Rev-erb-α antagonism in alveolar macrophages protects against pneumococcal infection in elderly mice

Authors: Fabiola Silva Angulo, Claudine Vanessa Joseph, Lou Delval, Lucie Deruyter, Séverine Heumel, Marie Bicharel, Patricia Brito Rodrigues, Valentin Sencio, Tom Bourguignon, Marina Gomes Machado, Marie Fourcot, Stéphane Delhaye, Sophie Salomé-Desnoulez, Philippe Valet, Serge Adnot, Isabelle Wolowczuk, Jean-Claude Sirard, Muriel Pichavant, Bart Staels, Joel T. Haas, Ruxandra Gref, Jimmy Vandel, Arnaud Machelart, Hélène Duez, Benoit Pourcet, François Trottein

Source: Cell Reports, Vol 44, Iss 2, Pp 115273- (2025)

Subject Terms: CP: Microbiology, CP: Immunology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124725000440; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/daa291d32d904bd9bb15ab8fb98a8451

Tirap controls Mycobacterium tuberculosis phagosomal acidification.

Authors: Imène Belhaouane, Amine Pochet, Jonathan Chatagnon, Eik Hoffmann, Christophe J Queval, Nathalie Deboosère, Céline Boidin-Wichlacz, Laleh Majlessi, Valentin Sencio, Séverine Heumel, Alexandre Vandeputte, Elisabeth Werkmeister, Laurence Fievez, Fabrice Bureau, Yves Rouillé, François Trottein, Mathias Chamaillard, Priscille Brodin, Arnaud Machelart

Source: PLoS Pathogens, Vol 19, Iss 3, p e1011192 (2023)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/b076df58fca44a32911ed45f8f9c632b

Alteration of the gut microbiota following SARS-CoV-2 infection correlates with disease severity in hamsters

Authors: Valentin Sencio, Arnaud Machelart, Cyril Robil, Nicolas Benech, Eik Hoffmann, Chloé Galbert, Lucie Deryuter, Séverine Heumel, Aline Hantute-Ghesquier, Anne Flourens, Priscille Brodin, Fabrice Infanti, Virgile Richard, Jean Dubuisson, Corinne Grangette, Thierry Sulpice, Isabelle Wolowczuk, Florence Pinet, Vincent Prévot, Sandrine Belouzard, François Briand, Martine Duterque-Coquillaud, Harry Sokol, François Trottein

Source: Gut Microbes, Vol 14, Iss 1 (2022)

Subject Terms: sars-cov-2, covid-19, hamsters, gut microbiota, markers of disease severity, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/1949-0976; https://doaj.org/toc/1949-0984

Access URL: https://doaj.org/article/550d4d66dfae45ffb125630022a5aad4

Alteration of the gut microbiota’s composition and metabolic output correlates with COVID-19-like severity in obese NASH hamsters

Authors: Valentin Sencio, Nicolas Benech, Cyril Robil, Lucie Deruyter, Séverine Heumel, Arnaud Machelart, Thierry Sulpice, Antonin Lamazière, Corinne Grangette, François Briand, Harry Sokol, François Trottein

Source: Gut Microbes, Vol 14, Iss 1 (2022)

Subject Terms: SARS-CoV-2, hamsters, gut microbiota, obesity, NASH, COVID-19, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/1949-0976; https://doaj.org/toc/1949-0984

Access URL: https://doaj.org/article/a5f3a88364964b48ab00ce67879bbede

C910 chemical compound inhibits the traffiking of several bacterial AB toxins with cross-protection against influenza virus

Authors: Yu Wu, Nassim Mahtal, Eléa Paillares, Léa Swistak, Sara Sagadiev, Mridu Acharya, Caroline Demeret, Sylvie Van Der Werf, Florence Guivel-Benhassine, Olivier Schwartz, Serena Petracchini, Amel Mettouchi, Lucie Caramelle, Pierre Couvineau, Robert Thai, Peggy Barbe, Mathilde Keck, Priscille Brodin, Arnaud Machelart, Valentin Sencio, François Trottein, Martin Sachse, Gaëtan Chicanne, Bernard Payrastre, Florian Ville, Victor Kreis, Michel-Robert Popoff, Ludger Johannes, Jean-Christophe Cintrat, Julien Barbier, Daniel Gillet, Emmanuel Lemichez

Source: iScience, Vol 25, Iss 7, Pp 104537- (2022)

Subject Terms: Biological sciences, Microbiology, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004222008082; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/a1115a643e6e4c1fb159e5c28cc1dc8c

Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice.

Authors: Sandrine Belouzard, Arnaud Machelart, Valentin Sencio, Thibaut Vausselin, Eik Hoffmann, Nathalie Deboosere, Yves Rouillé, Lowiese Desmarets, Karin Séron, Adeline Danneels, Cyril Robil, Loic Belloy, Camille Moreau, Catherine Piveteau, Alexandre Biela, Alexandre Vandeputte, Séverine Heumel, Lucie Deruyter, Julie Dumont, Florence Leroux, Ilka Engelmann, Enagnon Kazali Alidjinou, Didier Hober, Priscille Brodin, Terence Beghyn, François Trottein, Benoit Deprez, Jean Dubuisson

Source: PLoS Pathogens, Vol 18, Iss 5, p e1010498 (2022)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/ef24a1fe221949deb66833f87060787b

Occurrence and repair of alkylating stress in the intracellular pathogen Brucella abortus

Authors: Katy Poncin, Agnès Roba, Ravikumar Jimmidi, Georges Potemberg, Antonella Fioravanti, Nayla Francis, Kévin Willemart, Nicolas Zeippen, Arnaud Machelart, Emanuele G. Biondi, Eric Muraille, Stéphane P. Vincent, Xavier De Bolle

Source: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/0e9cb03fdb914652b78daf4b8a72caac

Aconitate decarboxylase 1 participates in the control of pulmonary Brucella infection in mice.

Authors: Aurore Demars, Armelle Vitali, Audrey Comein, Elodie Carlier, Abdulkader Azouz, Stanislas Goriely, Justine Smout, Véronique Flamand, Mégane Van Gysel, Johan Wouters, Jan Abendroth, Thomas E Edwards, Arnaud Machelart, Eik Hoffmann, Priscille Brodin, Xavier De Bolle, Eric Muraille

Source: PLoS Pathogens, Vol 17, Iss 9, p e1009887 (2021)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/0ebdeb0dee1242609d7b967c5f88f4d6

Diet-Induced Obesity and NASH Impair Disease Recovery in SARS-CoV-2-Infected Golden Hamsters

Authors: François Briand, Valentin Sencio, Cyril Robil, Séverine Heumel, Lucie Deruyter, Arnaud Machelart, Johanna Barthelemy, Gemma Bogard, Eik Hoffmann, Fabrice Infanti, Oliver Domenig, Audrey Chabrat, Virgile Richard, Vincent Prévot, Ruben Nogueiras, Isabelle Wolowczuk, Florence Pinet, Thierry Sulpice, François Trottein

Source: Viruses, Vol 14, Iss 9, p 2067 (2022)

Subject Terms: obesity, non-alcoholic steatohepatitis, coronavirus disease 2019, SARS-CoV-2, hamster, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/14/9/2067; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/e0f3dac631bc44eea379559d5efb400a

SARS-CoV-2 infection in nonhuman primates alters the composition and functional activity of the gut microbiota

Authors: Harry Sokol, Vanessa Contreras, Pauline Maisonnasse, Aurore Desmons, Benoit Delache, Valentin Sencio, Arnaud Machelart, Angela Brisebarre, Lydie Humbert, Lucie Deryuter, Emilie Gauliard, Severine Heumel, Dominique Rainteau, Nathalie Dereuddre-Bosquet, Elisabeth Menu, Raphael Ho Tsong Fang, Antonin Lamaziere, Loic Brot, Celine Wahl, Cyriane Oeuvray, Nathalie Rolhion, Sylvie Van Der Werf, Stéphanie Ferreira, Roger Le Grand, François Trottein

Source: Gut Microbes, Vol 13, Iss 1 (2021)

Subject Terms: gut microbiota, sars-cov-2, nonhuman primates, gut dysbiosis, metabolic output, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/1949-0976; https://doaj.org/toc/1949-0984

Access URL: https://doaj.org/article/96114ecd567a452385dfa9b0689f78e6

Paradoxical Roles of the MAL/Tirap Adaptor in Pathologies

Authors: Imène Belhaouane, Eik Hoffmann, Mathias Chamaillard, Priscille Brodin, Arnaud Machelart

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: TLRs, MAL/Tirap, chronic diseases, signaling pathways, inflammation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2020.569127/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/f34cb8fa349941d8a85101ce177b40a2

Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles

Authors: Joana Costa-Gouveia, Elisabetta Pancani, Samuel Jouny, Arnaud Machelart, Vincent Delorme, Giuseppina Salzano, Raffaella Iantomasi, Catherine Piveteau, Christophe J. Queval, Ok-Ryul Song, Marion Flipo, Benoit Deprez, Jean-Paul Saint-André, José Hureaux, Laleh Majlessi, Nicolas Willand, Alain Baulard, Priscille Brodin, Ruxandra Gref

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/b72ffe20c51947b68f1019be57e2cb02

Route of Infection Strongly Impacts the Host-Pathogen Relationship

Authors: Aurore Demars, Aurore Lison, Arnaud Machelart, Margaux Van Vyve, Georges Potemberg, Jean-Marie Vanderwinden, Xavier De Bolle, Jean-Jacques Letesson, Eric Muraille

Source: Frontiers in Immunology, Vol 10 (2019)

Subject Terms: Brucella melitensis, brucellosis, infection control, live vaccine, virulence genes, reservoir cells, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.01589/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/4f160955635d45c18637bd532bcf3353

Allergic Asthma Favors Brucella Growth in the Lungs of Infected Mice

Authors: Arnaud Machelart, Georges Potemberg, Laurye Van Maele, Aurore Demars, Maxime Lagneaux, Carl De Trez, Catherine Sabatel, Fabrice Bureau, Sofie De Prins, Pauline Percier, Olivier Denis, Fabienne Jurion, Marta Romano, Jean-Marie Vanderwinden, Jean-Jacques Letesson, Eric Muraille

Source: Frontiers in Immunology, Vol 9 (2018)

Subject Terms: allergic asthma, infection, Brucella melitensis, Streptococcus pneumoniae, brucellosis, Mycobacterium tuberculosis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2018.01856/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/9fb7971b7e914ae9985b5ab2e2d99d4e

Proteomics of Mycobacterium Infection: Moving towards a Better Understanding of Pathogen-Driven Immunomodulation

Authors: Eik Hoffmann, Arnaud Machelart, Ok-Ryul Song, Priscille Brodin

Source: Frontiers in Immunology, Vol 9 (2018)

Subject Terms: host–pathogen interactions, immunometabolism, mass spectrometry, mycobacterial infection, Mycobacterium tuberculosis, phagocytosis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fimmu.2018.00086/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/aa02bef203fe4b5ba1f61624536700ca

Trypanosoma Infection Favors Brucella Elimination via IL-12/IFNγ-Dependent Pathways

Authors: Arnaud Machelart, Margaux Van Vyve, Georges Potemberg, Aurore Demars, Carl De Trez, Hermann Giresse Tima, Gilles Vanwalleghem, Marta Romano, Carine Truyens, Jean-Jacques Letesson, Eric Muraille

Source: Frontiers in Immunology, Vol 8 (2017)

Subject Terms: infection control, Trypanosoma cruzi, Trypanosoma brucei brucei, Brucella melitensis, Brucella abortus, brucellosis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fimmu.2017.00903/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/e3b9ba9861d241f98d200b6ed77d17b2

Erythritol Availability in Bovine, Murine and Human Models Highlights a Potential Role for the Host Aldose Reductase during Brucella Infection

Authors: Thibault Barbier, Arnaud Machelart, Amaia Zúñiga-Ripa, Hubert Plovier, Charlotte Hougardy, Elodie Lobet, Kevin Willemart, Eric Muraille, Xavier De Bolle, Emile Van Schaftingen, Ignacio Moriyón, Jean-Jacques Letesson

Source: Frontiers in Microbiology, Vol 8 (2017)

Subject Terms: Brucella, erythritol, aldose reductase, murine model, bovine trophoblast, human trophoblast, Microbiology, QR1-502

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fmicb.2017.01088/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/575807365bd94234a9acf1ac1f3de78e

Publisher Correction: Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles

Authors: Joana Costa-Gouveia, Elisabetta Pancani, Samuel Jouny, Arnaud Machelart, Vincent Delorme, Giuseppina Salzano, Raffaella Iantomasi, Catherine Piveteau, Christophe J. Queval, Ok-Ryul Song, Marion Flipo, Benoit Deprez, Jean-Paul Saint-André, José Hureaux, Laleh Majlessi, Nicolas Willand, Alain Baulard, Priscille Brodin, Ruxandra Gref

Source: Scientific Reports, Vol 8, Iss 1, Pp 1-1 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/b18214c8b972422fbd41c9543e4edc14

In Situ Characterization of Splenic Brucella melitensis Reservoir Cells during the Chronic Phase of Infection in Susceptible Mice.

Authors: Delphine Hanot Mambres, Arnaud Machelart, Jean-Marie Vanderwinden, Carl De Trez, Bernhard Ryffel, Jean-Jacques Letesson, Eric Muraille

Source: PLoS ONE, Vol 10, Iss 9, p e0137835 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/512256312d5e4e838d14692d2a8de107

In situ microscopy analysis reveals local innate immune response developed around Brucella infected cells in resistant and susceptible mice.

Authors: Richard Copin, Marie-Alice Vitry, Delphine Hanot Mambres, Arnaud Machelart, Carl De Trez, Jean-Marie Vanderwinden, Stefan Magez, Shizuo Akira, Bernhard Ryffel, Yves Carlier, Jean-Jacques Letesson, Eric Muraille

Source: PLoS Pathogens, Vol 8, Iss 3, p e1002575 (2012)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3315488?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/a5115f1744a94d1e86c5dfa0bfb0bea3