Genetic toxicology in silico protocol

Authors: Hasselgren, Catrin, Ahlberg, Ernst, Akahori, Yumi, Amberg, Alexander, Anger, Lennart T., Atienzar, Franck, Auerbach, Scott, Beilke, Lisa, Bellion, Phillip, Benigni, Romualdo, Bercu, Joel, Booth, Ewan D., Bower, Dave, Brigo, Alessandro, Cammerer, Zoryana, Cronin, Mark T.D., Crooks, Ian, Cross, Kevin P., Custer, Laura, Dobo, Krista, Doktorova, Tatyana, Faulkner, David, Ford, Kevin A., Fortin, Marie C., Frericks, Markus, Gad-McDonald, Samantha E., Gellatly, Nichola, Gerets, Helga, Gervais, Véronique, Glowienke, Susanne, Van Gompel, Jacky, Harvey, James S., Hillegass, Jedd, Honma, Masamitsu, Hsieh, Jui-Hua, Hsu, Chia-Wen, Barton-Maclaren, Tara S., Johnson, Candice, Jolly, Robert, Jones, David, Kemper, Ray, Kenyon, Michelle O., Kruhlak, Naomi L., Kulkarni, Sunil A., Kümmerer, Klaus, Leavitt, Penny, Masten, Scott, Miller, Scott, Moudgal, Chandrika, Muster, Wolfgang, Paulino, Alexandre, Lo Piparo, Elena, Powley, Mark, Quigley, Donald P., Reddy, M. Vijayaray, Richarz, Andrea-Nicole, Schilter, Benoit, Snyder, Ronald D., Stavitskaya, Lidiya, Stidl, Reinhard, Szabo, David T., Teasdale, Andrew, Tice, Raymond R., Trejo-Martin, Alejandra, Vuorinen, Anna, Wall, Brian A., Watts, Pete, White, Angela T., Wichard, Joerg, Witt, Kristine L., Woolley, Adam, Woolley, David, Zwickl, Craig, Myatt, Glenn J.

Source: In Regulatory Toxicology and Pharmacology October 2019 107

A pharma-wide approach to address the genotoxicity prediction of primary aromatic amines

Authors: Patel, Mukesh, Kranz, Michael, Munoz-Muriedas, Jordi, Harvey, James S., Giddings, Amanda, Swallow, Steve, Fellows, Mick, Naven, Russell, Werner, Anne-Laure, Yeo, David J., Bringezu, Frank, Wichard, Joerg, Sutter, Andreas, Glowienke, Susanne, Whitehead, Lewis, Selby, Matt, Reuberson, James, Atienzar, Franck, Gerets, Helga, Kenyon, Michelle O., Dobo, Krista L., Walter, Magnus W., Jolly, Robert A., Amberg, Alexander, Spirkl, Hans-Peter, Muster, Wolfgang, Van Gompel, Jacques

Source: In Computational Toxicology August 2018 7:27-35

Current trends in in silico, in vitro toxicology, and safety biomarkers in early drug development

Authors: Loiodice, Simon, Nogueira da Costa, Andre, Atienzar, Franck

Source: Drug and chemical toxicology. 42(2):113-121

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100105355341.0x000001&indx=1&recIds=ETOCvdc_100105355341.0x000001

Predictivity of dog co-culture model, primary human hepatocytes and HepG2 cells for the detection of hepatotoxic drugs in humans

Authors: Atienzar, Franck A., Novik, Eric I., Gerets, Helga H., Parekh, Amit, Delatour, Claude, Cardenas, Alvaro, MacDonald, James, Yarmush, Martin L., Dhalluin, Stéphane

Source: In Toxicology and Applied Pharmacology 15 February 2014 275(1):44-61

The Use of Real-Time Cell Analyzer Technology in Drug Discovery: Defining Optimal Cell Culture Conditions and Assay Reproducibility with Different Adherent Cellular Models

Authors: Atienzar, Franck A. ^*, Tilmant, Karen, Gerets, Helga H., Toussaint, Gaelle, Speeckaert, Sebastien, Hanon, Etienne, Depelchin, Olympe, Dhalluin, Stephane

Source: In SLAS Discovery July 2011 16(6):575-587

The random amplified polymorphic DNA (RAPD) assay and related techniques applied to genotoxicity and carcinogenesis studies: A critical review

Authors: Atienzar, Franck A., Jha, Awadhesh N.

Source: In Mutation Research-Reviews in Mutation Research 2006 613(2):76-102

Genotoxic, cytotoxic, developmental and survival effects of tritiated water in the early life stages of the marine mollusc, Mytilus edulis

Authors: Hagger, Josephine A., Atienzar, Franck A., Jha, Awadhesh N. ^*

Source: In Aquatic Toxicology 2005 74(3):205-217

Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans.

Authors: Atienzar, Franck A.¹, Blomme, Eric A.², Chen, Minjun³, Hewitt, Philip⁴, Kenna, J. Gerry⁵, Labbe, Gilles⁶, Moulin, Frederic⁷, Pognan, Francois⁸, Roth, Adrian B.⁹, Suter-Dick, Laura¹⁰, Ukairo, Okechukwu¹¹, Weaver, Richard J.¹², Will, Yvonne¹³, Dambach, Donna M.¹⁴

Source: BioMed Research International. 9/5/2016, Vol. 2016, p1-20. 20p.

Subject Terms: *LIVER disease diagnosis, *BIOLOGICAL assay, *BIOLOGICAL models, *DRUG design, *CLINICAL drug trials, *HEPATOTOXICOLOGY, *LIVER diseases, *REFERENCE values, *RISK assessment, *DRUG development, *INVESTIGATIONAL drugs, *IN vitro studies, *DISEASE risk factors

The random amplified polymorphic DNA (RAPD) assay to determine DNA alterations, repair and transgenerational effects in B( a)P exposed Daphnia magna

Authors: Atienzar, Franck A, Jha, Awadhesh N

Source: In Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 2004 552(1):125-140

Transcriptomic effects of di-(2-ethylhexyl)-phthalate in Syrian hamster embryo cells: an important role of early cytoskeleton disturbances in carcinogenesis?

Authors: Atienzar Franck, Poupin Pascal, Landkocz Yann, Vasseur Paule

Source: BMC Genomics, Vol 12, Iss 1, p 524 (2011)

Subject Terms: Biotechnology, TP248.13-248.65, Genetics, QH426-470

File Description: electronic resource

Relation: http://www.biomedcentral.com/1471-2164/12/524; https://doaj.org/toc/1471-2164

Access URL: https://doaj.org/article/e48a80b30eee4b938bab8e5f6e6a8ec0

Evaluation of the random amplified polymorphic DNA (RAPD) assay for the detection of DNA damage and mutations

Authors: Atienzar, Franck A, Venier, Paola, Jha, Awadhesh N, Depledge, Michael H

Source: In Mut.Res.-Genetic Toxicology and Environmental Mutagenesis 2002 521(1):151-163

4- n-Nonylphenol and 17-β estradiol may induce common DNA effects in developing barnacle larvae

Authors: Atienzar, Franck A, Billinghurst, Zoë, Depledge, Michael H

Source: In Environmental Pollution 2002 120(3):735-738

Comparison of ultraviolet-induced genotoxicity detected by random amplified polymorphic DNA with chlorophyll fluorescence and growth in a marine macroalgae, Palmariapalmata

Authors: Atienzar, Franck A ^*, Cordi, Britt, Donkin, Maria E, Evenden, Andrew J, Jha, Awadhesh N, Depledge, Michael H

Source: In Aquatic Toxicology 2000 50(1):1-12

Evaluation of Impedance-Based Label-Free Technology as a Tool for Pharmacology and Toxicology Investigations.

Authors: Atienzar, Franck André¹, Gerets, Helga¹, helga.gerets@ucb.com, Tilmant, Karen¹, karen.tilmant@ucb.com, Toussaint, Gaë lle¹, gaelle.toussaint@ucb.com, Dhalluin, Stéphane¹, stephane.dhalluin@ucb.com

Source: Biosensors (2079-6374); Mar2013, Vol. 3 Issue 1, p132-156, 25p

Use of the random amplif|ed polymorphic DNA (RAPD) assay for the detection of DNA damage and mutations: possible implications of confounding factors.

Authors: Atienzar, Franck A., Evenden, Andrew J., Jha, Awadhesh N., Depledge, Michael H.

Source: Biomarkers. Jan/Feb2002, Vol. 7 Issue 1, p94-101. 8p. 1 Chart, 4 Graphs.

Subject Terms: *GENE expression

Molecular diversity of Renibacterium salmoninarum isolates determined by randomly amplified polymorphic DNA analysis.

Authors: Grayson, T. Hilton, Atienzar, Franck A., Alexander, Sarah M.

Source: Applied & Environmental Microbiology; January 2000, Vol. 66 Issue 1, p435-438, 4p

Molecular differentiation of Renibacterium salmoninarum isolates from worldwide locations.

Authors: Grayson, Thomas H., Cooper, Lynne F., Atienzar, Franck A.

Source: Applied & Environmental Microbiology; March 1999, Vol. 65 Issue 3, p961-968, 8p

De-risking primary and secondary pharmacology mediated adverse effects as a path to increase likelihood of success in drug development

Authors: Valentin, Jean-Pierre, Atienzar, Franck, Class, Reiner, Delaunois, Annie, Fleurance, Renaud, Gerets, Helga, Glineur, Stéphanie, Gryshkova, Vitalina, Hall, Peter, Hasselgren, Catrin, Tilmant, Karen

Source: Toxicology letters. 280(1):S77-S77

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100061453831.0x000001&indx=1&recIds=ETOCvdc_100061453831.0x000001

A data-driven modeling method to analyze cardiomyocyte impedance data

Authors: Batista, Levy, Bastogne, Thierry, Atienzar, Franck, Delaunois, Annie, Valentin, Jean-Pierre

Source: In Journal of Pharmacological and Toxicological Methods September-October 2018 93:140-140

Investigation of the Nrf2 Stress Response at Cellular Level to Detect Compounds Inducing Oxidative and Electrophilic Stress.

Authors: Gerets, Helga H. J., Tilmant, Karen, Valentin, Jean-Pierre, Atienzar, Franck A.

Source: Applied In Vitro Toxicology; Sep2018, Vol. 4 Issue 3, p248-264, 17p