doaj.org/article/0ce8700eddb94a95bb375e6a47d0cea5

Pre-Clinical Proof of Concept: Intra-Carotid Injection of Autologous CD34-Positive Cells for Chronic Ischemic Stroke

Authors: Yuko Ogawa, Yuka Okinaka, Akie Kikuchi-Taura, Orie Saino, Ayumi Tani-Yokoyama, Satoru Masuda, Miki Komatsu-Horii, Yoshihiko Ikemoto, Atsuhiko Kawamoto, Masanori Fukushima, Akihiko Taguchi

Source: Frontiers in Medicine, Vol 9 (2022)

Subject Terms: chronic stroke, peripheral blood CD34 positive cells, hematopoietic stem cells, internal carotid artery, pre-clinical proof of concept, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2022.681316/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/2d937bb7b7eb4906b9ea8701e52ba131

Hematopoietic stem-cell senescence and myocardial repair - Coronary artery disease genotype/phenotype analysis of post-MI myocardial regeneration response induced by CABG/CD133+ bone marrow hematopoietic stem cell treatment in RCT PERFECT Phase 3

Authors: Markus Wolfien, Denise Klatt, Amankeldi A. Salybekov, Masaaki Ii, Miki Komatsu-Horii, Ralf Gaebel, Julia Philippou-Massier, Eric Schrinner, Hiroshi Akimaru, Erika Akimaru, Robert David, Jens Garbade, Jan Gummert, Axel Haverich, Holger Hennig, Hiroto Iwasaki, Alexander Kaminski, Atsuhiko Kawamoto, Christian Klopsch, Johannes T. Kowallick, Stefan Krebs, Julia Nesteruk, Hermann Reichenspurner, Christian Ritter, Christof Stamm, Ayumi Tani-Yokoyama, Helmut Blum, Olaf Wolkenhauer, Axel Schambach, Takayuki Asahara, Gustav Steinhoff

Source: EBioMedicine, Vol 57, Iss , Pp 102862- (2020)

Subject Terms: Clonal hematopoiesis of indeterminate pathology, CHIP, SH2B3, Myocardial regeneration, Cardiac stem cell therapy, Angiogenesis induction, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396420302371; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/dd58128840ab4b1fb0fa839501efef79

Sonic Hedgehog signaling regulates vascular differentiation and function in human CD34 positive cells

Authors: Kurando Kanaya, Masaaki Ii, Teiji Okazaki, Toru Nakamura, Miki Horii-Komatsu, Cantas Alev, Hiroshi Akimaru, Atsuhiko Kawamoto, Hidetoshi Akashi, Hiroyuki Tanaka, Michio Asahi, Takayuki Asahara

Source: Stem Cell Research, Vol 14, Iss 2, Pp 165-176 (2015)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1873506115000045; https://doaj.org/toc/1873-5061; https://doaj.org/toc/1876-7753

Access URL: https://doaj.org/article/70f19c8012dd4450881077516a3a3135

Ex vivo expansion of circulating CD34+ cells enhances the regenerative effect on rat liver cirrhosis

Authors: Toru Nakamura, Hironori Koga, Hideki Iwamoto, Victor Tsutsumi, Yasuko Imamura, Masako Naitou, Atsutaka Masuda, Yu Ikezono, Mitsuhiko Abe, Fumitaka Wada, Takahiko Sakaue, Takato Ueno, Masaaki Ii, Cantas Alev, Atsuhiko Kawamoto, Takayuki Asahara, Takuji Torimura

Source: Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)

Subject Terms: Genetics, QH426-470, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S232905011630167X; https://doaj.org/toc/2329-0501

Access URL: https://doaj.org/article/ba8dfbdb893c47a8b0a8c5883ae2f795

Superior Potential of CD34-Positive Cells Compared to Total Mononuclear Cells for Healing of Nonunion following Bone Fracture

Authors: Tomoaki Fukui, Yutaka Mifune, Tomoyuki Matsumoto, Taro Shoji, Yohei Kawakami, Atsuhiko Kawamoto, Masaaki Ii, Hiroshi Akimaru, Tomoya Kuroda, Miki Horii, Ayumi Yokoyama, Cantas Alev, Ryosuke Kuroda, Masahiro Kurosaka, Takayuki Asahara M.D., Ph.D.

Source: Cell Transplantation, Vol 24 (2015)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/0963-6897; https://doaj.org/toc/1555-3892

Access URL: https://doaj.org/article/2933f687f1c84ad6b01e267cd92be207

Improvement of Cardiac Stem Cell Sheet Therapy for Chronic Ischemic Injury by Adding Endothelial Progenitor Cell Transplantation: Analysis of Layer-Specific Regional Cardiac Function

Authors: Sokichi Kamata, Shigeru Miyagawa, Satsuki Fukushima, Satoshi Nakatani, Atsuhiko Kawamoto, Atsuhiro Saito, Akima Harada, Tatsuya Shimizu, Takashi Daimon, Teruo Okano, Takayuki Asahara, Yoshiki Sawa

Source: Cell Transplantation, Vol 23 (2014)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/0963-6897; https://doaj.org/toc/1555-3892

Access URL: https://doaj.org/article/07e26a9140ae4ade8e299ff6b6f4b57b

Therapeutic Superiority for Cartilage Repair by CD271-Positive Marrow Stromal Cell Transplantation

Authors: Yutaka Mifune, Tomoyuki Matsumoto M.D., Ph.D., Satoshi Murasawa, Atsuhiko Kawamoto, Ryosuke Kuroda, Taro Shoji, Tomoya Kuroda, Tomoaki Fukui, Yohei Kawakami, Masahiro Kurosaka, Takayuki Asahara M.D., Ph.D.

Source: Cell Transplantation, Vol 22 (2013)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/0963-6897; https://doaj.org/toc/1555-3892

Access URL: https://doaj.org/article/d10cf6cf75344b7f9568391142ac1b83

Local Transplantation of Ex Vivo Expanded Bone Marrow-Derived CD34-Positive Cells Accelerates Fracture Healing

Authors: Yohei Kawakami, Masaaki Ii, Cantas Alev, Atsuhiko Kawamoto, Tomoyuki Matsumoto, Ryosuke Kuroda, Taro Shoji, Tomoaki Fukui, Haruchika Masuda, Hiroshi Akimaru, Yutaka Mifune, Tomoya Kuroda, Miki Horii, Ayumi Yokoyama, Masahiro Kurosaka, Takayuki Asahara M.D., Ph.D.

Source: Cell Transplantation, Vol 21 (2012)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/0963-6897; https://doaj.org/toc/1555-3892

Access URL: https://doaj.org/article/3792f2357e0a4fc7ba5b12df04c5cc2c

Local Transplantation of Granulocyte Colony-Stimulating Factor-Mobilized Human Peripheral Blood Mononuclear Cells for Unhealing Bone Fractures

Authors: Tomoaki Fukui, Tomoyuki Matsumoto M.D., Ph.D., Yutaka Mifune, Taro Shoji, Tomoya Kuroda, Yohei Kawakami, Atsuhiko Kawamoto, Masaaki Ii, Shin Kawamata, Masahiro Kurosaka, Takayuki Asahara, Ryosuke Kuroda

Source: Cell Transplantation, Vol 21 (2012)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/0963-6897; https://doaj.org/toc/1555-3892

Access URL: https://doaj.org/article/849dd184bc8a41daa537380589fae0b2

Local Transplantation of G-CSF-Mobilized CD34 Cells in a Patient with Tibial Nonunion: A Case Report

Authors: Ryosuke Kuroda, Tomoyuki Matsumoto, Masahiko Miwa, Atsuhiko Kawamoto, Yutaka Mifune, Tomoaki Fukui, Yohei Kawakami, Takahiro Niikura, Sang Yang Lee, Keisuke Oe, Taro Shoji, Tomoya Kuroda M.D., Miki Horii, Ayumi Yokoyama, Takayuki Ono, Yasushi Koibuchi, Shin Kawamata, Masanori Fukushima, Masahiro Kurosaka, Takayuki Asahara

Source: Cell Transplantation, Vol 20 (2011)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/0963-6897; https://doaj.org/toc/1555-3892

Access URL: https://doaj.org/article/012543922ae5473090c2e2af2e560b7f

PlGF repairs myocardial ischemia through mechanisms of angiogenesis, cardioprotection and recruitment of myo-angiogenic competent marrow progenitors.

Authors: Hiroto Iwasaki, Atsuhiko Kawamoto, Marc Tjwa, Miki Horii, Saeko Hayashi, Akira Oyamada, Tomoyuki Matsumoto, Shigefumi Suehiro, Peter Carmeliet, Takayuki Asahara

Source: PLoS ONE, Vol 6, Iss 9, p e24872 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3182165?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/004d51c656d649998e8bcb5094d6a224

CD34+ cells represent highly functional endothelial progenitor cells in murine bone marrow.

Authors: Junjie Yang, Masaaki Ii, Naosuke Kamei, Cantas Alev, Sang-Mo Kwon, Atsuhiko Kawamoto, Hiroshi Akimaru, Haruchika Masuda, Yoshiki Sawa, Takayuki Asahara

Source: PLoS ONE, Vol 6, Iss 5, p e20219 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3105013?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/4aeca3021cee4338842977456d5e06b9

Hard-to-heal wound treatment medical devices: clinical trial protocol in Japan.

Authors: Tatsuya Matsuda, Norihiko Ohura, Koji Mineta, Mami Ho, Kaku, I., Kensuke Ishii, Madoka Inoue, Shigeru Ichioka, Rica Tanaka, Atsuhiko Kawamoto, Hiroto Terashi, Kazuo Kishi, Yoko Kobayashi

Source: Journal of Wound Care; Aug2021, Vol. 30 Issue 8, p666-676, 9p

Subject Terms: ULCER treatment, WOUND healing, EXPERIMENTAL design, THOUGHT & thinking, TRAUMATOLOGY diagnosis, CHRONIC wounds & injuries, CLINICAL trials, RESEARCH protocols, MEDICAL protocols, RANDOMIZED controlled trials, NEGATIVE-pressure wound therapy, WOUND care, SURGICAL dressings

Geographic Terms: JAPAN

Local Transplantation of Granulocyte Colony Stimulating Factor-Mobilized CD34⁺ Cells for Patients With Femoral and Tibial Nonunion: Pilot Clinical Trial.

Authors: RYOSUKE KURODA, TOMOYUKI MATSUMOTO, TAKAHIRO NIIKURA, YOHEI KAWAKAMI, TOMOAKI FUKUI, SANG YANG LEE, YUTAKA MIFUNE, SHIN KAWAMATA, MASANORI FUKUSHIMA, TAKAYUKI ASAHARA, ATSUHIKO KAWAMOTO, MASAHIRO KUROSAKA

Source: Stem Cells Translational Medicine; Jan2014, Vol. 3 Issue 1, p128-134, 7p

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