Modeling Anti-HIV-1 HSPC-Based Gene Therapy in Humanized Mice Previously Infected with HIV-1

Authors: Khamaikawin, Wannisa, Shimizu, Saki, Kamata, Masakazu, Cortado, Ruth, Jung, Yujin, Lam, Jennifer, Wen, Jing, Kim, Patrick, Xie, Yiming, Kim, Sanggu, Arokium, Hubert, Presson, Angela P., Chen, Irvin S.Y., An, Dong Sung

Source: In Molecular Therapy - Methods & Clinical Development 15 June 2018 9:23-32

Longitudinal clonal tracking in humanized mice reveals sustained polyclonal repopulation of gene-modified human-HSPC despite vector integration bias.

Authors: Suryawanshi, Gajendra W.^1,2 (AUTHOR), Arokium, Hubert^1,2 (AUTHOR), Kim, Sanggu^3,4,5 (AUTHOR), Khamaikawin, Wannisa^6,7 (AUTHOR), Lin, Samantha⁶ (AUTHOR), Shimizu, Saki⁶ (AUTHOR), Chupradit, Koollawat⁶ (AUTHOR), Lee, YooJin^1,2 (AUTHOR), Xie, Yiming^1,2 (AUTHOR), Guan, Xin^1,2 (AUTHOR), Suryawanshi, Vasantika⁸ (AUTHOR), Presson, Angela P.^9,10 (AUTHOR), An, Dong-Sung^2,6 (AUTHOR), Chen, Irvin S. Y.^1,2,11 (AUTHOR) syuchen@mednet.ucla.edu

Source: Stem Cell Research & Therapy. 10/7/2021, Vol. 12 Issue 1, p1-20. 20p.

Subject Terms: *MICE, *HEMATOPOIETIC stem cells, *LABORATORY mice, *STEM cell treatment, *HEMATOPOIESIS

Bcl-xL stimulates Bax relocation to mitochondria and primes cells to ABT-737

Authors: Renault, Thibaud T., Teijido, Oscar, Missire, Florent, Ganesan, Yogesh Tengarai, Velours, Gisèle, Arokium, Hubert, Beaumatin, Florian, Llanos, Raul, Athané, Axel, Camougrand, Nadine, Priault, Muriel, Antonsson, Bruno, Dejean, Laurent M., Manon, Stéphen

Source: In International Journal of Biochemistry and Cell Biology July 2015 64:136-146

Non-phosphorylatable mutants of Ser184 lead to incomplete activation of Bax.

Authors: Simonyan, Lilit, Gonin, Mathilde, Hanks, James, Friedlein, Jordan, Dutrec, Kevin, Arokium, Hubert, Eyitayo, Akandé Rouchidane, Doudy, Toukounou Megann, Chaignepain, Stéphane, Manon, Stéphen, Dejean, Laurent

Source: Frontiers in Oncology; 1/19/2023, Vol. 13, p1-13, 13p

Subject Terms: CYTOCHROME c, MITOCHONDRIAL membranes, LIPOSOMES, MITOCHONDRIA, OLIGOMERS

Substitutions of Potentially Phosphorylatable Serine Residues of Bax Reveal How They May Regulate Its Interaction with Mitochondria

Authors: Arokium, Hubert, Ouerfelli, Hakim, Velours, Gisèle, Camougrand, Nadine, Vallette, François M., Manon, Stéphen

Source: In Journal of Biological Chemistry 30 November 2007 282(48):35104-35112

Distinct Domains Control the Addressing and the Insertion of Bax into Mitochondria

Authors: Cartron, Pierre-François ^{‡, §}, Arokium, Hubert ^{‡, ¶}, Oliver, Lisa ^‡, Meflah, Khaled ^‡, Manon, Stephen ^¶, Vallette, François M. ^{‡, ∥}

Source: In Journal of Biological Chemistry 18 March 2005 280(11):10587-10598

Studies of the Interaction of Substituted Mutants of BAX with Yeast Mitochondria Reveal That the C-terminal Hydrophobic α-Helix Is a Second ART Sequence and Plays a Role in the Interaction with Anti-apoptotic BCL-xL

Authors: Arokium, Hubert ^‡, Camougrand, Nadine ^‡, Vallette, François M. ^§, Manon, Stéphen ^{‡, ¶}

Source: In Journal of Biological Chemistry 10 December 2004 279(50):52566-52573

Deep Sequencing Reveals Low Incidence of Endogenous LINE-1 Retrotransposition in Human Induced Pluripotent Stem Cells.

Authors: Arokium, Hubert¹, Kamata, Masakazu¹, Kim, Sanggu¹, Kim, Namshin², Liang, Min¹, Presson, Angela P.³, Chen, Irvin S.¹ syuchen@mednet.ucla.edu

Source: PLoS ONE. Oct2014, Vol. 9 Issue 10, p1-11. 11p.

Subject Terms: *PLURIPOTENT stem cells, *SOMATIC cells, *HUMAN endogenous retroviruses, *GENETIC toxicology, *MOLECULAR genetics

The cytosolic domain of human Tom22 modulates human Bax mitochondrial translocation and conformation in yeast

Authors: Renault, Thibaud T., Grandier-Vazeille, Xavier, Arokium, Hubert, Velours, Gisèle, Camougrand, Nadine, Priault, Muriel, Teijido, Oscar, Dejean, Laurent M., Manon, Stéphen

Source: In FEBS Letters 20 January 2012 586(2):116-121

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

Contribution of Yeast Studies to the Understanding of BCL-2 Family Intracellular Trafficking.

Authors: Rouchidane Eyitayo, Akandé, Gonin, Mathilde, Arokium, Hubert, Manon, Stéphen

Source: International Journal of Molecular Sciences; Apr2021, Vol. 22 Issue 8, p4086, 1p

Subject Terms: YEAST, ENDOPLASMIC reticulum, MOLECULAR genetics, SACCHAROMYCES cerevisiae, CELL death, INTRACELLULAR pathogens

The clonal repopulation of HSPC gene modified with anti-HIV-1 RNAi is not affected by preexisting HIV-1 infection.

Authors: Suryawanshi, Gajendra W.^1,2, Khamaikawin, Wannisa^2,3, Jing Wen^1,2, Shimizu, Saki³, Arokium, Hubert^1,2, Yiming Xie^1,2, Wang, Eugene¹, Shihyoung Kim^4,5,6, Hyewon Choi^1,2,4, Chong Zhang⁷, Hannah Yu^4,5,6, Presson, Angela P.^7,8, Kim, Namshin⁹, Dong-Sung An^2,3, Chen, Irvin S. Y.^1,2,10 syuchen@mednet.ucla.edu, Sanggu Kim^4,5,6

Source: Science Advances. 7/24/2020, Vol. 6 Issue 30, p1-13. 13p.

Subject Terms: *HEMATOPOIESIS, *HIV infections, *HIGHLY active antiretroviral therapy, *PYROSEQUENCING, *BUSULFAN