Cardiovascular Risk Factors and Genetic Risk in Transthyretin V142I Carriers

Authors: Shetty, Naman S. ^{a, b}, Gaonkar, Mokshad ^c, Pampana, Akhil ^c, Patel, Nirav ^c, Morrison, Alanna C. ^d, Reiner, Alexander P. ^{e, f}, Carson, April P. ^g, Yu, Bing ^d, Psaty, Bruce M. ^{e, h, i}, Kooperberg, Charles ^f, Fatkin, Diane ^{j, k, l}, Boerwinkle, Eric ^d, Rotter, Jerome I. ^m, Taylor, Kent D. ^m, Hou, Lifang ⁿ, Irvin, Marguerite R. ^o, Hall, Michael E. ^g, Maurer, Mathew ^p, Fornage, Myriam ^q, Armstrong, Nicole D. ^o, Bart, Nicole ^{j, k, l}, Goyal, Parag ^r, Rich, Stephen S. ^s, Vasan, Ramachandran S. ^t, Li, Peng ^u, Arora, Garima ^c, Arora, Pankaj ^{c, v, ∗}

Source: In JACC: Heart Failure January 2025 13(1):91-101

Utility of a Systolic Blood Pressure Polygenic Risk Score With Chlorthalidone Response.

Authors: Armstrong, Nicole D., Srinivasasainagendra, Vinodh, Patki, Amit, Jones, Alana C., Parcha, Vibhu, Pampana, Akhil, Broeckel, Ulrich, Lange, Leslie A., Arora, Pankaj, Limdi, Nita A., Tiwari, Hemant K., Irvin, Marguerite R.

Source: JAMA Cardiology; Dec2024, Vol. 9 Issue 12, p1134-1141, 8p

The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet and Metabolites in Chronic Kidney Disease.

Authors: Couch, Catharine A., Ament, Zsuzsanna, Patki, Amit, Kijpaisalratana, Naruchorn, Bhave, Varun, Jones, Alana C., Armstrong, Nicole D., Cheung, Katharine L., Kimberly, W. Taylor, Tiwari, Hemant K., Irvin, Marguerite Ryan

Source: Nutrients; Aug2024, Vol. 16 Issue 15, p2458, 12p

A methylation risk score for chronic kidney disease: a HyperGEN study.

Authors: Jones, Alana C., Patki, Amit, Srinivasasainagendra, Vinodh, Hidalgo, Bertha A., Tiwari, Hemant K., Limdi, Nita A., Armstrong, Nicole D., Chaudhary, Ninad S., Minniefield, Bré, Absher, Devin, Arnett, Donna K., Lange, Leslie A., Lange, Ethan M., Young, Bessie A., Diamantidis, Clarissa J., Rich, Stephen S., Mychaleckyj, Josyf C., Rotter, Jerome I., Taylor, Kent D., Kramer, Holly J.

Source: Scientific Reports; 8/1/2024, Vol. 14 Issue 1, p1-10, 10p

Subject Terms: DISEASE risk factors, CHRONIC kidney failure, GENETIC epidemiology, DNA methylation, GLOMERULAR filtration rate

Telomere shortening and the transition to family caregiving in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study.

Authors: Armstrong, Nicole D.¹ (AUTHOR), Irvin, Marguerite R.¹ (AUTHOR), Haley, William E.² (AUTHOR), Blinka, Marcela D.³ (AUTHOR), Kamin Mukaz, Debora⁴ (AUTHOR), Patki, Amit⁵ (AUTHOR), Rutherford Siegel, Sue⁶ (AUTHOR), Shalev, Idan⁶ (AUTHOR), Durda, Peter⁷ (AUTHOR), Mathias, Rasika A.⁸ (AUTHOR), Walston, Jeremy D.³ (AUTHOR), Roth, David L.³ (AUTHOR) droth@jhu.edu

Source: PLoS ONE. 6/3/2022, Vol. 17 Issue 6, p1-14. 14p.

Subject Terms: *RACIAL differences, *CELLULAR aging, *FAMILY roles, *CROSS-sectional method, *LONGITUDINAL method, *TELOMERES

Polygenic Risk for Type 2 Diabetes in African Americans.

Authors: Irvin, Marguerite R., Ge, Tian, Patki, Amit, Srinivasasainagendra, Vinodh, Armstrong, Nicole D., Davis, Brittney, Jones, Alana C., Perez, Emma, Stalbow, Lauren, Lebo, Matthew, Kenny, Eimear, Loos, Ruth J.F., Ng, Maggie C.Y., Smoller, Jordan W., Meigs, James B., Lange, Leslie A., Karlson, Elizabeth W., Limdi, Nita A., Tiwari, Hemant K.

Source: Diabetes; Jun2024, Vol. 73 Issue 6, p993-1001, 9p

Subject Terms: GENETIC risk score, TYPE 2 diabetes, MONOGENIC & polygenic inheritance (Genetics), AFRICAN Americans, ODDS ratio

Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes.

Authors: Kwak, Soo Heon, Hernandez-Cancela, Ryan B., DiCorpo, Daniel A., Condon, David E., Merino, Jordi, Wu, Peitao, Brody, Jennifer A., Yao, Jie, Guo, Xiuqing, Ahmadizar, Fariba, Meyer, Mariah, Sincan, Murat, Mercader, Josep M., Lee, Sujin, Haessler, Jeffrey, Vy, Ha My T., Lin, Zhaotong, Armstrong, Nicole D., Gu, Shaopeng, Tsao, Noah L.

Source: Diabetes Care; Jun2024, Vol. 47 Issue 6, p1042-1047, 6p

Subject Terms: GENOME-wide association studies, TYPE 2 diabetes, CARDIOVASCULAR diseases, CARDIOVASCULAR diseases risk factors, CORONARY artery disease

Sex-Associated Metabolites and Incident Stroke, Incident Coronary Heart Disease, Hypertension, and Chronic Kidney Disease in the REGARDS Cohort.

Authors: Couch, Catharine A., Ament, Zsuzsanna, Patki, Amit, Kijpaisalratana, Naruchorn, Bhave, Varun, Jones, Alana C., Armstrong, Nicole D., Cushman, Mary, Kimberly, W. Taylor, Irvin, M. Ryan

Source: Journal of the American Heart Association; 5/7/2024, Vol. 13 Issue 9, p1-13, 13p

Diversity in genetic risk of recurrent stroke: a genome-wide association study meta-analysis.

Authors: Aldridge, Chad M., Armstrong, Nicole D., Sunmonu, N. Abimbola, Becker, Christopher, Palakshappa, Deepak, Lindgren, Arne G., Pedersen, Annie, Stanne, Tara M., Jern, Christina, Maguire, Jane, Fang-Chi Hsu, Keene, Keith L., Sale, Michele, Irvin, Marguerite R., Worrall, Bradford B.

Source: Frontiers in Stroke; 2024, p1-10, 10p

The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes.

Authors: Denorme, Frederik^1,2, Armstrong, Nicole D.³, Stoller, Michelle L.¹, Portier, Irina¹, Tugolukova, Emilia A.¹, Tanner, Rikki M.³, Montenont, Emilie¹, Bhatlekar, Seema¹, Cody, Mark¹, Rustad, John L.¹, Ajanel, Abigail¹, Tolley, Neal D.¹, Murray, Darian C.¹, Boyle, Julie L.⁴, Nieman, Marvin T.⁵, McKenzie, Steven E.⁶, Yost, Christian Con^1,7, Lange, Leslie A.⁸, Cushman, Mary⁹, Irvin, Marguerite R.²

Source: Journal of Clinical Investigation. 9/15/2023, Vol. 133 Issue 18, p1-18. 18p.

Subject Terms: *ISCHEMIC stroke, *PROTEASE-activated receptors, *BLACK people, *BLOOD platelet aggregation, *BLOOD platelet activation

Circulating Metabolites Associated with Albuminuria in a Hispanic/Latino Population

Authors: Reynolds, Kaylia M., Lin, Bridget M., Armstrong, Nicole D., Ottosson, Filip, Zhang, Ying, Williams, Ashley S., Yu, Bing, Boerwinkle, Eric, Thygarajan, Bharat, Daviglus, Martha L., Muoio, Deborah, Qi, Qibin, Kaplan, Robert, Melander, Olle, Lash, James P., Cai, Jianwen, Irvin, Marguerite R., Newgard, Christopher B., Sofer, Tamar, Franceschini, Nora

Source: Clinical Journal of The American Society of Nephrology; February 2023, Vol. 18 Issue: 2 p204-212, 9p

Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations.

Authors: Ge, Tian, Irvin, Marguerite R., Patki, Amit, Srinivasasainagendra, Vinodh, Lin, Yen-Feng, Tiwari, Hemant K., Armstrong, Nicole D., Benoit, Barbara, Chen, Chia-Yen, Choi, Karmel W., Cimino, James J., Davis, Brittney H., Dikilitas, Ozan, Etheridge, Bethany, Feng, Yen-Chen Anne, Gainer, Vivian, Huang, Hailiang, Jarvik, Gail P., Kachulis, Christopher, Kenny, Eimear E.

Source: Genome Medicine; 7/8/2022, Vol. 14, p1-16, 16p

Subject Terms: MONOGENIC & polygenic inheritance (Genetics), DISEASE risk factors, TYPE 2 diabetes, EAST Asians, GENOME-wide association studies

Genetic Contributors of Efficacy and Adverse Metabolic Effects of Chlorthalidone in African Americans from the Genetics of Hypertension Associated Treatments (GenHAT) Study.

Authors: Armstrong, Nicole D.¹ (AUTHOR) nmda@uab.edu, Srinivasasainagendra, Vinodh² (AUTHOR) vinodh@uab.edu, Chekka, Lakshmi Manasa S.³ (AUTHOR) lakshmimanasa.chekka@fda.hhs.gov, Nguyen, Nam H. K.⁴ (AUTHOR) namnguyen@ufl.edu, Nahid, Noor A.⁴ (AUTHOR) n.nahid@ufl.edu, Jones, Alana C.^1,5 (AUTHOR) acjones@uab.edu, Tanner, Rikki M.¹ (AUTHOR) rmdeitz@uab.edu, Hidalgo, Bertha A.¹ (AUTHOR) bhidalgo@uab.edu, Limdi, Nita A.⁶ (AUTHOR) nlimdi@uabmc.edu, Claas, Steven A.⁷ (AUTHOR) steven.claas@uky.edu, Gong, Yan⁴ (AUTHOR) gong@cop.ufl.edu, McDonough, Caitrin W.⁴ (AUTHOR) cmcdonough@cop.ufl.edu, Cooper-DeHoff, Rhonda M.^4,8 (AUTHOR) dehoff@cop.ufl.edu, Johnson, Julie A.^4,8 (AUTHOR) julie.johnson@ufl.edu, Tiwari, Hemant K.² (AUTHOR) htiwari@uab.edu, Arnett, Donna K.^7,9 (AUTHOR) donna.arnett@uky.edu, Irvin, Marguerite R.¹ (AUTHOR) irvinr@uab.edu

Source: Genes. Jul2022, Vol. 13 Issue 7, p1260-1260. 14p.

Subject Terms: *AFRICAN Americans, *HYPERTENSION, *BLOOD pressure, *DISEASE risk factors, CARDIOVASCULAR disease related mortality

Geographic Terms: UNITED States

Corin Missense Variants, Blood Pressure, and Hypertension in 11 322 Black Individuals: Insights From REGARDS and the Jackson Heart Study.

Authors: Parcha, Vibhu, Irvin, Marguerite R., Lange, Leslie A., Armstrong, Nicole D., Pampana, Akhil, Meyer, Mariah, Judd, Suzanne E., Arora, Garima, Arora, Pankaj

Source: Journal of the American Heart Association; 6/21/2022, Vol. 11 Issue 12, p1-20, 20p

Stroke genetics informs drug discovery and risk prediction across ancestries

Authors: Mishra, Aniket, Malik, Rainer, Hachiya, Tsuyoshi, Jürgenson, Tuuli, Namba, Shinichi, Posner, Daniel C., Kamanu, Frederick K., Koido, Masaru, Le Grand, Quentin, Shi, Mingyang, He, Yunye, Georgakis, Marios K., Caro, Ilana, Krebs, Kristi, Liaw, Yi-Ching, Vaura, Felix C., Lin, Kuang, Winsvold, Bendik Slagsvold, Srinivasasainagendra, Vinodh, Parodi, Livia, Bae, Hee-Joon, Chauhan, Ganesh, Chong, Michael R., Tomppo, Liisa, Akinyemi, Rufus, Roshchupkin, Gennady V., Habib, Naomi, Jee, Yon Ho, Thomassen, Jesper Qvist, Abedi, Vida, Cárcel-Márquez, Jara, Nygaard, Marianne, Leonard, Hampton L., Yang, Chaojie, Yonova-Doing, Ekaterina, Knol, Maria J., Lewis, Adam J., Judy, Renae L., Ago, Tetsuro, Amouyel, Philippe, Armstrong, Nicole D., Bakker, Mark K., Bartz, Traci M., Bennett, David A., Bis, Joshua C., Bordes, Constance, Børte, Sigrid, Cain, Anael, Ridker, Paul M., Cho, Kelly, Chen, Zhengming, Cruchaga, Carlos, Cole, John W., de Jager, Phil L., de Cid, Rafael, Endres, Matthias, Ferreira, Leslie E., Geerlings, Mirjam I., Gasca, Natalie C., Gudnason, Vilmundur, Hata, Jun, He, Jing, Heath, Alicia K., Ho, Yuk-Lam, Havulinna, Aki S., Hopewell, Jemma C., Hyacinth, Hyacinth I., Inouye, Michael, Jacob, Mina A., Jeon, Christina E., Jern, Christina, Kamouchi, Masahiro, Keene, Keith L., Kitazono, Takanari, Kittner, Steven J., Konuma, Takahiro, Kumar, Amit, Lacaze, Paul, Launer, Lenore J., Lee, Keon-Joo, Lepik, Kaido, Li, Jiang, Li, Liming, Manichaikul, Ani, Markus, Hugh S., Marston, Nicholas A., Meitinger, Thomas, Mitchell, Braxton D., Montellano, Felipe A., Morisaki, Takayuki, Mosley, Thomas H., Nalls, Mike A., Nordestgaard, Børge G., O’Donnell, Martin J., Okada, Yukinori, Onland-Moret, N. Charlotte, Ovbiagele, Bruce, Peters, Annette, Psaty, Bruce M., Rich, Stephen S., Rosand, Jonathan, Sabatine, Marc S., Sacco, Ralph L., Saleheen, Danish, Sandset, Else Charlotte, Salomaa, Veikko, Sargurupremraj, Muralidharan, Sasaki, Makoto, Satizabal, Claudia L., Schmidt, Carsten O., Shimizu, Atsushi, Smith, Nicholas L., Sloane, Kelly L., Sutoh, Yoichi, Sun, Yan V., Tanno, Kozo, Tiedt, Steffen, Tatlisumak, Turgut, Torres-Aguila, Nuria P., Tiwari, Hemant K., Trégouët, David-Alexandre, Trompet, Stella, Tuladhar, Anil Man, Tybjærg-Hansen, Anne, van Vugt, Marion, Vibo, Riina, Verma, Shefali S., Wiggins, Kerri L., Wennberg, Patrik, Woo, Daniel, Wilson, Peter W. F., Xu, Huichun, Yang, Qiong, Yoon, Kyungheon, Millwood, Iona Y., Gieger, Christian, Ninomiya, Toshiharu, Grabe, Hans J., Jukema, J. Wouter, Rissanen, Ina L., Strbian, Daniel, Kim, Young Jin, Chen, Pei-Hsin, Mayerhofer, Ernst, Howson, Joanna M. M., Irvin, Marguerite R., Adams, Hieab, Wassertheil-Smoller, Sylvia, Christensen, Kaare, Ikram, Mohammad A., Rundek, Tatjana, Worrall, Bradford B., Lathrop, G. Mark, Riaz, Moeen, Simonsick, Eleanor M., Kõrv, Janika, França, Paulo H. C., Zand, Ramin, Prasad, Kameshwar, Frikke-Schmidt, Ruth, de Leeuw, Frank-Erik, Liman, Thomas, Haeusler, Karl Georg, Ruigrok, Ynte M., Heuschmann, Peter Ulrich, Longstreth, W. T., Jung, Keum Ji, Bastarache, Lisa, Paré, Guillaume, Damrauer, Scott M., Chasman, Daniel I., Rotter, Jerome I., Anderson, Christopher D., Zwart, John-Anker, Niiranen, Teemu J., Fornage, Myriam, Liaw, Yung-Po, Seshadri, Sudha, Fernández-Cadenas, Israel, Walters, Robin G., Ruff, Christian T., Owolabi, Mayowa O., Huffman, Jennifer E., Milani, Lili, Kamatani, Yoichiro, Dichgans, Martin, Debette, Stephanie

Source: Nature; November 2022, Vol. 611 Issue: 7934 p115-123, 9p

Association of Transthyretin Val122Ile Variant With Incident Heart Failure Among Black Individuals.

Authors: Parcha, Vibhu¹, Malla, Gargya², Ivin, Marguerite R.², Armstrong, Nicole D.², Judd, Suzanne E.³, Lange, Leslie A.^4,5, Maurer, Mathew S.⁶, Levitan, Emily B.², Goyal, Parag⁷, Arora, Garima¹, Arora, Pankaj^1,8, parora@uabmc.edu

Source: JAMA: Journal of the American Medical Association; 4/12/2022, Vol. 327 Issue 14, p1368-1378, 11p

Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study.

Authors: Downie, Carolina G., Dimos, Sofia F., Bien, Stephanie A., Hu, Yao, Darst, Burcu F., Polfus, Linda M., Wang, Yujie, Wojcik, Genevieve L., Tao, Ran, Raffield, Laura M., Armstrong, Nicole D., Polikowsky, Hannah G., Below, Jennifer E., Correa, Adolfo, Irvin, Marguerite R., Rasmussen-Torvik, Laura J. F., Carlson, Christopher S., Phillips, Lawrence S., Liu, Simin, Pankow, James S.

Source: Diabetologia; Mar2022, Vol. 65 Issue 3, p477-489, 13p

Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke

Authors: Jaworek, Thomas, Xu, Huichun, Gaynor, Brady J., Cole, John W., Rannikmae, Kristiina, Stanne, Tara M., Tomppo, Liisa, Abedi, Vida, Amouyel, Philippe, Armstrong, Nicole D., Attia, John, Bell, Steven, Benavente, Oscar R., Boncoraglio, Giorgio B., Butterworth, Adam, Carcel-Marquez, Jara, Chen, Zhengming, Chong, Michael, Cruchaga, Carlos, Cushman, Mary, Danesh, John, Debette, Stéphanie, Duggan, David J., Durda, Jon Peter, Engstrom, Gunnar, Enzinger, Chris, Faul, Jessica D., Fecteau, Natalie S., Fernandez-Cadenas, Israel, Gieger, Christian, Giese, Anne-Katrin, Grewal, Raji P., Grittner, Ulrike, Havulinna, Aki S., Heitsch, Laura, Hochberg, Marc C., Holliday, Elizabeth, Hu, Jie, Ilinca, Andreea, Irvin, Marguerite R., Jackson, Rebecca D., Jacob, Mina A., Rabionet, Raquel, Jimenez-Conde, Jordi, Johnson, Julie A., Kamatani, Yoichiro, Kardia, Sharon L.R., Koido, Masaru, Kubo, Michiaki, Lange, Leslie, Lee, Jin-Moo, Lemmens, Robin, Levi, Christopher R., Li, Jiang, Li, Liming, Lin, Kuang, Lopez, Haley, Luke, Sothear, Maguire, Jane, McArdle, Patrick F., McDonough, Caitrin W., Meschia, James F., Metso, Tiina, Müller-Nurasyid, Martina, O'Connor, Timothy D., O'Donnell, Martin, Peddareddygari, Leema R., Pera, Joanna, Perry, James A., Peters, Annette, Putaala, Jukka, Ray, Debashree, Rexrode, Kathryn, Ribases, Marta, Rosand, Jonathan, Rothwell, Peter M., Rundek, Tatjana, Ryan, Kathleen A., Sacco, Ralph L., Salomaa, Veikko, Sanchez-Mora, Cristina, Schmidt, Reinhold, Sharma, Pankaj, Slowik, Agnieszka, Smith, Jennifer A., Smith, Nicholas L., Wassertheil-Smoller, Sylvia, Söderholm, Martin, Stine, O. Colin, Strbian, Daniel, Sudlow, Cathie L.M., Tatlisumak, Turgut, Terao, Chikashi, Thijs, Vincent, Torres-Aguila, Nuria P., Trégouët, David-Alexandre, Tuladhar, Anil M., Veldink, Jan H., Walters, Robin G., Weir, David R., Woo, Daniel, Worrall, Bradford B., Hong, Charles C., Ross, Owen A., Zand, Ramin, Leeuw, Frank-Erik de, Lindgren, Arne G., Pare, Guillaume, Anderson, Christopher D., Markus, Hugh S., Jern, Christina, Malik, Rainer, Dichgans, Martin, Mitchell, Braxton D., Kittner, Steven J.

Source: Neurology (Ovid); October 2022, Vol. 99 Issue: 16 pe1738-e1754, 17p

Genetic Contributors of Incident Stroke in 10,700 African Americans With Hypertension: A Meta-Analysis From the Genetics of Hypertension Associated Treatments and Reasons for Geographic and Racial Differences in Stroke Studies.

Authors: Armstrong, Nicole D., Srinivasasainagendra, Vinodh, Patki, Amit, Tanner, Rikki M., Hidalgo, Bertha A., Tiwari, Hemant K., Limdi, Nita A., Lange, Ethan M., Lange, Leslie A., Arnett, Donna K., Irvin, Marguerite R.

Source: Frontiers in Genetics; 12/21/2021, Vol. 12, p1-10, 10p

Subject Terms: EUGENICS, RACIAL differences, AFRICAN Americans, DISEASE risk factors, META-analysis, HYPERTENSION, MONOGENIC & polygenic inheritance (Genetics)

Higher Serum Urate Levels Are Associated With an Increased Risk for Sudden Cardiac Death.

Authors: Colantonio, Lisandro D., Reynolds, Richard J., Merriman, Tony R., Gaffo, Angelo, Singh, Jasvinder A., Plante, Timothy B., Chaudhary, Ninad S., Armstrong, Nicole D., Soliman, Elsayed Z., Curtis, Jeffrey R., Bridges Jr., S. Louis, Lang, Leslie, Howard, George, Safford, Monika M., Saag, Kenneth G., Muntner, Paul, Irvin, Marguerite Ryan

Source: Journal of Rheumatology; Nov2021, Vol. 48 Issue 11, p1745-1753, 9p